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CDKN1C cDNA ORF clone, Homo sapiens (human)

Gene Symbol CDKN1C
Entrez Gene ID 1028
Full Name cyclin-dependent kinase inhibitor 1C (p57, Kip2)
Synonyms BWCR, BWS, KIP2, WBS, p57, p57Kip2
General protein information
Preferred Names
cyclin-dependent kinase inhibitor 1C
Names
cyclin-dependent kinase inhibitor 1C
cyclin-dependent kinase inhibitor p57
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. lac of sum
Disorder MIM:

600856

Disorder Html: Beckwith-Wiedemann syndrome, 130650 (3)





The following CDKN1C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CDKN1C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu44738 XM_005252732 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu44738 XM_006725126 PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $99.00
OHu27234 NM_000076 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $309.00
OHu26977 NM_001122630 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.30
$309.00
OHu26977 NM_001122631 Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$216.30
$309.00

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu44738
Accession Version XM_005252732.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 528bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase inhibitor 1C isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_009237.19) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578820274. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGATTTC TTCGCCAAGC GCAAGAGATC AGCGCCTGAG AAGTCGTCGG
GCGATGTCCC CGCGCCGTGT CCCTCTCCAA GCGCCGCCCC TGGCGTGGGC TCGGTGGAGC
AGACCCCGCG CAAGAGGCTG CGGTGAGCCA AAGCCCAAAG AGCCCCGAGG GAACCTGCCG
GGGCAGCGGA CGTTGGAAGG GCGCTGGGCC TCGGCTGGGA CCGTTCATGT AGCAGCAACC
GGCGGCGGCT GCCGCAGAGC AGCGTTCGGT TTTGTTTTTA AATTTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_005252789.1
CDS194..721
Misc Feature(1)251..409(+)
Translation
Position Chain Variation Link
22 22 c, g dbSNP:550429501
47 47 a, g dbSNP:535384026
62 62 a, g dbSNP:147317732
63 63 c, t dbSNP:546464981
83 83 c, t dbSNP:573323825
126 126 a, t dbSNP:528330778
152 152 c, t dbSNP:560380736
180 180 c, t dbSNP:1054463
193 193 g, t dbSNP:780549417
204 204 c, t dbSNP:756961090
211 211 c, t dbSNP:556519658
232 232 a, g dbSNP:3852522
233 233 a, g, t dbSNP:758244300
234 234 g, t dbSNP:752482298
236 236 c, g dbSNP:765255367
250 250 c, t dbSNP:759365577
254 254 a, c dbSNP:753973370
277 277 a, c, t dbSNP:760980314
292 292 c, t dbSNP:149717696
298 298 a, g, t dbSNP:762337324
299 299 c, t dbSNP:137852766
303 303 c, t dbSNP:774548414
304 304 c, t dbSNP:769255937
305 305 c, t dbSNP:749713233
313 313 c, g dbSNP:776240688
325 325 c, g, t dbSNP:546920371
331 331 c, t dbSNP:777465972
339 339 g, t dbSNP:758011168
340 340 c, t dbSNP:747982670
347 347 g, t dbSNP:778520280
349 349 c, t dbSNP:754972138
368 368 a, c dbSNP:753651871
369 369 a, c dbSNP:766493778
379 379 c, t dbSNP:756321814
386 386 c, t dbSNP:750526402
406 406 a, g dbSNP:141005361
440 440 a, t dbSNP:400377
443 443 a, g dbSNP:762106424
454 454 g, t dbSNP:387907223
455 455 c, t dbSNP:387907224
457 457 a, g dbSNP:759474789
460 460 a, g dbSNP:387907226
464 464 c, g, t dbSNP:318240750
473 473 a, c, g dbSNP:267606716
476 476 c, t dbSNP:776541692
489 489 a, g dbSNP:373252940
492 492 a, g dbSNP:370564696
504 504 a, c dbSNP:773166985
511 511 a, t dbSNP:772130948
514 514 c, t dbSNP:531059713
516 516 c, t dbSNP:779172459
526 526 g, t dbSNP:755160554
529 529 g, t dbSNP:749702191
531 531 a, c dbSNP:1802775
534 534 c, t dbSNP:780417247
537 537 c, t dbSNP:377216794
545 545 c, g dbSNP:750876855
549 549 g, t dbSNP:763529383
571 571 c, t dbSNP:757986512
590 590 a, g dbSNP:761689994
591 591 a, g dbSNP:774447378
604 604 a, g dbSNP:768656669
612 612 c, t dbSNP:763176740
624 624 c, t dbSNP:775842083
625 625 a, g dbSNP:574318429
634 634 c, g dbSNP:769907193
635 635 c, t dbSNP:552955353
688 688 c, g dbSNP:11550171
725 725 c, t dbSNP:13563
752 752 g, t dbSNP:540697744
777 777 a, g dbSNP:370352968
838 838 -, ct dbSNP:776125747
852 852 a, g dbSNP:1052593
925 925 a, g dbSNP:752550090
1010 1010 c, t dbSNP:767474496
1025 1025 a, c dbSNP:12801085
1026 1026 a, c dbSNP:12793537
1063 1063 a, c dbSNP:558934701
1098 1098 c, g dbSNP:181826383
1216 1216 a, g dbSNP:778643023
1229 1229 a, g dbSNP:759397245
1237 1237 g, t dbSNP:751488966

Target ORF information:

RefSeq Version XM_005252732
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005252732

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGATTTC TTCGCCAAGC GCAAGAGATC AGCGCCTGAG AAGTCGTCGG
GCGATGTCCC CGCGCCGTGT CCCTCTCCAA GCGCCGCCCC TGGCGTGGGC TCGGTGGAGC
AGACCCCGCG CAAGAGGCTG CGGTGAGCCA AAGCCCAAAG AGCCCCGAGG GAACCTGCCG
GGGCAGCGGA CGTTGGAAGG GCGCTGGGCC TCGGCTGGGA CCGTTCATGT AGCAGCAACC
GGCGGCGGCT GCCGCAGAGC AGCGTTCGGT TTTGTTTTTA AATTTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu44738
Accession Version XM_006725126.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 528bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase inhibitor 1C isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_187585.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578839819. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGATTTC TTCGCCAAGC GCAAGAGATC AGCGCCTGAG AAGTCGTCGG
GCGATGTCCC CGCGCCGTGT CCCTCTCCAA GCGCCGCCCC TGGCGTGGGC TCGGTGGAGC
AGACCCCGCG CAAGAGGCTG CGGTGAGCCA AAGCCCAAAG AGCCCCGAGG GAACCTGCCG
GGGCAGCGGA CGTTGGAAGG GCGCTGGGCC TCGGCTGGGA CCGTTCATGT AGCAGCAACC
GGCGGCGGCT GCCGCAGAGC AGCGTTCGGT TTTGTTTTTA AATTTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqXP_006725189.1
CDS194..721
Misc Feature(1)251..409(+)
Translation
Position Chain Variation Link
22 22 c, g dbSNP:550429501
47 47 a, g dbSNP:535384026
62 62 a, g dbSNP:147317732
63 63 c, t dbSNP:546464981
83 83 c, t dbSNP:573323825
126 126 a, t dbSNP:528330778
152 152 c, t dbSNP:560380736
180 180 c, t dbSNP:1054463
193 193 g, t dbSNP:780549417
204 204 c, t dbSNP:756961090
211 211 c, t dbSNP:556519658
232 232 a, g dbSNP:3852522
233 233 a, g, t dbSNP:758244300
234 234 g, t dbSNP:752482298
236 236 c, g dbSNP:765255367
250 250 c, t dbSNP:759365577
254 254 a, c dbSNP:753973370
277 277 a, c, t dbSNP:760980314
292 292 c, t dbSNP:149717696
298 298 a, g, t dbSNP:762337324
299 299 c, t dbSNP:137852766
303 303 c, t dbSNP:774548414
304 304 c, t dbSNP:769255937
305 305 c, t dbSNP:749713233
313 313 c, g dbSNP:776240688
325 325 c, g, t dbSNP:546920371
331 331 c, t dbSNP:777465972
339 339 g, t dbSNP:758011168
340 340 c, t dbSNP:747982670
347 347 g, t dbSNP:778520280
349 349 c, t dbSNP:754972138
368 368 a, c dbSNP:753651871
369 369 a, c dbSNP:766493778
379 379 c, t dbSNP:756321814
386 386 c, t dbSNP:750526402
406 406 a, g dbSNP:141005361
440 440 a, t dbSNP:400377
443 443 a, g dbSNP:762106424
454 454 g, t dbSNP:387907223
455 455 c, t dbSNP:387907224
457 457 a, g dbSNP:759474789
460 460 a, g dbSNP:387907226
464 464 c, g, t dbSNP:318240750
473 473 a, c, g dbSNP:267606716
476 476 c, t dbSNP:776541692
489 489 a, g dbSNP:373252940
492 492 a, g dbSNP:370564696
504 504 a, c dbSNP:773166985
511 511 a, t dbSNP:772130948
514 514 c, t dbSNP:531059713
516 516 c, t dbSNP:779172459
526 526 g, t dbSNP:755160554
529 529 g, t dbSNP:749702191
531 531 a, c dbSNP:1802775
534 534 c, t dbSNP:780417247
537 537 c, t dbSNP:377216794
545 545 c, g dbSNP:750876855
549 549 g, t dbSNP:763529383
571 571 c, t dbSNP:757986512
590 590 a, g dbSNP:761689994
591 591 a, g dbSNP:774447378
604 604 a, g dbSNP:768656669
612 612 c, t dbSNP:763176740
624 624 c, t dbSNP:775842083
625 625 a, g dbSNP:574318429
634 634 c, g dbSNP:769907193
635 635 c, t dbSNP:552955353
688 688 c, g dbSNP:11550171
725 725 c, t dbSNP:13563
752 752 g, t dbSNP:540697744
777 777 a, g dbSNP:370352968
838 838 -, ct dbSNP:776125747
852 852 a, g dbSNP:1052593
925 925 a, g dbSNP:752550090
1010 1010 c, t dbSNP:767474496
1025 1025 a, c dbSNP:12801085
1026 1026 a, c dbSNP:12793537
1063 1063 a, c dbSNP:558934701
1098 1098 c, g dbSNP:181826383
1216 1216 a, g dbSNP:778643023
1229 1229 a, g dbSNP:759397245
1237 1237 g, t dbSNP:751488966

Target ORF information:

RefSeq Version XM_006725126
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006725126

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGATTTC TTCGCCAAGC GCAAGAGATC AGCGCCTGAG AAGTCGTCGG
GCGATGTCCC CGCGCCGTGT CCCTCTCCAA GCGCCGCCCC TGGCGTGGGC TCGGTGGAGC
AGACCCCGCG CAAGAGGCTG CGGTGAGCCA AAGCCCAAAG AGCCCCGAGG GAACCTGCCG
GGGCAGCGGA CGTTGGAAGG GCGCTGGGCC TCGGCTGGGA CCGTTCATGT AGCAGCAACC
GGCGGCGGCT GCCGCAGAGC AGCGTTCGGT TTTGTTTTTA AATTTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27234
Accession Version NM_000076.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 951bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase inhibitor 1C isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039188.1, U22398.1, AC013791.9 and CD676249.1. This sequence is a reference standard in the RefSeqGene project. On Mar 12, 2008 this sequence version replaced gi:4557440. Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## imprinted gene :: PMID: 8610162 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: U22398.1, BM719233.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307, SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTCCGACG CGTCCCTCCG CAGCACATCC ACGATGGAGC GTCTTGTCGC CCGTGGGACC 
TTCCCAGTAC TAGTGCGCAC CAGCGCCTGC CGCAGCCTCT TCGGGCCGGT GGACCACGAG
GAGCTGAGCC GCGAGCTGCA GGCCCGCCTG GCCGAGCTGA ACGCCGAGGA CCAGAACCGC
TGGGATTACG ACTTCCAGCA GGACATGCCG CTGCGGGGCC CTGGACGCCT GCAGTGGACC
GAAGTGGACA GCGACTCGGT GCCCGCGTTC TACCGCGAGA CGGTGCAGGT GGGGCGCTGC
CGCCTGCTGC TGGCGCCGCG GCCCGTCGCG GTCGCGGTGG CTGTCAGCCC GCCCCTCGAG
CCGGCCGCTG AGTCCCTCGA CGGCCTCGAG GAGGCGCCGG AGCAGCTGCC TAGTGTCCCG
GTCCCGGCCC CGGCGTCCAC CCCGCCCCCA GTCCCGGTCC TGGCTCCAGC CCCGGCCCCG
GCTCCGGCTC CGGTCGCGGC TCCGGTCGCG GCTCCGGTCG CGGTCGCGGT CCTGGCCCCG
GCCCCGGCCC CGGCTCCGGC TCCGGCTCCG GCCCCGGCTC CAGTCGCGGC CCCGGCCCCA
GCCCCGGCCC CGGCCCCGGC CCCGGCCCCC GCCCCGGCCC CGGCCCCGGA CGCGGCGCCT
CAAGAGAGCG CCGAGCAGGG CGCGAACCAG GGGCAGCGCG GCCAGGAGCC TCTCGCTGAC
CAGCTGCACT CGGGGATTTC GGGACGTCCC GCGGCCGGCA CCGCGGCCGC CAGCGCCAAC
GGCGCGGCGA TCAAGAAGCT GTCCGGGCCT CTGATCTCCG ATTTCTTCGC CAAGCGCAAG
AGATCAGCGC CTGAGAAGTC GTCGGGCGAT GTCCCCGCGC CGTGTCCCTC TCCAAGCGCC
GCCCCTGGCG TGGGCTCGGT GGAGCAGACC CCGCGCAAGA GGCTGCGGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000067.1
CDS277..1227
Misc Feature(1)34..36(+)
Misc Feature(2)367..525(+)
Misc Feature(3)742..915(+)
Misc Feature(4)1078..1080(+)
Misc Feature(5)1108..1119(+)
Exon (1)1..1096
Gene:CDKN1C
Gene Synonym:
Exon (2)1097..1232
Gene:CDKN1C
Gene Synonym:
Exon (3)1233..1930
Gene:CDKN1C
Gene Synonym:
Translation
Position Chain Variation Link
11 11 a, g dbSNP:147317732
12 12 c, t dbSNP:546464981
32 32 c, t dbSNP:573323825
75 75 a, t dbSNP:528330778
101 101 c, t dbSNP:560380736
129 129 c, t dbSNP:1054463
144 144 a, g dbSNP:551909142
151 151 a, g dbSNP:533326001
156 156 c, t dbSNP:562886157
166 166 g, t dbSNP:544892298
183 183 c, t dbSNP:553160322
188 188 g, t dbSNP:574366375
192 192 a, g dbSNP:143992355
193 193 a, g dbSNP:188494894
201 201 c, g dbSNP:573428261
206 206 c, t dbSNP:747583756
227 227 -, tct dbSNP:775427512
241 241 c, t dbSNP:780580834
251 251 c, t dbSNP:760758691
271 271 c, t dbSNP:773741430
274 274 g, t dbSNP:772497485
276 276 -, c dbSNP:770109299
276 276 c, g dbSNP:756768240
280 280 g, t dbSNP:748680303
287 287 c, t dbSNP:201368350
293 293 c, t dbSNP:201715947
295 295 c, t dbSNP:374634184
309 309 g, t dbSNP:780549417
320 320 c, t dbSNP:756961090
327 327 c, t dbSNP:556519658
348 348 a, g dbSNP:3852522
349 349 a, g, t dbSNP:758244300
350 350 g, t dbSNP:752482298
352 352 c, g dbSNP:765255367
366 366 c, t dbSNP:759365577
370 370 a, c dbSNP:753973370
393 393 a, c, t dbSNP:760980314
408 408 c, t dbSNP:149717696
414 414 a, g, t dbSNP:762337324
415 415 c, t dbSNP:137852766
419 419 c, t dbSNP:774548414
420 420 c, t dbSNP:769255937
421 421 c, t dbSNP:749713233
429 429 c, g dbSNP:776240688
441 441 c, g, t dbSNP:546920371
447 447 c, t dbSNP:777465972
455 455 g, t dbSNP:758011168
456 456 c, t dbSNP:747982670
463 463 g, t dbSNP:778520280
465 465 c, t dbSNP:754972138
484 484 a, c dbSNP:753651871
485 485 a, c dbSNP:766493778
495 495 c, t dbSNP:756321814
502 502 c, t dbSNP:750526402
522 522 a, g dbSNP:141005361
556 556 a, t dbSNP:400377
559 559 a, g dbSNP:762106424
581 581 a, t dbSNP:774805080
585 585 g, t dbSNP:764328739
586 586 ct, g dbSNP:387906399
596 596 a, g dbSNP:763525000
600 600 c, t dbSNP:534471786
621 621 a, c dbSNP:770277810
625 625 c, t dbSNP:570636789
628 628 c, g dbSNP:772684721
629 629 c, t dbSNP:771731330
639 639 a, g dbSNP:747757242
640 640 a, g dbSNP:551863674
666 666 g, t dbSNP:778772076
719 719 a, c dbSNP:754671425
727 727 a, g dbSNP:753342439
728 728 c, t dbSNP:385101
752 752 c, t dbSNP:372633
795 795 a, c dbSNP:399771
804 804 c, g dbSNP:533485167
815 815 c, t dbSNP:113374868
831 831 c, t dbSNP:191294997
837 837 c, t dbSNP:384713
843 843 c, t dbSNP:112196492
846 846 a, g dbSNP:550978405
869 869 c, g dbSNP:2583439
876 876 a, g dbSNP:529326848
887 887 c, g dbSNP:2583440
893 893 c, g dbSNP:1182342
894 894 -, ggccccggcccc dbSNP:759134767
894 894 -, ggcccc dbSNP:760463569
901 901 a, g dbSNP:750581456
906 906 c, g dbSNP:767656648
908 908 -, accggc dbSNP:771450542
915 915 c, t dbSNP:757586907
916 916 a, c dbSNP:562237921
925 925 -, ccccgg dbSNP:772704243
926 926 a, t dbSNP:3741342
927 927 c, g dbSNP:751669088
933 933 g, t dbSNP:764536797
935 935 c, t dbSNP:763289302
940 940 c, g dbSNP:775889163
945 945 c, t dbSNP:540923047
946 946 a, g dbSNP:528634940
952 952 c, g dbSNP:772737614
955 955 g, t dbSNP:771502215
960 960 a, g dbSNP:761539484
973 973 c, t dbSNP:773932111
974 974 a, c, g dbSNP:564726941
975 975 c, g dbSNP:779975908
978 978 c, g dbSNP:546016935
984 984 a, g dbSNP:3741341
991 991 g, t dbSNP:781428134
993 993 c, t dbSNP:757359164
1008 1008 c, g dbSNP:751650132
1011 1011 a, g dbSNP:556682082
1016 1016 a, c dbSNP:104894200
1023 1023 a, t dbSNP:758620755
1025 1025 a, c dbSNP:753022994
1028 1028 c, t dbSNP:765542916
1039 1039 a, g dbSNP:760038657
1045 1045 g, t dbSNP:754283907
1049 1049 a, g dbSNP:766858608
1050 1050 c, t dbSNP:761296394
1051 1051 g, t dbSNP:773881541
1057 1057 a, g dbSNP:768242627
1059 1059 a, c dbSNP:762619956
1062 1062 g, t dbSNP:775458829
1077 1077 a, c, g dbSNP:745815931
1078 1078 a, t dbSNP:781340171
1080 1080 a, c, t dbSNP:747104008
1091 1091 g, t dbSNP:515726203
1096 1096 a, g dbSNP:387907225
1102 1102 g, t dbSNP:387907223
1103 1103 c, t dbSNP:387907224
1105 1105 a, g dbSNP:759474789
1108 1108 a, g dbSNP:387907226
1112 1112 c, g, t dbSNP:318240750
1121 1121 a, c, g dbSNP:267606716
1124 1124 c, t dbSNP:776541692
1137 1137 a, g dbSNP:373252940
1140 1140 a, g dbSNP:370564696
1152 1152 a, c dbSNP:773166985
1159 1159 a, t dbSNP:772130948
1162 1162 c, t dbSNP:531059713
1164 1164 c, t dbSNP:779172459
1174 1174 g, t dbSNP:755160554
1177 1177 g, t dbSNP:749702191
1179 1179 a, c dbSNP:1802775
1182 1182 c, t dbSNP:780417247
1185 1185 c, t dbSNP:377216794
1193 1193 c, g dbSNP:750876855
1197 1197 g, t dbSNP:763529383
1219 1219 c, t dbSNP:757986512
1243 1243 a, g dbSNP:761689994
1244 1244 a, g dbSNP:774447378
1257 1257 a, g dbSNP:768656669
1265 1265 c, t dbSNP:763176740
1277 1277 c, t dbSNP:775842083
1278 1278 a, g dbSNP:574318429
1287 1287 c, g dbSNP:769907193
1288 1288 c, t dbSNP:552955353
1341 1341 c, g dbSNP:11550171
1378 1378 c, t dbSNP:13563
1405 1405 g, t dbSNP:540697744
1430 1430 a, g dbSNP:370352968
1491 1491 -, ct dbSNP:776125747
1505 1505 a, g dbSNP:1052593
1578 1578 a, g dbSNP:752550090
1663 1663 c, t dbSNP:767474496
1678 1678 a, c dbSNP:12801085
1679 1679 a, c dbSNP:12793537
1716 1716 a, c dbSNP:558934701
1751 1751 c, g dbSNP:181826383
1869 1869 a, g dbSNP:778643023
1882 1882 a, g dbSNP:759397245
1890 1890 g, t dbSNP:751488966

Target ORF information:

RefSeq Version NM_000076
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000076

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGTCCGACG CGTCCCTCCG CAGCACATCC ACGATGGAGC GTCTTGTCGC CCGTGGGACC 
TTCCCAGTAC TAGTGCGCAC CAGCGCCTGC CGCAGCCTCT TCGGGCCGGT GGACCACGAG
GAGCTGAGCC GCGAGCTGCA GGCCCGCCTG GCCGAGCTGA ACGCCGAGGA CCAGAACCGC
TGGGATTACG ACTTCCAGCA GGACATGCCG CTGCGGGGCC CTGGACGCCT GCAGTGGACC
GAAGTGGACA GCGACTCGGT GCCCGCGTTC TACCGCGAGA CGGTGCAGGT GGGGCGCTGC
CGCCTGCTGC TGGCGCCGCG GCCCGTCGCG GTCGCGGTGG CTGTCAGCCC GCCCCTCGAG
CCGGCCGCTG AGTCCCTCGA CGGCCTCGAG GAGGCGCCGG AGCAGCTGCC TAGTGTCCCG
GTCCCGGCCC CGGCGTCCAC CCCGCCCCCA GTCCCGGTCC TGGCTCCAGC CCCGGCCCCG
GCTCCGGCTC CGGTCGCGGC TCCGGTCGCG GCTCCGGTCG CGGTCGCGGT CCTGGCCCCG
GCCCCGGCCC CGGCTCCGGC TCCGGCTCCG GCCCCGGCTC CAGTCGCGGC CCCGGCCCCA
GCCCCGGCCC CGGCCCCGGC CCCGGCCCCC GCCCCGGCCC CGGCCCCGGA CGCGGCGCCT
CAAGAGAGCG CCGAGCAGGG CGCGAACCAG GGGCAGCGCG GCCAGGAGCC TCTCGCTGAC
CAGCTGCACT CGGGGATTTC GGGACGTCCC GCGGCCGGCA CCGCGGCCGC CAGCGCCAAC
GGCGCGGCGA TCAAGAAGCT GTCCGGGCCT CTGATCTCCG ATTTCTTCGC CAAGCGCAAG
AGATCAGCGC CTGAGAAGTC GTCGGGCGAT GTCCCCGCGC CGTGTCCCTC TCCAAGCGCC
GCCCCTGGCG TGGGCTCGGT GGAGCAGACC CCGCGCAAGA GGCTGCGGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26977
Accession Version NM_001122630.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 918bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase inhibitor 1C isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039188.1, AC013791.9, U22398.1 and CD676249.1. Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## imprinted gene :: PMID: 8610162 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: EU570054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153307, SAMEA2162568 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGGTGGG GCGCTGCCGC CTGCTGCTGG CGCCGCGGCC CGTCGCGGTC
GCGGTGGCTG TCAGCCCGCC CCTCGAGCCG GCCGCTGAGT CCCTCGACGG CCTCGAGGAG
GCGCCGGAGC AGCTGCCTAG TGTCCCGGTC CCGGCCCCGG CGTCCACCCC GCCCCCAGTC
CCGGTCCTGG CTCCAGCCCC GGCCCCGGCT CCGGCTCCGG TCGCGGCTCC GGTCGCGGCT
CCGGTCGCGG TCGCGGTCCT GGCCCCGGCC CCGGCCCCGG CTCCGGCTCC GGCTCCGGCC
CCGGCTCCAG TCGCGGCCCC GGCCCCAGCC CCGGCCCCGG CCCCGGCCCC GGCCCCCGCC
CCGGCCCCGG CCCCGGACGC GGCGCCTCAA GAGAGCGCCG AGCAGGGCGC GAACCAGGGG
CAGCGCGGCC AGGAGCCTCT CGCTGACCAG CTGCACTCGG GGATTTCGGG ACGTCCCGCG
GCCGGCACCG CGGCCGCCAG CGCCAACGGC GCGGCGATCA AGAAGCTGTC CGGGCCTCTG
ATCTCCGATT TCTTCGCCAA GCGCAAGAGA TCAGCGCCTG AGAAGTCGTC GGGCGATGTC
CCCGCGCCGT GTCCCTCTCC AAGCGCCGCC CCTGGCGTGG GCTCGGTGGA GCAGACCCCG
CGCAAGAGGC TGCGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001116102.1
CDS143..1060
Misc Feature(1)47..49(+)
Misc Feature(2)200..358(+)
Exon (1)1..132
Gene:CDKN1C
Gene Synonym:
Exon (2)133..929
Gene:CDKN1C
Gene Synonym:
Exon (3)930..1065
Gene:CDKN1C
Gene Synonym:
Exon (4)1066..1763
Gene:CDKN1C
Gene Synonym:
Translation
Position Chain Variation Link
11 11 a, g dbSNP:147317732
12 12 c, t dbSNP:546464981
32 32 c, t dbSNP:573323825
75 75 a, t dbSNP:528330778
101 101 c, t dbSNP:560380736
129 129 c, t dbSNP:1054463
142 142 g, t dbSNP:780549417
153 153 c, t dbSNP:756961090
160 160 c, t dbSNP:556519658
181 181 a, g dbSNP:3852522
182 182 a, g, t dbSNP:758244300
183 183 g, t dbSNP:752482298
185 185 c, g dbSNP:765255367
199 199 c, t dbSNP:759365577
203 203 a, c dbSNP:753973370
226 226 a, c, t dbSNP:760980314
241 241 c, t dbSNP:149717696
247 247 a, g, t dbSNP:762337324
248 248 c, t dbSNP:137852766
252 252 c, t dbSNP:774548414
253 253 c, t dbSNP:769255937
254 254 c, t dbSNP:749713233
262 262 c, g dbSNP:776240688
274 274 c, g, t dbSNP:546920371
280 280 c, t dbSNP:777465972
288 288 g, t dbSNP:758011168
289 289 c, t dbSNP:747982670
296 296 g, t dbSNP:778520280
298 298 c, t dbSNP:754972138
317 317 a, c dbSNP:753651871
318 318 a, c dbSNP:766493778
328 328 c, t dbSNP:756321814
335 335 c, t dbSNP:750526402
355 355 a, g dbSNP:141005361
389 389 a, t dbSNP:400377
392 392 a, g dbSNP:762106424
414 414 a, t dbSNP:774805080
418 418 g, t dbSNP:764328739
419 419 ct, g dbSNP:387906399
429 429 a, g dbSNP:763525000
433 433 c, t dbSNP:534471786
454 454 a, c dbSNP:770277810
458 458 c, t dbSNP:570636789
461 461 c, g dbSNP:772684721
462 462 c, t dbSNP:771731330
472 472 a, g dbSNP:747757242
473 473 a, g dbSNP:551863674
499 499 g, t dbSNP:778772076
552 552 a, c dbSNP:754671425
560 560 a, g dbSNP:753342439
561 561 c, t dbSNP:385101
585 585 c, t dbSNP:372633
628 628 a, c dbSNP:399771
637 637 c, g dbSNP:533485167
648 648 c, t dbSNP:113374868
664 664 c, t dbSNP:191294997
670 670 c, t dbSNP:384713
676 676 c, t dbSNP:112196492
679 679 a, g dbSNP:550978405
702 702 c, g dbSNP:2583439
709 709 a, g dbSNP:529326848
720 720 c, g dbSNP:2583440
726 726 c, g dbSNP:1182342
727 727 -, ggccccggcccc dbSNP:759134767
727 727 -, ggcccc dbSNP:760463569
734 734 a, g dbSNP:750581456
739 739 c, g dbSNP:767656648
741 741 -, accggc dbSNP:771450542
748 748 c, t dbSNP:757586907
749 749 a, c dbSNP:562237921
758 758 -, ccccgg dbSNP:772704243
759 759 a, t dbSNP:3741342
760 760 c, g dbSNP:751669088
766 766 g, t dbSNP:764536797
768 768 c, t dbSNP:763289302
773 773 c, g dbSNP:775889163
778 778 c, t dbSNP:540923047
779 779 a, g dbSNP:528634940
785 785 c, g dbSNP:772737614
788 788 g, t dbSNP:771502215
793 793 a, g dbSNP:761539484
806 806 c, t dbSNP:773932111
807 807 a, c, g dbSNP:564726941
808 808 c, g dbSNP:779975908
811 811 c, g dbSNP:546016935
817 817 a, g dbSNP:3741341
824 824 g, t dbSNP:781428134
826 826 c, t dbSNP:757359164
841 841 c, g dbSNP:751650132
844 844 a, g dbSNP:556682082
849 849 a, c dbSNP:104894200
856 856 a, t dbSNP:758620755
858 858 a, c dbSNP:753022994
861 861 c, t dbSNP:765542916
872 872 a, g dbSNP:760038657
878 878 g, t dbSNP:754283907
882 882 a, g dbSNP:766858608
883 883 c, t dbSNP:761296394
884 884 g, t dbSNP:773881541
890 890 a, g dbSNP:768242627
892 892 a, c dbSNP:762619956
895 895 g, t dbSNP:775458829
910 910 a, c, g dbSNP:745815931
911 911 a, t dbSNP:781340171
913 913 a, c, t dbSNP:747104008
924 924 g, t dbSNP:515726203
929 929 a, g dbSNP:387907225
935 935 g, t dbSNP:387907223
936 936 c, t dbSNP:387907224
938 938 a, g dbSNP:759474789
941 941 a, g dbSNP:387907226
945 945 c, g, t dbSNP:318240750
954 954 a, c, g dbSNP:267606716
957 957 c, t dbSNP:776541692
970 970 a, g dbSNP:373252940
973 973 a, g dbSNP:370564696
985 985 a, c dbSNP:773166985
992 992 a, t dbSNP:772130948
995 995 c, t dbSNP:531059713
997 997 c, t dbSNP:779172459
1007 1007 g, t dbSNP:755160554
1010 1010 g, t dbSNP:749702191
1012 1012 a, c dbSNP:1802775
1015 1015 c, t dbSNP:780417247
1018 1018 c, t dbSNP:377216794
1026 1026 c, g dbSNP:750876855
1030 1030 g, t dbSNP:763529383
1052 1052 c, t dbSNP:757986512
1076 1076 a, g dbSNP:761689994
1077 1077 a, g dbSNP:774447378
1090 1090 a, g dbSNP:768656669
1098 1098 c, t dbSNP:763176740
1110 1110 c, t dbSNP:775842083
1111 1111 a, g dbSNP:574318429
1120 1120 c, g dbSNP:769907193
1121 1121 c, t dbSNP:552955353
1174 1174 c, g dbSNP:11550171
1211 1211 c, t dbSNP:13563
1238 1238 g, t dbSNP:540697744
1263 1263 a, g dbSNP:370352968
1324 1324 -, ct dbSNP:776125747
1338 1338 a, g dbSNP:1052593
1411 1411 a, g dbSNP:752550090
1496 1496 c, t dbSNP:767474496
1511 1511 a, c dbSNP:12801085
1512 1512 a, c dbSNP:12793537
1549 1549 a, c dbSNP:558934701
1584 1584 c, g dbSNP:181826383
1702 1702 a, g dbSNP:778643023
1715 1715 a, g dbSNP:759397245
1723 1723 g, t dbSNP:751488966

Target ORF information:

RefSeq Version NM_001122630
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001122630

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGGTGGG GCGCTGCCGC CTGCTGCTGG CGCCGCGGCC CGTCGCGGTC
GCGGTGGCTG TCAGCCCGCC CCTCGAGCCG GCCGCTGAGT CCCTCGACGG CCTCGAGGAG
GCGCCGGAGC AGCTGCCTAG TGTCCCGGTC CCGGCCCCGG CGTCCACCCC GCCCCCAGTC
CCGGTCCTGG CTCCAGCCCC GGCCCCGGCT CCGGCTCCGG TCGCGGCTCC GGTCGCGGCT
CCGGTCGCGG TCGCGGTCCT GGCCCCGGCC CCGGCCCCGG CTCCGGCTCC GGCTCCGGCC
CCGGCTCCAG TCGCGGCCCC GGCCCCAGCC CCGGCCCCGG CCCCGGCCCC GGCCCCCGCC
CCGGCCCCGG CCCCGGACGC GGCGCCTCAA GAGAGCGCCG AGCAGGGCGC GAACCAGGGG
CAGCGCGGCC AGGAGCCTCT CGCTGACCAG CTGCACTCGG GGATTTCGGG ACGTCCCGCG
GCCGGCACCG CGGCCGCCAG CGCCAACGGC GCGGCGATCA AGAAGCTGTC CGGGCCTCTG
ATCTCCGATT TCTTCGCCAA GCGCAAGAGA TCAGCGCCTG AGAAGTCGTC GGGCGATGTC
CCCGCGCCGT GTCCCTCTCC AAGCGCCGCC CCTGGCGTGG GCTCGGTGGA GCAGACCCCG
CGCAAGAGGC TGCGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26977
Accession Version NM_001122631.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 918bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase inhibitor 1C isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC039188.1, AC013791.9, U22398.1, BM673714.1 and CD676249.1. Summary: This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]. Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate splice junction in the 3' UTR compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode isoform b. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## imprinted gene :: PMID: 8610162 ##RefSeq-Attributes-END## ##Evidence-Data-START## CDS exon combination :: EU570054.1, BC067842.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1968189, SAMEA2142853 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGGTGGG GCGCTGCCGC CTGCTGCTGG CGCCGCGGCC CGTCGCGGTC
GCGGTGGCTG TCAGCCCGCC CCTCGAGCCG GCCGCTGAGT CCCTCGACGG CCTCGAGGAG
GCGCCGGAGC AGCTGCCTAG TGTCCCGGTC CCGGCCCCGG CGTCCACCCC GCCCCCAGTC
CCGGTCCTGG CTCCAGCCCC GGCCCCGGCT CCGGCTCCGG TCGCGGCTCC GGTCGCGGCT
CCGGTCGCGG TCGCGGTCCT GGCCCCGGCC CCGGCCCCGG CTCCGGCTCC GGCTCCGGCC
CCGGCTCCAG TCGCGGCCCC GGCCCCAGCC CCGGCCCCGG CCCCGGCCCC GGCCCCCGCC
CCGGCCCCGG CCCCGGACGC GGCGCCTCAA GAGAGCGCCG AGCAGGGCGC GAACCAGGGG
CAGCGCGGCC AGGAGCCTCT CGCTGACCAG CTGCACTCGG GGATTTCGGG ACGTCCCGCG
GCCGGCACCG CGGCCGCCAG CGCCAACGGC GCGGCGATCA AGAAGCTGTC CGGGCCTCTG
ATCTCCGATT TCTTCGCCAA GCGCAAGAGA TCAGCGCCTG AGAAGTCGTC GGGCGATGTC
CCCGCGCCGT GTCCCTCTCC AAGCGCCGCC CCTGGCGTGG GCTCGGTGGA GCAGACCCCG
CGCAAGAGGC TGCGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001116103.1
CDS143..1060
Misc Feature(1)47..49(+)
Misc Feature(2)200..358(+)
Exon (1)1..132
Gene:CDKN1C
Gene Synonym:
Exon (2)133..929
Gene:CDKN1C
Gene Synonym:
Exon (3)930..1065
Gene:CDKN1C
Gene Synonym:
Exon (4)1066..1758
Gene:CDKN1C
Gene Synonym:
Translation
Position Chain Variation Link
11 11 a, g dbSNP:147317732
12 12 c, t dbSNP:546464981
32 32 c, t dbSNP:573323825
75 75 a, t dbSNP:528330778
101 101 c, t dbSNP:560380736
129 129 c, t dbSNP:1054463
142 142 g, t dbSNP:780549417
153 153 c, t dbSNP:756961090
160 160 c, t dbSNP:556519658
181 181 a, g dbSNP:3852522
182 182 a, g, t dbSNP:758244300
183 183 g, t dbSNP:752482298
185 185 c, g dbSNP:765255367
199 199 c, t dbSNP:759365577
203 203 a, c dbSNP:753973370
226 226 a, c, t dbSNP:760980314
241 241 c, t dbSNP:149717696
247 247 a, g, t dbSNP:762337324
248 248 c, t dbSNP:137852766
252 252 c, t dbSNP:774548414
253 253 c, t dbSNP:769255937
254 254 c, t dbSNP:749713233
262 262 c, g dbSNP:776240688
274 274 c, g, t dbSNP:546920371
280 280 c, t dbSNP:777465972
288 288 g, t dbSNP:758011168
289 289 c, t dbSNP:747982670
296 296 g, t dbSNP:778520280
298 298 c, t dbSNP:754972138
317 317 a, c dbSNP:753651871
318 318 a, c dbSNP:766493778
328 328 c, t dbSNP:756321814
335 335 c, t dbSNP:750526402
355 355 a, g dbSNP:141005361
389 389 a, t dbSNP:400377
392 392 a, g dbSNP:762106424
414 414 a, t dbSNP:774805080
418 418 g, t dbSNP:764328739
419 419 ct, g dbSNP:387906399
429 429 a, g dbSNP:763525000
433 433 c, t dbSNP:534471786
454 454 a, c dbSNP:770277810
458 458 c, t dbSNP:570636789
461 461 c, g dbSNP:772684721
462 462 c, t dbSNP:771731330
472 472 a, g dbSNP:747757242
473 473 a, g dbSNP:551863674
499 499 g, t dbSNP:778772076
552 552 a, c dbSNP:754671425
560 560 a, g dbSNP:753342439
561 561 c, t dbSNP:385101
585 585 c, t dbSNP:372633
628 628 a, c dbSNP:399771
637 637 c, g dbSNP:533485167
648 648 c, t dbSNP:113374868
664 664 c, t dbSNP:191294997
670 670 c, t dbSNP:384713
676 676 c, t dbSNP:112196492
679 679 a, g dbSNP:550978405
702 702 c, g dbSNP:2583439
709 709 a, g dbSNP:529326848
720 720 c, g dbSNP:2583440
726 726 c, g dbSNP:1182342
727 727 -, ggccccggcccc dbSNP:759134767
727 727 -, ggcccc dbSNP:760463569
734 734 a, g dbSNP:750581456
739 739 c, g dbSNP:767656648
741 741 -, accggc dbSNP:771450542
748 748 c, t dbSNP:757586907
749 749 a, c dbSNP:562237921
758 758 -, ccccgg dbSNP:772704243
759 759 a, t dbSNP:3741342
760 760 c, g dbSNP:751669088
766 766 g, t dbSNP:764536797
768 768 c, t dbSNP:763289302
773 773 c, g dbSNP:775889163
778 778 c, t dbSNP:540923047
779 779 a, g dbSNP:528634940
785 785 c, g dbSNP:772737614
788 788 g, t dbSNP:771502215
793 793 a, g dbSNP:761539484
806 806 c, t dbSNP:773932111
807 807 a, c, g dbSNP:564726941
808 808 c, g dbSNP:779975908
811 811 c, g dbSNP:546016935
817 817 a, g dbSNP:3741341
824 824 g, t dbSNP:781428134
826 826 c, t dbSNP:757359164
841 841 c, g dbSNP:751650132
844 844 a, g dbSNP:556682082
849 849 a, c dbSNP:104894200
856 856 a, t dbSNP:758620755
858 858 a, c dbSNP:753022994
861 861 c, t dbSNP:765542916
872 872 a, g dbSNP:760038657
878 878 g, t dbSNP:754283907
882 882 a, g dbSNP:766858608
883 883 c, t dbSNP:761296394
884 884 g, t dbSNP:773881541
890 890 a, g dbSNP:768242627
892 892 a, c dbSNP:762619956
895 895 g, t dbSNP:775458829
910 910 a, c, g dbSNP:745815931
911 911 a, t dbSNP:781340171
913 913 a, c, t dbSNP:747104008
924 924 g, t dbSNP:515726203
929 929 a, g dbSNP:387907225
935 935 g, t dbSNP:387907223
936 936 c, t dbSNP:387907224
938 938 a, g dbSNP:759474789
941 941 a, g dbSNP:387907226
945 945 c, g, t dbSNP:318240750
954 954 a, c, g dbSNP:267606716
957 957 c, t dbSNP:776541692
970 970 a, g dbSNP:373252940
973 973 a, g dbSNP:370564696
985 985 a, c dbSNP:773166985
992 992 a, t dbSNP:772130948
995 995 c, t dbSNP:531059713
997 997 c, t dbSNP:779172459
1007 1007 g, t dbSNP:755160554
1010 1010 g, t dbSNP:749702191
1012 1012 a, c dbSNP:1802775
1015 1015 c, t dbSNP:780417247
1018 1018 c, t dbSNP:377216794
1026 1026 c, g dbSNP:750876855
1030 1030 g, t dbSNP:763529383
1052 1052 c, t dbSNP:757986512
1071 1071 a, g dbSNP:761689994
1072 1072 a, g dbSNP:774447378
1085 1085 a, g dbSNP:768656669
1093 1093 c, t dbSNP:763176740
1105 1105 c, t dbSNP:775842083
1106 1106 a, g dbSNP:574318429
1115 1115 c, g dbSNP:769907193
1116 1116 c, t dbSNP:552955353
1169 1169 c, g dbSNP:11550171
1206 1206 c, t dbSNP:13563
1233 1233 g, t dbSNP:540697744
1258 1258 a, g dbSNP:370352968
1319 1319 -, ct dbSNP:776125747
1333 1333 a, g dbSNP:1052593
1406 1406 a, g dbSNP:752550090
1491 1491 c, t dbSNP:767474496
1506 1506 a, c dbSNP:12801085
1507 1507 a, c dbSNP:12793537
1544 1544 a, c dbSNP:558934701
1579 1579 c, g dbSNP:181826383
1697 1697 a, g dbSNP:778643023
1710 1710 a, g dbSNP:759397245
1718 1718 g, t dbSNP:751488966

Target ORF information:

RefSeq Version NM_001122631
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001122631

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGGAGCGTC TTGTCGCCCG TGGGACCTTC CCAGTACTAG TGCGCACCAG CGCCTGCCGC 
AGCCTCTTCG GGCCGGTGGA CCACGAGGAG CTGAGCCGCG AGCTGCAGGC CCGCCTGGCC
GAGCTGAACG CCGAGGACCA GAACCGCTGG GATTACGACT TCCAGCAGGA CATGCCGCTG
CGGGGCCCTG GACGCCTGCA GTGGACCGAA GTGGACAGCG ACTCGGTGCC CGCGTTCTAC
CGCGAGACGG TGCAGGTGGG GCGCTGCCGC CTGCTGCTGG CGCCGCGGCC CGTCGCGGTC
GCGGTGGCTG TCAGCCCGCC CCTCGAGCCG GCCGCTGAGT CCCTCGACGG CCTCGAGGAG
GCGCCGGAGC AGCTGCCTAG TGTCCCGGTC CCGGCCCCGG CGTCCACCCC GCCCCCAGTC
CCGGTCCTGG CTCCAGCCCC GGCCCCGGCT CCGGCTCCGG TCGCGGCTCC GGTCGCGGCT
CCGGTCGCGG TCGCGGTCCT GGCCCCGGCC CCGGCCCCGG CTCCGGCTCC GGCTCCGGCC
CCGGCTCCAG TCGCGGCCCC GGCCCCAGCC CCGGCCCCGG CCCCGGCCCC GGCCCCCGCC
CCGGCCCCGG CCCCGGACGC GGCGCCTCAA GAGAGCGCCG AGCAGGGCGC GAACCAGGGG
CAGCGCGGCC AGGAGCCTCT CGCTGACCAG CTGCACTCGG GGATTTCGGG ACGTCCCGCG
GCCGGCACCG CGGCCGCCAG CGCCAACGGC GCGGCGATCA AGAAGCTGTC CGGGCCTCTG
ATCTCCGATT TCTTCGCCAA GCGCAAGAGA TCAGCGCCTG AGAAGTCGTC GGGCGATGTC
CCCGCGCCGT GTCCCTCTCC AAGCGCCGCC CCTGGCGTGG GCTCGGTGGA GCAGACCCCG
CGCAAGAGGC TGCGGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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