Gene Symbol | Nptx2 |
Entrez Gene ID | 53324 |
Full Name | neuronal pentraxin 2 |
Synonyms | Narp,np2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nptx2 cDNA ORF clone
gRNAs
Gene Symbol | Nptx2 |
Entrez Gene ID | 53324 |
Full Name | neuronal pentraxin 2 |
Synonyms | Narp,np2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_016789.3 | NP_058069.1 | neuronal pentraxin-2 precursor |
Homo sapiens (human) | NPTX2 | NP_002514.1 |
Bos taurus (cattle) | NPTX2 | XP_002698264.1 |
NPTX2 | XP_001111081.2 | |
Rattus norvegicus (Norway rat) | Nptx2 | NP_001029371.1 |
Gallus gallus (chicken) | NPTX2 | XP_414750.3 |
Mus musculus (house mouse) | Nptx2 | NP_058069.1 |
Danio rerio (zebrafish) | nptx2a | NP_001103238.1 |
Danio rerio (zebrafish) | nptx2b | NP_001165055.1 |
Pan troglodytes (chimpanzee) | NPTX2 | XP_001136152.2 |
Canis lupus familiaris (dog) | NPTX2 | XP_003639131.1 |
Xenopus tropicalis (tropical clawed frog) | nptx2 | NP_001096304.1 |
Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures.
Chang AD, Vaidya PV, Retzbach EP, Chung SJ, Kim U, Baselice K, Maynard K, Stepanian A, Staley M, Xiao L, Blouin A, Han S, Lee J, Worley PF, Tamashiro KL, Hempstead BL, Martinowich K, Ann Wilson M, Baraban JM, Reti IM
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology(2017 Oct)
Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.
Muczynski V, Aym? G, Regnault V, Vasse M, Borgel D, Legendre P, Bazaa A, Harel A, Loubi?re C, Lenting PJ, Denis CV, Christophe OD
Blood129(17)2443-2454(2017 04)
NPTX2 and cognitive dysfunction in Alzheimer's Disease.
Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF
eLife6(2017 Mar)
Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
Pelkey KA, Barksdale E, Craig MT, Yuan X, Sukumaran M, Vargish GA, Mitchell RM, Wyeth MS, Petralia RS, Chittajallu R, Karlsson RM, Cameron HA, Murata Y, Colonnese MT, Worley PF, McBain CJ
Neuron85(6)1257-72(2015 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PTX2 was identified PTX2 as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
Title: Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions.
Early postnatal NPTX2(-/-)/NPTXR(-/-) mice exhibit delayed circuit maturation with a prolonged critical period permissive for giant depolarizing potentials
Title: Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons.
Nptx2 contributes to the development of L-DOPA-induced dyskinesia.
Title: Gene expression analyses identify Narp contribution in the development of L-DOPA-induced dyskinesia.
These findings suggest that Narp, and perhaps other neuronal pentraxins, also regulate inflammation in the nervous system.
Title: Selective expression of Narp in primary nociceptive neurons: role in microglia/macrophage activation following nerve injury.
Narp KO mice do not have abnormal reactivity to novelty but show deficits in adapting behavior to reflect the updated value of a stimulus.
Title: Narp knockout mice show normal reactivity to novelty but attenuated recovery from neophobia.
The following Nptx2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nptx2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22625 | |
Clone ID Related Accession (Same CDS sequence) | NM_016789.3 | |
Accession Version | NM_016789.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1290bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | neuronal pentraxin-2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK134806.1, DV649643.1 and AC164119.4. On Mar 19, 2008 this sequence version replaced NM_016789.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC026054.1, AK134806.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCTGGCGC TGCTGACCGT CGGCGTGGCG CTCGCCGTGG CCGCCGGACG AGCCCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_058069.1 |
CDS | 178..1467 |
Translation |
Target ORF information:
Target ORF information:
|
NM_016789.3 |
1 | ATGCTGGCGC TGCTGACCGT CGGCGTGGCG CTCGCCGTGG CCGCCGGACG AGCCCAGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures. |
Complex formation with pentraxin-2 regulates factor X plasma levels and macrophage interactions. |
NPTX2 and cognitive dysfunction in Alzheimer's Disease. |
Pentraxins coordinate excitatory synapse maturation and circuit integration of parvalbumin interneurons. |