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CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) [Homo sapiens (human)]

Gene Symbol CDKN2B
Entrez Gene ID 1030
Full Name cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
Synonyms CDK4I, INK4B, MTS2, P15, TP15, p15INK4b
General protein information
Preferred Names
cyclin-dependent kinase 4 inhibitor B
Names
cyclin-dependent kinase 4 inhibitor B
MTS-2
p14-INK4b
p14_INK4B
p15-INK4b
p15_INK4B
CDK4B inhibitor
p14_CDK inhibitor
p15 CDK inhibitor
CDK inhibitory protein
multiple tumor suppressor 2
cyclin-dependent kinases 4 and 6 binding protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9p21

Summary This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600431

Disorder Html:
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu10080 NM_004936 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In stock -1 Starting from $99.00
OHu18518 NM_078487 Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK Not in stock -1 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu10080D
Sequence Information ORF Nucleotide Sequence (Length: 417bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase 4 inhibitor B isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI560960.1, BC014469.1, BC018984.2 and AF488731.1. On May 12, 2004 this sequence version replaced gi:17981693. Summary: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC014469.1, AL555679.3 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTCA TGATGATGGG CAGCGCCCGC
GTGGCGGAGC TGCTGCTGCT CCACGGCGCG GAGCCCAACT GCGCAGACCC TGCCACTCTC
ACCCGACCGG TGCATGATGC TGCCCGGGAG GGCTTCCTGG ACACGCTGGT GGTGCTGCAC
CGGGCCGGGG CGCGGCTGGA CGTGCGCGAT GCCTGGGGTC GTCTGCCCGT GGACTTGGCC
GAGGAGCGGG GCCACCGCGA CGTTGCAGGG TACCTGCGCA CAGCCACGGG GGACTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_004927.2
CDS361..777
Misc Feature(1)34..36(+)
Misc Feature(2)397..477(+)
Misc Feature(3)412..690(+)
Misc Feature(4)421..756(+)
Misc Feature(5)496..582(+)
Misc Feature(6)595..684(+)
Misc Feature(7)694..774(+)
Exon (1)1..516
Gene:CDKN2B
Gene Synonym:
Exon (2)517..3861
Gene:CDKN2B
Gene Synonym:
Translation
Position Chain Variation Link
19 19 a, t dbSNP:186697981
22 22 c, g dbSNP:544145698
23 23 a, g dbSNP:377053737
26 26 c, t dbSNP:761445735
27 27 g, t dbSNP:575060525
46 46 g, t dbSNP:776973752
56 56 c, t dbSNP:555150370
82 82 c, t dbSNP:534381467
103 103 c, g dbSNP:572099629
125 125 a, g dbSNP:558416419
134 134 c, g dbSNP:538226445
138 138 a, g dbSNP:369032987
147 147 a, g dbSNP:374702031
159 159 c, g dbSNP:72550842
183 183 c, t dbSNP:779167538
194 194 c, t dbSNP:569345626
198 198 a, g dbSNP:181360070
231 231 a, t dbSNP:548690253
233 233 a, c dbSNP:536144156
270 270 c, g, t dbSNP:150655569
273 273 a, g dbSNP:138552700
282 282 g, t dbSNP:775516570
303 303 a, g dbSNP:772097155
314 314 a, g, t dbSNP:540255346
317 317 c, t dbSNP:767144669
319 319 a, g dbSNP:761373705
323 323 g, t dbSNP:773900368
324 324 c, g dbSNP:768552154
326 326 a, t dbSNP:552736070
327 327 c, t dbSNP:377687208
330 330 a, t dbSNP:769642333
332 332 c, t dbSNP:746010479
335 335 g, t dbSNP:781471383
337 337 c, t dbSNP:771112476
338 338 c, g dbSNP:747087113
342 342 c, g, t dbSNP:373722871
343 343 a, g dbSNP:753272006
345 345 a, g, t dbSNP:755368672
355 355 c, t dbSNP:369397388
357 357 c, g, t dbSNP:761414872
359 359 g, t dbSNP:751030214
365 365 a, g dbSNP:763615328
369 369 c, g dbSNP:762817639
371 371 a, t dbSNP:775410324
375 375 a, c dbSNP:769686129
380 380 a, g dbSNP:150973276
392 392 c, g dbSNP:375797351
394 394 a, g dbSNP:771151576
395 395 g, t dbSNP:747263748
396 396 c, t dbSNP:777945760
399 399 -, c dbSNP:753957850
402 402 c, t dbSNP:772284792
408 408 c, g dbSNP:748308679
412 412 c, t dbSNP:779465219
413 413 c, t dbSNP:372664976
416 416 a, c dbSNP:184392037
422 422 a, c dbSNP:754200597
439 439 c, g dbSNP:780316323
444 444 a, g dbSNP:756887421
448 448 c, g, t dbSNP:746394467
475 475 a, g dbSNP:537747623
478 478 c, g dbSNP:762444993
481 481 a, g dbSNP:369983875
482 482 a, g, t dbSNP:375443156
491 491 a, g dbSNP:776444022
496 496 g, t dbSNP:770648244
499 499 c, g dbSNP:760916164
502 502 a, g dbSNP:773567747
507 507 c, g dbSNP:772483505
509 509 -, cg dbSNP:764016512
510 510 c, g dbSNP:748216703
511 511 a, g dbSNP:774336535
515 515 a, c dbSNP:769168016
517 517 c, g dbSNP:748720669
521 521 c, t dbSNP:779743053
523 523 a, t dbSNP:756067582
534 534 c, t dbSNP:531754702
536 536 c, t dbSNP:781070051
537 537 a, c dbSNP:756996826
538 538 c, t dbSNP:751427195
540 540 a, c dbSNP:764199965
541 541 a, c, g dbSNP:752675430
546 546 c, g, t dbSNP:759975176
547 547 c, g dbSNP:777125202
549 549 c, g dbSNP:771488156
551 551 g, t dbSNP:760928344
553 553 c, t dbSNP:773670765
554 554 a, t dbSNP:768154528
556 556 c, t dbSNP:144131923
561 561 c, g dbSNP:201282617
562 562 a, c dbSNP:752985220
564 564 a, c dbSNP:748993568
565 565 a, g dbSNP:779655098
567 567 c, t dbSNP:769434878
568 568 a, g dbSNP:370236504
574 574 a, c dbSNP:368412874
578 578 a, g dbSNP:757266462
582 582 c, t dbSNP:751280469
586 586 c, g dbSNP:777650997
587 587 a, c dbSNP:758497193
588 588 c, g dbSNP:752926081
589 589 c, t dbSNP:765231771
590 590 a, c dbSNP:759601088
596 596 c, t dbSNP:753970895
599 599 c, t dbSNP:766769221
600 600 c, g dbSNP:761279768
607 607 c, t dbSNP:773400600
609 609 a, g, t dbSNP:142570894
611 611 g, t dbSNP:762447471
615 615 c, t dbSNP:565688322
616 616 a, g dbSNP:148421170
620 620 c, t dbSNP:745348156
621 621 c, t dbSNP:776320098
625 625 c, g dbSNP:770734081
633 633 a, c dbSNP:746984960
639 639 a, g dbSNP:777370833
642 642 c, g dbSNP:758215089
644 644 c, t dbSNP:748001006
652 652 a, g dbSNP:779087967
654 654 -, gtg dbSNP:761289662
672 672 a, g dbSNP:755236254
673 673 c, t dbSNP:753878524
674 674 a, g dbSNP:376104829
679 679 g, t dbSNP:756525134
682 682 a, g dbSNP:202221094
686 686 a, g dbSNP:377723228
688 688 a, g dbSNP:762253433
690 690 c, t dbSNP:774902423
703 703 c, t dbSNP:372284765
704 704 -, t dbSNP:773447852
715 715 c, t dbSNP:759288984
720 720 a, c, t dbSNP:62637622
721 721 a, g dbSNP:746854404
722 722 a, t dbSNP:191233212
735 735 a, c dbSNP:773194349
736 736 c, t dbSNP:371415045
741 741 c, t dbSNP:771954435
742 742 a, g dbSNP:747908376
749 749 a, g dbSNP:778016656
750 750 a, g dbSNP:759710557
755 755 a, t dbSNP:755144182
757 757 c, t dbSNP:749530069
758 758 g, t dbSNP:140430251
761 761 c, t dbSNP:779934422
763 763 g, t dbSNP:756217982
768 768 a, g dbSNP:750528782
770 770 a, g dbSNP:768043782
771 771 a, g dbSNP:757876781
773 773 a, g dbSNP:751928822
782 782 a, g dbSNP:764571136
783 783 a, g dbSNP:545104474
784 784 a, g dbSNP:753532408
787 787 c, t dbSNP:766011722
788 788 c, t dbSNP:760216883
795 795 a, g, t dbSNP:747033447
804 804 -, gac dbSNP:375565366
804 804 a, g dbSNP:761761620
806 806 c, t dbSNP:774079532
811 811 c, t dbSNP:768447646
822 822 a, c dbSNP:146540928
823 823 a, g dbSNP:749150773
829 829 c, t dbSNP:368728826
862 862 a, c dbSNP:539846785
871 871 c, t dbSNP:577743794
881 881 a, g dbSNP:189341541
893 893 c, t dbSNP:774265225
908 908 c, t dbSNP:756209608
911 911 a, g dbSNP:531705888
924 924 a, g dbSNP:544534160
972 972 c, t dbSNP:575482260
989 989 a, g dbSNP:184190153
1002 1002 a, g dbSNP:766446762
1014 1014 c, t dbSNP:542047894
1023 1023 a, g dbSNP:574045583
1082 1082 c, t dbSNP:562885506
1100 1100 c, g dbSNP:191774214
1116 1116 a, g dbSNP:3217982
1140 1140 c, t dbSNP:3217983
1149 1149 c, t dbSNP:557999070
1150 1150 a, g dbSNP:551180192
1192 1192 a, g dbSNP:752604024
1195 1195 a, g dbSNP:763396728
1228 1228 c, t dbSNP:538150287
1270 1270 c, g dbSNP:3217984
1310 1310 a, g dbSNP:3217985
1329 1329 a, c dbSNP:759296073
1330 1330 c, g dbSNP:751353700
1334 1334 -, t dbSNP:766085320
1376 1376 -, ct dbSNP:542878873
1386 1386 c, t dbSNP:564825636
1399 1399 c, t dbSNP:770283653
1420 1420 c, g dbSNP:748516732
1433 1433 a, c dbSNP:3217986
1442 1442 a, c dbSNP:529540396
1470 1470 a, c dbSNP:531182018
1497 1497 a, g dbSNP:187657501
1553 1553 a, g dbSNP:183610933
1554 1554 c, g dbSNP:564092888
1621 1621 -, a, c, ca, caca dbSNP:3028393
1621 1621 a, t dbSNP:183171776
1622 1622 -, c, ca dbSNP:35965489
1623 1623 -, a dbSNP:35712670
1630 1630 c, t dbSNP:190793848
1633 1633 a, t dbSNP:186836905
1636 1636 a, c dbSNP:11792944
1640 1640 c, t dbSNP:11792943
1649 1649 -, ac, ca dbSNP:66650443
1650 1650 -, ca dbSNP:765457409
1651 1651 -, ca, cacaca dbSNP:112857145
1682 1682 g, t dbSNP:544472833
1683 1683 c, t dbSNP:530815253
1702 1702 c, t dbSNP:3217987
1719 1719 a, c dbSNP:193073423
1772 1772 g, t dbSNP:560957226
1792 1792 a, g dbSNP:111751296
1794 1794 a, g dbSNP:769325023
1826 1826 c, t dbSNP:79703126
1843 1843 a, g dbSNP:573026381
1865 1865 c, t dbSNP:140726127
1950 1950 -, c dbSNP:35819291
1977 1977 a, c dbSNP:542318941
2032 2032 c, t dbSNP:187514719
2065 2065 c, t dbSNP:761355542
2080 2080 g, t dbSNP:572111377
2094 2094 c, t dbSNP:10965209
2138 2138 a, t dbSNP:577566745
2194 2194 a, t dbSNP:150924737
2213 2213 a, g dbSNP:775912142
2251 2251 c, g dbSNP:778317778
2359 2359 a, g dbSNP:142459906
2360 2360 c, t dbSNP:528876639
2388 2388 a, g dbSNP:756740443
2391 2391 g, t dbSNP:569207453
2395 2395 g, t dbSNP:377277689
2434 2434 a, g dbSNP:556056796
2441 2441 a, c dbSNP:41306083
2479 2479 a, g dbSNP:148786939
2556 2556 a, g dbSNP:546352392
2557 2557 c, g dbSNP:189152764
2577 2577 a, g dbSNP:570601308
2610 2610 c, t dbSNP:2285329
2624 2624 c, g dbSNP:530550051
2679 2679 a, g dbSNP:72693621
2681 2681 a, g dbSNP:3217988
2738 2738 g, t dbSNP:528242265
2799 2799 g, t dbSNP:559500160
2808 2808 g, t dbSNP:186542376
2876 2876 a, t dbSNP:181031884
2877 2877 a, t dbSNP:184884421
2883 2883 -, a dbSNP:149822153
2884 2884 -, a dbSNP:750688659
2909 2909 a, t dbSNP:564289170
2973 2973 a, g dbSNP:3217989
3005 3005 -, c dbSNP:397975070
3008 3008 c, t dbSNP:754527109
3012 3012 a, c dbSNP:575632072
3013 3013 -, c dbSNP:58215444
3017 3017 a, g dbSNP:781434887
3045 3045 a, c, t dbSNP:79203451
3056 3056 g, t dbSNP:75158970
3119 3119 c, t dbSNP:573310907
3172 3172 a, g dbSNP:185130567
3180 3180 a, g dbSNP:559265716
3210 3210 c, t dbSNP:751758721
3242 3242 a, c dbSNP:3217990
3249 3249 a, t dbSNP:145582009
3289 3289 c, t dbSNP:763027110
3323 3323 c, t dbSNP:186915914
3346 3346 g, t dbSNP:749548001
3396 3396 c, t dbSNP:1063192
3427 3427 c, t dbSNP:568067727
3456 3456 -, t dbSNP:397823852
3463 3463 -, t, tt dbSNP:34503303
3464 3464 -, t, tt dbSNP:3217991
3486 3486 g, t dbSNP:548134818
3494 3494 g, t dbSNP:78827673
3532 3532 -, t dbSNP:36058624
3540 3540 a, g dbSNP:3217992
3584 3584 c, t dbSNP:368814059
3594 3594 c, t dbSNP:3217993
3685 3685 c, t dbSNP:551951718
3703 3703 g, t dbSNP:181736450
3759 3759 a, g dbSNP:572607024
3777 3777 c, t dbSNP:564227803
3785 3785 c, g dbSNP:781046289
3795 3795 a, g dbSNP:544317719
3823 3823 -, aga dbSNP:754937067
3839 3839 a, g dbSNP:759131779
3845 3845 g, t dbSNP:575523216
3853 3853 g, t dbSNP:773996947

Target ORF information:

RefSeq Version NM_004936
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_004936

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTCA TGATGATGGG CAGCGCCCGC
GTGGCGGAGC TGCTGCTGCT CCACGGCGCG GAGCCCAACT GCGCAGACCC TGCCACTCTC
ACCCGACCGG TGCATGATGC TGCCCGGGAG GGCTTCCTGG ACACGCTGGT GGTGCTGCAC
CGGGCCGGGG CGCGGCTGGA CGTGCGCGAT GCCTGGGGTC GTCTGCCCGT GGACTTGGCC
GAGGAGCGGG GCCACCGCGA CGTTGCAGGG TACCTGCGCA CAGCCACGGG GGACTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu18518D
Sequence Information ORF Nucleotide Sequence (Length: 237bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cyclin-dependent kinase 4 inhibitor B isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BI560960.1, AF004819.1, BC014469.1, BC018984.2 and AF488731.1. This sequence is a reference standard in the RefSeqGene project. On May 12, 2004 this sequence version replaced gi:17981695. Summary: This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) uses a different splice site, which leads to a translation frame shift, when compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus when compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF004819.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152568, SAMEA2153980 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTAG CTGGGGCCCC AGGGCCTCGC
CGGCAGGGGG CGCGCGAACG CGGGGCGCGG CCTCGGCGGA TCGGGGCTGG AACCTAG
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_511042.1
CDS361..597
Misc Feature(1)34..36(+)
Misc Feature(2)397..477(+)
Misc Feature(3)412..>522(+)
Misc Feature(4)421..>522(+)
Misc Feature(5)517..639(+)
Exon (1)1..639
Gene:CDKN2B
Gene Synonym:
Exon (2)640..3984
Gene:CDKN2B
Gene Synonym:
Translation
Position Chain Variation Link
19 19 a, t dbSNP:186697981
22 22 c, g dbSNP:544145698
23 23 a, g dbSNP:377053737
26 26 c, t dbSNP:761445735
27 27 g, t dbSNP:575060525
46 46 g, t dbSNP:776973752
56 56 c, t dbSNP:555150370
82 82 c, t dbSNP:534381467
103 103 c, g dbSNP:572099629
125 125 a, g dbSNP:558416419
134 134 c, g dbSNP:538226445
138 138 a, g dbSNP:369032987
147 147 a, g dbSNP:374702031
159 159 c, g dbSNP:72550842
183 183 c, t dbSNP:779167538
194 194 c, t dbSNP:569345626
198 198 a, g dbSNP:181360070
231 231 a, t dbSNP:548690253
233 233 a, c dbSNP:536144156
270 270 c, g, t dbSNP:150655569
273 273 a, g dbSNP:138552700
282 282 g, t dbSNP:775516570
303 303 a, g dbSNP:772097155
314 314 a, g, t dbSNP:540255346
317 317 c, t dbSNP:767144669
319 319 a, g dbSNP:761373705
323 323 g, t dbSNP:773900368
324 324 c, g dbSNP:768552154
326 326 a, t dbSNP:552736070
327 327 c, t dbSNP:377687208
330 330 a, t dbSNP:769642333
332 332 c, t dbSNP:746010479
335 335 g, t dbSNP:781471383
337 337 c, t dbSNP:771112476
338 338 c, g dbSNP:747087113
342 342 c, g, t dbSNP:373722871
343 343 a, g dbSNP:753272006
345 345 a, g, t dbSNP:755368672
355 355 c, t dbSNP:369397388
357 357 c, g, t dbSNP:761414872
359 359 g, t dbSNP:751030214
365 365 a, g dbSNP:763615328
369 369 c, g dbSNP:762817639
371 371 a, t dbSNP:775410324
375 375 a, c dbSNP:769686129
380 380 a, g dbSNP:150973276
392 392 c, g dbSNP:375797351
394 394 a, g dbSNP:771151576
395 395 g, t dbSNP:747263748
396 396 c, t dbSNP:777945760
399 399 -, c dbSNP:753957850
402 402 c, t dbSNP:772284792
408 408 c, g dbSNP:748308679
412 412 c, t dbSNP:779465219
413 413 c, t dbSNP:372664976
416 416 a, c dbSNP:184392037
422 422 a, c dbSNP:754200597
439 439 c, g dbSNP:780316323
444 444 a, g dbSNP:756887421
448 448 c, g, t dbSNP:746394467
475 475 a, g dbSNP:537747623
478 478 c, g dbSNP:762444993
481 481 a, g dbSNP:369983875
482 482 a, g, t dbSNP:375443156
491 491 a, g dbSNP:776444022
496 496 g, t dbSNP:770648244
499 499 c, g dbSNP:760916164
502 502 a, g dbSNP:773567747
507 507 c, g dbSNP:772483505
509 509 -, cg dbSNP:764016512
510 510 c, g dbSNP:748216703
511 511 a, g dbSNP:774336535
515 515 a, c dbSNP:769168016
517 517 -, g dbSNP:762500467
517 517 g, t dbSNP:749784563
519 519 -, agct dbSNP:752359825
522 522 g, t dbSNP:544085281
525 525 a, g dbSNP:371777152
528 528 c, t dbSNP:746298063
533 533 a, g dbSNP:777390916
534 534 g, t dbSNP:372340557
535 535 c, t dbSNP:752167737
538 538 c, t dbSNP:202161436
543 543 a, g dbSNP:754893158
546 546 c, g dbSNP:188670390
550 550 -, g dbSNP:764662629
556 556 c, g dbSNP:190140075
561 561 a, c dbSNP:766409949
567 567 a, g dbSNP:546509178
569 569 a, g dbSNP:368328782
575 575 g, t dbSNP:773194994
576 576 a, g dbSNP:767817760
577 577 c, g, t dbSNP:200266212
578 578 a, g dbSNP:768633034
582 582 c, g dbSNP:749734284
583 583 a, g dbSNP:201305174
584 584 g, t dbSNP:770343149
587 587 c, t dbSNP:746208436
590 590 a, g dbSNP:779222136
592 592 a, c dbSNP:758002977
607 607 a, g dbSNP:372045410
610 610 g, t dbSNP:778422657
613 613 -, gatt dbSNP:759079787
615 615 c, g dbSNP:754444716
616 616 c, t dbSNP:753450386
619 619 a, c dbSNP:766401440
621 621 a, g dbSNP:756160608
624 624 -, agt dbSNP:777078006
627 627 c, g dbSNP:750203452
631 631 g, t dbSNP:767443985
635 635 c, t dbSNP:200344272
636 636 a, g dbSNP:771395123
637 637 g, t dbSNP:774439061
640 640 c, g dbSNP:748720669
644 644 c, t dbSNP:779743053
646 646 a, t dbSNP:756067582
657 657 c, t dbSNP:531754702
659 659 c, t dbSNP:781070051
660 660 a, c dbSNP:756996826
661 661 c, t dbSNP:751427195
663 663 a, c dbSNP:764199965
664 664 a, c, g dbSNP:752675430
669 669 c, g, t dbSNP:759975176
670 670 c, g dbSNP:777125202
672 672 c, g dbSNP:771488156
674 674 g, t dbSNP:760928344
676 676 c, t dbSNP:773670765
677 677 a, t dbSNP:768154528
679 679 c, t dbSNP:144131923
684 684 c, g dbSNP:201282617
685 685 a, c dbSNP:752985220
687 687 a, c dbSNP:748993568
688 688 a, g dbSNP:779655098
690 690 c, t dbSNP:769434878
691 691 a, g dbSNP:370236504
697 697 a, c dbSNP:368412874
701 701 a, g dbSNP:757266462
705 705 c, t dbSNP:751280469
709 709 c, g dbSNP:777650997
710 710 a, c dbSNP:758497193
711 711 c, g dbSNP:752926081
712 712 c, t dbSNP:765231771
713 713 a, c dbSNP:759601088
719 719 c, t dbSNP:753970895
722 722 c, t dbSNP:766769221
723 723 c, g dbSNP:761279768
730 730 c, t dbSNP:773400600
732 732 a, g, t dbSNP:142570894
734 734 g, t dbSNP:762447471
738 738 c, t dbSNP:565688322
739 739 a, g dbSNP:148421170
743 743 c, t dbSNP:745348156
744 744 c, t dbSNP:776320098
748 748 c, g dbSNP:770734081
756 756 a, c dbSNP:746984960
762 762 a, g dbSNP:777370833
765 765 c, g dbSNP:758215089
767 767 c, t dbSNP:748001006
775 775 a, g dbSNP:779087967
777 777 -, gtg dbSNP:761289662
795 795 a, g dbSNP:755236254
796 796 c, t dbSNP:753878524
797 797 a, g dbSNP:376104829
802 802 g, t dbSNP:756525134
805 805 a, g dbSNP:202221094
809 809 a, g dbSNP:377723228
811 811 a, g dbSNP:762253433
813 813 c, t dbSNP:774902423
826 826 c, t dbSNP:372284765
827 827 -, t dbSNP:773447852
838 838 c, t dbSNP:759288984
843 843 a, c, t dbSNP:62637622
844 844 a, g dbSNP:746854404
845 845 a, t dbSNP:191233212
858 858 a, c dbSNP:773194349
859 859 c, t dbSNP:371415045
864 864 c, t dbSNP:771954435
865 865 a, g dbSNP:747908376
872 872 a, g dbSNP:778016656
873 873 a, g dbSNP:759710557
878 878 a, t dbSNP:755144182
880 880 c, t dbSNP:749530069
881 881 g, t dbSNP:140430251
884 884 c, t dbSNP:779934422
886 886 g, t dbSNP:756217982
891 891 a, g dbSNP:750528782
893 893 a, g dbSNP:768043782
894 894 a, g dbSNP:757876781
896 896 a, g dbSNP:751928822
905 905 a, g dbSNP:764571136
906 906 a, g dbSNP:545104474
907 907 a, g dbSNP:753532408
910 910 c, t dbSNP:766011722
911 911 c, t dbSNP:760216883
918 918 a, g, t dbSNP:747033447
927 927 -, gac dbSNP:375565366
927 927 a, g dbSNP:761761620
929 929 c, t dbSNP:774079532
934 934 c, t dbSNP:768447646
945 945 a, c dbSNP:146540928
946 946 a, g dbSNP:749150773
952 952 c, t dbSNP:368728826
985 985 a, c dbSNP:539846785
994 994 c, t dbSNP:577743794
1004 1004 a, g dbSNP:189341541
1016 1016 c, t dbSNP:774265225
1031 1031 c, t dbSNP:756209608
1034 1034 a, g dbSNP:531705888
1047 1047 a, g dbSNP:544534160
1095 1095 c, t dbSNP:575482260
1112 1112 a, g dbSNP:184190153
1125 1125 a, g dbSNP:766446762
1137 1137 c, t dbSNP:542047894
1146 1146 a, g dbSNP:574045583
1205 1205 c, t dbSNP:562885506
1223 1223 c, g dbSNP:191774214
1239 1239 a, g dbSNP:3217982
1263 1263 c, t dbSNP:3217983
1272 1272 c, t dbSNP:557999070
1273 1273 a, g dbSNP:551180192
1315 1315 a, g dbSNP:752604024
1318 1318 a, g dbSNP:763396728
1351 1351 c, t dbSNP:538150287
1393 1393 c, g dbSNP:3217984
1433 1433 a, g dbSNP:3217985
1452 1452 a, c dbSNP:759296073
1453 1453 c, g dbSNP:751353700
1457 1457 -, t dbSNP:766085320
1499 1499 -, ct dbSNP:542878873
1509 1509 c, t dbSNP:564825636
1522 1522 c, t dbSNP:770283653
1543 1543 c, g dbSNP:748516732
1556 1556 a, c dbSNP:3217986
1565 1565 a, c dbSNP:529540396
1593 1593 a, c dbSNP:531182018
1620 1620 a, g dbSNP:187657501
1676 1676 a, g dbSNP:183610933
1677 1677 c, g dbSNP:564092888
1744 1744 -, a, c, ca, caca dbSNP:3028393
1744 1744 a, t dbSNP:183171776
1745 1745 -, c, ca dbSNP:35965489
1746 1746 -, a dbSNP:35712670
1753 1753 c, t dbSNP:190793848
1756 1756 a, t dbSNP:186836905
1759 1759 a, c dbSNP:11792944
1763 1763 c, t dbSNP:11792943
1772 1772 -, ac, ca dbSNP:66650443
1773 1773 -, ca dbSNP:765457409
1774 1774 -, ca, cacaca dbSNP:112857145
1805 1805 g, t dbSNP:544472833
1806 1806 c, t dbSNP:530815253
1825 1825 c, t dbSNP:3217987
1842 1842 a, c dbSNP:193073423
1895 1895 g, t dbSNP:560957226
1915 1915 a, g dbSNP:111751296
1917 1917 a, g dbSNP:769325023
1949 1949 c, t dbSNP:79703126
1966 1966 a, g dbSNP:573026381
1988 1988 c, t dbSNP:140726127
2073 2073 -, c dbSNP:35819291
2100 2100 a, c dbSNP:542318941
2155 2155 c, t dbSNP:187514719
2188 2188 c, t dbSNP:761355542
2203 2203 g, t dbSNP:572111377
2217 2217 c, t dbSNP:10965209
2261 2261 a, t dbSNP:577566745
2317 2317 a, t dbSNP:150924737
2336 2336 a, g dbSNP:775912142
2374 2374 c, g dbSNP:778317778
2482 2482 a, g dbSNP:142459906
2483 2483 c, t dbSNP:528876639
2511 2511 a, g dbSNP:756740443
2514 2514 g, t dbSNP:569207453
2518 2518 g, t dbSNP:377277689
2557 2557 a, g dbSNP:556056796
2564 2564 a, c dbSNP:41306083
2602 2602 a, g dbSNP:148786939
2679 2679 a, g dbSNP:546352392
2680 2680 c, g dbSNP:189152764
2700 2700 a, g dbSNP:570601308
2733 2733 c, t dbSNP:2285329
2747 2747 c, g dbSNP:530550051
2802 2802 a, g dbSNP:72693621
2804 2804 a, g dbSNP:3217988
2861 2861 g, t dbSNP:528242265
2922 2922 g, t dbSNP:559500160
2931 2931 g, t dbSNP:186542376
2999 2999 a, t dbSNP:181031884
3000 3000 a, t dbSNP:184884421
3006 3006 -, a dbSNP:149822153
3007 3007 -, a dbSNP:750688659
3032 3032 a, t dbSNP:564289170
3096 3096 a, g dbSNP:3217989
3128 3128 -, c dbSNP:397975070
3131 3131 c, t dbSNP:754527109
3135 3135 a, c dbSNP:575632072
3136 3136 -, c dbSNP:58215444
3140 3140 a, g dbSNP:781434887
3168 3168 a, c, t dbSNP:79203451
3179 3179 g, t dbSNP:75158970
3242 3242 c, t dbSNP:573310907
3295 3295 a, g dbSNP:185130567
3303 3303 a, g dbSNP:559265716
3333 3333 c, t dbSNP:751758721
3365 3365 a, c dbSNP:3217990
3372 3372 a, t dbSNP:145582009
3412 3412 c, t dbSNP:763027110
3446 3446 c, t dbSNP:186915914
3469 3469 g, t dbSNP:749548001
3519 3519 c, t dbSNP:1063192
3550 3550 c, t dbSNP:568067727
3579 3579 -, t dbSNP:397823852
3586 3586 -, t, tt dbSNP:34503303
3587 3587 -, t, tt dbSNP:3217991
3609 3609 g, t dbSNP:548134818
3617 3617 g, t dbSNP:78827673
3655 3655 -, t dbSNP:36058624
3663 3663 a, g dbSNP:3217992
3707 3707 c, t dbSNP:368814059
3717 3717 c, t dbSNP:3217993
3808 3808 c, t dbSNP:551951718
3826 3826 g, t dbSNP:181736450
3882 3882 a, g dbSNP:572607024
3900 3900 c, t dbSNP:564227803
3908 3908 c, g dbSNP:781046289
3918 3918 a, g dbSNP:544317719
3946 3946 -, aga dbSNP:754937067
3962 3962 a, g dbSNP:759131779
3968 3968 g, t dbSNP:575523216
3976 3976 g, t dbSNP:773996947

Target ORF information:

RefSeq Version NM_078487
Organism Homo sapiens (human)
Definition Homo sapiens cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (CDKN2B), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_078487

ORF Insert Sequence:

1
61
121
181
ATGCGCGAGG AGAACAAGGG CATGCCCAGT GGGGGCGGCA GCGATGAGGG TCTGGCCAGC 
GCCGCGGCGC GGGGACTAGT GGAGAAGGTG CGACAGCTCC TGGAAGCCGG CGCGGATCCC
AACGGAGTCA ACCGTTTCGG GAGGCGCGCG ATCCAGGTAG CTGGGGCCCC AGGGCCTCGC
CGGCAGGGGG CGCGCGAACG CGGGGCGCGG CCTCGGCGGA TCGGGGCTGG AACCTAG

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.