The following TPP1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TPP1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1692bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||tripeptidyl-peptidase 1 preproprotein
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BP287220.1, BP279860.1,
BC014863.1, AC091564.12 and AI023962.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 1, 2006 this sequence version replaced gi:5597012.
Summary: This gene encodes a member of the sedolisin family of
serine proteases. The protease functions in the lysosome to cleave
N-terminal tripeptides from substrates, and has weaker
endopeptidase activity. It is synthesized as a
catalytically-inactive enzyme which is activated and
auto-proteolyzed upon acidification. Mutations in this gene result
in late-infantile neuronal ceroid lipofuscinosis, which is
associated with the failure to degrade specific neuropeptides and a
subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
CDS uses downstream in-frame AUG :: downstream AUG is associated
with N-terminal localization
Transcript exon combination :: AF017456.1, BC014863.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: full length.