||ORF Nucleotide Sequence (Length: 1188bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DB106393.1, AB029886.1 and
This sequence is a reference standard in the RefSeqGene project.
On Jun 27, 2009 this sequence version replaced gi:23238259.
Summary: Choline kinase (CK) and ethanolamine kinase (EK) catalyze
the phosphorylation of choline/ethanolamine to
phosphocholine/phosphoethanolamine. This is the first enzyme in the
biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all
animal cells. The highly purified CKs from mammalian sources and
their recombinant gene products have been shown to have EK activity
also, indicating that both activities reside on the same protein.
The choline kinase-like protein encoded by CHKL belongs to the
choline/ethanolamine kinase family; however, its exact function is
not known. Read-through transcripts are expressed from this locus
that include exons from the downstream CPT1B locus. [provided by
RefSeq, Jun 2009].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AL096780.1, BC082263.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.