||ORF Nucleotide Sequence (Length: 1692bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||tripeptidyl-peptidase 1 preproprotein
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP287220.1, BP279860.1,
BC014863.1, AC091564.12 and AI023962.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 1, 2006 this sequence version replaced gi:5597012.
Summary: This gene encodes a member of the sedolisin family of
serine proteases. The protease functions in the lysosome to cleave
N-terminal tripeptides from substrates, and has weaker
endopeptidase activity. It is synthesized as a
catalytically-inactive enzyme which is activated and
auto-proteolyzed upon acidification. Mutations in this gene result
in late-infantile neuronal ceroid lipofuscinosis, which is
associated with the failure to degrade specific neuropeptides and a
subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
CDS uses downstream in-frame AUG :: downstream AUG is associated
with N-terminal localization
Transcript exon combination :: AF017456.1, BC014863.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: full length.