The following CDKN1B gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN1B gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 597bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||cyclin-dependent kinase inhibitor 1B
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from HY097069.1, AK312461.1,
BC001971.1, AA833962.1 and HY246392.1.
This sequence is a reference standard in the RefSeqGene project.
On Feb 12, 2014 this sequence version replaced gi:207113192.
Summary: This gene encodes a cyclin-dependent kinase inhibitor,
which shares a limited similarity with CDK inhibitor CDKN1A/p21.
The encoded protein binds to and prevents the activation of cyclin
E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle
progression at G1. The degradation of this protein, which is
triggered by its CDK dependent phosphorylation and subsequent
ubiquitination by SCF complexes, is required for the cellular
transition from quiescence to the proliferative state. Mutations in
this gene are associated with multiple endocrine neoplasia type IV
(MEN4). [provided by RefSeq, Apr 2014].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
regulatory uORF :: PMID: 12837699
Transcript exon combination :: BC001971.1, AY004255.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.