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CATSPER1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CATSPER1
Entrez Gene ID 117144
Full Name cation channel, sperm associated 1
Synonyms CATSPER, SPGF7
General protein information
Preferred Names
cation channel sperm-associated protein 1
Names
cation channel sperm-associated protein 1
hCatSper
sperm ion channel
sperm-associated cation channel 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q12.1

Summary Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

606389

Disorder Html: Male infertility, nonsyndromic, autosomal recessive, 612997 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_053054 NP_444282 cation channel sperm-associated protein 1



Homo sapiens (human) CATSPER1 NP_444282.3
Pan troglodytes (chimpanzee) CATSPER1 XP_003313190.1
Macaca mulatta (Rhesus monkey) CATSPER1 XP_001118063.1
Canis lupus familiaris (dog) CATSPER1 XP_005631803.1
Bos taurus (cattle) CATSPER1 XP_005227286.1
Mus musculus (house mouse) Catsper1 NP_647462.1
Rattus norvegicus (Norway rat) Catsper1 XP_001070492.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CATSPER1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CATSPER1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu22164 NM_053054 Homo sapiens cation channel, sperm associated 1 (CATSPER1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
$559.00
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22164
Clone ID Related Accession (Same CDS sequence) NM_053054
Accession Version NM_053054.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2343bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cation channel sperm-associated protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP006287.2, BC032950.2, BC036522.2 and AF407333.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2009 this sequence version replaced gi:26051219. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032950.2, AF407333.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGATCAAA ACTCAGTGCC TGAAAAGGCT CAGAATGAGG CAGACACCAA TAACGCAGAT 
AGGTTCTTTC GCTCTCACTC ATCACCCCCA CACCACAGGC CAGGCCACAG CAGAGCTCTC
CACCATTACG AGTTGCACCA TCACGGCGTG CCCCACCAAC GTGGTGAATC TCACCACCCT
CCGGAGTTCC AAGACTTCCA CGACCAAGCC TTGTCCTCCC ATGTCCACCA ATCTCACCAC
CACAGCGAGG CACGGAATCA CGGCAGAGCC CATGGCCCCA CAGGCTTTGG TCTGGCTCCC
TCTCAAGGCG CCGTCCCCTC CCACCGTTCC TACGGTGAGG ACTACCATGA TGAGCTCCAA
CGTGATGGCA GGAGGCATCA TGATGGGTCC CAATACGGTG GGTTCCATCA GCAGAGTGAC
TCCCATTACC ATAGGGGGTC TCACCATGGC AGACCCCAAT ATCTCGGTGA GAATTTATCC
CACTATTCCT CTGGCGTGCC CCACCACGGT GAGGCTTCCC ACCATGGTGG GTCCTACCTC
CCCCATGGAC CCAATCCCTA CAGTGAGTCC TTCCACCACA GCGAGGCTTC CCACCTTAGC
GGGCTCCAAC ACGATGAGTC CCAGCATCAC CAAGTCCCCC ACCGTGGCTG GCCCCACCAT
CACCAAGTCC ACCACCATGG CAGGTCCCGT CATCATGAAG CCCACCAGCA TGGAAAGTCT
CCTCATCACG GAGAGACCAT TTCCCCTCAT TCCTCTGTGG GGTCCTACCA GCGTGGGATA
TCTGACTATC ACAGCGAGTA CCACCAAGGT GATCACCACC CCAGTGAGTA CCACCATGGC
GACCATCCCC ACCACACACA GCACCACTAC CACCAGACCC ACCGGCACCG AGACTACCAT
CAGCACCAAG ACCACCACGG CGCGTATCAT TCCAGTTACC TCCATGGCGA CTACGTCCAG
AGCACTTCCC AACTCTCTAT CCCACACACA TCCCGGAGCC TGATTCACGA TGCCCCCGGC
CCTGCTGCTT CTCGTACAGG AGTCTTCCCC TATCACGTAG CACACCCACG GGGCTCGGCT
CACAGCATGA CTCGGTCCTC CAGCACAATC CGCTCACGTG TCACCCAGAT GTCCAAAAAA
GTCCATACCC AGGATATCTC CACCAAACAT TCAGAAGACT GGGGCAAAGA AGAAGGGCAA
TTTCAGAAAC GCAAAACCGG CCGGCTCCAG CGGACCCGCA AGAAGGGACA CTCTACCAAT
CTCTTCCAGT GGCTGTGGGA AAAGCTAACC TTCCTCATTC AGGGCTTCCG GGAAATGATC
CGGAACCTGA CCCAATCCTT GGCCTTTGAA ACTTTCATCT TCTTCGTTGT CTGCCTCAAC
ACCGTCATGC TGGTGGCCCA GACCTTCGCT GAAGTCGAGA TCCGGGGCGA GTGGTACTTC
ATGGCCTTGG ACTCCATATT CTTCTGCATC TACGTGGTGG AAGCCCTGCT CAAGATCATC
GCCCTGGGCC TCTCGTACTT CTTTGACTTC TGGAACAATT TGGACTTCTT CATTATGGCC
ATGGCCGTGC TGGACTTCTT GCTGATGCAG ACCCACTCCT TCGCCATCTA CCACCAAAGC
CTCTTCCGGA TCCTCAAGGT CTTCAAGAGC CTGCGGGCCC TGAGGGCAAT CCGGGTCCTG
CGGAGGCTCA GCTTCCTGAC CAGCGTCCAG GAAGTGACAG GGACCCTGGG CCAGTCCTTG
CCGTCCATCG CAGCCATCCT CATCCTCATG TTTACCTGCC TCTTCCTCTT CTCCGCGGTC
CTCCGGGCAC TGTTCCGCAA ATCTGACCCC AAGCGCTTCC AGAACATCTT CACCACCATC
TTCACCCTCT TCACCTTGCT CACGCTGGAT GACTGGTCCC TCATCTACAT GGACAGCCGT
GCCCAGGGCG CCTGGTACAT CATTCCCATC CTCGTAATTT ACATCATCAT CCAGTACTTC
ATCTTCCTCA ACCTGGTGAT TACTGTCCTG GTGGATAGCT TCCAGACGGC GCTGTTCAAA
GGCCTTGAGA AAGCGAAGCA GGAGAGGGCC GCCCGGATCC AAGAGAAGCT GCTGGAAGAC
TCACTGACGG AGCTCAGAGC TGCAGAGCCC AAAGAGGTGG CGAGTGAAGG CACCATGCTG
AAGCGGCTCA TCGAGAAAAA GTTTGGGACC ATGACTGAGA AGCAGCAGGA GCTCCTGTTC
CATTACCTGC AGCTGGTGGC AAGCGTGGAG CAGGAGCAGC AGAAGTTCCG CTCCCAGGCA
GCCGTCATCG ATGAGATTGT GGACACCACA TTTGAGGCTG GAGAAGAGGA CTTCAGGAAT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_444282.3
CDS139..2481
Misc Feature(1)1474..1536(+)
Misc Feature(2)1585..2076(+)
Misc Feature(3)1594..2025(+)
Misc Feature(4)1594..1656(+)
Misc Feature(5)1684..1746(+)
Misc Feature(6)1762..1824(+)
Misc Feature(7)1876..1938(+)
Misc Feature(8)2077..2139(+)
Exon (1)1..1354
Gene:CATSPER1
Gene Synonym:
Exon (2)1355..1567
Gene:CATSPER1
Gene Synonym:
Exon (3)1568..1681
Gene:CATSPER1
Gene Synonym:
Exon (4)1682..1829
Gene:CATSPER1
Gene Synonym:
Exon (5)1830..1921
Gene:CATSPER1
Gene Synonym:
Exon (6)1922..2065
Gene:CATSPER1
Gene Synonym:
Exon (7)2066..2129
Gene:CATSPER1
Gene Synonym:
Exon (8)2130..2202
Gene:CATSPER1
Gene Synonym:
Exon (9)2203..2263
Gene:CATSPER1
Gene Synonym:
Exon (10)2264..2339
Gene:CATSPER1
Gene Synonym:
Exon (11)2340..2454
Gene:CATSPER1
Gene Synonym:
Exon (12)2455..2619
Gene:CATSPER1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_053054
Organism Homo sapiens (human)
Definition Homo sapiens cation channel, sperm associated 1 (CATSPER1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_053054

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGATCAAA ACTCAGTGCC TGAAAAGGCT CAGAATGAGG CAGACACCAA TAACGCAGAT 
AGGTTCTTTC GCTCTCACTC ATCACCCCCA CACCACAGGC CAGGCCACAG CAGAGCTCTC
CACCATTACG AGTTGCACCA TCACGGCGTG CCCCACCAAC GTGGTGAATC TCACCACCCT
CCGGAGTTCC AAGACTTCCA CGACCAAGCC TTGTCCTCCC ATGTCCACCA ATCTCACCAC
CACAGCGAGG CACGGAATCA CGGCAGAGCC CATGGCCCCA CAGGCTTTGG TCTGGCTCCC
TCTCAAGGCG CCGTCCCCTC CCACCGTTCC TACGGTGAGG ACTACCATGA TGAGCTCCAA
CGTGATGGCA GGAGGCATCA TGATGGGTCC CAATACGGTG GGTTCCATCA GCAGAGTGAC
TCCCATTACC ATAGGGGGTC TCACCATGGC AGACCCCAAT ATCTCGGTGA GAATTTATCC
CACTATTCCT CTGGCGTGCC CCACCACGGT GAGGCTTCCC ACCATGGTGG GTCCTACCTC
CCCCATGGAC CCAATCCCTA CAGTGAGTCC TTCCACCACA GCGAGGCTTC CCACCTTAGC
GGGCTCCAAC ACGATGAGTC CCAGCATCAC CAAGTCCCCC ACCGTGGCTG GCCCCACCAT
CACCAAGTCC ACCACCATGG CAGGTCCCGT CATCATGAAG CCCACCAGCA TGGAAAGTCT
CCTCATCACG GAGAGACCAT TTCCCCTCAT TCCTCTGTGG GGTCCTACCA GCGTGGGATA
TCTGACTATC ACAGCGAGTA CCACCAAGGT GATCACCACC CCAGTGAGTA CCACCATGGC
GACCATCCCC ACCACACACA GCACCACTAC CACCAGACCC ACCGGCACCG AGACTACCAT
CAGCACCAAG ACCACCACGG CGCGTATCAT TCCAGTTACC TCCATGGCGA CTACGTCCAG
AGCACTTCCC AACTCTCTAT CCCACACACA TCCCGGAGCC TGATTCACGA TGCCCCCGGC
CCTGCTGCTT CTCGTACAGG AGTCTTCCCC TATCACGTAG CACACCCACG GGGCTCGGCT
CACAGCATGA CTCGGTCCTC CAGCACAATC CGCTCACGTG TCACCCAGAT GTCCAAAAAA
GTCCATACCC AGGATATCTC CACCAAACAT TCAGAAGACT GGGGCAAAGA AGAAGGGCAA
TTTCAGAAAC GCAAAACCGG CCGGCTCCAG CGGACCCGCA AGAAGGGACA CTCTACCAAT
CTCTTCCAGT GGCTGTGGGA AAAGCTAACC TTCCTCATTC AGGGCTTCCG GGAAATGATC
CGGAACCTGA CCCAATCCTT GGCCTTTGAA ACTTTCATCT TCTTCGTTGT CTGCCTCAAC
ACCGTCATGC TGGTGGCCCA GACCTTCGCT GAAGTCGAGA TCCGGGGCGA GTGGTACTTC
ATGGCCTTGG ACTCCATATT CTTCTGCATC TACGTGGTGG AAGCCCTGCT CAAGATCATC
GCCCTGGGCC TCTCGTACTT CTTTGACTTC TGGAACAATT TGGACTTCTT CATTATGGCC
ATGGCCGTGC TGGACTTCTT GCTGATGCAG ACCCACTCCT TCGCCATCTA CCACCAAAGC
CTCTTCCGGA TCCTCAAGGT CTTCAAGAGC CTGCGGGCCC TGAGGGCAAT CCGGGTCCTG
CGGAGGCTCA GCTTCCTGAC CAGCGTCCAG GAAGTGACAG GGACCCTGGG CCAGTCCTTG
CCGTCCATCG CAGCCATCCT CATCCTCATG TTTACCTGCC TCTTCCTCTT CTCCGCGGTC
CTCCGGGCAC TGTTCCGCAA ATCTGACCCC AAGCGCTTCC AGAACATCTT CACCACCATC
TTCACCCTCT TCACCTTGCT CACGCTGGAT GACTGGTCCC TCATCTACAT GGACAGCCGT
GCCCAGGGCG CCTGGTACAT CATTCCCATC CTCGTAATTT ACATCATCAT CCAGTACTTC
ATCTTCCTCA ACCTGGTGAT TACTGTCCTG GTGGATAGCT TCCAGACGGC GCTGTTCAAA
GGCCTTGAGA AAGCGAAGCA GGAGAGGGCC GCCCGGATCC AAGAGAAGCT GCTGGAAGAC
TCACTGACGG AGCTCAGAGC TGCAGAGCCC AAAGAGGTGG CGAGTGAAGG CACCATGCTG
AAGCGGCTCA TCGAGAAAAA GTTTGGGACC ATGACTGAGA AGCAGCAGGA GCTCCTGTTC
CATTACCTGC AGCTGGTGGC AAGCGTGGAG CAGGAGCAGC AGAAGTTCCG CTCCCAGGCA
GCCGTCATCG ATGAGATTGT GGACACCACA TTTGAGGCTG GAGAAGAGGA CTTCAGGAAT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction
Mol. Cell. Endocrinol. 374 (1-2), 82-91 (2013)
Sagare-Patil V, Vernekar M, Galvankar M and Modi D.


book

Molecular cloning and analysis of the Catsper1 gene promoter
Mol. Hum. Reprod. 19 (5), 336-347 (2013)
Mata-Rocha M, Alvarado-Cuevas E, Hernandez-Sanchez J, Cerecedo D, Felix R, Hernandez-Reyes A, Tesoro-Cruz E and Oviedo N.


book

Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient
Proc. Natl. Acad. Sci. U.S.A. 110 (17), 6823-6828 (2013)
Smith JF, Syritsyna O, Fellous M, Serres C, Mannowetz N, Kirichok Y and Lishko PV.


book

Ca2+ signals generated by CatSper and Ca2+ stores regulate different behaviors in human sperm
J. Biol. Chem. 288 (9), 6248-6258 (2013)
Alasmari W, Costello S, Correia J, Oxenham SK, Morris J, Fernandes L, Ramalho-Santos J, Kirkman-Brown J, Michelangeli F, Publicover S and Barratt CL.


book

The CatSper channel: a polymodal chemosensor in human sperm
EMBO J. 31 (7), 1654-1665 (2012)
Brenker C, Goodwin N, Weyand I, Kashikar ND, Naruse M, Krahling M, Muller A, Kaupp UB and Strunker T.


book

CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility
Hum. Reprod. 19 (1), 124-128 (2004)
Nikpoor P, Mowla SJ, Movahedin M, Ziaee SA and Tiraihi T.


book

A voltage-gated ion channel expressed specifically in spermatozoa
Proc. Natl. Acad. Sci. U.S.A. 98 (22), 12527-12531 (2001)
Quill TA, Ren D, Clapham DE and Garbers DL.


book

A sperm ion channel required for sperm motility and male fertility
Nature 413 (6856), 603-609 (2001)
Ren D, Navarro B, Perez G, Jackson AC, Hsu S, Shi Q, Tilly JL and Clapham DE.


book

Ion channels. Swimming with sperm
Nature 413 (6856), 579 (2001)
Garbers,D.L.


book

CATSPER-Related Male Infertility
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Hildebrand,M.S., Avenarius,M.R. and Smith,R.J.H.


 
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