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Fibrotic Disease Models
 With a revolutionary technology for imaging and quantification of fibrosis

Fibrotic diseases are progressive chronic diseases which contribute to about 45% of death in developed countries. To date effective and safe therapies are very limited and treatment of fibrosis remains a largely unmet medical need. To facilitate the discovery of anti-fibrosis drugs, GenScript has established expertise in providing fibrotic disease models (liver, lung, and kidney) that are validated with clinical-grade drugs and analyzed with comprehensive endpoints. Our revolutionary new technology provides accurate quantification and characterization of fibrosis (both collagen fibers and structure) by Second Harmonic Generation (SHG) and label-free Two Photon Excitation (TPE) fluorescence. Fibrotic disease models webinar »


Imaging and Quantification of Fibrosis


SHG imaging of
CCl4-induced liver fibrosis

Segmental analysis of
Bleomycin-induced pulmonary fibrosis

Key Features:

Fibrotic Disease Models Available at GenScript

Several experimental models of fibrosis are available for preclinical testing for anti-fibrosis drug candidates. GenScript has established expertise in fibrotic disease models for liver, lung and kidney. Biochemical and histopathological endpoints that mimic fibrotic diseases in human, defined for each model below, are measured to determine efficacy of therapeutic being tested.

Model Model induction Related clinical conditions Animal species Histological endpoints Other endpoints
Liver (Hepatic) Fibrosis Injection of CCl4 Hepatotoxin-induced liver fibrosis Mouse
  • Staining-free, non-destructive detection of fibrosis
  • H&E staining
  • Sirius red staining
  • Masson’s trichrome staining
  • IHC for myofibroblasts, macrophages, etc
  • Score of fibrosis
  • Quantitative analysis of images
  • Serum biochemistry for organ functions
  • Hydroxyproline assay
  • Biomarker profiling by RT-qPCR
  • Fibrotic organ coefficient
BDL surgery Cholestasis-induced liver fibrosis (e.g. primary biliary cirrhosis) Rat
Mouse
Lung (Pulmonary) Fibrosis Intratracheal instillation of BLM Idiopathic pulmonary fibrosis Mouse
Kidney (Renal) Fibrosis UUO surgery for left kidney Interstitial renal fibrosis in chronic kidney diseases Rat
Mouse


Quotation and Ordering

 
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