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KCNE3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol KCNE3
Entrez Gene ID 10008
Full Name potassium channel, voltage gated subfamily E regulatory beta subunit 3
Synonyms HOKPP, HYPP, MiRP2
General protein information
Preferred Names
potassium voltage-gated channel subfamily E member 3
Names
potassium voltage-gated channel subfamily E member 3
minK-related peptide 2
potassium channel subunit beta MiRP2
voltage-gated K+ channel subunit MIRP2
minimum potassium ion channel-related peptide 2
cardiac voltage-gated potassium channel accessory subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q13.4

Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. A missense mutation in this gene is associated with hypokalemic periodic paralysis. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604433

Disorder Html: Brugada syndrome 6, 613119 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_011544713 XP_011543015 potassium voltage-gated channel subfamily E member 3 isoform X1
NM_005472 NP_005463 potassium voltage-gated channel subfamily E member 3



Homo sapiens (human) KCNE3 NP_005463.1
Pan troglodytes (chimpanzee) KCNE3 XP_003952024.1
Macaca mulatta (Rhesus monkey) LOC718902 XP_001115704.2
Canis lupus familiaris (dog) KCNE3 XP_005633571.1
Bos taurus (cattle) KCNE3 XP_005201011.1
Mus musculus (house mouse) Kcne3 NP_001177879.1
Rattus norvegicus (Norway rat) Kcne3 NP_071571.1
Gallus gallus (chicken) KCNE3 XP_425664.1
Xenopus (Silurana) tropicalis (western clawed frog) kcne3 XP_002942498.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KCNE3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNE3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu63600 XM_011544713 PREDICTED: Homo sapiens potassium channel, voltage gated subfamily E regulatory beta subunit 3 (KCNE3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu17923
NM_005472 Homo sapiens potassium channel, voltage gated subfamily E regulatory beta subunit 3 (KCNE3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu63600
Clone ID Related Accession (Same CDS sequence) XM_011544713
Accession Version XM_011544713.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 444bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product potassium voltage-gated channel subfamily E member 3 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_167190.2) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
ATGCACAGGG TCGCAGCGCT TGGGCCACCC TCGGTCAGAG GGCGCCGTGT CCAGCGAGCA 
AACGGGCGCC CCGGAGCCTT GCTGAGAGGC AGAGCTTCTA CCGAGTCTTC CCCCACCTCA
ATCCCTGTTG CTATGGAGAC TACCAATGGA ACGGAGACCT GGTATGAGAG CCTGCATGCC
GTGCTGAAGG CTCTAAATGC CACTCTTCAC AGCAATTTGC TCTGCCGGCC AGGGCCAGGG
CTGGGGCCAG ACAACCAGAC TGAAGAGAGG CGGGCCAGCC TACCTGGCCG TGATGACAAC
TCCTACATGT ACATTCTCTT TGTCATGTTT CTATTTGCTG TAACTGTGGG CAGCCTCATC
CTGGGATACA CCCGCTCCCG CAAAGTGGAC AAGCGTAGTG ACCCCTATCA TGTGTATATC
AAGAACCGTG TGTCTATGAT CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011543015.1
CDS69..512
Misc Feature(1)309..>491(+)
Translation

Target ORF information:

RefSeq Version XM_011544713
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens potassium channel, voltage gated subfamily E regulatory beta subunit 3 (KCNE3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011544713

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGCACAGGG TCGCAGCGCT TGGGCCACCC TCGGTCAGAG GGCGCCGTGT CCAGCGAGCA 
AACGGGCGCC CCGGAGCCTT GCTGAGAGGC AGAGCTTCTA CCGAGTCTTC CCCCACCTCA
ATCCCTGTTG CTATGGAGAC TACCAATGGA ACGGAGACCT GGTATGAGAG CCTGCATGCC
GTGCTGAAGG CTCTAAATGC CACTCTTCAC AGCAATTTGC TCTGCCGGCC AGGGCCAGGG
CTGGGGCCAG ACAACCAGAC TGAAGAGAGG CGGGCCAGCC TACCTGGCCG TGATGACAAC
TCCTACATGT ACATTCTCTT TGTCATGTTT CTATTTGCTG TAACTGTGGG CAGCCTCATC
CTGGGATACA CCCGCTCCCG CAAAGTGGAC AAGCGTAGTG ACCCCTATCA TGTGTATATC
AAGAACCGTG TGTCTATGAT CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17923
Clone ID Related Accession (Same CDS sequence) NM_005472
Accession Version NM_005472.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 312bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product potassium voltage-gated channel subfamily E member 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DR006135.1, BC032235.1 and AP001372.4. This sequence is a reference standard in the RefSeqGene project. On Sep 28, 2006 this sequence version replaced gi:62388886. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA902931.1, CR936625.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGGAGACTA CCAATGGAAC GGAGACCTGG TATGAGAGCC TGCATGCCGT GCTGAAGGCT 
CTAAATGCCA CTCTTCACAG CAATTTGCTC TGCCGGCCAG GGCCAGGGCT GGGGCCAGAC
AACCAGACTG AAGAGAGGCG GGCCAGCCTA CCTGGCCGTG ATGACAACTC CTACATGTAC
ATTCTCTTTG TCATGTTTCT ATTTGCTGTA ACTGTGGGCA GCCTCATCCT GGGATACACC
CGCTCCCGCA AAGTGGACAA GCGTAGTGAC CCCTATCATG TGTATATCAA GAACCGTGTG
TCTATGATCT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005463.1
CDS348..659
Misc Feature(1)306..308(+)
Misc Feature(2)456..>638(+)
Misc Feature(3)519..581(+)
Exon (1)1..158
Gene:KCNE3
Gene Synonym:
Exon (2)159..307
Gene:KCNE3
Gene Synonym:
Exon (3)308..3070
Gene:KCNE3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005472
Organism Homo sapiens (human)
Definition Homo sapiens potassium channel, voltage gated subfamily E regulatory beta subunit 3 (KCNE3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005472

ORF Insert Sequence:

1
61
121
181
241
301
ATGGAGACTA CCAATGGAAC GGAGACCTGG TATGAGAGCC TGCATGCCGT GCTGAAGGCT 
CTAAATGCCA CTCTTCACAG CAATTTGCTC TGCCGGCCAG GGCCAGGGCT GGGGCCAGAC
AACCAGACTG AAGAGAGGCG GGCCAGCCTA CCTGGCCGTG ATGACAACTC CTACATGTAC
ATTCTCTTTG TCATGTTTCT ATTTGCTGTA ACTGTGGGCA GCCTCATCCT GGGATACACC
CGCTCCCGCA AAGTGGACAA GCGTAGTGAC CCCTATCATG TGTATATCAA GAACCGTGTG
TCTATGATCT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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