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IL21 cDNA ORF clone, Bos taurus (cattle)

Gene Symbol IL21
Entrez Gene ID 378475
Full Name interleukin 21
Synonyms
General protein information
Preferred Names
interleukin-21
Names
interleukin-21
IL-21
Gene Type protein-coding
Organism Bos taurus (cattle)
Genome

17

Summary lac of sum
Disorder MIM:

Disorder Html:

mRNA and Protein(s)

mRNA Protein Name
NM_198832 NP_942129 interleukin-21 precursor

KEGG
bta04060 Cytokine-cytokine receptor interaction
bta04630 Jak-STAT signaling pathway
bta05321 Inflammatory bowel disease (IBD)


Homo sapiens (human) IL21 NP_068575.1
Pan troglodytes (chimpanzee) IL21 XP_526677.2
Macaca mulatta (Rhesus monkey) IL21 XP_001103613.1
Canis lupus familiaris (dog) IL21 NP_001003347.1
Bos taurus (cattle) IL21 NP_942129.1
Mus musculus (house mouse) Il21 NP_068554.1
Rattus norvegicus (Norway rat) Il21 NP_001102413.1

Component

ID Name Evidence
GO:0005576 extracellular region IEA
GO:0005615 extracellular space IEA

Function

ID Name Evidence
GO:0005125 cytokine activity IEA
GO:0005134 interleukin-2 receptor binding IEA

Process

ID Name Evidence
GO:0002729 positive regulation of natural killer cell cytokine production IEA
GO:0006955 immune response IEA
GO:0032733 positive regulation of interleukin-10 production IEA
GO:0032740 positive regulation of interleukin-17 production IEA
GO:0032825 positive regulation of natural killer cell differentiation IEA
GO:0042102 positive regulation of T cell proliferation IEA
GO:0045078 positive regulation of interferon-gamma biosynthetic process IEA
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity IEA
GO:0048469 cell maturation IEA

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following IL21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OBa41827 NM_198832 Bos taurus interleukin 21 (IL21), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $149.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).


CloneID OBa41827
Accession Version NM_198832.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 459bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 04-JAN-2015
Organism Bos taurus (cattle)
Product interleukin-21 precursor
Comment PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB073021.1. ##Evidence-Data-START## Transcript exon combination :: AB073021.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02403648, SAMN02403656 [ECO:0000348] ##Evidence-Data-END##

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61
121
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421
ATGCGGTGGC CGGGGAACAT GGAGAGAATA GTCATTTGCC TGATGGTCAT CTTCTCTGGG 
ACAGTGGCCC ATAAGTCAAG CTCCCAAGGG CAAGATCGCC TCTTTATTAG ACTGCGTCAA
CTTATAGACA TTGTTGATCA GCTGAAAAAC TATGTGAATG ACTTGGATCC TGAATTTCTG
CCAGCTCCAG AAGATGTAAA GAGACACTGT GAGCGGTCAG CTTTTTCATG TTTTCAGAAG
GTTCAACTAA AGTCAGCAAA TAATGGAGAC AACGAAAAGA TAATCAACAT ATTAACTAAA
CAGCTGAAGA GGAAACTACC TGCCACAAAT ACAGGGAGAA GACAGAAACA TGAAGTAACA
TGTCCTTCTT GTGATTCTTA TGAGAAAAAA CCACCCAAGG AATACCTAGA AAGACTGAAA
TCACTCATCC AAAAGATGAT TCATCAGCAT CTGTCCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_942129.1
CDS1..459
Misc Feature(1)121..441(+)
Translation
Position Chain Variation Link
151 151 c, t dbSNP:208550114
331 331 a, g dbSNP:207687222

Target ORF information:

RefSeq Version NM_198832
Organism Bos taurus (cattle)
Definition Bos taurus interleukin 21 (IL21), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_198832

ORF Insert Sequence:

1
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121
181
241
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361
421
ATGCGGTGGC CGGGGAACAT GGAGAGAATA GTCATTTGCC TGATGGTCAT CTTCTCTGGG 
ACAGTGGCCC ATAAGTCAAG CTCCCAAGGG CAAGATCGCC TCTTTATTAG ACTGCGTCAA
CTTATAGACA TTGTTGATCA GCTGAAAAAC TATGTGAATG ACTTGGATCC TGAATTTCTG
CCAGCTCCAG AAGATGTAAA GAGACACTGT GAGCGGTCAG CTTTTTCATG TTTTCAGAAG
GTTCAACTAA AGTCAGCAAA TAATGGAGAC AACGAAAAGA TAATCAACAT ATTAACTAAA
CAGCTGAAGA GGAAACTACC TGCCACAAAT ACAGGGAGAA GACAGAAACA TGAAGTAACA
TGTCCTTCTT GTGATTCTTA TGAGAAAAAA CCACCCAAGG AATACCTAGA AAGACTGAAA
TCACTCATCC AAAAGATGAT TCATCAGCAT CTGTCCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

A whole-genome assembly of the domestic cow, Bos taurus
Genome Biol. 10 (4), R42 (2009)
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Marcais G, Roberts M, Subramanian P, Yorke JA and Salzberg SL.


book

Cloning, expression, and tissue distribution of bovine interleukin-21
Vet. Immunol. Immunopathol. 95 (1-2), 73-80 (2003)
Muneta Y, Kikuma R, Yoshihara K and Mori Y.


 
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