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MRLN myoregulin [Homo sapiens (human)]

Gene Symbol MRLN
Entrez Gene ID 100507027
Full Name myoregulin
Synonyms LINC00948, M1, MLN, MUSER1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

Summary This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]. lac of sum
Disorder MIM:

616246

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu81121 XM_011539100 PREDICTED: Homo sapiens myoregulin (MRLN), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu81121 NM_001304731 Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00
OHu81121 NM_001304732 Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu81121D
Sequence Information ORF Nucleotide Sequence (Length: 141bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product myoregulin isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_030059.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTTA G
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqXP_011537402.1
CDS254..394
Translation
Position Chain Variation Link
20 20 c, g dbSNP:561189533
46 46 c, t dbSNP:150128274
61 61 c, g dbSNP:191952542
78 78 a, t dbSNP:187144156
83 83 -, c dbSNP:34526216
98 98 c, t dbSNP:764399908
99 99 a, g dbSNP:546876182
126 126 a, t dbSNP:373107656
145 145 a, g dbSNP:149511602
165 165 a, c dbSNP:187274435
171 171 c, t dbSNP:534568932
177 177 c, g dbSNP:184077216
186 186 a, g dbSNP:552887363
196 196 a, g dbSNP:531155053
201 201 c, t dbSNP:138065987
238 238 c, t dbSNP:777887177
239 239 a, g dbSNP:756119003
243 243 g, t dbSNP:77788409
254 254 a, g dbSNP:563405627
255 255 c, t dbSNP:550292166
284 284 a, g dbSNP:781039410
290 290 a, t dbSNP:542021027
335 335 a, g dbSNP:574531009
360 360 c, t dbSNP:559517905
372 372 c, t dbSNP:145022139
423 423 c, g dbSNP:531853712

Target ORF information:

RefSeq Version XM_011539100
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens myoregulin (MRLN), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
XM_011539100

ORF Insert Sequence:

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTTA G

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu81121D
Sequence Information ORF Nucleotide Sequence (Length: 141bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 02-JUN-2015
Organism Homo sapiens (human)
Product myoregulin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB019391.1 and BG210823.1. On Feb 6, 2015 this sequence version replaced gi:333108229. Summary: This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]. Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AB019391.1, AF086308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTTA G
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001291660.1
CDS217..357
Misc Feature(1)106..108(+)
Misc Feature(2)280..342(+)
Exon (1)1..92
Gene:MRLN
Gene Synonym:
Exon (2)93..196
Gene:MRLN
Gene Synonym:
Exon (3)197..427
Gene:MRLN
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, t dbSNP:150128274
35 35 c, g dbSNP:191952542
52 52 a, t dbSNP:187144156
57 57 -, c dbSNP:34526216
72 72 c, t dbSNP:764399908
73 73 a, g dbSNP:546876182
108 108 a, g dbSNP:149511602
128 128 a, c dbSNP:187274435
134 134 c, t dbSNP:534568932
140 140 c, g dbSNP:184077216
149 149 a, g dbSNP:552887363
159 159 a, g dbSNP:531155053
164 164 c, t dbSNP:138065987
201 201 c, t dbSNP:777887177
202 202 a, g dbSNP:756119003
206 206 g, t dbSNP:77788409
217 217 a, g dbSNP:563405627
218 218 c, t dbSNP:550292166
247 247 a, g dbSNP:781039410
253 253 a, t dbSNP:542021027
298 298 a, g dbSNP:574531009
323 323 c, t dbSNP:559517905
335 335 c, t dbSNP:145022139
386 386 c, g dbSNP:531853712

Target ORF information:

RefSeq Version NM_001304731
Organism Homo sapiens (human)
Definition Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001304731

ORF Insert Sequence:

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTTA G

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu81121D
Sequence Information ORF Nucleotide Sequence (Length: 141bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 02-JUN-2015
Organism Homo sapiens (human)
Product myoregulin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB019391.1, BM021470.1 and BG210823.1. On Feb 6, 2015 this sequence version replaced gi:333108237. Summary: This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BM021470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTTA G
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001291661.1
CDS339..479
Misc Feature(1)228..230(+)
Misc Feature(2)402..464(+)
Exon (1)1..92
Gene:MRLN
Gene Synonym:
Exon (2)93..214
Gene:MRLN
Gene Synonym:
Exon (3)215..318
Gene:MRLN
Gene Synonym:
Exon (4)319..549
Gene:MRLN
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, t dbSNP:150128274
35 35 c, g dbSNP:191952542
52 52 a, t dbSNP:187144156
57 57 -, c dbSNP:34526216
72 72 c, t dbSNP:764399908
73 73 a, g dbSNP:546876182
102 102 c, t dbSNP:61863111
105 105 g, t dbSNP:187774105
110 110 c, t dbSNP:182647794
111 111 a, g dbSNP:191652577
148 148 c, t dbSNP:368906636
160 160 c, g dbSNP:780740954
171 171 a, c dbSNP:568043382
182 182 c, t dbSNP:543961853
199 199 a, g dbSNP:547016794
230 230 a, g dbSNP:149511602
250 250 a, c dbSNP:187274435
256 256 c, t dbSNP:534568932
262 262 c, g dbSNP:184077216
271 271 a, g dbSNP:552887363
281 281 a, g dbSNP:531155053
286 286 c, t dbSNP:138065987
323 323 c, t dbSNP:777887177
324 324 a, g dbSNP:756119003
328 328 g, t dbSNP:77788409
339 339 a, g dbSNP:563405627
340 340 c, t dbSNP:550292166
369 369 a, g dbSNP:781039410
375 375 a, t dbSNP:542021027
420 420 a, g dbSNP:574531009
445 445 c, t dbSNP:559517905
457 457 c, t dbSNP:145022139
508 508 c, g dbSNP:531853712

Target ORF information:

RefSeq Version NM_001304732
Organism Homo sapiens (human)
Definition Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001304732

ORF Insert Sequence:

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTTA G

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.