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PARK7 cDNA ORF clone, Homo sapiens (human)

Gene Symbol PARK7
Entrez Gene ID 11315
Full Name parkinson protein 7
Synonyms DJ-1, DJ1, HEL-S-67p
General protein information
Preferred Names
protein DJ-1
Names
protein DJ-1
oncogene DJ1
Parkinson disease (autosomal recessive, early onset) 7
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.23

Summary The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602533

Disorder Html: Parkinson disease 7, autosomal recessive early-onset, 606324 (3);

mRNA and Protein(s)

mRNA Protein Name
XM_005263424 XP_005263481 protein DJ-1 isoform X1
NM_007262 NP_009193 protein DJ-1
NM_001123377 NP_001116849 protein DJ-1



Homo sapiens (human) PARK7 NP_009193.2
Canis lupus familiaris (dog) PARK7 XP_859031.1
Bos taurus (cattle) PARK7 NP_001015572.1
Mus musculus (house mouse) Park7 NP_065594.2
Rattus norvegicus (Norway rat) Park7 NP_001264180.1
Gallus gallus (chicken) PARK7 NP_989916.1
Danio rerio (zebrafish) park7 NP_001005938.1
Drosophila melanogaster (fruit fly) dj-1beta NP_651825.3
Drosophila melanogaster (fruit fly) DJ-1alpha NP_610916.1
Caenorhabditis elegans djr-1.1 NP_493696.1
Caenorhabditis elegans djr-1.2 NP_504132.1
Arabidopsis thaliana (thale cress) AT3G14990 NP_188117.1
Arabidopsis thaliana (thale cress) AT1G53280 NP_564626.1
Xenopus (Silurana) tropicalis (western clawed frog) park7 NP_001015851.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following PARK7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PARK7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu26877 XM_005263424 PREDICTED: Homo sapiens parkinson protein 7 (PARK7), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OHu26877 NM_007262 Homo sapiens parkinson protein 7 (PARK7), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OHu26877 NM_001123377 Homo sapiens parkinson protein 7 (PARK7), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26877
Clone ID Related Accession (Same CDS sequence) NM_001123377 , NM_007262 , XM_005263424
Accession Version XM_005263424.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 570bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product protein DJ-1 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_032977.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:530360486. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
ATGGCTTCCA AAAGAGCTCT GGTCATCCTG GCTAAAGGAG CAGAGGAAAT GGAGACGGTC 
ATCCCTGTAG ATGTCATGAG GCGAGCTGGG ATTAAGGTCA CCGTTGCAGG CCTGGCTGGA
AAAGACCCAG TACAGTGTAG CCGTGATGTG GTCATTTGTC CTGATGCCAG CCTTGAAGAT
GCAAAAAAAG AGGGACCATA TGATGTGGTG GTTCTACCAG GAGGTAATCT GGGCGCACAG
AATTTATCTG AGTCTGCTGC TGTGAAGGAG ATACTGAAGG AGCAGGAAAA CCGGAAGGGC
CTGATAGCCG CCATCTGTGC AGGTCCTACT GCTCTGTTGG CTCATGAAAT AGGTTTTGGA
AGTAAAGTTA CAACACACCC TCTTGCTAAA GACAAAATGA TGAATGGAGG TCATTACACC
TACTCTGAGA ATCGTGTGGA AAAAGACGGC CTGATTCTTA CAAGCCGGGG GCCTGGGACC
AGCTTCGAGT TTGCGCTTGC AATTGTTGAA GCCCTGAATG GCAAGGAGGT GGCGGCTCAA
GTGAAGGCTC CACTTGTTCT TAAAGACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005263481.1
CDS184..753
Misc Feature(1)196..735(+)
Misc Feature(2)199..699(+)
Misc Feature(3)499..501(+)
Translation

Target ORF information:

RefSeq Version XM_005263424
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens parkinson protein 7 (PARK7), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005263424

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCTTCCA AAAGAGCTCT GGTCATCCTG GCTAAAGGAG CAGAGGAAAT GGAGACGGTC 
ATCCCTGTAG ATGTCATGAG GCGAGCTGGG ATTAAGGTCA CCGTTGCAGG CCTGGCTGGA
AAAGACCCAG TACAGTGTAG CCGTGATGTG GTCATTTGTC CTGATGCCAG CCTTGAAGAT
GCAAAAAAAG AGGGACCATA TGATGTGGTG GTTCTACCAG GAGGTAATCT GGGCGCACAG
AATTTATCTG AGTCTGCTGC TGTGAAGGAG ATACTGAAGG AGCAGGAAAA CCGGAAGGGC
CTGATAGCCG CCATCTGTGC AGGTCCTACT GCTCTGTTGG CTCATGAAAT AGGTTTTGGA
AGTAAAGTTA CAACACACCC TCTTGCTAAA GACAAAATGA TGAATGGAGG TCATTACACC
TACTCTGAGA ATCGTGTGGA AAAAGACGGC CTGATTCTTA CAAGCCGGGG GCCTGGGACC
AGCTTCGAGT TTGCGCTTGC AATTGTTGAA GCCCTGAATG GCAAGGAGGT GGCGGCTCAA
GTGAAGGCTC CACTTGTTCT TAAAGACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26877
Clone ID Related Accession (Same CDS sequence) NM_001123377 , NM_007262 , XM_005263424
Accession Version NM_007262.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 570bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein DJ-1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP248330.1, BC008188.2, AK312000.1 and D61380.2. This sequence is a reference standard in the RefSeqGene project. On Apr 16, 2008 this sequence version replaced gi:34222306. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BQ436114.1, BI552690.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

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181
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361
421
481
541
ATGGCTTCCA AAAGAGCTCT GGTCATCCTG GCTAAAGGAG CAGAGGAAAT GGAGACGGTC 
ATCCCTGTAG ATGTCATGAG GCGAGCTGGG ATTAAGGTCA CCGTTGCAGG CCTGGCTGGA
AAAGACCCAG TACAGTGTAG CCGTGATGTG GTCATTTGTC CTGATGCCAG CCTTGAAGAT
GCAAAAAAAG AGGGACCATA TGATGTGGTG GTTCTACCAG GAGGTAATCT GGGCGCACAG
AATTTATCTG AGTCTGCTGC TGTGAAGGAG ATACTGAAGG AGCAGGAAAA CCGGAAGGGC
CTGATAGCCG CCATCTGTGC AGGTCCTACT GCTCTGTTGG CTCATGAAAT AGGTTTTGGA
AGTAAAGTTA CAACACACCC TCTTGCTAAA GACAAAATGA TGAATGGAGG TCATTACACC
TACTCTGAGA ATCGTGTGGA AAAAGACGGC CTGATTCTTA CAAGCCGGGG GCCTGGGACC
AGCTTCGAGT TTGCGCTTGC AATTGTTGAA GCCCTGAATG GCAAGGAGGT GGCGGCTCAA
GTGAAGGCTC CACTTGTTCT TAAAGACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_009193.2
CDS164..733
Misc Feature(1)146..148(+)
Misc Feature(2)176..715(+)
Misc Feature(3)179..679(+)
Misc Feature(4)362..364(+)
Misc Feature(5)362..364(+)
Misc Feature(6)479..481(+)
Misc Feature(7)479..481(+)
Misc Feature(8)551..553(+)
Exon (1)1..140
Gene:PARK7
Gene Synonym:
Exon (2)141..253
Gene:PARK7
Gene Synonym:
Exon (3)254..355
Gene:PARK7
Gene Synonym:
Exon (4)356..415
Gene:PARK7
Gene Synonym:
Exon (5)416..485
Gene:PARK7
Gene Synonym:
Exon (6)486..572
Gene:PARK7
Gene Synonym:
Exon (7)573..961
Gene:PARK7
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_007262
Organism Homo sapiens (human)
Definition Homo sapiens parkinson protein 7 (PARK7), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_007262

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCTTCCA AAAGAGCTCT GGTCATCCTG GCTAAAGGAG CAGAGGAAAT GGAGACGGTC 
ATCCCTGTAG ATGTCATGAG GCGAGCTGGG ATTAAGGTCA CCGTTGCAGG CCTGGCTGGA
AAAGACCCAG TACAGTGTAG CCGTGATGTG GTCATTTGTC CTGATGCCAG CCTTGAAGAT
GCAAAAAAAG AGGGACCATA TGATGTGGTG GTTCTACCAG GAGGTAATCT GGGCGCACAG
AATTTATCTG AGTCTGCTGC TGTGAAGGAG ATACTGAAGG AGCAGGAAAA CCGGAAGGGC
CTGATAGCCG CCATCTGTGC AGGTCCTACT GCTCTGTTGG CTCATGAAAT AGGTTTTGGA
AGTAAAGTTA CAACACACCC TCTTGCTAAA GACAAAATGA TGAATGGAGG TCATTACACC
TACTCTGAGA ATCGTGTGGA AAAAGACGGC CTGATTCTTA CAAGCCGGGG GCCTGGGACC
AGCTTCGAGT TTGCGCTTGC AATTGTTGAA GCCCTGAATG GCAAGGAGGT GGCGGCTCAA
GTGAAGGCTC CACTTGTTCT TAAAGACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26877
Clone ID Related Accession (Same CDS sequence) NM_001123377 , NM_007262 , XM_005263424
Accession Version NM_001123377.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 570bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product protein DJ-1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP248330.1, AK312000.1 and D61380.2. Transcript Variant: This variant (2) represents the shorter transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM554785.1, BI092098.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
ATGGCTTCCA AAAGAGCTCT GGTCATCCTG GCTAAAGGAG CAGAGGAAAT GGAGACGGTC 
ATCCCTGTAG ATGTCATGAG GCGAGCTGGG ATTAAGGTCA CCGTTGCAGG CCTGGCTGGA
AAAGACCCAG TACAGTGTAG CCGTGATGTG GTCATTTGTC CTGATGCCAG CCTTGAAGAT
GCAAAAAAAG AGGGACCATA TGATGTGGTG GTTCTACCAG GAGGTAATCT GGGCGCACAG
AATTTATCTG AGTCTGCTGC TGTGAAGGAG ATACTGAAGG AGCAGGAAAA CCGGAAGGGC
CTGATAGCCG CCATCTGTGC AGGTCCTACT GCTCTGTTGG CTCATGAAAT AGGTTTTGGA
AGTAAAGTTA CAACACACCC TCTTGCTAAA GACAAAATGA TGAATGGAGG TCATTACACC
TACTCTGAGA ATCGTGTGGA AAAAGACGGC CTGATTCTTA CAAGCCGGGG GCCTGGGACC
AGCTTCGAGT TTGCGCTTGC AATTGTTGAA GCCCTGAATG GCAAGGAGGT GGCGGCTCAA
GTGAAGGCTC CACTTGTTCT TAAAGACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001116849.1
CDS106..675
Misc Feature(1)88..90(+)
Misc Feature(2)118..657(+)
Misc Feature(3)121..621(+)
Misc Feature(4)304..306(+)
Misc Feature(5)421..423(+)
Misc Feature(6)421..423(+)
Exon (1)1..82
Gene:PARK7
Gene Synonym:
Exon (2)83..195
Gene:PARK7
Gene Synonym:
Exon (3)196..297
Gene:PARK7
Gene Synonym:
Exon (4)298..357
Gene:PARK7
Gene Synonym:
Exon (5)358..427
Gene:PARK7
Gene Synonym:
Exon (6)428..514
Gene:PARK7
Gene Synonym:
Exon (7)515..903
Gene:PARK7
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001123377
Organism Homo sapiens (human)
Definition Homo sapiens parkinson protein 7 (PARK7), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001123377

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGCTTCCA AAAGAGCTCT GGTCATCCTG GCTAAAGGAG CAGAGGAAAT GGAGACGGTC 
ATCCCTGTAG ATGTCATGAG GCGAGCTGGG ATTAAGGTCA CCGTTGCAGG CCTGGCTGGA
AAAGACCCAG TACAGTGTAG CCGTGATGTG GTCATTTGTC CTGATGCCAG CCTTGAAGAT
GCAAAAAAAG AGGGACCATA TGATGTGGTG GTTCTACCAG GAGGTAATCT GGGCGCACAG
AATTTATCTG AGTCTGCTGC TGTGAAGGAG ATACTGAAGG AGCAGGAAAA CCGGAAGGGC
CTGATAGCCG CCATCTGTGC AGGTCCTACT GCTCTGTTGG CTCATGAAAT AGGTTTTGGA
AGTAAAGTTA CAACACACCC TCTTGCTAAA GACAAAATGA TGAATGGAGG TCATTACACC
TACTCTGAGA ATCGTGTGGA AAAAGACGGC CTGATTCTTA CAAGCCGGGG GCCTGGGACC
AGCTTCGAGT TTGCGCTTGC AATTGTTGAA GCCCTGAATG GCAAGGAGGT GGCGGCTCAA
GTGAAGGCTC CACTTGTTCT TAAAGACTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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