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CDK3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CDK3
Entrez Gene ID 1018
Full Name cyclin-dependent kinase 3
General protein information
Preferred Names
cyclin-dependent kinase 3
Names
cyclin-dependent kinase 3
cell division protein kinase 3
NP_001249.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q25.1

Summary This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

123828


mRNA and Protein(s)

mRNA Protein Name
NM_001258 NP_001249 cyclin-dependent kinase 3


Homo sapiens (human) CDK3 NP_001249.1
Pan troglodytes (chimpanzee) CDK3 XP_523720.2
Macaca mulatta (Rhesus monkey) CDK3 XP_001102314.2
Canis lupus familiaris (dog) CDK3 XP_540442.3
Bos taurus (cattle) CDK3 NP_001092648.1
Gallus gallus (chicken) CDK3 NP_001075175.2


The following CDK3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu31943 NM_001258 Homo sapiens cyclin-dependent kinase 3 (CDK3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $216.30
$309.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu31943
Clone ID Related Accession (Same CDS sequence) NM_001258
Accession Version NM_001258.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 918bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase 3
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB455174.1, X66357.1, BU784937.1, AU146328.1 and BX098771.1. On Jan 9, 2008 this sequence version replaced gi:4557438. Sequence Note: A downstream translational start codon is selected for this RefSeq based on its better conservation in mammalian species and on a strong Kozak signal. An upstream in-frame start codon is also present but has a weaker Kozak signal and is poorly conserved. Use of the upstream start codon would result in a protein that is 20 aa longer at the N-terminus. Leaky scanning by ribosomes may allow translation initiation at the downstream start codon. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## ##Evidence-Data-START## CDS exon combination :: AK097104.1, X66357.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGATATGT TCCAGAAGGT AGAGAAGATC GGAGAGGGCA CCTATGGGGT GGTGTACAAG 
GCCAAGAACA GGGAGACAGG GCAGCTGGTG GCCCTGAAGA AGATCAGACT GGATTTGGAG
ATGGAGGGGG TCCCAAGCAC TGCCATCAGG GAGATCTCGC TGCTCAAGGA ACTGAAGCAC
CCCAACATCG TCCGACTGCT GGACGTGGTG CACAACGAGA GGAAGCTCTA TCTGGTGTTT
GAGTTCCTCA GCCAGGACCT GAAGAAGTAC ATGGACTCCA CCCCAGGCTC AGAGCTCCCC
CTGCACCTCA TCAAGAGCTA CCTCTTCCAG CTGCTGCAGG GGGTGAGTTT CTGCCACTCA
CATCGGGTCA TCCACCGAGA CCTGAAGCCC CAGAACCTGC TCATCAATGA GTTGGGTGCC
ATCAAGCTGG CTGACTTCGG CCTGGCTCGC GCCTTCGGGG TGCCCCTGCG CACCTACACC
CATGAGGTGG TGACACTGTG GTATCGCGCC CCCGAGATTC TCTTGGGCAG CAAGTTCTAT
ACCACAGCTG TGGATATCTG GAGCATTGGT TGCATCTTTG CAGAGATGGT GACTCGAAAA
GCCCTGTTTC CTGGTGACTC TGAGATTGAC CAGCTCTTTC GTATCTTTCG TATGCTGGGG
ACACCCAGCG AAGACACATG GCCCGGGGTC ACCCAGCTGC CTGACTATAA GGGCAGCTTC
CCTAAGTGGA CCAGGAAGGG ACTGGAAGAG ATTGTGCCCA ATCTGGAGCC AGAGGGCAGG
GACCTGCTCA TGCAACTCCT GCAGTATGAC CCCAGCCAGC GGATCACAGC CAAGACTGCC
CTGGCCCACC CGTACTTCTC ATCCCCTGAG CCCTCCCCAG CTGCCCGCCA GTATGTGCTG
CAGCGATTCC GCCATTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001249.1
CDS77..994
Misc Feature(1)77..955(+)
Misc Feature(2)83..934(+)
Misc Feature(3)104..694(+)
Misc Feature(4)104..511(+)
Misc Feature(5)116..118(+)
Misc Feature(6)119..121(+)
Misc Feature(7)131..133(+)
Misc Feature(8)185..910(+)
Misc Feature(9)224..694(+)
Misc Feature(10)506..577(+)
Misc Feature(11)554..556(+)
Misc Feature(12)695..697(+)
Exon (1)1..62
Gene:CDK3
Gene Synonym:
Exon (2)63..192
Gene:CDK3
Gene Synonym:
Exon (3)193..270
Gene:CDK3
Gene Synonym:
Exon (4)271..391
Gene:CDK3
Gene Synonym:
Exon (5)392..562
Gene:CDK3
Gene Synonym:
Exon (6)563..664
Gene:CDK3
Gene Synonym:
Exon (7)665..868
Gene:CDK3
Gene Synonym:
Exon (8)869..1570
Gene:CDK3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001258
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase 3 (CDK3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001258

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGATATGT TCCAGAAGGT AGAGAAGATC GGAGAGGGCA CCTATGGGGT GGTGTACAAG 
GCCAAGAACA GGGAGACAGG GCAGCTGGTG GCCCTGAAGA AGATCAGACT GGATTTGGAG
ATGGAGGGGG TCCCAAGCAC TGCCATCAGG GAGATCTCGC TGCTCAAGGA ACTGAAGCAC
CCCAACATCG TCCGACTGCT GGACGTGGTG CACAACGAGA GGAAGCTCTA TCTGGTGTTT
GAGTTCCTCA GCCAGGACCT GAAGAAGTAC ATGGACTCCA CCCCAGGCTC AGAGCTCCCC
CTGCACCTCA TCAAGAGCTA CCTCTTCCAG CTGCTGCAGG GGGTGAGTTT CTGCCACTCA
CATCGGGTCA TCCACCGAGA CCTGAAGCCC CAGAACCTGC TCATCAATGA GTTGGGTGCC
ATCAAGCTGG CTGACTTCGG CCTGGCTCGC GCCTTCGGGG TGCCCCTGCG CACCTACACC
CATGAGGTGG TGACACTGTG GTATCGCGCC CCCGAGATTC TCTTGGGCAG CAAGTTCTAT
ACCACAGCTG TGGATATCTG GAGCATTGGT TGCATCTTTG CAGAGATGGT GACTCGAAAA
GCCCTGTTTC CTGGTGACTC TGAGATTGAC CAGCTCTTTC GTATCTTTCG TATGCTGGGG
ACACCCAGCG AAGACACATG GCCCGGGGTC ACCCAGCTGC CTGACTATAA GGGCAGCTTC
CCTAAGTGGA CCAGGAAGGG ACTGGAAGAG ATTGTGCCCA ATCTGGAGCC AGAGGGCAGG
GACCTGCTCA TGCAACTCCT GCAGTATGAC CCCAGCCAGC GGATCACAGC CAAGACTGCC
CTGGCCCACC CGTACTTCTC ATCCCCTGAG CCCTCCCCAG CTGCCCGCCA GTATGTGCTG
CAGCGATTCC GCCATTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The retroviral cyclin of walleye dermal sarcoma virus binds cyclin-dependent kinases 3 and 8
Virology 409 (2), 299-307 (2011)
Brewster CD, Birkenheuer CH, Vogt MB, Quackenbush SL and Rovnak J.


book

Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation
Cancer Res. 68 (18), 7650-7660 (2008)
Zheng D, Cho YY, Lau AT, Zhang J, Ma WY, Bode AM and Dong Z.


book

Cyclin C/cdk3 promotes Rb-dependent G0 exit
Cell 117 (2), 239-251 (2004)
Ren S and Rollins BJ.


book

Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4
J. Virol. 76 (15), 7724-7735 (2002)
Schang LM, Bantly A and Schaffer PA.


book

ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl
Biochim. Biophys. Acta 1574 (2), 157-163 (2002)
Sato H, Nishimoto I and Matsuoka M.


book

Suppression of apoptosis by dominant negative mutants of cyclin-dependent protein kinases
J. Biol. Chem. 271 (17), 10205-10209 (1996)
Meikrantz W and Schlegel R.


book

Phorbol ester inhibits the phosphorylation of the retinoblastoma protein without suppressing cyclin D-associated kinase in vascular smooth muscle cells
J. Biol. Chem. 271 (14), 8345-8351 (1996)
Sasaguri T, Ishida A, Kosaka C, Nojima H and Ogata J.


book

Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer
Cancer Res. 55 (6), 1199-1205 (1995)
Bullrich F, MacLachlan TK, Sang N, Druck T, Veronese ML, Allen SL, Chiorazzi N, Koff A, Heubner K and Croce CM.


book

Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2
Cell 75 (4), 791-803 (1993)
Gyuris J, Golemis E, Chertkov H and Brent R.


book

A family of human cdc2-related protein kinases
EMBO J. 11 (8), 2909-2917 (1992)
Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E and Tsai LH.


 
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