Reviewed (UniProtKB/Swiss-Prot)

  • THAT AND
  • THAT AND

Reviewed (UniProtKB/Swiss-Prot)





Protein Names | ProteinIDs  | Organism | Gene Names  | GeneID | Genome Annotation(Ensembl) |  Protein Sequence | 
General annotation |  References | Order
Protein Names
Recommended name:
 Alpha-2C adrenergic receptor;
Alternative name(s):
 Alpha-2C adrenoreceptor
Protein IDs
(Accession numbers)
UniProtKB
 Q60476
NCBI RefSeq
Organism
Latin Name/
(Common Name)
Cavia porcellus (Guinea pig).
Taxonomic Identifier (NCBI)
 10141
Gene Names
 ADRA2C
GeneID
Genome
Annotation (Ensembl)
Protein Sequence
 
SEQUENCE   455 AA;  49351 MW;  6B657D247FF8A3F4 CRC64;
MASPALAAAL LAAEGPNASG AGEGGGGVNA SGAVWGPPPS QYSAGAVAGL AAVVGFLIVF
TVVGNVLVVI AVLTSRALRA PQNLFLVSLA SADILVATLV MPFSLANELM AYWYFGQVWC
GVYLALDVLF CTSSIVHLCA ISLDRYWSVT QAVEYNLKRT PRRVKATIVA VWLISAIISF
PPLVSFYRQP DGAAYPRCGL NDETWYILSS CIGSFFAPCL IMGLVYARIY RVAKLRTRTL
SEKRGPAGPE GESPTTENGL GAAAAAAAGE NGHCAPPRAD VEPDESSAAE RRRRRGALRR
GARQREAGVE APGPGLGSAA ADPGALSVSR SPGPGGRLSR ASSRSVEFFL SRRRRARSSV
CRRKVAQARE KRFTFVLAVV MGVFVLCWFP FFFSYSLYGI CREACQLPTP LFKFFFWIGY
CNSSLNPVIY TIFNQDFRRS FKHILFRRRR RGFRQ
General annotation
Function
 Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins.
Cofactor
Subunit structure
Subcellular location

Cell membrane; Multi-pass membrane protein.
Tissue specificity
Induction
Domain
Post-translational modification

Involvement in disease

References

  • "Heterologous expression of the cloned guinea pig alpha 2A, alpha 2B, and alpha 2C adrenoceptor subtypes. Radioligand binding and functional coupling to a cAMP-responsive reporter gene.", Svensson S.P., Bailey T.J., Porter A.C., Richman J.G., Regan J.W., Biochem. Pharmacol. 51:291-300(1996)., PubMed:8573196 DOI:10.1016/0006-2952(95)02179-5

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Protein Domain Databases
InterPro

IPR017452, GPCR_Rhodpsn_supfam.

IPR002233, Adrnrgc_rcpt.

IPR000735, Adren_rcpt_A2C.

IPR000276, 7TM_GPCR_Rhodpsn.
Gene3D
PANTHER
Pfam

PF00001, 7tm_1; 1.
PRINTS

PR00237, GPCRRHODOPSN.

PR00560, ADRENRGCA2CR.

PR01103, ADRENERGICR.
SUPFAM
PROSITE

PS00237, G_PROTEIN_RECEP_F1_1; 1.

PS50262, G_PROTEIN_RECEP_F1_2; 1.
3D Structure
Database (PDB)
Entry
Method
Resolution (A)
Chain
Positions
PDBsum
Sequence
Annotation
Feature key
Position(s)
Length
Description
Site1271Implicated in ligand binding (By similarity).
Site2101Implicated in catechol agonist binding and receptor activation (By similarity).
Site2141Implicated in catechol agonist binding and receptor activation (By similarity).
Glycosylation site171N-linked (GlcNAc...) (Potential).
Glycosylation site291N-linked (GlcNAc...) (Potential).
Transmembrane region48 - 7225Helical; Name=1; (By similarity).
Transmembrane region85 - 11026Helical; Name=2; (By similarity).
Transmembrane region121 - 14323Helical; Name=3; (By similarity).
Transmembrane region165 - 18723Helical; Name=4; (By similarity).
Transmembrane region204 - 22724Helical; Name=5; (By similarity).
Transmembrane region377 - 40024Helical; Name=6; (By similarity).
Transmembrane region414 - 43421Helical; Name=7; (By similarity).
Polypeptide chain1 - 455455Alpha-2C adrenergic receptor.
Topological domain1 - 4747Extracellular (By similarity).
Topological domain73 - 8412Cytoplasmic (By similarity).
Topological domain111 - 12010Extracellular (By similarity).
Topological domain144 - 16421Cytoplasmic (By similarity).
Topological domain188 - 20316Extracellular (By similarity).
Topological domain228 - 376149Cytoplasmic (By similarity).
Topological domain401 - 41313Extracellular (By similarity).
Topological domain435 - 45521Cytoplasmic (By similarity).
Disulfide bond120 - 19879By similarity.
Protein-protein
Interaction
Databases
DIP
IntAct
MINT
STRING
Binary Interactions
With
Entry
#Exp.
IntAct
Enzyme and Pathway Databases
Pathway
Interaction DB
Reactome
Phylogenomic Database
HOVERGEN

HBG106962
InParanoid
OMA
OrthoDB
Proteomics
Database (PRIDE)
Comparative
Toxicogenomics
Database (CTD)
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