Mirror-Image Peptide Drug Discovery Service
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One significant problem facing peptide drug discovery is that the natural L-peptide leads often suffer rapid degradation from endogenous proteases. Mirror-image techniques provide a solution to this problem. The mirror-image D-forms of natural L-peptides are much more resistant to protease degradation. In addition, D-peptides also tend to be less immunogenic than their L-counterparts or even non-immunogenic. Nevertheless, the construction of D-peptide libraries can be prohibitively costly due to the large numbers of peptide requirement. GenScript constructs libraries with natural L-peptides, which are easily amendable. These libraries are then screened with synthetic mirror-image D-forms of the target proteins to identify potent leads that can guide the synthesis of their mirror-image D-peptides.
GenScript's mirror-image techniques provide a novel drug discovery service. First, the D-enantiomer of the target protein is chemically synthesized and used to isolate natural L-peptide leads from a phage display library or chemically synthesized peptide library. Then the D-enantiomers of the most potent leads are produced for optimization and clinical trials. Our service covers the entire early stage of peptide drug discovery, including library screening and functional assays.
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Applications:
- Determine epitope specificities of antibodies
- Characterize binding specificities of nucleic acid binding proteins
- Identify potential binding partners of a given macromolecule
- Optimize the stability of target proteins
- Apply for diagnostic and therapeutic use in living animals and humans
Service:
GenScript is currently the only company in the industry to provide mirror-image peptide screening services. Our service is highly flexible and can be tailored a variety of specific goals and situations:
1. Synthesis and purification of D-enantiomers of target protein
2. Synthesis and screening of L-peptide libraries
3. Construction and screening of L-peptide phage display libraries
4. Synthesis of D-enantiomers of isolated peptide leads
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Delivery Specifications:All protein mirror-image processes are subject to GenScript's stringent quality control. The final delivery package may vary dependent on customer’s order. We can deliver the following:
1. Chemically synthesized and purified D-enantiomers of the target protein
2. Libraries of chemically synthesized L-peptides
3. Libraries of L-peptide phage display
4. D-enantiomers of the isolated L-peptide leads
5. Functional characterization data of the leads (if applicable)
6. QC reports
Quotations and Ordering:
Please send quotation requests via our secure and convenient online messaging system or by email at order@genscript.fr. In the body of the message, please include the following:
1. The sequence of the protein
2. Any specific requests regarding the synthetic or phage-display library
3. Any specifications regarding the desired quantities and purity levels, if applicable
4. Any library screening requests, if applicable
5. Any request for potent D-peptide synthesis including specifications for quantity and purity, if applicable
6. Description of any functional characterization requirements, if applicable
Orders can be placed by email, phone, or fax with a formal PO (Purchase Order) or credit card. We recommend that you submit your protein sequence via our Secure Web Server.
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Quotation and Order by Email: order@genscript.fr
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Phones: 1-732-885-9188 (USA), 32-27-470-921 (Belgium)
Toll-free: 08-05-10-22-28 (France), 0800-369-254 (Switzerland) |
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Fax: 1-732-210-0262, 1-732-885-5878 |
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