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TPP1 tripeptidyl peptidase I [Homo sapiens (human)]

Gene Symbol TPP1
Entrez Gene ID 1200
Full Name tripeptidyl peptidase I
Synonyms CLN2, GIG1, LPIC, SCAR7, TPP-1
General protein information
Preferred Names
tripeptidyl-peptidase 1
Names
tripeptidyl-peptidase 1
tripeptidyl aminopeptidase
growth-inhibiting protein 1
cell growth-inhibiting gene 1 protein
lysosomal pepstatin insensitive protease
NP_000382.3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15

Summary This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

607998

Disorder Html: Ceroid-lipofuscinosis, neuronal 2, classic late infantile, 204500





The following TPP1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TPP1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu28414 NM_000391 Homo sapiens tripeptidyl peptidase I (TPP1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu28414
Accession Version NM_000391.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1692bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product tripeptidyl-peptidase 1 preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP287220.1, BP279860.1, BC014863.1, AC091564.12 and AI023962.1. This sequence is a reference standard in the RefSeqGene project. On Dec 1, 2006 this sequence version replaced gi:5597012. Summary: This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:11054422) ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AF017456.1, BC014863.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGGACTCC AAGCCTGCCT CCTAGGGCTC TTTGCCCTCA TCCTCTCTGG CAAATGCAGT 
TACAGCCCGG AGCCCGACCA GCGGAGGACG CTGCCCCCAG GCTGGGTGTC CCTGGGCCGT
GCGGACCCTG AGGAAGAGCT GAGTCTCACC TTTGCCCTGA GACAGCAGAA TGTGGAAAGA
CTCTCGGAGC TGGTGCAGGC TGTGTCGGAT CCCAGCTCTC CTCAATACGG AAAATACCTG
ACCCTAGAGA ATGTGGCTGA TCTGGTGAGG CCATCCCCAC TGACCCTCCA CACGGTGCAA
AAATGGCTCT TGGCAGCCGG AGCCCAGAAG TGCCATTCTG TGATCACACA GGACTTTCTG
ACTTGCTGGC TGAGCATCCG ACAAGCAGAG CTGCTGCTCC CTGGGGCTGA GTTTCATCAC
TATGTGGGAG GACCTACGGA AACCCATGTT GTAAGGTCCC CACATCCCTA CCAGCTTCCA
CAGGCCTTGG CCCCCCATGT GGACTTTGTG GGGGGACTGC ACCGTTTTCC CCCAACATCA
TCCCTGAGGC AACGTCCTGA GCCGCAGGTG ACAGGGACTG TAGGCCTGCA TCTGGGGGTA
ACCCCCTCTG TGATCCGTAA GCGATACAAC TTGACCTCAC AAGACGTGGG CTCTGGCACC
AGCAATAACA GCCAAGCCTG TGCCCAGTTC CTGGAGCAGT ATTTCCATGA CTCAGACCTG
GCTCAGTTCA TGCGCCTCTT CGGTGGCAAC TTTGCACATC AGGCATCAGT AGCCCGTGTG
GTTGGACAAC AGGGCCGGGG CCGGGCCGGG ATTGAGGCCA GTCTAGATGT GCAGTACCTG
ATGAGTGCTG GTGCCAACAT CTCCACCTGG GTCTACAGTA GCCCTGGCCG GCATGAGGGA
CAGGAGCCCT TCCTGCAGTG GCTCATGCTG CTCAGTAATG AGTCAGCCCT GCCACATGTG
CATACTGTGA GCTATGGAGA TGATGAGGAC TCCCTCAGCA GCGCCTACAT CCAGCGGGTC
AACACTGAGC TCATGAAGGC TGCCGCTCGG GGTCTCACCC TGCTCTTCGC CTCAGGTGAC
AGTGGGGCCG GGTGTTGGTC TGTCTCTGGA AGACACCAGT TCCGCCCTAC CTTCCCTGCC
TCCAGCCCCT ATGTCACCAC AGTGGGAGGC ACATCCTTCC AGGAACCTTT CCTCATCACA
AATGAAATTG TTGACTATAT CAGTGGTGGT GGCTTCAGCA ATGTGTTCCC ACGGCCTTCA
TACCAGGAGG AAGCTGTAAC GAAGTTCCTG AGCTCTAGCC CCCACCTGCC ACCATCCAGT
TACTTCAATG CCAGTGGCCG TGCCTACCCA GATGTGGCTG CACTTTCTGA TGGCTACTGG
GTGGTCAGCA ACAGAGTGCC CATTCCATGG GTGTCCGGAA CCTCGGCCTC TACTCCAGTG
TTTGGGGGGA TCCTATCCTT GATCAATGAG CACAGGATCC TTAGTGGCCG CCCCCCTCTT
GGCTTTCTCA ACCCAAGGCT CTACCAGCAG CATGGGGCAG GACTCTTTGA TGTAACCCGT
GGCTGCCATG AGTCCTGTCT GGATGAAGAG GTAGAGGGCC AGGGTTTCTG CTCTGGTCCT
GGCTGGGATC CTGTAACAGG CTGGGGAACA CCCAACTTCC CAGCTTTGCT GAAGACTCTA
CTCAACCCCT GA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000382.3
CDS62..1753
Misc Feature(1)30..30(+)
Misc Feature(2)161..580(+)
Misc Feature(3)209..577(+)
Misc Feature(4)656..1732(+)
Misc Feature(5)725..727(+)
Misc Feature(6)875..1486(+)
Misc Feature(7)875..1486(+)
Misc Feature(8)1610..1690(+)
Exon (1)1..78
Gene:TPP1
Gene Synonym:
Exon (2)79..150
Gene:TPP1
Gene Synonym:
Exon (3)151..290
Gene:TPP1
Gene Synonym:
Exon (4)291..441
Gene:TPP1
Gene Synonym:
Exon (5)442..569
Gene:TPP1
Gene Synonym:
Exon (6)570..748
Gene:TPP1
Gene Synonym:
Exon (7)749..947
Gene:TPP1
Gene Synonym:
Exon (8)948..1136
Gene:TPP1
Gene Synonym:
Exon (9)1137..1206
Gene:TPP1
Gene Synonym:
Exon (10)1207..1327
Gene:TPP1
Gene Synonym:
Exon (11)1328..1486
Gene:TPP1
Gene Synonym:
Exon (12)1487..1612
Gene:TPP1
Gene Synonym:
Exon (13)1613..3533
Gene:TPP1
Gene Synonym:
Translation
Position Chain Variation Link
3 3 c, t dbSNP:576582372
10 10 a, c, g dbSNP:377520438
11 11 a, t dbSNP:780416668
15 15 -, g dbSNP:751942598
22 22 c, t dbSNP:200184958
26 26 a, t dbSNP:750756922
29 29 c, g, t dbSNP:757508432
31 31 a, t dbSNP:754095424
33 33 -, a dbSNP:778195460
38 38 a, t dbSNP:764420383
40 40 a, g dbSNP:767860643
41 41 a, g dbSNP:760667554
42 42 c, g dbSNP:368143492
44 44 a, g dbSNP:371279534
48 48 c, t dbSNP:377697624
49 49 g, t dbSNP:774091871
50 50 c, t dbSNP:770733577
57 57 -, g dbSNP:758909520
59 59 a, g dbSNP:762785189
60 60 a, g dbSNP:772707851
65 65 c, g dbSNP:769552465
67 67 a, t dbSNP:747594496
68 68 a, c dbSNP:142163063
72 72 a, t dbSNP:567523850
75 75 a, c dbSNP:138976576
85 85 a, g dbSNP:756251551
87 87 g, t dbSNP:748423428
103 103 a, c dbSNP:35903915
110 110 c, g dbSNP:754540584
112 112 c, g dbSNP:755019471
114 114 a, t dbSNP:751704816
115 115 a, t dbSNP:753509905
118 118 c, t dbSNP:758366251
119 119 a, c dbSNP:750116414
126 126 a, g, t dbSNP:202025584
130 130 a, g dbSNP:141680923
134 134 a, c dbSNP:373323264
139 139 a, c dbSNP:760252179
140 140 c, g dbSNP:775155638
143 143 c, t dbSNP:771499448
144 144 a, g dbSNP:369126677
162 162 a, c, g dbSNP:138448968
176 176 a, g dbSNP:770270239
178 178 c, t dbSNP:545601370
179 179 c, t dbSNP:794727482
180 180 a, g dbSNP:549309216
183 183 c, t dbSNP:768795654
184 184 a, g dbSNP:747260298
187 187 c, t dbSNP:780057326
194 194 a, g dbSNP:772163356
196 196 a, g dbSNP:746004484
199 199 g, t dbSNP:778900807
203 203 a, c dbSNP:201847207
206 206 c, g dbSNP:752191339
208 208 c, t dbSNP:757158698
209 209 a, g dbSNP:753620806
210 210 c, t dbSNP:777743384
212 212 g, t dbSNP:755780692
238 238 -, aagactctcggagct dbSNP:766010868
246 246 c, t dbSNP:2734715
249 249 a, t dbSNP:767113956
255 255 -, tgc dbSNP:760206881
257 257 c, t dbSNP:759080581
258 258 a, t dbSNP:751088292
260 260 a, c, g dbSNP:762309607
263 263 a, g dbSNP:776937435
267 267 c, t dbSNP:769028551
268 268 a, g dbSNP:761070664
270 270 a, g dbSNP:775780584
274 274 c, t dbSNP:143730817
282 282 c, t dbSNP:745907280
286 286 a, g dbSNP:368709098
289 289 -, c dbSNP:750166461
289 289 c, t dbSNP:373318861
290 290 a, g dbSNP:121908195
304 304 c, t dbSNP:774441925
305 305 c, t dbSNP:794727623
310 310 g, t dbSNP:771113565
317 317 a, g dbSNP:140663603
318 318 c, g dbSNP:773275639
321 321 a, g dbSNP:148064565
322 322 g, t dbSNP:747918185
323 323 a, c dbSNP:780849847
326 326 a, g dbSNP:754615268
328 328 a, g dbSNP:746660467
335 335 a, c, t dbSNP:372102190
336 336 a, c dbSNP:771957036
345 345 c, g dbSNP:535584300
354 354 c, t dbSNP:140726254
355 355 a, g dbSNP:141417655
356 356 a, g dbSNP:756622036
358 358 a, g dbSNP:753066277
359 359 c, t dbSNP:201661852
360 360 a, c, g dbSNP:1800746
370 370 c, t dbSNP:774408040
371 371 c, t dbSNP:766772440
372 372 a, t dbSNP:202189057
374 374 g, t dbSNP:368435226
379 379 c, t dbSNP:774528021
380 380 a, g dbSNP:201613668
382 382 a, g dbSNP:776434116
383 383 a, g dbSNP:754458076
384 384 c, t dbSNP:374132017
391 391 a, g dbSNP:145853102
397 397 a, t dbSNP:199539943
401 401 a, g dbSNP:552111650
413 413 a, g dbSNP:745319827
439 439 c, g dbSNP:778429963
440 440 c, t dbSNP:756564767
441 441 a, g, t dbSNP:121908204
450 450 a, g dbSNP:765595428
457 457 a, g dbSNP:761793068
468 468 c, t dbSNP:753967232
469 469 c, t dbSNP:763872439
483 483 a, c dbSNP:769043106
486 486 c, g, t dbSNP:775217501
489 489 a, g dbSNP:771835626
491 491 a, g dbSNP:759370128
496 496 c, t dbSNP:188822344
497 497 a, g dbSNP:770677434
498 498 c, t dbSNP:748686068
499 499 a, g dbSNP:777339172
502 502 a, g dbSNP:2555170
507 507 a, g dbSNP:747540137
510 510 c, t dbSNP:780755290
520 520 c, t dbSNP:758804147
522 522 c, t dbSNP:746299333
526 526 c, t dbSNP:778947332
532 532 c, t dbSNP:553522118
534 534 a, c dbSNP:757507462
540 540 c, t dbSNP:753822217
542 542 c, t dbSNP:764256845
550 550 c, g dbSNP:756202166
563 563 g, t dbSNP:370920825
565 565 c, g dbSNP:752603109
568 568 c, t dbSNP:767512838
571 571 c, g dbSNP:751488322
573 573 a, g dbSNP:779895571
574 574 g, t dbSNP:145224171
584 584 c, t dbSNP:750241218
585 585 a, g dbSNP:764922748
590 590 a, c dbSNP:761591327
591 591 c, t dbSNP:753351050
593 593 c, g, t dbSNP:149986601
595 595 a, g dbSNP:774921716
603 603 c, t dbSNP:139059149
605 605 c, t dbSNP:776858324
609 609 c, g dbSNP:573539804
614 614 c, t dbSNP:34758634
615 615 a, g dbSNP:773455971
624 624 c, t dbSNP:550590502
625 625 a, g dbSNP:748389153
629 629 g, t dbSNP:546294509
664 664 a, c dbSNP:781437176
666 666 c, t dbSNP:121908205
667 667 c, t dbSNP:768687217
669 669 c, t dbSNP:747124374
677 677 c, t dbSNP:28940573
678 678 a, g dbSNP:121908209
683 683 c, t dbSNP:119455955
684 684 a, g dbSNP:778875097
685 685 a, t dbSNP:757167692
695 695 a, g dbSNP:753510626
696 696 a, c dbSNP:760791212
697 697 c, g dbSNP:763910597
699 699 c, t dbSNP:773546205
701 701 c, t dbSNP:752164603
706 706 c, t dbSNP:766845531
713 713 c, t dbSNP:763398665
718 718 c, t dbSNP:773514151
722 722 a, g dbSNP:770118313
726 726 a, g dbSNP:372787642
729 729 -, a dbSNP:768291817
729 729 a, g dbSNP:538565229
730 730 -, c dbSNP:143313287
759 759 a, g dbSNP:751126292
794 794 a, c, t dbSNP:587780481
795 795 a, g dbSNP:754161261
796 796 c, t dbSNP:376072689
802 802 c, t dbSNP:372817942
814 814 c, t dbSNP:752859219
816 816 c, t dbSNP:767839250
818 818 c, t dbSNP:759634452
829 829 a, g, t dbSNP:770954145
831 831 c, t dbSNP:763009524
833 833 g, t dbSNP:773247372
834 834 a, c dbSNP:769442364
836 836 c, t dbSNP:748038934
837 837 a, g dbSNP:140176031
842 842 c, g dbSNP:768368553
843 843 c, t dbSNP:146136938
857 857 c, t dbSNP:200138397
858 858 a, g dbSNP:757953998
861 861 a, g dbSNP:754314582
863 863 c, t dbSNP:778410642
864 864 a, c, g dbSNP:141920079
868 868 c, t dbSNP:148222726
869 869 a, c, g dbSNP:561854371
873 873 c, t dbSNP:766541487
888 888 a, t dbSNP:763162812
890 890 a, g dbSNP:121908207
899 899 c, g dbSNP:769824907
901 901 c, g dbSNP:140349036
904 904 a, g dbSNP:776489592
912 912 g, t dbSNP:119455957
918 918 a, g dbSNP:119455958
920 920 a, g dbSNP:578253592
921 921 a, t dbSNP:121908196
924 924 a, c dbSNP:201561710
948 948 a, g dbSNP:766770330
950 950 c, t dbSNP:553122824
952 952 g, t dbSNP:750527536
967 967 g, t dbSNP:765015698
969 969 c, t dbSNP:761839654
978 978 a, t dbSNP:201192562
986 986 a, g dbSNP:763854371
991 991 c, g dbSNP:760531038
992 992 c, t dbSNP:775113283
1008 1008 a, c dbSNP:149463616
1012 1012 c, g dbSNP:576988866
1017 1017 a, g dbSNP:745310554
1026 1026 c, t dbSNP:773946638
1029 1029 c, t dbSNP:770155767
1033 1033 -, ctatggag dbSNP:778232650
1042 1042 c, t dbSNP:137937009
1043 1043 c, g dbSNP:202086458
1045 1045 a, t dbSNP:781773805
1053 1053 c, t dbSNP:755386210
1060 1060 c, t dbSNP:747433613
1064 1064 a, g dbSNP:146927291
1068 1068 a, g dbSNP:758649621
1076 1076 c, t dbSNP:750428882
1077 1077 a, g dbSNP:765380155
1088 1088 a, g dbSNP:121908197
1094 1094 a, c dbSNP:141482368
1095 1095 c, t dbSNP:764077257
1096 1096 a, g dbSNP:760406360
1102 1102 c, t dbSNP:775269391
1104 1104 a, c dbSNP:370144405
1105 1105 c, t dbSNP:35706972
1110 1110 a, c, g dbSNP:199866669
1118 1118 a, c dbSNP:121908206
1119 1119 a, c dbSNP:145966505
1126 1126 c, g dbSNP:777261002
1129 1129 c, t dbSNP:769297657
1138 1138 g, t dbSNP:779139008
1142 1142 a, g dbSNP:771065283
1147 1147 a, g dbSNP:140809393
1150 1150 c, t dbSNP:151068181
1151 1151 a, g dbSNP:756237773
1154 1154 c, t dbSNP:119455953
1155 1155 a, g dbSNP:119455954
1157 1157 c, t dbSNP:781062347
1165 1165 c, t dbSNP:528380320
1175 1175 c, t dbSNP:371314926
1177 1177 c, g dbSNP:751321300
1178 1178 c, g dbSNP:112812685
1184 1184 c, t dbSNP:368914445
1185 1185 a, g dbSNP:546003291
1186 1186 c, t dbSNP:587780972
1199 1199 a, g dbSNP:190013230
1202 1202 c, t dbSNP:200959385
1206 1206 a, g dbSNP:761448855
1209 1209 a, c dbSNP:763492759
1215 1215 a, t dbSNP:121908198
1216 1216 c, t dbSNP:755693820
1227 1227 a, g dbSNP:121908199
1247 1247 a, c, t dbSNP:766934252
1250 1250 c, t dbSNP:763241128
1252 1252 c, t dbSNP:148950375
1253 1253 c, t dbSNP:149319579
1270 1270 c, t dbSNP:761960935
1278 1278 a, c, g dbSNP:780670020
1279 1279 c, t dbSNP:747179298
1280 1280 a, g dbSNP:775276482
1302 1302 a, t dbSNP:146798796
1313 1313 c, t dbSNP:143584882
1314 1314 a, g dbSNP:138744051
1321 1321 a, g dbSNP:770900822
1327 1327 c, g dbSNP:121908200
1340 1340 a, t dbSNP:769487055
1341 1341 -, g dbSNP:34736006
1341 1341 c, t dbSNP:201034755
1342 1342 a, g dbSNP:577520250
1350 1350 a, t dbSNP:780656523
1358 1358 a, g dbSNP:754529721
1364 1364 a, c dbSNP:755829911
1365 1365 a, c dbSNP:750896655
1368 1368 c, t dbSNP:150039898
1381 1381 g, t dbSNP:761998339
1384 1384 c, t dbSNP:757548236
1388 1388 a, c dbSNP:754243461
1389 1389 a, g dbSNP:139343938
1392 1392 a, c dbSNP:760974302
1396 1396 c, t dbSNP:150872335
1401 1401 a, g dbSNP:119455956
1403 1403 -, g dbSNP:767317024
1408 1408 c, t dbSNP:756095870
1422 1422 a, c dbSNP:121908201
1423 1423 a, g dbSNP:141701073
1440 1440 a, g dbSNP:786204753
1444 1444 a, g dbSNP:202190396
1457 1457 a, g dbSNP:78970155
1458 1458 g, t dbSNP:398122959
1468 1468 a, g dbSNP:750546113
1477 1477 c, t dbSNP:773086052
1478 1478 a, g dbSNP:121908203
1479 1479 c, g dbSNP:747773491
1483 1483 c, g dbSNP:776302678
1485 1485 c, t dbSNP:121908202
1486 1486 a, c, g dbSNP:779333902
1496 1496 c, g dbSNP:756530648
1505 1505 c, g dbSNP:121908208
1512 1512 c, t dbSNP:748533410
1518 1518 a, c dbSNP:781495096
1521 1521 c, t dbSNP:769802678
1522 1522 c, g dbSNP:532438658
1527 1527 a, g dbSNP:751645191
1531 1531 a, c, g, t dbSNP:367681647
1539 1539 -, at dbSNP:749714444
1550 1550 c, t dbSNP:377700188
1551 1551 a, g dbSNP:549928656
1555 1555 c, t dbSNP:117942457
1556 1556 a, c, g, t dbSNP:201126448
1557 1557 -, c dbSNP:756963463
1557 1557 a, c, g, t dbSNP:773707856
1558 1558 c, t dbSNP:142672910
1561 1561 c, t dbSNP:748480091
1575 1575 c, g dbSNP:138941580
1584 1584 a, g dbSNP:769195711
1587 1587 a, g dbSNP:149529997
1602 1602 c, g dbSNP:780210201
1603 1603 -, tactta dbSNP:751120981
1603 1603 a, t dbSNP:1128396
1604 1604 c, t dbSNP:748345018
1608 1608 -, tt dbSNP:763961289
1619 1619 a, c dbSNP:371204585
1620 1620 a, g dbSNP:368697480
1643 1643 a, g dbSNP:375364589
1653 1653 c, t dbSNP:757367088
1666 1666 c, t dbSNP:555048430
1671 1671 a, g dbSNP:777744177
1674 1674 c, g dbSNP:755878872
1675 1675 c, t dbSNP:55684773
1691 1691 c, t dbSNP:121908210
1695 1695 c, t dbSNP:752436484
1698 1698 c, t dbSNP:767154380
1708 1708 a, g dbSNP:535082174
1714 1714 c, g, t dbSNP:372564255
1720 1720 c, g dbSNP:762621276
1725 1725 a, c dbSNP:200880556
1732 1732 a, g dbSNP:777267276
1739 1739 -, ct dbSNP:759664259
1742 1742 a, c dbSNP:566120191
1749 1749 a, c dbSNP:761034565
1763 1763 a, g dbSNP:775748851
1765 1765 a, c, t dbSNP:368345241
1766 1766 a, c dbSNP:774621082
1767 1767 a, g dbSNP:374983247
1768 1768 a, g dbSNP:749381175
1772 1772 c, g dbSNP:777617537
1782 1782 c, t dbSNP:756034137
1783 1783 c, t dbSNP:747924226
1789 1789 a, c dbSNP:780823344
1791 1791 c, t dbSNP:754846292
1795 1795 a, g dbSNP:751256397
1797 1797 a, t dbSNP:370517226
1801 1801 a, t dbSNP:367879648
1822 1822 a, g dbSNP:534509297
1824 1824 a, g dbSNP:140680586
1893 1893 g, t dbSNP:2555171
1920 1920 a, g dbSNP:780382042
1930 1930 a, g dbSNP:769938108
1940 1940 a, g dbSNP:12289910
1944 1944 -, c dbSNP:34210291
1976 1976 c, t dbSNP:538963672
1994 1994 c, t dbSNP:74843914
2005 2005 c, t dbSNP:111594949
2012 2012 a, g dbSNP:151296958
2065 2065 c, t dbSNP:201122774
2067 2067 c, t dbSNP:560874549
2067 2067 -, t dbSNP:202155605
2084 2084 a, g dbSNP:547507980
2094 2094 c, t dbSNP:142480159
2099 2099 a, g dbSNP:149218047
2128 2128 c, t dbSNP:759788927
2185 2185 a, t dbSNP:372993882
2188 2188 c, g dbSNP:544588217
2227 2227 a, t dbSNP:145461599
2240 2240 c, t dbSNP:776646246
2278 2278 c, t dbSNP:756647977
2301 2301 c, t dbSNP:564030461
2328 2328 -, t dbSNP:34308615
2380 2380 c, t dbSNP:543709208
2442 2442 c, t dbSNP:750410699
2449 2449 a, g dbSNP:574987094
2458 2458 a, g dbSNP:527455171
2464 2464 a, c dbSNP:781318237
2503 2503 g, t dbSNP:757393698
2504 2504 c, t dbSNP:751760114
2538 2538 g, t dbSNP:764323122
2558 2558 a, c dbSNP:762699066
2564 2564 -, gtg dbSNP:540240086
2567 2567 a, t dbSNP:752543057
2582 2582 c, t dbSNP:533616443
2597 2597 c, t dbSNP:541585954
2600 2600 -, caatcaacaagtcct dbSNP:146267350
2625 2625 -, c dbSNP:749857183
2668 2668 c, t dbSNP:572550190
2695 2695 c, t dbSNP:559030321
2706 2706 c, t dbSNP:539053677
2719 2719 a, c dbSNP:144157135
2724 2724 a, g dbSNP:748797777
2739 2739 c, g dbSNP:188148381
2769 2769 c, g dbSNP:536145175
2781 2781 c, t dbSNP:1802018
2809 2809 g, t dbSNP:759507831
2838 2838 g, t dbSNP:374765991
2847 2847 a, g dbSNP:140414512
2862 2862 -, tc dbSNP:534434328
2864 2864 c, g dbSNP:747102064
2871 2871 c, g dbSNP:1045450
2889 2889 c, g dbSNP:770448338
2969 2969 -, t dbSNP:575737269
2973 2973 c, g dbSNP:183015906
2977 2977 c, t dbSNP:527416025
2984 2984 a, g dbSNP:368452233
2993 2993 c, g dbSNP:772947912
3003 3003 a, t dbSNP:193029892
3005 3005 a, c dbSNP:1802017
3039 3039 a, c dbSNP:749596981
3040 3040 c, t dbSNP:551033286
3065 3065 a, g dbSNP:779742098
3151 3151 a, g dbSNP:531209481
3181 3181 c, t dbSNP:188544089
3228 3228 ga, tt dbSNP:386750286
3230 3230 a, g dbSNP:147581280
3231 3231 a, t dbSNP:775934269
3234 3234 c, t dbSNP:530326282
3261 3261 a, g dbSNP:561558362
3262 3262 a, g dbSNP:541622708
3279 3279 c, t dbSNP:770113060
3293 3293 c, t dbSNP:374146578
3313 3313 c, t dbSNP:541932361
3323 3323 c, t dbSNP:369352772
3341 3341 c, t dbSNP:7487
3358 3358 a, g dbSNP:576395587
3381 3381 a, g dbSNP:7488
3395 3395 g, t dbSNP:747125336
3440 3440 a, g dbSNP:3185635
3443 3443 a, g dbSNP:377714674
3475 3475 a, c dbSNP:1802019
3493 3493 a, t dbSNP:777906139
3503 3503 g, t dbSNP:139164847
3532 3532 c, t dbSNP:553615759

Target ORF information:

RefSeq Version NM_000391
Organism Homo sapiens (human)
Definition Homo sapiens tripeptidyl peptidase I (TPP1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000391

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGGACTCC AAGCCTGCCT CCTAGGGCTC TTTGCCCTCA TCCTCTCTGG CAAATGCAGT 
TACAGCCCGG AGCCCGACCA GCGGAGGACG CTGCCCCCAG GCTGGGTGTC CCTGGGCCGT
GCGGACCCTG AGGAAGAGCT GAGTCTCACC TTTGCCCTGA GACAGCAGAA TGTGGAAAGA
CTCTCGGAGC TGGTGCAGGC TGTGTCGGAT CCCAGCTCTC CTCAATACGG AAAATACCTG
ACCCTAGAGA ATGTGGCTGA TCTGGTGAGG CCATCCCCAC TGACCCTCCA CACGGTGCAA
AAATGGCTCT TGGCAGCCGG AGCCCAGAAG TGCCATTCTG TGATCACACA GGACTTTCTG
ACTTGCTGGC TGAGCATCCG ACAAGCAGAG CTGCTGCTCC CTGGGGCTGA GTTTCATCAC
TATGTGGGAG GACCTACGGA AACCCATGTT GTAAGGTCCC CACATCCCTA CCAGCTTCCA
CAGGCCTTGG CCCCCCATGT GGACTTTGTG GGGGGACTGC ACCGTTTTCC CCCAACATCA
TCCCTGAGGC AACGTCCTGA GCCGCAGGTG ACAGGGACTG TAGGCCTGCA TCTGGGGGTA
ACCCCCTCTG TGATCCGTAA GCGATACAAC TTGACCTCAC AAGACGTGGG CTCTGGCACC
AGCAATAACA GCCAAGCCTG TGCCCAGTTC CTGGAGCAGT ATTTCCATGA CTCAGACCTG
GCTCAGTTCA TGCGCCTCTT CGGTGGCAAC TTTGCACATC AGGCATCAGT AGCCCGTGTG
GTTGGACAAC AGGGCCGGGG CCGGGCCGGG ATTGAGGCCA GTCTAGATGT GCAGTACCTG
ATGAGTGCTG GTGCCAACAT CTCCACCTGG GTCTACAGTA GCCCTGGCCG GCATGAGGGA
CAGGAGCCCT TCCTGCAGTG GCTCATGCTG CTCAGTAATG AGTCAGCCCT GCCACATGTG
CATACTGTGA GCTATGGAGA TGATGAGGAC TCCCTCAGCA GCGCCTACAT CCAGCGGGTC
AACACTGAGC TCATGAAGGC TGCCGCTCGG GGTCTCACCC TGCTCTTCGC CTCAGGTGAC
AGTGGGGCCG GGTGTTGGTC TGTCTCTGGA AGACACCAGT TCCGCCCTAC CTTCCCTGCC
TCCAGCCCCT ATGTCACCAC AGTGGGAGGC ACATCCTTCC AGGAACCTTT CCTCATCACA
AATGAAATTG TTGACTATAT CAGTGGTGGT GGCTTCAGCA ATGTGTTCCC ACGGCCTTCA
TACCAGGAGG AAGCTGTAAC GAAGTTCCTG AGCTCTAGCC CCCACCTGCC ACCATCCAGT
TACTTCAATG CCAGTGGCCG TGCCTACCCA GATGTGGCTG CACTTTCTGA TGGCTACTGG
GTGGTCAGCA ACAGAGTGCC CATTCCATGG GTGTCCGGAA CCTCGGCCTC TACTCCAGTG
TTTGGGGGGA TCCTATCCTT GATCAATGAG CACAGGATCC TTAGTGGCCG CCCCCCTCTT
GGCTTTCTCA ACCCAAGGCT CTACCAGCAG CATGGGGCAG GACTCTTTGA TGTAACCCGT
GGCTGCCATG AGTCCTGTCT GGATGAAGAG GTAGAGGGCC AGGGTTTCTG CTCTGGTCCT
GGCTGGGATC CTGTAACAGG CTGGGGAACA CCCAACTTCC CAGCTTTGCT GAAGACTCTA
CTCAACCCCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.