×

GNB2L1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GNB2L1
Entrez Gene ID 10399
Full Name guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Synonyms Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1
General protein information
Preferred Names
guanine nucleotide-binding protein subunit beta-2-like 1
Names
guanine nucleotide-binding protein subunit beta-2-like 1
lung cancer oncogene 7
proliferation-inducing gene 21
receptor for activated C kinase 1
human lung cancer oncogene 7 protein
receptor of activated protein kinase C 1
cell proliferation-inducing gene 21 protein
guanine nucleotide-binding protein subunit beta-like protein 12.3
protein homologous to chicken B complex protein, guanine nucleotide binding
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.3

Summary lac of sum
Disorder MIM:

176981


mRNA and Protein(s)

mRNA Protein Name
NM_006098 NP_006089 guanine nucleotide-binding protein subunit beta-2-like 1

KEGG
hsa05162 Measles
Pathway Interaction Database
cxcr4_pathway CXCR4-mediated signaling events
igf1_pathway IGF1 pathway
syndecan_2_pathway Syndecan-2-mediated signaling events
ar_tf_pathway Regulation of Androgen receptor activity
hif1apathway Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
tnfpathway TNF receptor signaling pathway
WikiPathways
WP138 Androgen receptor signaling pathway
WP231 TNF-alpha/NF-kB Signaling Pathway
WP286 IL-3 Signaling Pathway
WP2380 BDNF signaling pathway
WP585 Interferon type I


Homo sapiens (human) GNB2L1 NP_006089.1
Pan troglodytes (chimpanzee) GNB2L1 XP_518165.3
Macaca mulatta (Rhesus monkey) LOC708526 XP_001105066.1
Canis lupus familiaris (dog) GNB2L1 XP_005626337.1
Bos taurus (cattle) GNB2L1 XP_005209294.1
Mus musculus (house mouse) Gnb2l1 NP_032169.1
Rattus norvegicus (Norway rat) Gnb2l1 NP_570090.2
Gallus gallus (chicken) GNB2L1 NP_001004378.1
Danio rerio (zebrafish) gnb2l1 NP_571519.1
Drosophila melanogaster (fruit fly) Rack1 NP_001260218.1
Caenorhabditis elegans rack-1 NP_501859.1
Arabidopsis thaliana (thale cress) ATARCA NP_173248.1
Arabidopsis thaliana (thale cress) RACK1B_AT NP_175296.1
Arabidopsis thaliana (thale cress) RACK1C_AT NP_188441.1
Xenopus (Silurana) tropicalis (western clawed frog) gnb2l1 NP_001004946.1

Component

ID Name Evidence
GO:0001891 phagocytic cup IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005886 plasma membrane IEA
GO:0015935 small ribosomal subunit ISS
GO:0030425 dendrite ISS
GO:0030496 midbody IDA
GO:0043025 neuronal cell body ISS
GO:0048471 perinuclear region of cytoplasm IDA

Function

ID Name Evidence
GO:0005080 protein kinase C binding IDA
GO:0005102 receptor binding NAS
GO:0005515 protein binding IPI
GO:0008200 ion channel inhibitor activity ISS
GO:0019903 protein phosphatase binding IPI
GO:0030292 protein tyrosine kinase inhibitor activity IDA
GO:0030971 receptor tyrosine kinase binding IDA
GO:0042169 SH2 domain binding IDA

Process

ID Name Evidence
GO:0001934 positive regulation of protein phosphorylation IDA
GO:0017148 negative regulation of translation ISS
GO:0030178 negative regulation of Wnt receptor signaling pathway ISS
GO:0030308 negative regulation of cell growth IDA
GO:0030335 positive regulation of cell migration IDA
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
GO:0032464 positive regulation of protein homooligomerization IDA
GO:0032880 regulation of protein localization ISS
GO:0043065 positive regulation of apoptosis IDA
GO:0043547 positive regulation of GTPase activity IDA
GO:0050765 negative regulation of phagocytosis IMP
GO:0051302 regulation of cell division ISS
GO:0051726 regulation of cell cycle IDA
GO:0061099 negative regulation of protein tyrosine kinase activity IDA
GO:2000114 regulation of establishment of cell polarity ISS
GO:2000543 positive regulation of gastrulation ISS

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GNB2L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNB2L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu15971
NM_006098 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $154.50
$309.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu15971
Clone ID Related Accession (Same CDS sequence) NM_006098
Accession Version NM_006098.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 954bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product guanine nucleotide-binding protein subunit beta-2-like 1
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AK222488.1, M24194.1 and BC029996.1. On Dec 14, 2005 this sequence version replaced gi:55742675. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222488.1, BC021993.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGACTGAGC AGATGACCCT TCGTGGCACC CTCAAGGGCC ACAACGGCTG GGTAACCCAG 
ATCGCTACTA CCCCGCAGTT CCCGGACATG ATCCTCTCCG CCTCTCGAGA TAAGACCATC
ATCATGTGGA AACTGACCAG GGATGAGACC AACTATGGAA TTCCACAGCG TGCTCTGCGG
GGTCACTCCC ACTTTGTTAG TGATGTGGTT ATCTCCTCAG ATGGCCAGTT TGCCCTCTCA
GGCTCCTGGG ATGGAACCCT GCGCCTCTGG GATCTCACAA CGGGCACCAC CACGAGGCGA
TTTGTGGGCC ATACCAAGGA TGTGCTGAGT GTGGCCTTCT CCTCTGACAA CCGGCAGATT
GTCTCTGGAT CTCGAGATAA AACCATCAAG CTATGGAATA CCCTGGGTGT GTGCAAATAC
ACTGTCCAGG ATGAGAGCCA CTCAGAGTGG GTGTCTTGTG TCCGCTTCTC GCCCAACAGC
AGCAACCCTA TCATCGTCTC CTGTGGCTGG GACAAGCTGG TCAAGGTATG GAACCTGGCT
AACTGCAAGC TGAAGACCAA CCACATTGGC CACACAGGCT ATCTGAACAC GGTGACTGTC
TCTCCAGATG GATCCCTCTG TGCTTCTGGA GGCAAGGATG GCCAGGCCAT GTTATGGGAT
CTCAACGAAG GCAAACACCT TTACACGCTA GATGGTGGGG ACATCATCAA CGCCCTGTGC
TTCAGCCCTA ACCGCTACTG GCTGTGTGCT GCCACAGGCC CCAGCATCAA GATCTGGGAT
TTAGAGGGAA AGATCATTGT AGATGAACTG AAGCAAGAAG TTATCAGTAC CAGCAGCAAG
GCAGAACCAC CCCAGTGCAC CTCCCTGGCC TGGTCTGCTG ATGGCCAGAC TCTGTTTGCT
GGCTACACGG ACAACCTGGT GCGAGTGTGG CAGGTGACCA TTGGCACACG CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006089.1
CDS107..1060
Misc Feature(1)1..1(+)
Misc Feature(2)3..3(+)
Misc Feature(3)107..109(+)
Misc Feature(4)110..1036(+)
Misc Feature(5)110..112(+)
Misc Feature(6)125..1039(+)
Misc Feature(7)143..238(+)
Misc Feature(8)146..1039(+)
Misc Feature(9)287..379(+)
Misc Feature(10)413..505(+)
Misc Feature(11)494..496(+)
Misc Feature(12)542..640(+)
Misc Feature(13)674..766(+)
Misc Feature(14)788..790(+)
Misc Feature(15)788..790(+)
Misc Feature(16)797..886(+)
Misc Feature(17)947..1039(+)
Exon (1)1..215
Gene:GNB2L1
Gene Synonym:
Exon (2)216..387
Gene:GNB2L1
Gene Synonym:
Exon (3)388..535
Gene:GNB2L1
Gene Synonym:
Exon (4)536..631
Gene:GNB2L1
Gene Synonym:
Exon (5)632..742
Gene:GNB2L1
Gene Synonym:
Exon (6)743..883
Gene:GNB2L1
Gene Synonym:
Exon (7)884..994
Gene:GNB2L1
Gene Synonym:
Exon (8)995..1109
Gene:GNB2L1
Gene Synonym:
Translation
Position Chain Variation Link
1 1 c, t dbSNP:536177657
2 2 -, ct dbSNP:746632997
3 3 -, ctct dbSNP:746639954
3 3 c, t dbSNP:61735487
5 5 c, t dbSNP:750045936
6 6 -, ct dbSNP:535433416
9 9 a, c dbSNP:41285573
12 12 a, t dbSNP:533647123
16 16 a, c dbSNP:540731944
22 22 c, t dbSNP:1279737
31 31 a, g, t dbSNP:11540176
33 33 a, c, g dbSNP:11540179
48 48 g, t dbSNP:11540182
49 49 c, g dbSNP:2241369
56 56 c, g dbSNP:1059315
58 58 a, t dbSNP:574132667
61 61 c, t dbSNP:777449136
62 62 a, c dbSNP:746964357
66 66 a, c, g dbSNP:758531415
70 70 c, t dbSNP:761337978
71 71 c, t dbSNP:11540178
73 73 c, t dbSNP:73814547
76 76 c, t dbSNP:11540174
77 77 g, t dbSNP:765591595
82 82 a, g dbSNP:757490189
83 83 c, g dbSNP:754170527
86 86 a, t dbSNP:764512172
89 89 c, g dbSNP:369560198
91 91 c, t dbSNP:776038456
93 93 a, c dbSNP:767959123
97 97 c, t dbSNP:762479736
98 98 a, g dbSNP:776216120
100 100 c, t dbSNP:772641866
103 103 c, t dbSNP:769447572
106 106 c, g, t dbSNP:11249779
115 115 a, g dbSNP:537314343
118 118 a, g dbSNP:776357433
122 122 a, g dbSNP:11540191
124 124 c, t dbSNP:768468889
139 139 c, t dbSNP:746969023
151 151 c, t dbSNP:11540164
154 154 c, t dbSNP:778459490
159 159 c, g, t dbSNP:745953408
170 170 a, g dbSNP:779081202
173 173 a, g dbSNP:757617206
175 175 c, t dbSNP:11540173
178 178 c, t dbSNP:754057723
187 187 c, t dbSNP:11540165
190 190 a, g dbSNP:756520547
199 199 c, t dbSNP:752963603
202 202 c, t dbSNP:578087778
212 212 a, c dbSNP:759976987
222 222 c, t dbSNP:11540168
223 223 c, t dbSNP:368192532
226 226 c, t dbSNP:758151181
228 228 c, t dbSNP:750193394
235 235 a, g dbSNP:11540171
238 238 a, g dbSNP:765093139
256 256 a, c dbSNP:371464588
266 266 a, g dbSNP:11540167
267 267 c, t dbSNP:11540177
269 269 c, t dbSNP:753979165
280 280 c, t dbSNP:764157587
284 284 c, g dbSNP:534105679
286 286 a, g dbSNP:59085681
289 289 a, t dbSNP:772294196
290 290 c, t dbSNP:759820556
295 295 a, c dbSNP:11540190
299 299 c, t dbSNP:11540192
322 322 a, c, t dbSNP:11249777
324 324 c, t dbSNP:11540166
326 326 g, t dbSNP:11540172
370 370 c, g dbSNP:771622332
374 374 -, g dbSNP:34318897
380 380 c, t dbSNP:11540188
387 387 c, t dbSNP:749806666
388 388 a, g dbSNP:758636714
397 397 c, t dbSNP:781441209
400 400 a, g dbSNP:750877608
404 404 a, c dbSNP:765631889
426 426 a, g dbSNP:762269467
429 429 a, t dbSNP:11540186
439 439 c, g dbSNP:11540180
450 450 c, t dbSNP:368015408
472 472 c, t dbSNP:11540163
478 478 g, t dbSNP:764463539
484 484 c, t dbSNP:759081911
486 486 a, g dbSNP:773788138
511 511 a, g dbSNP:374020184
517 517 a, g dbSNP:748931084
530 530 a, g dbSNP:773028960
532 532 c, g dbSNP:769607577
538 538 g, t dbSNP:764684586
543 543 a, g, t dbSNP:77794998
547 547 c, t dbSNP:776557502
551 551 c, g dbSNP:768541673
574 574 c, t dbSNP:760746631
577 577 a, g dbSNP:775593812
589 589 c, t dbSNP:772098539
601 601 c, t dbSNP:139942873
607 607 c, t dbSNP:774277440
617 617 c, g dbSNP:3204002
619 619 c, t dbSNP:373339403
641 641 c, t dbSNP:780426977
644 644 g, t dbSNP:200305657
646 646 a, t dbSNP:376487405
654 654 a, g dbSNP:772588134
664 664 c, g dbSNP:748825736
672 672 c, t dbSNP:777390691
676 676 c, t dbSNP:755901696
684 684 a, g dbSNP:752388576
695 695 a, g dbSNP:11540199
696 696 c, t dbSNP:780842393
697 697 a, g dbSNP:754736780
703 703 c, t dbSNP:751331029
704 704 a, g dbSNP:371509460
712 712 a, g dbSNP:762926985
716 716 a, g dbSNP:11540189
735 735 g, t dbSNP:11540196
739 739 c, t dbSNP:397843845
743 743 a, g dbSNP:145995963
744 744 a, g dbSNP:189953976
751 751 c, g dbSNP:767043301
755 755 a, g dbSNP:11540198
764 764 a, g dbSNP:11540187
772 772 c, t dbSNP:763524329
796 796 a, g dbSNP:776071682
802 802 c, t dbSNP:187034782
811 811 c, g dbSNP:746445861
813 813 -, tca dbSNP:761851164
814 814 c, g dbSNP:201404764
817 817 c, t dbSNP:771671631
820 820 c, t dbSNP:745683332
850 850 a, c, g dbSNP:568961277
858 858 c, g dbSNP:11540181
859 859 c, t dbSNP:11540200
870 870 g, t dbSNP:11540197
880 880 c, t dbSNP:1131424
901 901 c, g dbSNP:780364981
902 902 a, g dbSNP:200634984
916 916 a, g dbSNP:758794696
919 919 a, g dbSNP:761693579
940 940 c, t dbSNP:11540194
943 943 c, t dbSNP:138107666
956 956 c, t dbSNP:201194486
963 963 a, g dbSNP:11540195
964 964 c, t dbSNP:762201797
970 970 c, t dbSNP:752241294
976 976 c, g dbSNP:780688483
982 982 g, t dbSNP:144585710
1014 1014 c, t dbSNP:770353665
1015 1015 a, g dbSNP:149248823
1020 1020 a, g dbSNP:781682699
1024 1024 c, g dbSNP:757851080
1025 1025 g, t dbSNP:749907520
1026 1026 c, t dbSNP:778452699
1030 1030 a, g dbSNP:548459672
1039 1039 a, g dbSNP:753724246
1040 1040 a, g dbSNP:763974107
1041 1041 g, t dbSNP:199990971
1043 1043 a, g dbSNP:752585622
1054 1054 a, g dbSNP:138356698
1055 1055 a, c dbSNP:759561448
1064 1064 c, g, t dbSNP:771185433
1067 1067 a, t dbSNP:763160311
1080 1080 a, c dbSNP:773626363
1081 1081 a, c dbSNP:770159352
1085 1085 -, a dbSNP:113679128
1085 1085 a, t dbSNP:748478755
1086 1086 a, t dbSNP:568646577
1091 1091 -, a dbSNP:11445317
1091 1091 a, t dbSNP:769155820
1092 1092 -, a dbSNP:555559914
1092 1092 a, c dbSNP:745416693
1093 1093 -, aaa dbSNP:200119653
1094 1094 -, aa dbSNP:775380109
1095 1095 -, a, aa, aaa dbSNP:755178974
1095 1095 -, a dbSNP:776115306
1095 1095 a, c dbSNP:185952721
1096 1096 -, a dbSNP:774758890
1097 1097 -, t dbSNP:769235302
1101 1101 c, t dbSNP:757035539
1109 1109 a, c dbSNP:3179945

Target ORF information:

RefSeq Version NM_006098
Organism Homo sapiens (human)
Definition Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006098

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGACTGAGC AGATGACCCT TCGTGGCACC CTCAAGGGCC ACAACGGCTG GGTAACCCAG 
ATCGCTACTA CCCCGCAGTT CCCGGACATG ATCCTCTCCG CCTCTCGAGA TAAGACCATC
ATCATGTGGA AACTGACCAG GGATGAGACC AACTATGGAA TTCCACAGCG TGCTCTGCGG
GGTCACTCCC ACTTTGTTAG TGATGTGGTT ATCTCCTCAG ATGGCCAGTT TGCCCTCTCA
GGCTCCTGGG ATGGAACCCT GCGCCTCTGG GATCTCACAA CGGGCACCAC CACGAGGCGA
TTTGTGGGCC ATACCAAGGA TGTGCTGAGT GTGGCCTTCT CCTCTGACAA CCGGCAGATT
GTCTCTGGAT CTCGAGATAA AACCATCAAG CTATGGAATA CCCTGGGTGT GTGCAAATAC
ACTGTCCAGG ATGAGAGCCA CTCAGAGTGG GTGTCTTGTG TCCGCTTCTC GCCCAACAGC
AGCAACCCTA TCATCGTCTC CTGTGGCTGG GACAAGCTGG TCAAGGTATG GAACCTGGCT
AACTGCAAGC TGAAGACCAA CCACATTGGC CACACAGGCT ATCTGAACAC GGTGACTGTC
TCTCCAGATG GATCCCTCTG TGCTTCTGGA GGCAAGGATG GCCAGGCCAT GTTATGGGAT
CTCAACGAAG GCAAACACCT TTACACGCTA GATGGTGGGG ACATCATCAA CGCCCTGTGC
TTCAGCCCTA ACCGCTACTG GCTGTGTGCT GCCACAGGCC CCAGCATCAA GATCTGGGAT
TTAGAGGGAA AGATCATTGT AGATGAACTG AAGCAAGAAG TTATCAGTAC CAGCAGCAAG
GCAGAACCAC CCCAGTGCAC CTCCCTGGCC TGGTCTGCTG ATGGCCAGAC TCTGTTTGCT
GGCTACACGG ACAACCTGGT GCGAGTGTGG CAGGTGACCA TTGGCACACG CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma
Tumour Biol. 34 (6), 3893-3899 (2013)
Hu F, Tao Z, Wang M, Li G, Zhang Y, Zhong H, Xiao H, Xie X and Ju M.


book

Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity
Oncol. Rep. 30 (5), 2195-2202 (2013)
Peng R, Jiang B, Ma J, Ma Z, Wan X, Liu H, Chen Z, Cheng Q and Chen R.


book

Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK)
J. Biol. Chem. 288 (42), 30720-30733 (2013)
Dave JM, Kang H, Abbey CA, Maxwell SA and Bayless KJ.


book

RACK1 promotes prostate cancer cell proliferation, invasion and metastasis
Mol Med Rep 8 (4), 999-1004 (2013)
Shen F, Yan C, Liu M, Feng Y and Chen Y.


book

Modulation of Rack-1/PKCbetaII signalling by soluble AbetaPPalpha in SH-SY5Y cells
Curr Alzheimer Res 10 (7), 697-705 (2013)
Buoso E, Biundo F, Lanni C, Aiello S, Grossi S, Schettini G, Govoni S and Racchi M.


book

A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase
J. Biol. Chem. 270 (24), 14251-14254 (1995)
Pumiglia KM, LeVine H, Haske T, Habib T, Jove R and Decker SJ.


book

Construction of a human full-length cDNA bank
Gene 150 (2), 243-250 (1994)
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M and Aoki T.


book

p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C
Biochemistry 31 (35), 8120-8124 (1992)
Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J and Smith BL.


book

Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin
J. Infect. 24 (3), 317-320 (1992)
Dawson SJ and White LA.


book

Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex
Proc. Natl. Acad. Sci. U.S.A. 86 (12), 4594-4598 (1989)
Guillemot F, Billault A and Auffray C.


 
*
*
*
*