||ORF Nucleotide Sequence (Length: 693bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AU128761.1, CA488777.1,
BC001572.1 and BC001549.1.
This sequence is a reference standard in the RefSeqGene project.
On Mar 13, 2008 this sequence version replaced gi:5729809.
Summary: The protein encoded by this gene is an integral membrane
protein of the endoplasmic reticulum. It is a high affinity binding
protein for the antiischemic phenylalkylamine Ca2+ antagonist
[3H]emopamil and the photoaffinity label [3H]azidopamil. It is
similar to sigma receptors and may be a member of a superfamily of
high affinity drug-binding proteins in the endoplasmic reticulum of
different tissues. This protein shares structural features with
bacterial and eukaryontic drug transporting proteins. It has four
putative transmembrane segments and contains two conserved
glutamate residues which may be involved in the transport of
cationic amphiphilics. Another prominent feature of this protein is
its high content of aromatic amino acid residues (>23%) in its
transmembrane segments. These aromatic amino acid residues have
been suggested to be involved in the drug transport by the
P-glycoprotein. Mutations in this gene cause Chondrodysplasia
punctata 2 (CDPX2; also known as Conradi-Hunermann syndrome).
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC001549.1, AL559203.3 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.