||ORF Nucleotide Sequence (Length: 918bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||cyclin-dependent kinase 3
||VALIDATED REFSEQ: This record has undergone validation or
preliminary review. The reference sequence was derived from
DB455174.1, X66357.1, BU784937.1, AU146328.1 and BX098771.1.
On Jan 9, 2008 this sequence version replaced gi:4557438.
Summary: This gene encodes a member of the cyclin-dependent protein
kinase family. The protein promotes entry into S phase, in part by
activating members of the E2F family of transcription factors. The
protein also associates with cyclin C and phosphorylates the
retinoblastoma 1 protein to promote exit from G0. [provided by
RefSeq, Jul 2008].
Sequence Note: A downstream translational start codon is selected
for this RefSeq based on its better conservation in mammalian
species and on a strong Kozak signal. An upstream in-frame start
codon is also present but has a weaker Kozak signal and is poorly
conserved. Use of the upstream start codon would result in a
protein that is 20 aa longer at the N-terminus. Leaky scanning by
ribosomes may allow translation initiation at the downstream start
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
is not conserved
CDS exon combination :: AK097104.1, X66357.1 [ECO:0000331]
RNAseq introns :: single sample supports all introns
SAMEA1968968, SAMEA2148093 [ECO:0000348]
COMPLETENESS: complete on the 3' end.