Cardiac Ion Channel Panel Profiling Human ether-a-gogo-related (hERG) ion channel has a major role during the repolarization of the cardiac action potential, and it is well established that blockade of this ion channel can lead to potentially lethal arrhythmias. Several drugs had to be withdrawn from the market due to their hERG cardiac toxicities. As a result, hERG (IKr) pre-clinical safety data is an essential part of any investigational new drug submission recommended in FDA ICH S7B. Recently, investigations suggest that non-hERG cardiac ion channels are also involved in cardiac toxicity. GenScript offers cardiac ion channel panel for your safety risk assessment of drug candidates. For all the listed cardiac ion channels, GenScript has developed manual patch clamp assays. For the most important ion channel, hERG, GenScript also offers higher throughput solutions to detect the hERG blockers in early drug discovery. | | | Promotion (Valid through 11/30/2011)
Don’t Miss Your FREE Cardiac Ion Channel Test! | Screening Platforms: Platform | Instrument | Throughput | Comment | | | Low | Electrophysiological assay; gold standard. | | QPatch 16 | Medium | Electrophysiological assay | | FLIPRTetra?, FlexStation® 3, EnVison®, PHERAstar Plus | High | Cell-based functional assay | | TopCount® | High | Receptor binding assay | | Cardiac Ion Channel Panel Receptor/Channel | Function | Manual | QPatch 16 | Fluorescence | Radioligand | | hERG (hKv11.1) | Delayed rectifier potassium current | Yes | Yes | Yes | Yes | | hKv1.5 | Delayed rectifier potassium current | Yes | | | | | hKv4.2 | Transient outward potassium current | Yes | | | | | hNav1.5 | Sodium current | Yes | | Yes | |
| | | Quotations and Ordering:  To request a quotation, please download and complete the quotation form and send it back by email or fax.
- For manual patch clamp platform, please download the
 ;
- For automated patch clamp platform, please download the ;
- For fluorescence-based platform, please download the ;
- For radioligand-based platform, please download the ;
To order, please send the completed Quotation Form to us by email or fax with a formal PO (Purchase Order) or credit card information. You can also submit PO/credit card information by phone or via our Secure Online Messaging System. Our customer service representatives are available 24 hours a day, Monday through Friday to assist you.  | Email: bioassay@genscript.com |  | Phone: 1-877-436-7274 (Toll-Free), 1-732-885-9188 |  | Fax: 1-732-210-0262, 1-732-885-5878 | | |
