The following SRCAP gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SRCAP gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 9693bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK128030.1, AU140541.2,
DA109400.1, AC106886.3 and BM677852.1.
This sequence is a reference standard in the RefSeqGene project.
On May 3, 2007 this sequence version replaced gi:5730066.
Summary: This gene encodes the core catalytic component of the
multiprotein chromatin-remodeling SRCAP complex. The encoded
protein is an ATPase that is necessary for the incorporation of the
histone variant H2A.Z into nucleosomes. It can function as a
transcriptional activator in Notch-mediated, CREB-mediated and
steroid receptor-mediated transcription. Mutations in this gene
cause Floating-Harbor syndrome, a rare disorder characterized by
short stature, language deficits and dysmorphic facial features.
[provided by RefSeq, Feb 2012].
Sequence Note:This RefSeq record was created from transcript and
genomic sequence data to make the sequence consistent with the
reference genome assembly. The genomic coordinates used for the
transcript record were based on transcript alignments.
CCDS Note: The coding region has been updated to add an additional
internal exon and to extend the N-terminus to one that is more
supported by available transcript and conservation data. The
N-terminal extension adds a HSA domain (found in DNA binding
proteins and often associated with helicases) to the DEXDc, HELICc
and AT_hook domains that are also found in this protein, and this
is consistent with the function of this protein as a DNA helicase.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AK128030.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.