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Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA.

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_199161 Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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RefSeq Version NM_199161.3, 295821190
Length 531 bp
Structure linear
Update Date 17-APR-2013
Organism Homo sapiens (human)
Definition Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA.
Product serum amyloid A-1 protein preproprotein

Summary: This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012].

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

RefSeq NP_954630.1
CDS 41..409
Misc Feature(1)101..406
Exon (1)1..36
Gene Synonym:PIG4; SAA; SAA2; TP53I4
Exon (2)37..131
Gene Synonym:PIG4; SAA; SAA2; TP53I4
Exon (3)132..270
Gene Synonym:PIG4; SAA; SAA2; TP53I4
Exon (4)271..531
Gene Synonym:PIG4; SAA; SAA2; TP53I4
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Position Chain Variation Link
2+a, gdbSNP:2445166
5+a, gdbSNP:78359795
6+a, gdbSNP:189750793
32+a, gdbSNP:11545466
48+c, tdbSNP:11545470
49..50+c, tdbSNP:11545473
63+c, tdbSNP:11545474
109+a, gdbSNP:146330775
119+a, gdbSNP:139332456
166+a, gdbSNP:149926073
184+c, tdbSNP:144981113
249+c, tdbSNP:1136743
251+c, tdbSNP:11545468
256+c, tdbSNP:1136745
264+c, tdbSNP:1136747
270+c, gdbSNP:28720026
296+c, tdbSNP:1059559
299+a, tdbSNP:144465925
300+c, tdbSNP:1059560
301+a, tdbSNP:141113801
306+a, gdbSNP:2229338
309+a, gdbSNP:79681911
319+c, tdbSNP:15790
321+a, cdbSNP:150951768
322+a, gdbSNP:11545465
327+c, tdbSNP:145680768
328+a, gdbSNP:12218
341+a, gdbSNP:17850140
344+a, gdbSNP:1059567
355+g, tdbSNP:138257225
362..363+, aadbSNP:148453200
363+a, gdbSNP:1059571
380+c, tdbSNP:142961925
402+a, gdbSNP:61745680
439+c, tdbSNP:183981346
460+c, tdbSNP:11821600
513+g, tdbSNP:146642944
Gene SymbolSAA1
Gene SynonymPIG4; SAA; SAA2; TP53I4
Locus Map11p15.1
All Transcripts
RefSeq Accession Definition Stock Status Price Turnaround time Business Day Select
NM_000331 Homo sapiens serum amyloid A1 (SAA1), transcript variant 1, mRNA. In-stock $248.00 $199.00 10
NM_001178006 Homo sapiens serum amyloid A1 (SAA1), transcript variant 3, mRNA. In-stock $248.00 $199.00 10
NM_199161 Homo sapiens serum amyloid A1 (SAA1), transcript variant 2, mRNA. In-stock $248.00 $199.00 10
Title Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2 .
Author Srinivasan,S., Patke,S., Wang,Y., Ye,Z., Litt,J., Srivastava,S.K., Lopez,M.M., Kurouski,D., Lednev,I.K., Kane,R.S. and Colon,W.
Journal J. Biol. Chem. 288 (4), 2744-2755 (2013)
Title Serum amyloid a and C-reactive protein independently predict the recurrences of atrial fibrillation after cardioversion in patients with preserved left ventricular function .
Author Barassi,A., Pezzilli,R., Morselli-Labate,A.M., Lombardi,F., Belletti,S., Dogliotti,G., Corsi,M.M., Merlini,G. and Melzi d'Eril,G.V.
Journal Can J Cardiol 28 (5), 537-541 (2012)
Title Improved diagnostic accuracy of pancreatic diseases with a combination of various novel serum biomarkers--case control study from Manipal Teaching Hospital, Pokhara, Nepal .
Author Farooqui,M.S., Mittal,A., Poudel,B., Mall,S.K., Sathian,B., Tarique,M. and Farooqui,M.H.
Journal Asian Pac. J. Cancer Prev. 13 (5), 2171-2174 (2012)
Title Serum uric acid levels are associated with polymorphism in the SAA1 gene in Chinese subjects .
Author Xie,X., Ma,Y.T., Yang,Y.N., Li,X.M., Fu,Z.Y., Zheng,Y.Y., Ma,X., Chen,B.D., Liu,F., Huang,Y., Yu,Z.X. and Chen,Y.
Journal PLoS ONE 7 (6), E40263 (2012)
Title Human serum amyloid A protein. Complete amino acid sequence of a new variant .
Author Beach,C.M., De Beer,M.C., Sipe,J.D., Loose,L.D. and De Beer,F.C.
Journal Biochem. J. 282 (PT 2), 615-620 (1992)
Title The human acute-phase serum amyloid A gene family: structure, evolution and expression in hepatoma cells .
Author Betts,J.C., Edbrooke,M.R., Thakker,R.V. and Woo,P.
Journal Scand. J. Immunol. 34 (4), 471-482 (1991)
Title Serum amyloid A, an acute phase protein, inhibits platelet activation .
Author Zimlichman,S., Danon,A., Nathan,I., Mozes,G. and Shainkin-Kestenbaum,R.
Journal J. Lab. Clin. Med. 116 (2), 180-186 (1990)
Title Structure of a human serum amyloid A gene and modulation of its expression in transfected L cells .
Author Woo,P., Sipe,J., Dinarello,C.A. and Colten,H.R.
Journal J. Biol. Chem. 262 (32), 15790-15795 (1987)
Title Human serum amyloid A (SAA): biosynthesis and postsynthetic processing of preSAA and structural variants defined by complementary DNA .
Author Sipe,J.D., Colten,H.R., Goldberger,G., Edge,M.D., Tack,B.F., Cohen,A.S. and Whitehead,A.S.
Journal Biochemistry 24 (12), 2931-2936 (1985)
Title The complete amino acid sequence of an amyloid fibril protein AA1 of unusual size (64 residues) .
Author Sletten,K., Husby,G. and Natvig,J.B.
Journal Biochem. Biophys. Res. Commun. 69 (1), 19-25 (1976)

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