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CDK3 cyclin-dependent kinase 3 [Homo sapiens (human)]

Gene Symbol CDK3
Entrez Gene ID 1018
Full Name cyclin-dependent kinase 3
Synonyms
General protein information
Preferred Names
cyclin-dependent kinase 3
Names
cyclin-dependent kinase 3
cell division protein kinase 3
NP_001249.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q25.1

Summary This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

123828

Disorder Html:





The following CDK3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDK3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu31943 NM_001258 Homo sapiens cyclin-dependent kinase 3 (CDK3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $309

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu31943
Accession Version NM_001258.2
Sequence Information ORF Nucleotide Sequence (Length: 918bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase 3
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB455174.1, X66357.1, BU784937.1, AU146328.1 and BX098771.1. On Jan 9, 2008 this sequence version replaced gi:4557438. Summary: This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008]. Sequence Note: A downstream translational start codon is selected for this RefSeq based on its better conservation in mammalian species and on a strong Kozak signal. An upstream in-frame start codon is also present but has a weaker Kozak signal and is poorly conserved. Use of the upstream start codon would result in a protein that is 20 aa longer at the N-terminus. Leaky scanning by ribosomes may allow translation initiation at the downstream start codon. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## ##Evidence-Data-START## CDS exon combination :: AK097104.1, X66357.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGATATGT TCCAGAAGGT AGAGAAGATC GGAGAGGGCA CCTATGGGGT GGTGTACAAG 
GCCAAGAACA GGGAGACAGG GCAGCTGGTG GCCCTGAAGA AGATCAGACT GGATTTGGAG
ATGGAGGGGG TCCCAAGCAC TGCCATCAGG GAGATCTCGC TGCTCAAGGA ACTGAAGCAC
CCCAACATCG TCCGACTGCT GGACGTGGTG CACAACGAGA GGAAGCTCTA TCTGGTGTTT
GAGTTCCTCA GCCAGGACCT GAAGAAGTAC ATGGACTCCA CCCCAGGCTC AGAGCTCCCC
CTGCACCTCA TCAAGAGCTA CCTCTTCCAG CTGCTGCAGG GGGTGAGTTT CTGCCACTCA
CATCGGGTCA TCCACCGAGA CCTGAAGCCC CAGAACCTGC TCATCAATGA GTTGGGTGCC
ATCAAGCTGG CTGACTTCGG CCTGGCTCGC GCCTTCGGGG TGCCCCTGCG CACCTACACC
CATGAGGTGG TGACACTGTG GTATCGCGCC CCCGAGATTC TCTTGGGCAG CAAGTTCTAT
ACCACAGCTG TGGATATCTG GAGCATTGGT TGCATCTTTG CAGAGATGGT GACTCGAAAA
GCCCTGTTTC CTGGTGACTC TGAGATTGAC CAGCTCTTTC GTATCTTTCG TATGCTGGGG
ACACCCAGCG AAGACACATG GCCCGGGGTC ACCCAGCTGC CTGACTATAA GGGCAGCTTC
CCTAAGTGGA CCAGGAAGGG ACTGGAAGAG ATTGTGCCCA ATCTGGAGCC AGAGGGCAGG
GACCTGCTCA TGCAACTCCT GCAGTATGAC CCCAGCCAGC GGATCACAGC CAAGACTGCC
CTGGCCCACC CGTACTTCTC ATCCCCTGAG CCCTCCCCAG CTGCCCGCCA GTATGTGCTG
CAGCGATTCC GCCATTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001249.1
CDS77..994
Misc Feature(1)77..955(+)
Misc Feature(2)83..934(+)
Misc Feature(3)104..694(+)
Misc Feature(4)104..511(+)
Misc Feature(5)116..118(+)
Misc Feature(6)119..121(+)
Misc Feature(7)131..133(+)
Misc Feature(8)185..910(+)
Misc Feature(9)224..694(+)
Misc Feature(10)506..577(+)
Misc Feature(11)554..556(+)
Misc Feature(12)695..697(+)
Exon (1)1..62
Gene:CDK3
Gene Synonym:
Exon (2)63..192
Gene:CDK3
Gene Synonym:
Exon (3)193..270
Gene:CDK3
Gene Synonym:
Exon (4)271..391
Gene:CDK3
Gene Synonym:
Exon (5)392..562
Gene:CDK3
Gene Synonym:
Exon (6)563..664
Gene:CDK3
Gene Synonym:
Exon (7)665..868
Gene:CDK3
Gene Synonym:
Exon (8)869..1570
Gene:CDK3
Gene Synonym:
Translation
Position Chain Variation Link
13 13 c, t dbSNP:575466954
14 14 a, g dbSNP:544179820
66 66 g, t dbSNP:765170684
83 83 a, g dbSNP:750515867
85 85 a, g dbSNP:759038608
89 89 c, t dbSNP:780675488
99 99 a, c dbSNP:577105547
106 106 c, g, t dbSNP:201970325
118 118 c, g dbSNP:755248959
130 130 a, g dbSNP:780930058
136 136 a, g dbSNP:747690055
137 137 a, g dbSNP:769361969
139 139 c, t dbSNP:144487684
166 166 a, g dbSNP:148459625
172 172 -, gaa dbSNP:545204098
172 172 a, g dbSNP:770899084
181 181 c, g dbSNP:774253511
190 190 c, t dbSNP:201517026
203 203 a, g dbSNP:267605054
205 205 c, g dbSNP:745731017
206 206 c, g dbSNP:772030472
207 207 g, t dbSNP:61742972
207 207 -, t dbSNP:749185546
208 208 c, t dbSNP:775212671
214 214 c, t dbSNP:760515455
225 225 a, g dbSNP:142601065
234 234 -, cg dbSNP:534910354
234 234 c, t dbSNP:770199924
235 235 a, g dbSNP:773510637
244 244 -, g dbSNP:553417800
256 256 c, t dbSNP:763130017
261 261 a, c dbSNP:766526964
265 265 c, t dbSNP:200587883
266 266 a, g dbSNP:201723925
268 268 c, t dbSNP:150589656
270 270 a, g dbSNP:753067780
283 283 a, g, t dbSNP:534113059
285 285 g, t dbSNP:547553625
286 286 a, g, t dbSNP:567520898
288 288 -, aca dbSNP:774077788
289 289 c, t dbSNP:141186503
292 292 c, t dbSNP:556171163
293 293 a, g dbSNP:140567861
295 295 c, g dbSNP:144506173
307 307 c, t dbSNP:771254581
313 313 a, g dbSNP:778770257
330 330 a, g dbSNP:536521071
335 335 a, c dbSNP:774332704
337 337 a, g dbSNP:759655147
341 341 a, t dbSNP:747891051
346 346 c, t dbSNP:767964507
352 352 c, t dbSNP:776003784
355 355 c, t dbSNP:761027879
357 357 c, t dbSNP:764397013
358 358 a, c dbSNP:754183853
364 364 c, t dbSNP:756946506
368 368 a, g dbSNP:764867113
370 370 a, g dbSNP:372288050
375 375 c, t dbSNP:267605055
376 376 c, t dbSNP:757867913
387 387 c, t dbSNP:779860792
388 388 c, g dbSNP:746925159
396 396 a, g dbSNP:779004517
398 398 c, g dbSNP:746058055
414 414 a, c dbSNP:772166842
415 415 -, g dbSNP:760154229
417 417 a, g dbSNP:780226863
418 418 g, t dbSNP:747090635
419 419 g, t dbSNP:769212297
426 426 a, t dbSNP:777067823
430 430 a, c dbSNP:762171036
432 432 a, g dbSNP:770156329
440 440 c, t dbSNP:201685548
441 441 a, g dbSNP:762715989
442 442 g, t dbSNP:765915980
447 447 c, g, t dbSNP:34918446
453 453 a, g dbSNP:369742590
457 457 c, t dbSNP:201794034
464 464 c, t dbSNP:752611765
467 467 a, c dbSNP:373239489
473 473 c, t dbSNP:558068161
478 478 c, t dbSNP:777571429
488 488 c, g, t dbSNP:142329959
493 493 a, t dbSNP:780129446
496 496 c, t dbSNP:747107316
506 506 g, t dbSNP:768656670
514 514 c, t dbSNP:144754110
515 515 a, g dbSNP:748605731
520 520 a, g dbSNP:377464628
524 524 c, t dbSNP:369829842
526 526 c, t dbSNP:773664890
532 532 c, t dbSNP:763221782
533 533 a, g dbSNP:368861061
536 536 a, g dbSNP:145748425
538 538 a, g dbSNP:759118252
539 539 c, t dbSNP:148982467
547 547 c, t dbSNP:374525420
549 549 a, c, t dbSNP:201655552
550 550 c, g dbSNP:763937816
555 555 c, g, t dbSNP:753726718
562 562 g, t dbSNP:766594851
563 563 g, t dbSNP:775210941
576 576 a, g dbSNP:540948291
579 579 a, t dbSNP:760094955
581 581 c, t dbSNP:764108595
583 583 c, t dbSNP:61747000
584 584 a, g, t dbSNP:761700729
589 589 c, t dbSNP:374751140
595 595 g, t dbSNP:376616847
597 597 c, t dbSNP:767721527
599 599 c, t dbSNP:752878231
604 604 c, t dbSNP:756088442
610 610 c, g dbSNP:778345034
619 619 a, c dbSNP:749715451
630 630 a, c, g dbSNP:765907594
642 642 c, t dbSNP:779466474
644 644 a, g dbSNP:746233942
652 652 c, t dbSNP:542699103
659 659 a, g dbSNP:775227568
671 671 c, t dbSNP:200505631
672 672 a, g dbSNP:758771724
678 678 c, t dbSNP:779790633
682 682 a, g dbSNP:556210327
690 690 c, g dbSNP:768334124
697 697 c, t dbSNP:780608638
708 708 a, g, t dbSNP:112568448
716 716 c, t dbSNP:769781129
717 717 a, g, t dbSNP:34670267
718 718 c, t dbSNP:112384462
725 725 c, t dbSNP:372096923
727 727 a, t dbSNP:775801283
735 735 a, g dbSNP:760852282
738 738 c, t dbSNP:764342540
745 745 c, t dbSNP:753926548
746 746 a, g dbSNP:761930662
752 752 a, c dbSNP:765846044
753 753 c, t dbSNP:2069532
754 754 a, g dbSNP:748602091
756 756 a, g dbSNP:758857524
760 760 c, t dbSNP:141477491
761 761 a, g dbSNP:150330115
761 761 -, g dbSNP:752913271
778 778 -, tgacta dbSNP:756177694
781 781 c, g dbSNP:751922059
787 787 a, g dbSNP:754655024
789 789 g, t dbSNP:780883345
799 799 -, taag dbSNP:777845060
823 823 a, c dbSNP:747669949
828 828 g, t dbSNP:374536763
830 830 a, g dbSNP:777717646
837 837 a, g dbSNP:749171260
841 841 a, g dbSNP:770877545
844 844 a, g dbSNP:137860138
852 852 -, gcagggacct dbSNP:749238475
852 852 a, g dbSNP:202135680
853 853 c, t dbSNP:768777989
863 863 c, t dbSNP:776850758
867 867 c, t dbSNP:17884251
871 871 a, c dbSNP:141494807
874 874 c, g dbSNP:777019849
887 887 c, t dbSNP:748431056
888 888 c, g dbSNP:770109855
896 896 c, t dbSNP:201330551
898 898 a, g dbSNP:534373902
902 902 a, g dbSNP:372181171
907 907 c, g dbSNP:774852432
909 909 a, g dbSNP:759849744
910 910 c, g dbSNP:375455007
913 913 c, t dbSNP:753034211
917 917 c, t dbSNP:755799703
921 921 a, c dbSNP:200812167
923 923 c, t dbSNP:753400697
927 927 c, g dbSNP:567961585
928 928 a, g dbSNP:150329289
931 931 c, t dbSNP:745774161
939 939 c, g dbSNP:537078570
942 942 -, ct dbSNP:775030671
943 943 c, t dbSNP:780035476
946 946 g, t dbSNP:369611360
950 950 g, t dbSNP:374296670
956 956 a, g dbSNP:770201571
962 962 c, t dbSNP:778085696
963 963 a, g dbSNP:749331754
969 969 a, g dbSNP:771002514
971 971 a, g dbSNP:774742317
973 973 a, g dbSNP:557356270
974 974 c, t dbSNP:137958307
980 980 c, t dbSNP:775896948
981 981 a, g, t dbSNP:377317846
986 986 c, t dbSNP:753491759
987 987 a, g dbSNP:761255799
991 991 c, t dbSNP:764855928
1009 1009 c, t dbSNP:749871456
1010 1010 a, g dbSNP:368783272
1012 1012 -, ca dbSNP:746635016
1013 1013 c, t dbSNP:780128105
1023 1023 c, t dbSNP:751415672
1025 1025 c, t dbSNP:776970360
1026 1026 a, c, g dbSNP:546544216
1029 1029 a, c dbSNP:372693716
1031 1031 c, g dbSNP:779086818
1133 1133 a, g dbSNP:368676188
1146 1146 c, t dbSNP:759131564
1147 1147 a, g dbSNP:17879257
1185 1185 c, t dbSNP:555992296
1191 1191 c, t dbSNP:73997685
1219 1219 a, g dbSNP:2069539
1236 1236 a, g dbSNP:191601284
1253 1253 -, c dbSNP:778380506
1292 1292 -, g dbSNP:369976791
1307 1307 c, t dbSNP:146555944
1309 1309 -, tgccctgcct dbSNP:565168822
1309 1309 -, t dbSNP:749688316
1316 1316 c, t dbSNP:544558275
1318 1318 g, t dbSNP:564161618
1320 1320 -, ca dbSNP:548779597
1321 1321 a, g dbSNP:574559761
1323 1323 g, t dbSNP:532227044
1346 1346 -, c dbSNP:558855182
1352 1352 a, g dbSNP:552061773
1359 1359 c, t dbSNP:762712834
1396 1396 c, g dbSNP:763793944
1412 1412 c, t dbSNP:751402549
1446 1446 a, c dbSNP:565529097
1453 1453 c, t dbSNP:528336959
1489 1489 c, g dbSNP:547956603
1546 1546 g, t dbSNP:1135531

Target ORF information:

RefSeq Version NM_001258
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase 3 (CDK3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001258

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGATATGT TCCAGAAGGT AGAGAAGATC GGAGAGGGCA CCTATGGGGT GGTGTACAAG 
GCCAAGAACA GGGAGACAGG GCAGCTGGTG GCCCTGAAGA AGATCAGACT GGATTTGGAG
ATGGAGGGGG TCCCAAGCAC TGCCATCAGG GAGATCTCGC TGCTCAAGGA ACTGAAGCAC
CCCAACATCG TCCGACTGCT GGACGTGGTG CACAACGAGA GGAAGCTCTA TCTGGTGTTT
GAGTTCCTCA GCCAGGACCT GAAGAAGTAC ATGGACTCCA CCCCAGGCTC AGAGCTCCCC
CTGCACCTCA TCAAGAGCTA CCTCTTCCAG CTGCTGCAGG GGGTGAGTTT CTGCCACTCA
CATCGGGTCA TCCACCGAGA CCTGAAGCCC CAGAACCTGC TCATCAATGA GTTGGGTGCC
ATCAAGCTGG CTGACTTCGG CCTGGCTCGC GCCTTCGGGG TGCCCCTGCG CACCTACACC
CATGAGGTGG TGACACTGTG GTATCGCGCC CCCGAGATTC TCTTGGGCAG CAAGTTCTAT
ACCACAGCTG TGGATATCTG GAGCATTGGT TGCATCTTTG CAGAGATGGT GACTCGAAAA
GCCCTGTTTC CTGGTGACTC TGAGATTGAC CAGCTCTTTC GTATCTTTCG TATGCTGGGG
ACACCCAGCG AAGACACATG GCCCGGGGTC ACCCAGCTGC CTGACTATAA GGGCAGCTTC
CCTAAGTGGA CCAGGAAGGG ACTGGAAGAG ATTGTGCCCA ATCTGGAGCC AGAGGGCAGG
GACCTGCTCA TGCAACTCCT GCAGTATGAC CCCAGCCAGC GGATCACAGC CAAGACTGCC
CTGGCCCACC CGTACTTCTC ATCCCCTGAG CCCTCCCCAG CTGCCCGCCA GTATGTGCTG
CAGCGATTCC GCCATTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.