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MRLN cDNA ORF clone, Homo sapiens (human)

Gene Symbol MRLN
Entrez Gene ID 100507027
Full Name myoregulin
Synonyms LINC00948, M1, MLN, MUSER1
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

Summary This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]. lac of sum
Disorder MIM:

616246

Disorder Html:





The following MRLN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRLN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu81121 XM_011539100 PREDICTED: Homo sapiens myoregulin (MRLN), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu81121 NM_001304731 Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu81121 NM_001304732 Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00

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CloneID OHu81121
Accession Version XM_011539100.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 141bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product myoregulin isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_030059.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_011537402.1
CDS254..394
Translation
Position Chain Variation Link
20 20 c, g dbSNP:561189533
46 46 c, t dbSNP:150128274
61 61 c, g dbSNP:191952542
78 78 a, t dbSNP:187144156
83 83 -, c dbSNP:34526216
98 98 c, t dbSNP:764399908
99 99 a, g dbSNP:546876182
126 126 a, t dbSNP:373107656
145 145 a, g dbSNP:149511602
165 165 a, c dbSNP:187274435
171 171 c, t dbSNP:534568932
177 177 c, g dbSNP:184077216
186 186 a, g dbSNP:552887363
196 196 a, g dbSNP:531155053
201 201 c, t dbSNP:138065987
238 238 c, t dbSNP:777887177
239 239 a, g dbSNP:756119003
243 243 g, t dbSNP:77788409
254 254 a, g dbSNP:563405627
255 255 c, t dbSNP:550292166
284 284 a, g dbSNP:781039410
290 290 a, t dbSNP:542021027
335 335 a, g dbSNP:574531009
360 360 c, t dbSNP:559517905
372 372 c, t dbSNP:145022139
423 423 c, g dbSNP:531853712

Target ORF information:

RefSeq Version XM_011539100
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens myoregulin (MRLN), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011539100

ORF Insert Sequence:

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu81121
Accession Version NM_001304731.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 141bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 02-JUN-2015
Organism Homo sapiens (human)
Product myoregulin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB019391.1 and BG210823.1. On Feb 6, 2015 this sequence version replaced gi:333108229. Summary: This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]. Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AB019391.1, AF086308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001291660.1
CDS217..357
Misc Feature(1)106..108(+)
Misc Feature(2)280..342(+)
Exon (1)1..92
Gene:MRLN
Gene Synonym:
Exon (2)93..196
Gene:MRLN
Gene Synonym:
Exon (3)197..427
Gene:MRLN
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, t dbSNP:150128274
35 35 c, g dbSNP:191952542
52 52 a, t dbSNP:187144156
57 57 -, c dbSNP:34526216
72 72 c, t dbSNP:764399908
73 73 a, g dbSNP:546876182
108 108 a, g dbSNP:149511602
128 128 a, c dbSNP:187274435
134 134 c, t dbSNP:534568932
140 140 c, g dbSNP:184077216
149 149 a, g dbSNP:552887363
159 159 a, g dbSNP:531155053
164 164 c, t dbSNP:138065987
201 201 c, t dbSNP:777887177
202 202 a, g dbSNP:756119003
206 206 g, t dbSNP:77788409
217 217 a, g dbSNP:563405627
218 218 c, t dbSNP:550292166
247 247 a, g dbSNP:781039410
253 253 a, t dbSNP:542021027
298 298 a, g dbSNP:574531009
323 323 c, t dbSNP:559517905
335 335 c, t dbSNP:145022139
386 386 c, g dbSNP:531853712

Target ORF information:

RefSeq Version NM_001304731
Organism Homo sapiens (human)
Definition Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001304731

ORF Insert Sequence:

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu81121
Accession Version NM_001304732.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 141bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 02-JUN-2015
Organism Homo sapiens (human)
Product myoregulin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB019391.1, BM021470.1 and BG210823.1. On Feb 6, 2015 this sequence version replaced gi:333108237. Summary: This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015]. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BM021470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001291661.1
CDS339..479
Misc Feature(1)228..230(+)
Misc Feature(2)402..464(+)
Exon (1)1..92
Gene:MRLN
Gene Synonym:
Exon (2)93..214
Gene:MRLN
Gene Synonym:
Exon (3)215..318
Gene:MRLN
Gene Synonym:
Exon (4)319..549
Gene:MRLN
Gene Synonym:
Translation
Position Chain Variation Link
20 20 c, t dbSNP:150128274
35 35 c, g dbSNP:191952542
52 52 a, t dbSNP:187144156
57 57 -, c dbSNP:34526216
72 72 c, t dbSNP:764399908
73 73 a, g dbSNP:546876182
102 102 c, t dbSNP:61863111
105 105 g, t dbSNP:187774105
110 110 c, t dbSNP:182647794
111 111 a, g dbSNP:191652577
148 148 c, t dbSNP:368906636
160 160 c, g dbSNP:780740954
171 171 a, c dbSNP:568043382
182 182 c, t dbSNP:543961853
199 199 a, g dbSNP:547016794
230 230 a, g dbSNP:149511602
250 250 a, c dbSNP:187274435
256 256 c, t dbSNP:534568932
262 262 c, g dbSNP:184077216
271 271 a, g dbSNP:552887363
281 281 a, g dbSNP:531155053
286 286 c, t dbSNP:138065987
323 323 c, t dbSNP:777887177
324 324 a, g dbSNP:756119003
328 328 g, t dbSNP:77788409
339 339 a, g dbSNP:563405627
340 340 c, t dbSNP:550292166
369 369 a, g dbSNP:781039410
375 375 a, t dbSNP:542021027
420 420 a, g dbSNP:574531009
445 445 c, t dbSNP:559517905
457 457 c, t dbSNP:145022139
508 508 c, g dbSNP:531853712

Target ORF information:

RefSeq Version NM_001304732
Organism Homo sapiens (human)
Definition Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001304732

ORF Insert Sequence:

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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