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MAB21L2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MAB21L2
Entrez Gene ID 10586
Full Name mab-21-like 2 (C. elegans)
Synonyms MCOPS14
General protein information
Preferred Names
protein mab-21-like 2
Names
protein mab-21-like 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q31

Summary This gene is similar to the C. elegans MAB-21 cell fate-determining gene, a downstream target of transforming growth factor-beta signaling. It is thought that this gene may be involved in neural development. The protein encoded by this gene is primarily nuclear, although some cytoplasmic localization has been observed. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604357


mRNA and Protein(s)

mRNA Protein Name
NM_006439 NP_006430 protein mab-21-like 2


Homo sapiens (human) MAB21L2 NP_006430.1
Pan troglodytes (chimpanzee) MAB21L2 XP_001151747.1
Macaca mulatta (Rhesus monkey) MAB21L2 XP_001082398.1
Canis lupus familiaris (dog) MAB21L2 XP_867530.2
Bos taurus (cattle) MAB21L2 XP_002694365.1
Mus musculus (house mouse) Mab21l2 NP_035969.2
Rattus norvegicus (Norway rat) Mab21l2 NP_001102861.1
Danio rerio (zebrafish) mab21l2 NP_694507.1
Drosophila melanogaster (fruit fly) CG4766 NP_572287.1
Xenopus (Silurana) tropicalis (western clawed frog) mab21l2 NP_001096455.1


The following MAB21L2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MAB21L2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu31799 NM_006439 Homo sapiens mab-21-like 2 (C. elegans) (MAB21L2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $265.30
$379.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu31799
Clone ID Related Accession (Same CDS sequence) NM_006439
Accession Version NM_006439.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1080bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 06-AUG-2015
Organism Homo sapiens (human)
Product protein mab-21-like 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC110813.4 and BC009983.2. This sequence is a reference standard in the RefSeqGene project. On Aug 1, 2008 this sequence version replaced gi:18765720. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this RefSeq transcript is supported by transcript alignments. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGATCGCCG CTCAGGCCAA GCTGGTTTAC CAGCTCAATA AGTACTACAC TGAGCGCTGT 
CAGGCGCGCA AGGCGGCCAT CGCCAAAACC ATCCGAGAGG TCTGTAAGGT GGTCTCGGAC
GTGCTCAAGG AAGTGGAGGT GCAGGAGCCT CGCTTCATCA GCTCCTTGAG CGAGATCGAT
GCCCGCTACG AGGGGCTCGA GGTCATTTCG CCCACCGAAT TTGAGGTGGT GCTCTACCTA
AACCAGATGG GCGTCTTCAA CTTCGTGGAC GACGGCTCGC TGCCCGGCTG CGCAGTGCTC
AAACTGAGCG ATGGGCGGAA GCGGAGCATG TCTCTCTGGG TCGAGTTCAT CACGGCGTCG
GGCTATCTCT CAGCGCGTAA GATCCGCTCG CGTTTCCAGA CGCTGGTGGC CCAGGCGGTG
GACAAGTGCA GCTATCGGGA TGTGGTCAAG ATGATCGCGG ACACCAGCGA GGTCAAGTTG
CGCATCAGGG AGCGCTATGT GGTGCAAATC ACTCCGGCGT TCAAGTGCAC CGGGATCTGG
CCTCGCAGCG CGGCACAGTG GCCTATGCCC CACATCCCTT GGCCCGGCCC CAATCGGGTG
GCCGAGGTCA AGGCCGAAGG GTTCAACTTG CTCTCGAAGG AGTGCTACTC GCTGACCGGC
AAGCAGAGCT CGGCAGAGAG CGACGCCTGG GTGCTACAGT TCGGGGAGGC GGAGAACCGC
CTGCTGATGG GCGGCTGCCG AAACAAGTGC CTCTCAGTGC TGAAGACTCT GCGGGACCGC
CACCTGGAGC TACCCGGCCA GCCGCTCAAC AACTACCACA TGAAGACGCT GCTGCTGTAC
GAGTGCGAGA AACACCCACG AGAAACGGAC TGGGACGAGT CGTGCCTGGG CGACCGGCTC
AACGGCATCC TGCTGCAGCT CATCTCCTGC CTGCAGTGCC GCCGCTGCCC TCACTACTTT
CTGCCCAACC TCGACCTCTT TCAGGGCAAG CCCCATTCGG CCCTGGAGAG CGCTGCCAAG
CAGACCTGGA GGTTGGCCAG GGAAATTCTC ACCAATCCCA AAAGCCTGGA CAAACTATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006430.1
CDS1106..2185
Misc Feature(1)1043..1045(+)
Misc Feature(2)1289..2146(+)
Exon (1)1..2769
Gene:MAB21L2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006439
Organism Homo sapiens (human)
Definition Homo sapiens mab-21-like 2 (C. elegans) (MAB21L2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006439

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGATCGCCG CTCAGGCCAA GCTGGTTTAC CAGCTCAATA AGTACTACAC TGAGCGCTGT 
CAGGCGCGCA AGGCGGCCAT CGCCAAAACC ATCCGAGAGG TCTGTAAGGT GGTCTCGGAC
GTGCTCAAGG AAGTGGAGGT GCAGGAGCCT CGCTTCATCA GCTCCTTGAG CGAGATCGAT
GCCCGCTACG AGGGGCTCGA GGTCATTTCG CCCACCGAAT TTGAGGTGGT GCTCTACCTA
AACCAGATGG GCGTCTTCAA CTTCGTGGAC GACGGCTCGC TGCCCGGCTG CGCAGTGCTC
AAACTGAGCG ATGGGCGGAA GCGGAGCATG TCTCTCTGGG TCGAGTTCAT CACGGCGTCG
GGCTATCTCT CAGCGCGTAA GATCCGCTCG CGTTTCCAGA CGCTGGTGGC CCAGGCGGTG
GACAAGTGCA GCTATCGGGA TGTGGTCAAG ATGATCGCGG ACACCAGCGA GGTCAAGTTG
CGCATCAGGG AGCGCTATGT GGTGCAAATC ACTCCGGCGT TCAAGTGCAC CGGGATCTGG
CCTCGCAGCG CGGCACAGTG GCCTATGCCC CACATCCCTT GGCCCGGCCC CAATCGGGTG
GCCGAGGTCA AGGCCGAAGG GTTCAACTTG CTCTCGAAGG AGTGCTACTC GCTGACCGGC
AAGCAGAGCT CGGCAGAGAG CGACGCCTGG GTGCTACAGT TCGGGGAGGC GGAGAACCGC
CTGCTGATGG GCGGCTGCCG AAACAAGTGC CTCTCAGTGC TGAAGACTCT GCGGGACCGC
CACCTGGAGC TACCCGGCCA GCCGCTCAAC AACTACCACA TGAAGACGCT GCTGCTGTAC
GAGTGCGAGA AACACCCACG AGAAACGGAC TGGGACGAGT CGTGCCTGGG CGACCGGCTC
AACGGCATCC TGCTGCAGCT CATCTCCTGC CTGCAGTGCC GCCGCTGCCC TCACTACTTT
CTGCCCAACC TCGACCTCTT TCAGGGCAAG CCCCATTCGG CCCTGGAGAG CGCTGCCAAG
CAGACCTGGA GGTTGGCCAG GGAAATTCTC ACCAATCCCA AAAGCCTGGA CAAACTATAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mutations in MAB21L2 result in ocular Coloboma, microcornea and cataracts
PLoS Genet. 11 (2), E1005002 (2015)
Deml B, Kariminejad A, Borujerdi RH, Muheisen S, Reis LM and Semina EV.


book

A proteome-scale map of the human interactome network
Cell 159 (5), 1212-1226 (2014)
Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabasi AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP and Vidal M.


book

Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations
Am. J. Hum. Genet. 94 (6), 915-923 (2014)
Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L, Williamson KA, Ture M, Barker H, Rosendahl K, Spranger J, Horn D, Meynert A, Floyd JA, Prescott T, Anderson CA, Rainger JK, Karaca E, Gonzaga-Jauregui C, Jhangiani S, Muzny DM, Seawright A, Soares DC, Kharbanda M, Murday V, Finch A, Gibbs RA, van Heyningen V, Taylor MS, Yakut T, Knappskog PM, Hurles ME, Ponting CP, Lupski JR, Houge G and FitzPatrick DR.


book

hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes
Genomics 89 (3), 307-315 (2007)
Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G, Martin P, Rogers J, Lawlor S, McLaren S, Dricot A, Borick H, Cusick ME, Vandenhaute J, Dunham I, Hill DE and Vidal M.


book

Two murine and human homologs of mab-21, a cell fate determination gene involved in Caenorhabditis elegans neural development
Hum. Mol. Genet. 8 (13), 2397-2406 (1999)
Mariani M, Baldessari D, Francisconi S, Viggiano L, Rocchi M, Zappavigna V, Malgaretti N and Consalez GG.


 
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