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CKM creatine kinase, muscle [Homo sapiens (human)]

Gene Symbol CKM
Entrez Gene ID 1158
Full Name creatine kinase, muscle
Synonyms CKMM, M-CK
General protein information
Preferred Names
creatine kinase M-type
Names
creatine kinase M-type
creatine kinase M chain
NP_001815.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.32

Summary The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

123310

Disorder Html:





The following CKM gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CKM gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu14064 NM_001824 Homo sapiens creatine kinase, muscle (CKM), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu14064
Accession Version NM_001824.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1146bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product creatine kinase M-type
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC385783.1, DA896166.1, AK313281.1 and AJ572902.1. On May 25, 2012 this sequence version replaced gi:299473751. Summary: The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC007462.1, AK129878.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2155550, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCATTCG GTAACACCCA CAACAAGTTC AAGCTGAATT ACAAGCCTGA GGAGGAGTAC 
CCCGACCTCA GCAAACATAA CAACCACATG GCCAAGGTAC TGACCCTTGA ACTCTACAAG
AAGCTGCGGG ACAAGGAGAC TCCATCTGGC TTCACTGTAG ACGATGTCAT CCAGACAGGA
GTGGACAACC CAGGTCACCC CTTCATCATG ACCGTGGGCT GCGTGGCTGG TGATGAGGAG
TCCTACGAAG TTTTCAAGGA ACTCTTTGAC CCCATCATCT CGGATCGCCA CGGGGGCTAC
AAACCCACTG ACAAGCACAA GACTGACCTC AACCATGAAA ACCTCAAGGG TGGAGACGAC
CTGGACCCTA ACTACGTGCT CAGCAGCCGC GTCCGCACTG GCCGCAGCAT CAAGGGCTAC
ACGTTGCCCC CACACTGCTC CCGTGGCGAG CGCCGGGCGG TGGAGAAGCT CTCTGTGGAA
GCTCTCAACA GCCTGACGGG CGAGTTCAAA GGGAAGTACT ACCCTCTGAA GAGCATGACG
GAGAAGGAGC AGCAGCAGCT CATCGATGAC CACTTCCTGT TCGACAAGCC CGTGTCCCCG
CTGCTGCTGG CCTCAGGCAT GGCCCGCGAC TGGCCCGACG CCCGTGGCAT CTGGCACAAT
GACAACAAGA GCTTCCTGGT GTGGGTGAAC GAGGAGGATC ACCTCCGGGT CATCTCCATG
GAGAAGGGGG GCAACATGAA GGAGGTTTTC CGCCGCTTCT GCGTAGGGCT GCAGAAGATT
GAGGAGATCT TTAAGAAAGC TGGCCACCCC TTCATGTGGA ACCAGCACCT GGGCTACGTG
CTCACCTGCC CATCCAACCT GGGCACTGGG CTGCGTGGAG GCGTGCATGT GAAGCTGGCG
CACCTGAGCA AGCACCCCAA GTTCGAGGAG ATCCTCACCC GCCTGCGTCT GCAGAAGAGG
GGTACAGGTG GCGTGGACAC AGCTGCCGTG GGCTCAGTAT TTGACGTGTC CAACGCTGAT
CGGCTGGGCT CGTCCGAAGT AGAACAGGTG CAGCTGGTGG TGGATGGTGT GAAGCTCATG
GTGGAAATGG AGAAGAAGTT GGAGAAAGGC CAGTCCATTG ACGACATGAT CCCCGCCCAG
AAGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001815.2
CDS176..1321
Misc Feature(1)221..1294(+)
Misc Feature(2)389..1030(+)
Misc Feature(3)557..1180(+)
Misc Feature(4)1124..1189(+)
Exon (1)1..157
Gene:CKM
Gene Synonym:
Exon (2)158..368
Gene:CKM
Gene Synonym:
Exon (3)369..523
Gene:CKM
Gene Synonym:
Exon (4)524..656
Gene:CKM
Gene Synonym:
Exon (5)657..828
Gene:CKM
Gene Synonym:
Exon (6)829..952
Gene:CKM
Gene Synonym:
Exon (7)953..1142
Gene:CKM
Gene Synonym:
Exon (8)1143..1658
Gene:CKM
Gene Synonym:
Translation
Position Chain Variation Link
37 37 c, t dbSNP:371601035
101 101 a, g, t dbSNP:111770860
102 102 a, g, t dbSNP:111323781
111 111 a, g dbSNP:533491066
121 121 g, t dbSNP:12974541
125 125 a, g dbSNP:539018027
162 162 a, c dbSNP:761448521
166 166 a, c dbSNP:776346945
167 167 -, accgccac dbSNP:755791275
168 168 c, t dbSNP:768475139
169 169 c, g, t dbSNP:775525357
170 170 c, g dbSNP:371907095
175 175 c, g dbSNP:759985276
184 184 c, t dbSNP:368649875
185 185 a, g dbSNP:568900437
206 206 a, g dbSNP:756475007
209 209 a, c dbSNP:373928921
218 218 a, g dbSNP:781462342
219 219 a, c dbSNP:755339617
221 221 a, c dbSNP:751830939
227 227 c, g dbSNP:766933334
233 233 -, t dbSNP:745541804
234 234 a, t dbSNP:758846798
238 238 c, t dbSNP:138224618
239 239 c, g dbSNP:764713046
246 246 a, g dbSNP:377118696
247 247 c, g dbSNP:761502043
252 252 a, g, t dbSNP:763610345
259 259 c, t dbSNP:760537818
265 265 g, t dbSNP:145633772
278 278 a, g dbSNP:772143386
279 279 -, cccttga dbSNP:778179639
279 279 a, c dbSNP:745799406
280 280 c, t dbSNP:773487828
289 289 c, t dbSNP:769976062
292 292 c, t dbSNP:748359122
293 293 a, g dbSNP:781509935
302 302 a, c, g, t dbSNP:140651487
303 303 a, g dbSNP:372629132
304 304 a, g dbSNP:750906793
307 307 c, g dbSNP:532075800
308 308 a, t dbSNP:757316903
321 321 a, c dbSNP:371827047
336 336 a, g dbSNP:201470105
337 337 c, t dbSNP:753235410
338 338 a, g dbSNP:201048164
340 340 g, t dbSNP:760176828
349 349 a, g dbSNP:752606609
350 350 a, g dbSNP:759754446
365 365 a, c dbSNP:532081631
369 369 a, g dbSNP:533543986
375 375 c, g dbSNP:776827903
376 376 c, t dbSNP:571181525
384 384 a, t dbSNP:760997348
388 388 c, t dbSNP:377725988
389 389 a, g dbSNP:1803285
391 391 a, g, t dbSNP:11559023
396 396 a, g dbSNP:746241019
397 397 c, t dbSNP:563111119
398 398 a, g dbSNP:771533664
401 401 a, g dbSNP:779460216
406 406 c, t dbSNP:374628279
409 409 c, t dbSNP:370934579
410 410 a, g dbSNP:777394301
413 413 a, g dbSNP:755551868
414 414 a, c dbSNP:747625803
419 419 c, t dbSNP:766061130
421 421 c, t dbSNP:554894916
422 422 a, g dbSNP:200170574
423 423 a, g dbSNP:11559024
429 429 g, t dbSNP:149197296
431 431 a, t dbSNP:766274732
432 432 a, g dbSNP:758407982
435 435 a, g dbSNP:747251580
442 442 c, t dbSNP:750296124
445 445 c, t dbSNP:569054385
446 446 c, t dbSNP:765177605
447 447 c, g dbSNP:369274678
448 448 c, t dbSNP:775490110
456 456 c, g, t dbSNP:759748220
457 457 a, g dbSNP:777430864
461 461 c, t dbSNP:560561184
462 462 a, g dbSNP:780576836
464 464 c, t dbSNP:773700586
466 466 c, t dbSNP:749842509
467 467 a, g dbSNP:773623528
471 471 a, g dbSNP:770291117
474 474 a, g dbSNP:747678334
477 477 a, g dbSNP:780785911
479 479 c, t dbSNP:754747384
484 484 c, t dbSNP:550467373
487 487 c, g dbSNP:377387152
489 489 a, g dbSNP:779935915
497 497 a, g dbSNP:758155404
499 499 c, t dbSNP:750179345
501 501 a, g dbSNP:765099470
505 505 c, g, t dbSNP:373212762
511 511 c, t dbSNP:17875604
519 519 c, t dbSNP:752839911
520 520 c, g dbSNP:544987237
533 533 a, g dbSNP:771688624
544 544 c, t dbSNP:1133190
544 544 -, t dbSNP:779342699
551 551 a, c, g dbSNP:770684496
554 554 c, g, t dbSNP:17875653
556 556 c, t dbSNP:755988278
564 564 a, g dbSNP:755295582
565 565 c, g, t dbSNP:758609227
566 566 a, g dbSNP:200253404
570 570 a, g dbSNP:147574145
574 574 g, t dbSNP:757715560
578 578 c, t dbSNP:754193712
579 579 a, g dbSNP:370269966
581 581 a, g dbSNP:761240618
584 584 a, g dbSNP:774920113
590 590 a, g dbSNP:367804619
591 591 a, g dbSNP:759154185
596 596 a, c dbSNP:774084970
597 597 c, t dbSNP:770523008
598 598 a, g dbSNP:376033705
604 604 c, g dbSNP:772928825
605 605 c, t dbSNP:546491801
606 606 c, t dbSNP:748106567
613 613 c, t dbSNP:780048820
617 617 c, t dbSNP:201797734
618 618 a, g dbSNP:758534544
622 622 c, t dbSNP:745884156
626 626 c, t dbSNP:371426787
627 627 a, g dbSNP:377002933
629 629 c, t dbSNP:149872015
630 630 a, g dbSNP:146705516
633 633 c, t dbSNP:190519310
634 634 a, g, t dbSNP:370802777
642 642 a, g dbSNP:767872826
644 644 c, g dbSNP:773753476
647 647 a, t dbSNP:775443905
653 653 -, g dbSNP:765254074
656 656 a, g dbSNP:759109165
657 657 c, t dbSNP:762646021
658 658 c, t dbSNP:750049089
672 672 c, t dbSNP:17357122
673 673 a, g dbSNP:761680071
674 674 a, c, g dbSNP:745829453
676 676 c, g, t dbSNP:150802782
680 680 c, t dbSNP:746579943
682 682 c, g dbSNP:372948338
690 690 a, c dbSNP:141322657
691 691 a, g dbSNP:771101282
692 692 c, t dbSNP:768287412
702 702 c, t dbSNP:139922517
714 714 c, g, t dbSNP:145987658
715 715 a, c, g dbSNP:201284328
721 721 a, g dbSNP:781406880
734 734 -, agc dbSNP:753847862
740 740 a, g dbSNP:755569873
742 742 c, t dbSNP:752042970
743 743 c, g dbSNP:201705552
757 757 c, t dbSNP:373944704
758 758 a, g dbSNP:777073631
766 766 c, t dbSNP:142896147
767 767 a, g dbSNP:138317169
768 768 g, t dbSNP:764944218
769 769 -, gt dbSNP:766476441
773 773 c, t dbSNP:761363806
774 774 c, t dbSNP:529413092
775 775 a, g dbSNP:763773888
779 779 c, g dbSNP:761162879
797 797 g, t dbSNP:760734453
800 800 c, t dbSNP:775597882
802 802 a, c dbSNP:17875616
805 805 c, g dbSNP:763140355
808 808 a, g dbSNP:773099555
811 811 c, g, t dbSNP:748308189
812 812 a, g dbSNP:781660516
814 814 c, t dbSNP:768979645
815 815 -, gacg dbSNP:760835861
818 818 -, c dbSNP:750692007
818 818 c, t dbSNP:546735171
822 822 a, g dbSNP:780548638
825 825 a, t dbSNP:373872310
832 832 c, g dbSNP:754197288
834 834 a, t dbSNP:775825369
841 841 -, caa dbSNP:761572512
846 846 c, g dbSNP:772621306
848 848 c, t dbSNP:17850202
881 881 a, c dbSNP:370365708
882 882 a, g dbSNP:367853842
883 883 c, g dbSNP:756749534
901 901 a, g dbSNP:371276267
903 903 c, g dbSNP:17875625
905 905 g, t dbSNP:755762549
907 907 c, g dbSNP:60621776
908 908 a, c dbSNP:56905146
919 919 c, g dbSNP:752605673
926 926 a, c dbSNP:767407229
927 927 c, g dbSNP:149354459
929 929 c, t dbSNP:751425404
937 937 c, t dbSNP:766301926
938 938 a, c, g, t dbSNP:372379123
939 939 c, t dbSNP:764364130
944 944 a, c dbSNP:760870133
948 948 a, c dbSNP:775878391
952 952 a, g dbSNP:772394703
954 954 c, t dbSNP:774709360
957 957 a, g dbSNP:757580716
958 958 c, g dbSNP:771408722
961 961 a, g dbSNP:763504810
969 969 a, t dbSNP:760487207
974 974 a, g dbSNP:772900129
975 975 a, c dbSNP:138693691
976 976 c, t dbSNP:747623819
981 981 a, g dbSNP:775013601
984 984 c, g dbSNP:760826961
990 990 c, t dbSNP:781018931
999 999 a, g dbSNP:200633759
1003 1003 c, t dbSNP:374180272
1011 1011 a, g dbSNP:201697202
1012 1012 c, t dbSNP:779882440
1014 1014 c, t dbSNP:758314659
1031 1031 a, g dbSNP:750776616
1032 1032 a, t dbSNP:750327236
1034 1034 -, catccaacc dbSNP:745487202
1042 1042 c, t dbSNP:756392729
1045 1045 g, t dbSNP:370775757
1048 1048 c, g dbSNP:756206892
1057 1057 c, t dbSNP:752715405
1060 1060 c, g dbSNP:542554046
1062 1062 a, c, g dbSNP:565428059
1067 1067 a, t dbSNP:748849608
1070 1070 c, g dbSNP:150271912
1072 1072 a, g dbSNP:766745381
1074 1074 c, t dbSNP:763411131
1075 1075 a, g dbSNP:538248814
1080 1080 a, t dbSNP:765265712
1081 1081 a, g dbSNP:375831711
1088 1088 c, t dbSNP:185267891
1092 1092 a, c, g dbSNP:770377664
1100 1100 c, g dbSNP:374105815
1103 1103 -, gag dbSNP:780772191
1105 1105 g, t dbSNP:776217748
1107 1107 a, t dbSNP:768246830
1112 1112 a, c dbSNP:746647107
1125 1125 c, t dbSNP:768013382
1126 1126 a, g dbSNP:556510487
1131 1131 -, aga dbSNP:772466021
1139 1139 a, g dbSNP:771930230
1142 1142 a, g dbSNP:745611967
1143 1143 a, g dbSNP:755118893
1144 1144 c, t dbSNP:750341379
1148 1148 a, g dbSNP:747014280
1163 1163 a, g, t dbSNP:554506651
1170 1170 -, cagt dbSNP:755438258
1175 1175 a, t dbSNP:750888133
1180 1180 c, t dbSNP:201733122
1181 1181 g, t dbSNP:571861320
1184 1184 g, t dbSNP:754398806
1186 1186 c, t dbSNP:764457358
1188 1188 a, g dbSNP:760245192
1192 1192 c, t dbSNP:146587949
1198 1198 a, g dbSNP:373133726
1206 1206 c, t dbSNP:774793814
1207 1207 c, g dbSNP:767224509
1208 1208 a, t dbSNP:759175697
1211 1211 -, g dbSNP:754363919
1213 1213 a, g dbSNP:774181882
1221 1221 a, g dbSNP:199913939
1229 1229 c, t dbSNP:762699099
1235 1235 a, g dbSNP:773226812
1242 1242 a, g dbSNP:769563289
1254 1254 c, g, t dbSNP:76072092
1265 1265 c, g dbSNP:377736202
1271 1271 -, aag dbSNP:780083622
1274 1274 c, t dbSNP:373999453
1277 1277 a, g dbSNP:772467740
1278 1278 a, g dbSNP:746052741
1280 1280 a, g dbSNP:777946478
1285 1285 a, c, g dbSNP:147729252
1289 1289 c, t dbSNP:757715478
1294 1294 c, t dbSNP:4884
1303 1303 c, g dbSNP:376809982
1307 1307 c, t dbSNP:560579155
1308 1308 c, g dbSNP:756574362
1314 1314 -, agaag dbSNP:756225168
1315 1315 c, g dbSNP:752308232
1316 1316 -, aag dbSNP:750645954
1319 1319 c, t dbSNP:142092440
1323 1323 c, t dbSNP:766991883
1324 1324 a, g dbSNP:368059895
1332 1332 a, c dbSNP:759226984
1339 1339 a, g dbSNP:751246477
1341 1341 c, t dbSNP:202146659
1342 1342 a, g dbSNP:373583683
1345 1345 c, t dbSNP:772819873
1352 1352 a, c dbSNP:769841225
1355 1355 c, t dbSNP:561517633
1356 1356 a, g dbSNP:761647866
1357 1357 a, g dbSNP:775747356
1364 1364 a, g dbSNP:772305248
1367 1367 a, g dbSNP:370315406
1368 1368 a, g dbSNP:371920217
1389 1389 a, g dbSNP:117172220
1405 1405 a, c dbSNP:370579433
1417 1417 g, t dbSNP:8188
1431 1431 c, g dbSNP:566549420
1433 1433 c, t dbSNP:557530092
1443 1443 c, t dbSNP:17875628
1512 1512 c, t dbSNP:548144760
1529 1529 a, g dbSNP:9976
1565 1565 a, g dbSNP:527891971
1579 1579 c, t dbSNP:17875629
1632 1632 c, t dbSNP:186189112
1633 1633 a, g dbSNP:776625279
1644 1644 a, g dbSNP:75379365
1657 1657 a, t dbSNP:111843749

Target ORF information:

RefSeq Version NM_001824
Organism Homo sapiens (human)
Definition Homo sapiens creatine kinase, muscle (CKM), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001824

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCCATTCG GTAACACCCA CAACAAGTTC AAGCTGAATT ACAAGCCTGA GGAGGAGTAC 
CCCGACCTCA GCAAACATAA CAACCACATG GCCAAGGTAC TGACCCTTGA ACTCTACAAG
AAGCTGCGGG ACAAGGAGAC TCCATCTGGC TTCACTGTAG ACGATGTCAT CCAGACAGGA
GTGGACAACC CAGGTCACCC CTTCATCATG ACCGTGGGCT GCGTGGCTGG TGATGAGGAG
TCCTACGAAG TTTTCAAGGA ACTCTTTGAC CCCATCATCT CGGATCGCCA CGGGGGCTAC
AAACCCACTG ACAAGCACAA GACTGACCTC AACCATGAAA ACCTCAAGGG TGGAGACGAC
CTGGACCCTA ACTACGTGCT CAGCAGCCGC GTCCGCACTG GCCGCAGCAT CAAGGGCTAC
ACGTTGCCCC CACACTGCTC CCGTGGCGAG CGCCGGGCGG TGGAGAAGCT CTCTGTGGAA
GCTCTCAACA GCCTGACGGG CGAGTTCAAA GGGAAGTACT ACCCTCTGAA GAGCATGACG
GAGAAGGAGC AGCAGCAGCT CATCGATGAC CACTTCCTGT TCGACAAGCC CGTGTCCCCG
CTGCTGCTGG CCTCAGGCAT GGCCCGCGAC TGGCCCGACG CCCGTGGCAT CTGGCACAAT
GACAACAAGA GCTTCCTGGT GTGGGTGAAC GAGGAGGATC ACCTCCGGGT CATCTCCATG
GAGAAGGGGG GCAACATGAA GGAGGTTTTC CGCCGCTTCT GCGTAGGGCT GCAGAAGATT
GAGGAGATCT TTAAGAAAGC TGGCCACCCC TTCATGTGGA ACCAGCACCT GGGCTACGTG
CTCACCTGCC CATCCAACCT GGGCACTGGG CTGCGTGGAG GCGTGCATGT GAAGCTGGCG
CACCTGAGCA AGCACCCCAA GTTCGAGGAG ATCCTCACCC GCCTGCGTCT GCAGAAGAGG
GGTACAGGTG GCGTGGACAC AGCTGCCGTG GGCTCAGTAT TTGACGTGTC CAACGCTGAT
CGGCTGGGCT CGTCCGAAGT AGAACAGGTG CAGCTGGTGG TGGATGGTGT GAAGCTCATG
GTGGAAATGG AGAAGAAGTT GGAGAAAGGC CAGTCCATTG ACGACATGAT CCCCGCCCAG
AAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.