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GJB6 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GJB6
Entrez Gene ID 10804
Full Name gap junction protein, beta 6, 30kDa
Synonyms CX30, DFNA3, DFNA3B, DFNB1B, ECTD2, ED2, EDH, HED, HED2
General protein information
Preferred Names
gap junction beta-6 protein
Names
gap junction beta-6 protein
connexin 30
connexin-30
gap junction protein, beta 6 (connexin 30)
ectodermal dysplasia 2, hidrotic (Clouston syndrome)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q12

Summary Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in some families with hidrotic ectodermal dysplasia. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

604418

Disorder Html: Deafness, autosomal dominant 3B, 612643 (3); Ectodermal dysplasia,

mRNA and Protein(s)

mRNA Protein Name
NM_006783 NP_006774 gap junction beta-6 protein
NM_001110221 NP_001103691 gap junction beta-6 protein
NM_001110220 NP_001103690 gap junction beta-6 protein
NM_001110219 NP_001103689 gap junction beta-6 protein



Homo sapiens (human) GJB6 NP_006774.2
Pan troglodytes (chimpanzee) GJB6 XP_003314112.1
Macaca mulatta (Rhesus monkey) GJB6 XP_001086965.2
Canis lupus familiaris (dog) GJB6 XP_005635624.1
Bos taurus (cattle) GJB6 NP_001015546.1
Mus musculus (house mouse) Gjb6 NP_001010937.1
Rattus norvegicus (Norway rat) Gjb6 NP_445840.1
Gallus gallus (chicken) GJB6 NP_990262.1
Danio rerio (zebrafish) cx30.3 NP_997990.2
Xenopus (Silurana) tropicalis (western clawed frog) gjb2 NP_001016984.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GJB6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GJB6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu26102
NM_006783 Homo sapiens gap junction protein, beta 6, 30kDa (GJB6), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $49.50
$99.00
OHu26102
NM_001110221 Homo sapiens gap junction protein, beta 6, 30kDa (GJB6), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $49.50
$99.00
OHu26102
NM_001110220 Homo sapiens gap junction protein, beta 6, 30kDa (GJB6), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $49.50
$99.00
OHu26102
NM_001110219 Homo sapiens gap junction protein, beta 6, 30kDa (GJB6), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
Starting from $49.50
$99.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26102
Clone ID Related Accession (Same CDS sequence) NM_001110219 , NM_001110220 , NM_001110221 , NM_006783
Accession Version NM_006783.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 786bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product gap junction beta-6 protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC337465.1, AK289592.1, BE181310.1 and BC038934.1. This sequence is a reference standard in the RefSeqGene project. On Jul 18, 2008 this sequence version replaced gi:158966715. Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. All variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC038934.1, AK289592.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2145893 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 
GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTCGT GGTGGCTGCC
CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC
AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG
CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC
GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC
ATTAAAAAGC AGAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC
TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG
TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC
TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG
ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG
AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG
CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA
AGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006774.2
CDS554..1339
Misc Feature(1)542..544(+)
Misc Feature(2)557..877(+)
Misc Feature(3)620..688(+)
Misc Feature(4)779..847(+)
Misc Feature(5)947..1015(+)
Misc Feature(6)989..1192(+)
Misc Feature(7)1130..1198(+)
Exon (1)1..368
Gene:GJB6
Gene Synonym:
Exon (2)369..538
Gene:GJB6
Gene Synonym:
Exon (3)539..2072
Gene:GJB6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006783
Organism Homo sapiens (human)
Definition Homo sapiens gap junction protein, beta 6, 30kDa (GJB6), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006783

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 
GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTCGT GGTGGCTGCC
CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC
AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG
CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC
GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC
ATTAAAAAGC AGAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC
TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG
TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC
TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG
ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG
AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG
CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA
AGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26102
Clone ID Related Accession (Same CDS sequence) NM_001110219 , NM_001110220 , NM_001110221 , NM_006783
Accession Version NM_001110221.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 786bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product gap junction beta-6 protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN998505.1, BP227986.1, BC038934.1 and DB577868.1. On Jul 18, 2008 this sequence version replaced gi:158966716. Transcript Variant: This variant (4) lacks two 5' UTR segments, compared to variant 1. All variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA136206.1, BP227986.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 
GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTCGT GGTGGCTGCC
CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC
AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG
CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC
GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC
ATTAAAAAGC AGAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC
TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG
TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC
TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG
ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG
AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG
CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA
AGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001103691.1
CDS388..1173
Misc Feature(1)376..378(+)
Misc Feature(2)391..711(+)
Misc Feature(3)454..522(+)
Misc Feature(4)613..681(+)
Misc Feature(5)781..849(+)
Misc Feature(6)823..1026(+)
Misc Feature(7)964..1032(+)
Exon (1)1..202
Gene:GJB6
Gene Synonym:
Exon (2)203..372
Gene:GJB6
Gene Synonym:
Exon (3)373..1906
Gene:GJB6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001110221
Organism Homo sapiens (human)
Definition Homo sapiens gap junction protein, beta 6, 30kDa (GJB6), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001110221

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 
GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTCGT GGTGGCTGCC
CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC
AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG
CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC
GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC
ATTAAAAAGC AGAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC
TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG
TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC
TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG
ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG
AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG
CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA
AGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26102
Clone ID Related Accession (Same CDS sequence) NM_001110219 , NM_001110220 , NM_001110221 , NM_006783
Accession Version NM_001110220.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 786bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product gap junction beta-6 protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN998505.1, BP227986.1, AY789475.1, BC038934.1 and DB577868.1. On Jul 18, 2008 this sequence version replaced gi:158966713. Transcript Variant: This variant (2) lacks a segment in the 5' UTR, compared to variant 1. All variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BX441414.2, CV575718.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 
GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTCGT GGTGGCTGCC
CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC
AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG
CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC
GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC
ATTAAAAAGC AGAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC
TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG
TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC
TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG
ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG
AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG
CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA
AGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001103690.1
CDS512..1297
Misc Feature(1)500..502(+)
Misc Feature(2)515..835(+)
Misc Feature(3)578..646(+)
Misc Feature(4)737..805(+)
Misc Feature(5)905..973(+)
Misc Feature(6)947..1150(+)
Misc Feature(7)1088..1156(+)
Exon (1)1..202
Gene:GJB6
Gene Synonym:
Exon (2)203..326
Gene:GJB6
Gene Synonym:
Exon (3)327..496
Gene:GJB6
Gene Synonym:
Exon (4)497..2030
Gene:GJB6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001110220
Organism Homo sapiens (human)
Definition Homo sapiens gap junction protein, beta 6, 30kDa (GJB6), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001110220

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 
GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTCGT GGTGGCTGCC
CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC
AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG
CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC
GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC
ATTAAAAAGC AGAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC
TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG
TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC
TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG
ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG
AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG
CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA
AGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26102
Clone ID Related Accession (Same CDS sequence) NM_001110219 , NM_001110220 , NM_001110221 , NM_006783
Accession Version NM_001110219.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 786bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product gap junction beta-6 protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DN998505.1, BP227986.1, AK075247.1, CF453597.1 and BC038934.1. On Jul 18, 2008 this sequence version replaced gi:159032019. Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DN998505.1, AK075247.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2147596 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 
GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTCGT GGTGGCTGCC
CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC
AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG
CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC
GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC
ATTAAAAAGC AGAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC
TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG
TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC
TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG
ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG
AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG
CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA
AGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001103689.1
CDS622..1407
Misc Feature(1)610..612(+)
Misc Feature(2)625..945(+)
Misc Feature(3)688..756(+)
Misc Feature(4)847..915(+)
Misc Feature(5)1015..1083(+)
Misc Feature(6)1057..1260(+)
Misc Feature(7)1198..1266(+)
Exon (1)1..202
Gene:GJB6
Gene Synonym:
Exon (2)203..326
Gene:GJB6
Gene Synonym:
Exon (3)327..436
Gene:GJB6
Gene Synonym:
Exon (4)437..606
Gene:GJB6
Gene Synonym:
Exon (5)607..2140
Gene:GJB6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001110219
Organism Homo sapiens (human)
Definition Homo sapiens gap junction protein, beta 6, 30kDa (GJB6), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001110219

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGATTGGG GGACGCTGCA CACTTTCATC GGGGGTGTCA ACAAACACTC CACCAGCATC 
GGGAAGGTGT GGATCACAGT CATCTTTATT TTCCGAGTCA TGATCCTCGT GGTGGCTGCC
CAGGAAGTGT GGGGTGACGA GCAAGAGGAC TTCGTCTGCA ACACACTGCA ACCGGGATGC
AAAAATGTGT GCTATGACCA CTTTTTCCCG GTGTCCCACA TCCGGCTGTG GGCCCTCCAG
CTGATCTTCG TCTCCACCCC AGCGCTGCTG GTGGCCATGC ATGTGGCCTA CTACAGGCAC
GAAACCACTC GCAAGTTCAG GCGAGGAGAG AAGAGGAATG ATTTCAAAGA CATAGAGGAC
ATTAAAAAGC AGAAGGTTCG GATAGAGGGG TCGCTGTGGT GGACGTACAC CAGCAGCATC
TTTTTCCGAA TCATCTTTGA AGCAGCCTTT ATGTATGTGT TTTACTTCCT TTACAATGGG
TACCACCTGC CCTGGGTGTT GAAATGTGGG ATTGACCCCT GCCCCAACCT TGTTGACTGC
TTTATTTCTA GGCCAACAGA GAAGACCGTG TTTACCATTT TTATGATTTC TGCGTCTGTG
ATTTGCATGC TGCTTAACGT GGCAGAGTTG TGCTACCTGC TGCTGAAAGT GTGTTTTAGG
AGATCAAAGA GAGCACAGAC GCAAAAAAAT CACCCCAATC ATGCCCTAAA GGAGAGTAAG
CAGAATGAAA TGAATGAGCT GATTTCAGAT AGTGGTCAAA ATGCAATCAC AGGTTTCCCA
AGCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Expression of gap junction proteins connexins 26, 30, and 43 in Dupuytren's disease
Acta Orthop 85 (1), 97-101 (2014)
Holzer LA, Cor A and Holzer G.


book

Clouston syndrome with heterozygous GJB6 mutation p.Ala88Val and GJB2 variant p.Val27Ile revealing mild sensorineural hearing loss and photophobia
JAMA Dermatol 149 (11), 1350-1351 (2013)
Sugiura K, Teranishi M, Matsumoto Y and Akiyama M.


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Non-syndromic hearing impairment in a multi-ethnic population of Northeastern Brazil
Int. J. Pediatr. Otorhinolaryngol. 77 (7), 1077-1082 (2013)
Manzoli GN, Abe-Sandes K, Bittles AH, da Silva DS, Fernandes Lda C, Paulon RM, de Castro IC, Padovani CM and Acosta AX.


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Phage display cloning and characterization of an immunogenetic marker (perinuclear anti-neutrophil cytoplasmic antibody) in ulcerative colitis
J. Immunol. 156 (10), 4005-4011 (1996)
Eggena M, Targan SR, Iwanczyk L, Vidrich A, Gordon LK and Braun J.


book

The gene responsible for Clouston hidrotic ectodermal dysplasia maps to the pericentromeric region of chromosome 13q
Hum. Mol. Genet. 5 (4), 543-547 (1996)
Kibar Z, Der Kaloustian VM, Brais B, Hani V, Fraser FC and Rouleau GA.


book

Characterization of the two unique human anti-flavin monoclonal immunoglobulins
Eur. J. Biochem. 228 (3), 886-893 (1995)
Stoppini M, Bellotti V, Negri A, Merlini G, Garver F and Ferri G.


book

Nonsyndromic Hearing Loss and Deafness, DFNA3
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H., Sheffield,A.M. and Van Camp,G.


book

Deafness and Hereditary Hearing Loss Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H., Shearer,A.E., Hildebrand,M.S. and Van Camp,G.


book

Nonsyndromic Hearing Loss and Deafness, DFNB1
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H. and Van Camp,G.


book

Hidrotic Ectodermal Dysplasia 2
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Der Kaloustian,V.M.


 
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