FGF23 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	FGF23
Entrez Gene ID	8074
Full Name	fibroblast growth factor 23
Synonyms	ADHR,FGFN,HPDR2,HYPF,PHPTC
General protein information	Preferred Names fibroblast growth factor 23 Names fibroblast growth factor 23 phosphatonin tumor-derived hypophosphatemia inducing factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12p13.32
Summary	This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013].
Disorder MIM:	605380
Disorder Html:	Hypophosphatemic rickets, autosomal dominant, 193100 (3); Osteomalacia, tumor-induced (1); Tumoral calcinosis, hyperphosphatemic, familial, 211900 (3)

mRNA and Protein(s)

mRNA Protein Name

NM_020638.3 NP_065689.1 fibroblast growth factor 23 precursor

NM_020638.2 NP_065689.1 fibroblast growth factor 23 precursor
Pathways from BioSystems

mRNA	Protein	Name
NM_020638.3	NP_065689.1	fibroblast growth factor 23 precursor
NM_020638.2	NP_065689.1	fibroblast growth factor 23 precursor

Homologies

Homo sapiens (human)	FGF23	NP_065689.1
Bos taurus (cattle)	FGF23	XP_002687926.1
Mus musculus (house mouse)	Fgf23	NP_073148.1
Xenopus tropicalis (tropical clawed frog)	fgf23.1	XP_002940347.2
Canis lupus familiaris (dog)	FGF23	XP_854580.1
Danio rerio (zebrafish)	fgf23	NP_001009564.2
Pan troglodytes (chimpanzee)	FGF23	XP_001157070.1
	FGF23	XP_001099705.1
Rattus norvegicus (Norway rat)	Fgf23	NP_570110.1
Gallus gallus (chicken)	FGF23	XP_425663.1
Xenopus tropicalis (tropical clawed frog)	LOC100496800	XP_002940351.1

Gene Ontology

The following FGF23 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF23 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20032	NM_020638.3 Latest version!	Homo sapiens fibroblast growth factor 23 (FGF23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu20032	NM_020638.2	Homo sapiens fibroblast growth factor 23 (FGF23), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGF23 ( NM_020638.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_065689.1 Homo sapiens fibroblast growth factor 23 (FGF23), mRNA.

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CloneID	OHu20032
Clone ID Related Accession (Same CDS sequence)	NM_020638.3 , NM_020638.2
Accession Version	NM_020638.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	fibroblast growth factor 23 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF263537.1 and AB047858.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_020638.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB047858.1, AF263537.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159607, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000237837.2/ ENSP00000237837.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTTGGGGG CCCGCCTCAG GCTCTGGGTC TGTGCCTTGT GCAGCGTCTG CAGCATGAGC 
GTCCTCAGAG CCTATCCCAA TGCCTCCCCA CTGCTCGGCT CCAGCTGGGG TGGCCTGATC 
CACCTGTACA CAGCCACAGC CAGGAACAGC TACCACCTGC AGATCCACAA GAATGGCCAT 
GTGGATGGCG CACCCCATCA GACCATCTAC AGTGCCCTGA TGATCAGATC AGAGGATGCT 
GGCTTTGTGG TGATTACAGG TGTGATGAGC AGAAGATACC TCTGCATGGA TTTCAGAGGC 
AACATTTTTG GATCACACTA TTTCGACCCG GAGAACTGCA GGTTCCAACA CCAGACGCTG 
GAAAACGGGT ACGACGTCTA CCACTCTCCT CAGTATCACT TCCTGGTCAG TCTGGGCCGG 
GCGAAGAGAG CCTTCCTGCC AGGCATGAAC CCACCCCCGT ACTCCCAGTT CCTGTCCCGG 
AGGAACGAGA TCCCCCTAAT TCACTTCAAC ACCCCCATAC CACGGCGGCA CACCCGGAGC 
GCCGAGGACG ACTCGGAGCG GGACCCCCTG AACGTGCTGA AGCCCCGGGC CCGGATGACC 
CCGGCCCCGG CCTCCTGTTC ACAGGAGCTC CCGAGCGCCG AGGACAACAG CCCGATGGCC 
AGTGACCCAT TAGGGGTGGT CAGGGGCGGT CGAGTGAACA CGCACGCTGG GGGAACGGGC 
CCGGAAGGCT GCCGCCCCTT CGCCAAGTTC ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065689.1
CDS	131..886
Translation	MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI

Target ORF information:

RefSeq Version	NM_020638.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 23 (FGF23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020638.3

ORF Insert Sequence:

ATGTTGGGGG CCCGCCTCAG GCTCTGGGTC TGTGCCTTGT GCAGCGTCTG CAGCATGAGC 
GTCCTCAGAG CCTATCCCAA TGCCTCCCCA CTGCTCGGCT CCAGCTGGGG TGGCCTGATC 
CACCTGTACA CAGCCACAGC CAGGAACAGC TACCACCTGC AGATCCACAA GAATGGCCAT 
GTGGATGGCG CACCCCATCA GACCATCTAC AGTGCCCTGA TGATCAGATC AGAGGATGCT 
GGCTTTGTGG TGATTACAGG TGTGATGAGC AGAAGATACC TCTGCATGGA TTTCAGAGGC 
AACATTTTTG GATCACACTA TTTCGACCCG GAGAACTGCA GGTTCCAACA CCAGACGCTG 
GAAAACGGGT ACGACGTCTA CCACTCTCCT CAGTATCACT TCCTGGTCAG TCTGGGCCGG 
GCGAAGAGAG CCTTCCTGCC AGGCATGAAC CCACCCCCGT ACTCCCAGTT CCTGTCCCGG 
AGGAACGAGA TCCCCCTAAT TCACTTCAAC ACCCCCATAC CACGGCGGCA CACCCGGAGC 
GCCGAGGACG ACTCGGAGCG GGACCCCCTG AACGTGCTGA AGCCCCGGGC CCGGATGACC 
CCGGCCCCGG CCTCCTGTTC ACAGGAGCTC CCGAGCGCCG AGGACAACAG CCCGATGGCC 
AGTGACCCAT TAGGGGTGGT CAGGGGCGGT CGAGTGAACA CGCACGCTGG GGGAACGGGC 
CCGGAAGGCT GCCGCCCCTT CGCCAAGTTC ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF23 ( NM_020638.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_065689.1 Homo sapiens fibroblast growth factor 23 (FGF23), mRNA.

Price & Availability↑

CloneID	OHu20032
Clone ID Related Accession (Same CDS sequence)	NM_020638.3 , NM_020638.2
Accession Version	NM_020638.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 756bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-02
Organism	Homo sapiens(human)
Product	fibroblast growth factor 23 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF263537.1 and AB047858.1. This sequence is a reference standard in the RefSeqGene project. On Aug 1, 2001 this sequence version replaced NM_020638.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB047858.1, BC069333.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2159607, SAMEA2162895 [ECO:0000348] ##Evidence-Data-END##

ATGTTGGGGG CCCGCCTCAG GCTCTGGGTC TGTGCCTTGT GCAGCGTCTG CAGCATGAGC 
GTCCTCAGAG CCTATCCCAA TGCCTCCCCA CTGCTCGGCT CCAGCTGGGG TGGCCTGATC 
CACCTGTACA CAGCCACAGC CAGGAACAGC TACCACCTGC AGATCCACAA GAATGGCCAT 
GTGGATGGCG CACCCCATCA GACCATCTAC AGTGCCCTGA TGATCAGATC AGAGGATGCT 
GGCTTTGTGG TGATTACAGG TGTGATGAGC AGAAGATACC TCTGCATGGA TTTCAGAGGC 
AACATTTTTG GATCACACTA TTTCGACCCG GAGAACTGCA GGTTCCAACA CCAGACGCTG 
GAAAACGGGT ACGACGTCTA CCACTCTCCT CAGTATCACT TCCTGGTCAG TCTGGGCCGG 
GCGAAGAGAG CCTTCCTGCC AGGCATGAAC CCACCCCCGT ACTCCCAGTT CCTGTCCCGG 
AGGAACGAGA TCCCCCTAAT TCACTTCAAC ACCCCCATAC CACGGCGGCA CACCCGGAGC 
GCCGAGGACG ACTCGGAGCG GGACCCCCTG AACGTGCTGA AGCCCCGGGC CCGGATGACC 
CCGGCCCCGG CCTCCTGTTC ACAGGAGCTC CCGAGCGCCG AGGACAACAG CCCGATGGCC 
AGTGACCCAT TAGGGGTGGT CAGGGGCGGT CGAGTGAACA CGCACGCTGG GGGAACGGGC 
CCGGAAGGCT GCCGCCCCTT CGCCAAGTTC ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_065689.1
CDS	147..902
Translation	MLGARLRLWVCALCSVCSMSVLRAYPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVMSRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPYSQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPMASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFI

Target ORF information:

RefSeq Version	NM_020638.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 23 (FGF23), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_020638.2

ORF Insert Sequence:

ATGTTGGGGG CCCGCCTCAG GCTCTGGGTC TGTGCCTTGT GCAGCGTCTG CAGCATGAGC 
GTCCTCAGAG CCTATCCCAA TGCCTCCCCA CTGCTCGGCT CCAGCTGGGG TGGCCTGATC 
CACCTGTACA CAGCCACAGC CAGGAACAGC TACCACCTGC AGATCCACAA GAATGGCCAT 
GTGGATGGCG CACCCCATCA GACCATCTAC AGTGCCCTGA TGATCAGATC AGAGGATGCT 
GGCTTTGTGG TGATTACAGG TGTGATGAGC AGAAGATACC TCTGCATGGA TTTCAGAGGC 
AACATTTTTG GATCACACTA TTTCGACCCG GAGAACTGCA GGTTCCAACA CCAGACGCTG 
GAAAACGGGT ACGACGTCTA CCACTCTCCT CAGTATCACT TCCTGGTCAG TCTGGGCCGG 
GCGAAGAGAG CCTTCCTGCC AGGCATGAAC CCACCCCCGT ACTCCCAGTT CCTGTCCCGG 
AGGAACGAGA TCCCCCTAAT TCACTTCAAC ACCCCCATAC CACGGCGGCA CACCCGGAGC 
GCCGAGGACG ACTCGGAGCG GGACCCCCTG AACGTGCTGA AGCCCCGGGC CCGGATGACC 
CCGGCCCCGG CCTCCTGTTC ACAGGAGCTC CCGAGCGCCG AGGACAACAG CCCGATGGCC 
AGTGACCCAT TAGGGGTGGT CAGGGGCGGT CGAGTGAACA CGCACGCTGG GGGAACGGGC 
CCGGAAGGCT GCCGCCCCTT CGCCAAGTTC ATCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

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FGF23 cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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