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AMPK Profiling Service

AMPK Products

AMP-activated protein kinase (AMPK) plays a crucial role in cellular energy homeostasis and has emerged as intriguing drug targets for a variety of diseases, such as type 2 diabetes, hyperlipidemia, obesity, metabolic syndrome, and endocrine cancers. Metformin, a most common drug for diabetes, has been identified to function through indirect activation of AMPK. Now, scientists are eager to find new molecules which can directly stimulate AMPK. However, low activity and limited isoforms of AMPK protein in market is a large obstacle on their way to implement a high throughput screening (HTS).

To address the problems, GenScript has optimized mammalian and E. coli systems to offer the high quality AMPKs with highest activity and largest diversity in market. In addition to AMPKs, GenScript also offer AMPK substrate and antibodies to boost your in-house research.

With high-quality reagent and expertise on HTS, GenScript can offer your cost-effective solution for AMPK screening/profiling. Please download and complete the quotation form of AMPK Profiling Service and send to us for a quotation.

  • Showcases of HEK-293 System
  • AMPKs Products
  • Other Active Kinases

Specific Activity Comparison

  Specific Activity (nmol/min x mg)
Company GenScript Competitor I Competitor M Competitor C Competitor S
Expression System Mammalian Insect E. coli Insect Insect
AMPK (α1/β1/γ1) 26065 12900 6490 2755 737
AMPK (α1/β1/γ2) 2800 N/A N/A 897 980
AMPK (α1/β1/γ3) 3076 N/A N/A N/A 185
AMPK (α1/β2/γ1) 7774 N/A N/A N/A 390
AMPK (α1/β2/γ2) 1095 N/A N/A N/A N/A
AMPK (α2/β1/γ1) 1260 3206 2730 270 310
AMPK (α2/β1/γ2) 9900 N/A N/A N/A N/A
AMPK (α2/β1/γ3) 1201 N/A N/A N/A N/A
AMPK (α2/β2/γ1) 2345 N/A N/A N/A 280
AMPK (α2/β2/γ3) 1616 N/A N/A N/A N/A

Validation Assay

Activation of AMPK211   Inhibition of AMPK211
Name: AMPK (α2/β1/γ1)
Source: Human (HEK-293)
Substrate: SAMS peptide
Reference Compound:
  Activator: AMP
Measured Product: ADP
Detection Technique: HTRF
Name: AMPK (α2/β1/γ1)
Source: Human (HEK-293)
Substrate: SAMS peptide
Reference Compound:
  Inhibitor: Staurosporine
Measured Product: ADP
Detection Technique: HTRF

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