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CLN3 ceroid-lipofuscinosis, neuronal 3 [Homo sapiens (human)]

Gene Symbol CLN3
Entrez Gene ID 1201
Full Name ceroid-lipofuscinosis, neuronal 3
Synonyms BTS, JNCL
General protein information
Preferred Names
battenin
Names
battenin
batten disease protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p12.1

Summary This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

607042

Disorder Html: Ceroid-lipofuscinosis, neuronal-3, juvenile, 204200 (3)





The following CLN3 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLN3 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu27581 NM_001286104 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu16887 NM_001286105 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $319
OHu27575 NM_001286109 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $319
OHu16865 NM_001286110 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $319
OHu25863 NM_001042432 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $319
OHu25863 NM_000086 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu27581
Accession Version NM_001286104.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1245bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA703317.1 and AK302027.1. Summary: This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302027.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGCTGTGCT CCTGGCGGAC
ATCCTCCCCA CACTCGTCAT CAAATTGTTG GCTCCTCTTG GCCTTCACCT GCTGCCCTAC
AGCCCCCGGG TTCTCGTCAG TGGGATTTGT GCTGCTGGAA GCTTCGTCCT GGTTGCCTTT
TCTCATTCTG TGGGGACCAG CCTGTGTGGT GTGGTCTTCG CTAGCATCTC ATCAGGCCTT
GGGGAGGTCA CCTTCCTCTC CCTCACTGCC TTCTACCCCA GGGCCGTGAT CTCCTGGTGG
TCCTCAGGGA CTGGGGGAGC TGGGCTGCTG GGGGCCCTGT CCTACCTGGG CCTCACCCAG
GCCGGCCTCT CCCCTCAGCA GACCCTGCTG TCCATGCTGG GTATCCCTGC CCTGCTGCTG
GCCAGCTATT TCTTGTTGCT CACATCTCCT GAGGCCCAGG ACCCTGGAGG GGAAGAAGAA
GCAGAGAGCG CAGCCCGGCA GCCCCTCATA AGAACCGAGG CCCCGGAGTC GAAGCCAGGC
TCCAGCTCCA GCCTCTCCCT TCGGGAAAGG TGGACAGTGT TCAAGGGTCT GCTGTGGTAC
ATTGTTCCCT TGGTCGTAGT TTACTTTGCC GAGTATTTCA TTAACCAGGG ACTTTTTGAA
CTCCTCTTTT TCTGGAACAC TTCCCTGAGT CACGCTCAGC AATACCGCTG GTACCAGATG
CTGTACCAGG CTGGCGTCTT TGCCTCCCGC TCTTCTCTCC GCTGCTGTCG CATCCGTTTC
ACCTGGGCCC TGGCCCTGCT GCAGTGCCTC AACCTGGTGT TCCTGCTGGC AGACGTGTGG
TTCGGCTTTC TGCCAAGCAT CTACCTCGTC TTCCTGATCA TTCTGTATGA GGGGCTCCTG
GGAGGCGCAG CCTACGTGAA CACCTTCCAC AACATCGCCC TGGAGACCAG TGATGAGCAC
CGGGAGTTTG CAATGGCGGC CACCTGCATC TCTGACACAC TGGGGATCTC CCTGTCGGGG
CTCCTGGCTT TGCCTCTGCA TGACTTCCTC TGCCAGCTCT CCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001273033.1
CDS360..1604
Misc Feature(1)324..326(+)
Misc Feature(2)468..1601(+)
Exon (1)1..283
Gene:CLN3
Gene Synonym:
Exon (2)284..405
Gene:CLN3
Gene Synonym:
Exon (3)406..484
Gene:CLN3
Gene Synonym:
Exon (4)485..581
Gene:CLN3
Gene Synonym:
Exon (5)582..661
Gene:CLN3
Gene Synonym:
Exon (6)662..747
Gene:CLN3
Gene Synonym:
Exon (7)748..820
Gene:CLN3
Gene Synonym:
Exon (8)821..964
Gene:CLN3
Gene Synonym:
Exon (9)965..1077
Gene:CLN3
Gene Synonym:
Exon (10)1078..1124
Gene:CLN3
Gene Synonym:
Exon (11)1125..1193
Gene:CLN3
Gene Synonym:
Exon (12)1194..1249
Gene:CLN3
Gene Synonym:
Exon (13)1250..1343
Gene:CLN3
Gene Synonym:
Exon (14)1344..1484
Gene:CLN3
Gene Synonym:
Exon (15)1485..1840
Gene:CLN3
Gene Synonym:
Translation
Position Chain Variation Link
18 18 c, g dbSNP:528209961
80 80 a, c dbSNP:559560438
96 96 c, g dbSNP:187163584
104 104 c, t dbSNP:532405948
113 113 a, t dbSNP:563482688
156 156 a, c dbSNP:543778792
181 181 a, g dbSNP:544844147
213 213 -, a dbSNP:547169357
219 219 a, g, t dbSNP:760565039
230 230 c, t dbSNP:574775208
231 231 c, g dbSNP:141305257
246 246 a, g dbSNP:369500373
248 248 c, t dbSNP:572212180
255 255 a, t dbSNP:73533476
266 266 a, t dbSNP:565767570
286 286 c, t dbSNP:534657200
309 309 c, t dbSNP:767141815
310 310 -, ggagccccc dbSNP:760562597
310 310 c, t dbSNP:759135845
319 319 a, c dbSNP:370217726
322 322 -, t dbSNP:775483589
323 323 a, g dbSNP:766826715
327 327 a, c dbSNP:368494637
343 343 a, c, g dbSNP:770428655
347 347 g, t dbSNP:555894979
354 354 c, g dbSNP:776594074
355 355 a, g dbSNP:768881655
358 358 c, g dbSNP:747169563
359 359 c, g, t dbSNP:201274333
360 360 a, c, g dbSNP:386833708
361 361 c, t dbSNP:777625354
367 367 a, g dbSNP:756062000
388 388 -, g dbSNP:374055075
391 391 c, t dbSNP:752205710
396 396 a, g, t dbSNP:754562266
401 401 c, t dbSNP:751155598
404 404 a, g dbSNP:201824641
408 408 a, g, t dbSNP:386833726
415 415 c, t dbSNP:758020045
421 421 c, g, t dbSNP:562525993
426 426 c, t dbSNP:757558651
428 428 c, t dbSNP:754235288
430 430 a, g dbSNP:764455367
431 431 g, t dbSNP:756670390
432 432 a, c dbSNP:752737552
460 460 a, g, t dbSNP:759668300
461 461 c, t dbSNP:774549218
464 464 a, g dbSNP:386833700
467 467 a, g dbSNP:761453819
470 470 c, t dbSNP:776507846
471 471 a, g dbSNP:565082957
475 475 c, t dbSNP:760656860
485 485 a, g dbSNP:781617143
488 488 a, g dbSNP:755493834
506 506 c, t dbSNP:571216643
511 511 c, t dbSNP:780151271
515 515 c, t dbSNP:758454511
516 516 a, g dbSNP:750643595
522 522 a, g, t dbSNP:760481173
525 525 a, c, g dbSNP:767513559
527 527 a, g dbSNP:759581122
533 533 c, t dbSNP:138433617
534 534 a, g dbSNP:765893479
539 539 c, t dbSNP:150120797
540 540 a, g dbSNP:772851701
553 553 a, g dbSNP:574261896
556 556 a, g dbSNP:769447444
564 564 c, t dbSNP:748458737
565 565 c, t dbSNP:769840061
566 566 a, g dbSNP:551476103
568 568 a, g dbSNP:747526330
573 573 c, t dbSNP:386833709
574 574 a, t dbSNP:780482162
575 575 c, g dbSNP:758501983
579 579 c, t dbSNP:745941670
581 581 c, t dbSNP:201225986
589 589 c, t dbSNP:386833714
595 595 c, t dbSNP:760039703
596 596 a, g dbSNP:774996613
600 600 a, g dbSNP:11552531
605 605 c, t dbSNP:148248159
606 606 c, t dbSNP:149095062
610 610 c, t dbSNP:769953653
614 614 c, t dbSNP:748293490
615 615 a, g dbSNP:781534624
622 622 a, g dbSNP:771758062
624 624 c, t dbSNP:745665200
625 625 c, t dbSNP:778765250
626 626 a, g dbSNP:200356262
640 640 a, g dbSNP:753305901
645 645 a, c dbSNP:145749864
648 648 a, c, g dbSNP:752282954
653 653 a, g dbSNP:376960425
657 657 -, t dbSNP:386833715
658 658 -, t dbSNP:587779397
658 658 a, g dbSNP:546862372
659 659 c, t dbSNP:755330966
661 661 a, g dbSNP:386833716
662 662 c, t dbSNP:146076617
666 666 -, cc dbSNP:386833717
666 666 -, c dbSNP:386833718
666 666 c, t dbSNP:201168980
667 667 a, g dbSNP:780776829
668 668 c, g dbSNP:750889321
674 674 c, t dbSNP:765776873
675 675 a, c, g, t dbSNP:764261700
679 679 a, g dbSNP:144770450
680 680 c, t dbSNP:794727850
686 686 c, t dbSNP:775739498
687 687 c, t dbSNP:386833719
691 691 c, t dbSNP:770702932
695 695 c, t dbSNP:749176223
701 701 c, t dbSNP:772960606
705 705 a, g dbSNP:373034150
707 707 c, g dbSNP:544119921
711 711 -, g dbSNP:386833720
720 720 c, t dbSNP:780814580
723 723 c, t dbSNP:371590088
730 730 -, tgg dbSNP:752130042
730 730 g, t dbSNP:746644433
734 734 g, t dbSNP:779918787
735 735 a, c dbSNP:758767565
745 745 a, g dbSNP:750813350
748 748 c, g dbSNP:746178854
751 751 g, t dbSNP:779304920
758 758 c, t dbSNP:140670783
759 759 c, g dbSNP:386833723
761 761 c, t dbSNP:551927665
763 763 c, g dbSNP:754331166
769 769 c, g dbSNP:386833724
770 770 a, g dbSNP:778321651
772 772 c, g dbSNP:386833725
777 777 c, t dbSNP:758342160
779 779 -, g dbSNP:35832901
781 781 a, g dbSNP:786201028
796 796 c, t dbSNP:386833727
797 797 c, t dbSNP:756123046
803 803 c, t dbSNP:148846795
809 809 c, t dbSNP:371467190
810 810 c, t dbSNP:759769158
818 818 c, t dbSNP:751773646
821 821 c, g dbSNP:756640405
824 824 c, t dbSNP:147667964
825 825 a, g dbSNP:202215629
845 845 -, ag dbSNP:386833729
847 847 c, g dbSNP:386833730
852 852 c, g dbSNP:386833731
856 856 -, g dbSNP:763096461
856 856 -, g dbSNP:386833732
862 862 a, g dbSNP:386833733
863 863 a, g, t dbSNP:566516380
868 868 c, t dbSNP:751799615
869 869 g, t dbSNP:386833734
873 873 -, g dbSNP:386833735
874 874 c, t dbSNP:757018330
876 876 c, t dbSNP:753705869
878 878 a, g dbSNP:764082661
884 884 a, c dbSNP:267606737
885 885 c, g dbSNP:768149446
889 889 g, t dbSNP:775618174
902 902 c, t dbSNP:145631076
903 903 a, g dbSNP:370603922
909 909 -, t dbSNP:386833736
913 913 c, t dbSNP:139417824
918 918 c, t dbSNP:386833737
925 925 c, t dbSNP:554746072
928 928 c, t dbSNP:749609898
934 934 a, t dbSNP:773602052
936 936 a, c dbSNP:150913606
948 948 a, g dbSNP:748636727
952 952 c, t dbSNP:781613318
956 956 a, g dbSNP:755016673
957 957 c, t dbSNP:141508632
959 959 a, g dbSNP:747071263
968 968 c, t dbSNP:747068998
972 972 c, t dbSNP:779965094
974 974 a, g dbSNP:772327361
975 975 c, t dbSNP:746075287
980 980 c, t dbSNP:376590377
981 981 a, t dbSNP:755908083
982 982 c, t dbSNP:752450798
990 990 g, t dbSNP:781138637
994 994 c, t dbSNP:754906598
1011 1011 c, g dbSNP:751560016
1016 1016 -, a dbSNP:762192561
1021 1021 -, cag dbSNP:776966610
1026 1026 a, c dbSNP:765857735
1028 1028 c, t dbSNP:148782327
1029 1029 a, g dbSNP:750008067
1035 1035 c, t dbSNP:764881080
1036 1036 a, g dbSNP:374217931
1039 1039 a, c dbSNP:776890506
1041 1041 c, t dbSNP:769104531
1042 1042 c, t dbSNP:761065339
1044 1044 c, g dbSNP:776122422
1046 1046 a, c dbSNP:772274552
1048 1048 c, t dbSNP:745948575
1055 1055 c, t dbSNP:145967477
1056 1056 a, g dbSNP:771303379
1058 1058 a, g dbSNP:73533466
1060 1060 c, t dbSNP:780823167
1063 1063 c, t dbSNP:137858807
1064 1064 a, g dbSNP:751443804
1069 1069 c, t dbSNP:199627744
1070 1070 a, g dbSNP:752632879
1076 1076 a, c dbSNP:574450787
1081 1081 c, t dbSNP:749453498
1091 1091 a, c dbSNP:773546150
1101 1101 c, t dbSNP:113041302
1102 1102 a, g dbSNP:145270402
1111 1111 a, g dbSNP:779914525
1115 1115 -, ag dbSNP:755465037
1116 1116 a, g dbSNP:758360941
1118 1118 a, g dbSNP:1142183
1137 1137 c, t dbSNP:201090501
1140 1140 a, g dbSNP:748844685
1149 1149 g, t dbSNP:777244248
1152 1152 a, g dbSNP:755824692
1155 1155 a, g, t dbSNP:369008702
1162 1162 a, g dbSNP:755402909
1167 1167 a, g dbSNP:752112708
1169 1169 c, t dbSNP:766972077
1170 1170 a, g, t dbSNP:121434286
1173 1173 a, t dbSNP:750558528
1181 1181 c, t dbSNP:747222268
1184 1184 c, g dbSNP:765265208
1190 1190 a, g dbSNP:761976112
1192 1192 c, t dbSNP:776853352
1202 1202 c, g dbSNP:759304422
1203 1203 c, t dbSNP:774239875
1218 1218 a, g dbSNP:770660659
1223 1223 c, t dbSNP:762896453
1225 1225 c, t dbSNP:141816714
1228 1228 a, g dbSNP:769358990
1231 1231 -, a dbSNP:386833740
1232 1232 c, t dbSNP:747723206
1233 1233 a, g dbSNP:780974004
1245 1245 c, t dbSNP:768466445
1246 1246 a, g dbSNP:138636923
1257 1257 a, g dbSNP:779370547
1262 1262 a, g dbSNP:150174473
1266 1266 c, t dbSNP:386833743
1274 1274 c, t dbSNP:777779035
1275 1275 a, g, t dbSNP:386833744
1282 1282 c, t dbSNP:752894528
1287 1287 c, t dbSNP:386833694
1288 1288 a, g dbSNP:386833695
1289 1289 c, t dbSNP:140828382
1291 1291 c, g dbSNP:765157752
1294 1294 c, t dbSNP:761795794
1299 1299 c, t dbSNP:776725094
1300 1300 a, g dbSNP:557870972
1301 1301 c, t dbSNP:774284416
1304 1304 c, t dbSNP:768479701
1308 1308 c, t dbSNP:775195638
1309 1309 a, g dbSNP:201271341
1312 1312 a, t dbSNP:746211816
1314 1314 c, t dbSNP:201407601
1315 1315 a, g dbSNP:771305783
1319 1319 c, t dbSNP:749734787
1320 1320 a, c, t dbSNP:150986176
1335 1335 -, c dbSNP:386833696
1341 1341 c, t dbSNP:386833697
1343 1343 c, g dbSNP:386833699
1349 1349 c, t dbSNP:781086870
1358 1358 g, t dbSNP:146467602
1373 1373 c, g, t dbSNP:376907245
1374 1374 a, g dbSNP:370963882
1382 1382 c, t dbSNP:757106140
1383 1383 a, g dbSNP:772209464
1384 1384 a, g dbSNP:371214018
1385 1385 a, c dbSNP:367780407
1403 1403 c, t dbSNP:142456044
1404 1404 c, t dbSNP:752700529
1406 1406 c, t dbSNP:376478363
1407 1407 a, g dbSNP:759049027
1409 1409 c, t dbSNP:751205979
1415 1415 c, g dbSNP:766074736
1419 1419 a, c, g dbSNP:147658282
1438 1438 c, t dbSNP:770221497
1439 1439 c, g dbSNP:762171432
1445 1445 c, t dbSNP:145340637
1446 1446 a, g dbSNP:768614719
1449 1449 a, g dbSNP:747145427
1450 1450 c, t dbSNP:148514847
1451 1451 a, c dbSNP:772463617
1454 1454 c, t dbSNP:371025471
1455 1455 a, g dbSNP:777383109
1466 1466 c, t dbSNP:755948129
1472 1472 a, c dbSNP:747968377
1473 1473 a, g dbSNP:781253826
1476 1476 a, g dbSNP:754468227
1478 1478 c, t dbSNP:779338007
1479 1479 c, g dbSNP:751114018
1482 1482 g, t dbSNP:386833701
1487 1487 c, t dbSNP:754270222
1490 1490 a, t dbSNP:764585366
1496 1496 a, g dbSNP:377369610
1497 1497 a, c, t dbSNP:146610181
1498 1498 a, g dbSNP:77595156
1500 1500 c, g, t dbSNP:139842473
1501 1501 a, g dbSNP:747861558
1512 1512 a, g dbSNP:776443981
1516 1516 c, t dbSNP:369801432
1517 1517 a, g dbSNP:201206239
1527 1527 a, c, g dbSNP:146124686
1529 1529 a, g dbSNP:1064886
1534 1534 a, g dbSNP:386833703
1536 1536 a, g dbSNP:570472210
1539 1539 c, g dbSNP:778399559
1544 1544 g, t dbSNP:756893993
1547 1547 c, g dbSNP:753454206
1549 1549 c, t dbSNP:778225078
1555 1555 a, c, t dbSNP:386833706
1556 1556 a, g dbSNP:200719311
1558 1558 a, g dbSNP:753251101
1559 1559 -, g dbSNP:386833707
1567 1567 c, t dbSNP:768194285
1578 1578 c, t dbSNP:759510380
1579 1579 a, t dbSNP:751697176
1607 1607 a, c dbSNP:116985567
1611 1611 a, g dbSNP:763180323
1621 1621 a, g dbSNP:773432104
1623 1623 c, t dbSNP:768437444
1624 1624 a, g, t dbSNP:369540789
1628 1628 a, g dbSNP:772089665
1630 1630 a, c dbSNP:201685501
1633 1633 a, g dbSNP:778438984
1634 1634 c, t dbSNP:770360224
1644 1644 g, t dbSNP:748903907
1654 1654 c, t dbSNP:777635234
1659 1659 a, c dbSNP:199979207
1662 1662 a, c dbSNP:142958639
1682 1682 a, g dbSNP:751235567
1703 1703 c, t dbSNP:113845299
1713 1713 c, t dbSNP:777406780
1714 1714 c, g dbSNP:532573871
1746 1746 g, t dbSNP:755606047
1748 1748 a, g dbSNP:184662946
1753 1753 c, t dbSNP:145698326
1759 1759 a, c dbSNP:113112766
1804 1804 a, g dbSNP:561135374
1809 1809 a, g dbSNP:757923800
1814 1814 a, g dbSNP:1064912
1840 1840 g, t dbSNP:370999518

Target ORF information:

RefSeq Version NM_001286104
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001286104

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGCTGTGCT CCTGGCGGAC
ATCCTCCCCA CACTCGTCAT CAAATTGTTG GCTCCTCTTG GCCTTCACCT GCTGCCCTAC
AGCCCCCGGG TTCTCGTCAG TGGGATTTGT GCTGCTGGAA GCTTCGTCCT GGTTGCCTTT
TCTCATTCTG TGGGGACCAG CCTGTGTGGT GTGGTCTTCG CTAGCATCTC ATCAGGCCTT
GGGGAGGTCA CCTTCCTCTC CCTCACTGCC TTCTACCCCA GGGCCGTGAT CTCCTGGTGG
TCCTCAGGGA CTGGGGGAGC TGGGCTGCTG GGGGCCCTGT CCTACCTGGG CCTCACCCAG
GCCGGCCTCT CCCCTCAGCA GACCCTGCTG TCCATGCTGG GTATCCCTGC CCTGCTGCTG
GCCAGCTATT TCTTGTTGCT CACATCTCCT GAGGCCCAGG ACCCTGGAGG GGAAGAAGAA
GCAGAGAGCG CAGCCCGGCA GCCCCTCATA AGAACCGAGG CCCCGGAGTC GAAGCCAGGC
TCCAGCTCCA GCCTCTCCCT TCGGGAAAGG TGGACAGTGT TCAAGGGTCT GCTGTGGTAC
ATTGTTCCCT TGGTCGTAGT TTACTTTGCC GAGTATTTCA TTAACCAGGG ACTTTTTGAA
CTCCTCTTTT TCTGGAACAC TTCCCTGAGT CACGCTCAGC AATACCGCTG GTACCAGATG
CTGTACCAGG CTGGCGTCTT TGCCTCCCGC TCTTCTCTCC GCTGCTGTCG CATCCGTTTC
ACCTGGGCCC TGGCCCTGCT GCAGTGCCTC AACCTGGTGT TCCTGCTGGC AGACGTGTGG
TTCGGCTTTC TGCCAAGCAT CTACCTCGTC TTCCTGATCA TTCTGTATGA GGGGCTCCTG
GGAGGCGCAG CCTACGTGAA CACCTTCCAC AACATCGCCC TGGAGACCAG TGATGAGCAC
CGGGAGTTTG CAATGGCGGC CACCTGCATC TCTGACACAC TGGGGATCTC CCTGTCGGGG
CTCCTGGCTT TGCCTCTGCA TGACTTCCTC TGCCAGCTCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16887
Accession Version NM_001286105.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1017bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP252176.1, AK297690.1 and AK302027.1. Summary: This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two exons compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (c) with a shorter and distinct N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK297690.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGGACCC AGGCCCAACG CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT 
CTGTCTCTAC GGCTCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001273034.1
CDS465..1481
Misc Feature(1)411..413(+)
Misc Feature(2)540..1478(+)
Exon (1)1..369
Gene:CLN3
Gene Synonym:
Exon (2)370..466
Gene:CLN3
Gene Synonym:
Exon (3)467..538
Gene:CLN3
Gene Synonym:
Exon (4)539..624
Gene:CLN3
Gene Synonym:
Exon (5)625..697
Gene:CLN3
Gene Synonym:
Exon (6)698..841
Gene:CLN3
Gene Synonym:
Exon (7)842..954
Gene:CLN3
Gene Synonym:
Exon (8)955..1001
Gene:CLN3
Gene Synonym:
Exon (9)1002..1070
Gene:CLN3
Gene Synonym:
Exon (10)1071..1126
Gene:CLN3
Gene Synonym:
Exon (11)1127..1220
Gene:CLN3
Gene Synonym:
Exon (12)1221..1361
Gene:CLN3
Gene Synonym:
Exon (13)1362..1717
Gene:CLN3
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:574775208
11 11 c, g dbSNP:141305257
26 26 a, g dbSNP:369500373
28 28 c, t dbSNP:572212180
35 35 a, t dbSNP:73533476
46 46 a, t dbSNP:565767570
83 83 c, t dbSNP:374400500
97 97 c, t dbSNP:574173550
118 118 a, g dbSNP:538884310
134 134 a, g dbSNP:370165217
148 148 a, g dbSNP:28612835
178 178 a, g dbSNP:372566364
187 187 a, g dbSNP:148025951
234 234 a, g dbSNP:368542813
250 250 c, t dbSNP:534657200
273 273 c, t dbSNP:767141815
274 274 -, ggagccccc dbSNP:760562597
274 274 c, t dbSNP:759135845
283 283 a, c dbSNP:370217726
286 286 -, t dbSNP:775483589
287 287 a, g dbSNP:766826715
291 291 a, c dbSNP:368494637
307 307 a, c, g dbSNP:770428655
311 311 g, t dbSNP:555894979
318 318 c, g dbSNP:776594074
319 319 a, g dbSNP:768881655
322 322 c, g dbSNP:747169563
323 323 c, g, t dbSNP:201274333
324 324 a, c, g dbSNP:386833708
325 325 c, t dbSNP:777625354
331 331 a, g dbSNP:756062000
352 352 -, g dbSNP:374055075
355 355 c, t dbSNP:752205710
360 360 a, g, t dbSNP:754562266
365 365 c, t dbSNP:751155598
368 368 a, g dbSNP:201824641
370 370 a, g dbSNP:781617143
373 373 a, g dbSNP:755493834
391 391 c, t dbSNP:571216643
396 396 c, t dbSNP:780151271
400 400 c, t dbSNP:758454511
401 401 a, g dbSNP:750643595
407 407 a, g, t dbSNP:760481173
410 410 a, c, g dbSNP:767513559
412 412 a, g dbSNP:759581122
418 418 c, t dbSNP:138433617
419 419 a, g dbSNP:765893479
424 424 c, t dbSNP:150120797
425 425 a, g dbSNP:772851701
438 438 a, g dbSNP:574261896
441 441 a, g dbSNP:769447444
449 449 c, t dbSNP:748458737
450 450 c, t dbSNP:769840061
451 451 a, g dbSNP:551476103
453 453 a, g dbSNP:747526330
458 458 c, t dbSNP:386833709
459 459 a, t dbSNP:780482162
460 460 c, g dbSNP:758501983
464 464 c, t dbSNP:745941670
466 466 c, t dbSNP:201225986
477 477 -, g dbSNP:386833712
477 477 a, g dbSNP:768993577
482 482 a, t dbSNP:150348015
483 483 c, t dbSNP:775999656
484 484 a, g dbSNP:373911322
484 484 -, g dbSNP:748710466
486 486 c, t dbSNP:137906617
487 487 a, g dbSNP:779165392
488 488 a, t dbSNP:370020452
492 492 c, t dbSNP:749503213
494 494 a, c dbSNP:201329358
506 506 a, t dbSNP:754801166
508 508 a, c dbSNP:751321507
509 509 c, t dbSNP:386833713
510 510 a, g dbSNP:766287694
514 514 c, g, t dbSNP:145520962
521 521 a, c, g dbSNP:761369095
522 522 a, g dbSNP:140409296
527 527 c, g dbSNP:763659524
534 534 c, t dbSNP:376421578
535 535 a, g dbSNP:367945307
539 539 c, t dbSNP:146076617
543 543 -, cc dbSNP:386833717
543 543 -, c dbSNP:386833718
543 543 c, t dbSNP:201168980
544 544 a, g dbSNP:780776829
545 545 c, g dbSNP:750889321
551 551 c, t dbSNP:765776873
552 552 a, c, g, t dbSNP:764261700
556 556 a, g dbSNP:144770450
557 557 c, t dbSNP:794727850
563 563 c, t dbSNP:775739498
564 564 c, t dbSNP:386833719
568 568 c, t dbSNP:770702932
572 572 c, t dbSNP:749176223
578 578 c, t dbSNP:772960606
582 582 a, g dbSNP:373034150
584 584 c, g dbSNP:544119921
588 588 -, g dbSNP:386833720
597 597 c, t dbSNP:780814580
600 600 c, t dbSNP:371590088
607 607 -, tgg dbSNP:752130042
607 607 g, t dbSNP:746644433
611 611 g, t dbSNP:779918787
612 612 a, c dbSNP:758767565
622 622 a, g dbSNP:750813350
625 625 c, g dbSNP:746178854
628 628 g, t dbSNP:779304920
635 635 c, t dbSNP:140670783
636 636 c, g dbSNP:386833723
638 638 c, t dbSNP:551927665
640 640 c, g dbSNP:754331166
646 646 c, g dbSNP:386833724
647 647 a, g dbSNP:778321651
649 649 c, g dbSNP:386833725
654 654 c, t dbSNP:758342160
656 656 -, g dbSNP:35832901
658 658 a, g dbSNP:786201028
673 673 c, t dbSNP:386833727
674 674 c, t dbSNP:756123046
680 680 c, t dbSNP:148846795
686 686 c, t dbSNP:371467190
687 687 c, t dbSNP:759769158
695 695 c, t dbSNP:751773646
698 698 c, g dbSNP:756640405
701 701 c, t dbSNP:147667964
702 702 a, g dbSNP:202215629
722 722 -, ag dbSNP:386833729
724 724 c, g dbSNP:386833730
729 729 c, g dbSNP:386833731
733 733 -, g dbSNP:763096461
733 733 -, g dbSNP:386833732
739 739 a, g dbSNP:386833733
740 740 a, g, t dbSNP:566516380
745 745 c, t dbSNP:751799615
746 746 g, t dbSNP:386833734
750 750 -, g dbSNP:386833735
751 751 c, t dbSNP:757018330
753 753 c, t dbSNP:753705869
755 755 a, g dbSNP:764082661
761 761 a, c dbSNP:267606737
762 762 c, g dbSNP:768149446
766 766 g, t dbSNP:775618174
779 779 c, t dbSNP:145631076
780 780 a, g dbSNP:370603922
786 786 -, t dbSNP:386833736
790 790 c, t dbSNP:139417824
795 795 c, t dbSNP:386833737
802 802 c, t dbSNP:554746072
805 805 c, t dbSNP:749609898
811 811 a, t dbSNP:773602052
813 813 a, c dbSNP:150913606
825 825 a, g dbSNP:748636727
829 829 c, t dbSNP:781613318
833 833 a, g dbSNP:755016673
834 834 c, t dbSNP:141508632
836 836 a, g dbSNP:747071263
845 845 c, t dbSNP:747068998
849 849 c, t dbSNP:779965094
851 851 a, g dbSNP:772327361
852 852 c, t dbSNP:746075287
857 857 c, t dbSNP:376590377
858 858 a, t dbSNP:755908083
859 859 c, t dbSNP:752450798
867 867 g, t dbSNP:781138637
871 871 c, t dbSNP:754906598
888 888 c, g dbSNP:751560016
893 893 -, a dbSNP:762192561
898 898 -, cag dbSNP:776966610
903 903 a, c dbSNP:765857735
905 905 c, t dbSNP:148782327
906 906 a, g dbSNP:750008067
912 912 c, t dbSNP:764881080
913 913 a, g dbSNP:374217931
916 916 a, c dbSNP:776890506
918 918 c, t dbSNP:769104531
919 919 c, t dbSNP:761065339
921 921 c, g dbSNP:776122422
923 923 a, c dbSNP:772274552
925 925 c, t dbSNP:745948575
932 932 c, t dbSNP:145967477
933 933 a, g dbSNP:771303379
935 935 a, g dbSNP:73533466
937 937 c, t dbSNP:780823167
940 940 c, t dbSNP:137858807
941 941 a, g dbSNP:751443804
946 946 c, t dbSNP:199627744
947 947 a, g dbSNP:752632879
953 953 a, c dbSNP:574450787
958 958 c, t dbSNP:749453498
968 968 a, c dbSNP:773546150
978 978 c, t dbSNP:113041302
979 979 a, g dbSNP:145270402
988 988 a, g dbSNP:779914525
992 992 -, ag dbSNP:755465037
993 993 a, g dbSNP:758360941
995 995 a, g dbSNP:1142183
1014 1014 c, t dbSNP:201090501
1017 1017 a, g dbSNP:748844685
1026 1026 g, t dbSNP:777244248
1029 1029 a, g dbSNP:755824692
1032 1032 a, g, t dbSNP:369008702
1039 1039 a, g dbSNP:755402909
1044 1044 a, g dbSNP:752112708
1046 1046 c, t dbSNP:766972077
1047 1047 a, g, t dbSNP:121434286
1050 1050 a, t dbSNP:750558528
1058 1058 c, t dbSNP:747222268
1061 1061 c, g dbSNP:765265208
1067 1067 a, g dbSNP:761976112
1069 1069 c, t dbSNP:776853352
1079 1079 c, g dbSNP:759304422
1080 1080 c, t dbSNP:774239875
1095 1095 a, g dbSNP:770660659
1100 1100 c, t dbSNP:762896453
1102 1102 c, t dbSNP:141816714
1105 1105 a, g dbSNP:769358990
1108 1108 -, a dbSNP:386833740
1109 1109 c, t dbSNP:747723206
1110 1110 a, g dbSNP:780974004
1122 1122 c, t dbSNP:768466445
1123 1123 a, g dbSNP:138636923
1134 1134 a, g dbSNP:779370547
1139 1139 a, g dbSNP:150174473
1143 1143 c, t dbSNP:386833743
1151 1151 c, t dbSNP:777779035
1152 1152 a, g, t dbSNP:386833744
1159 1159 c, t dbSNP:752894528
1164 1164 c, t dbSNP:386833694
1165 1165 a, g dbSNP:386833695
1166 1166 c, t dbSNP:140828382
1168 1168 c, g dbSNP:765157752
1171 1171 c, t dbSNP:761795794
1176 1176 c, t dbSNP:776725094
1177 1177 a, g dbSNP:557870972
1178 1178 c, t dbSNP:774284416
1181 1181 c, t dbSNP:768479701
1185 1185 c, t dbSNP:775195638
1186 1186 a, g dbSNP:201271341
1189 1189 a, t dbSNP:746211816
1191 1191 c, t dbSNP:201407601
1192 1192 a, g dbSNP:771305783
1196 1196 c, t dbSNP:749734787
1197 1197 a, c, t dbSNP:150986176
1212 1212 -, c dbSNP:386833696
1218 1218 c, t dbSNP:386833697
1220 1220 c, g dbSNP:386833699
1226 1226 c, t dbSNP:781086870
1235 1235 g, t dbSNP:146467602
1250 1250 c, g, t dbSNP:376907245
1251 1251 a, g dbSNP:370963882
1259 1259 c, t dbSNP:757106140
1260 1260 a, g dbSNP:772209464
1261 1261 a, g dbSNP:371214018
1262 1262 a, c dbSNP:367780407
1280 1280 c, t dbSNP:142456044
1281 1281 c, t dbSNP:752700529
1283 1283 c, t dbSNP:376478363
1284 1284 a, g dbSNP:759049027
1286 1286 c, t dbSNP:751205979
1292 1292 c, g dbSNP:766074736
1296 1296 a, c, g dbSNP:147658282
1315 1315 c, t dbSNP:770221497
1316 1316 c, g dbSNP:762171432
1322 1322 c, t dbSNP:145340637
1323 1323 a, g dbSNP:768614719
1326 1326 a, g dbSNP:747145427
1327 1327 c, t dbSNP:148514847
1328 1328 a, c dbSNP:772463617
1331 1331 c, t dbSNP:371025471
1332 1332 a, g dbSNP:777383109
1343 1343 c, t dbSNP:755948129
1349 1349 a, c dbSNP:747968377
1350 1350 a, g dbSNP:781253826
1353 1353 a, g dbSNP:754468227
1355 1355 c, t dbSNP:779338007
1356 1356 c, g dbSNP:751114018
1359 1359 g, t dbSNP:386833701
1364 1364 c, t dbSNP:754270222
1367 1367 a, t dbSNP:764585366
1373 1373 a, g dbSNP:377369610
1374 1374 a, c, t dbSNP:146610181
1375 1375 a, g dbSNP:77595156
1377 1377 c, g, t dbSNP:139842473
1378 1378 a, g dbSNP:747861558
1389 1389 a, g dbSNP:776443981
1393 1393 c, t dbSNP:369801432
1394 1394 a, g dbSNP:201206239
1404 1404 a, c, g dbSNP:146124686
1406 1406 a, g dbSNP:1064886
1411 1411 a, g dbSNP:386833703
1413 1413 a, g dbSNP:570472210
1416 1416 c, g dbSNP:778399559
1421 1421 g, t dbSNP:756893993
1424 1424 c, g dbSNP:753454206
1426 1426 c, t dbSNP:778225078
1432 1432 a, c, t dbSNP:386833706
1433 1433 a, g dbSNP:200719311
1435 1435 a, g dbSNP:753251101
1436 1436 -, g dbSNP:386833707
1444 1444 c, t dbSNP:768194285
1455 1455 c, t dbSNP:759510380
1456 1456 a, t dbSNP:751697176
1484 1484 a, c dbSNP:116985567
1488 1488 a, g dbSNP:763180323
1498 1498 a, g dbSNP:773432104
1500 1500 c, t dbSNP:768437444
1501 1501 a, g, t dbSNP:369540789
1505 1505 a, g dbSNP:772089665
1507 1507 a, c dbSNP:201685501
1510 1510 a, g dbSNP:778438984
1511 1511 c, t dbSNP:770360224
1521 1521 g, t dbSNP:748903907
1531 1531 c, t dbSNP:777635234
1536 1536 a, c dbSNP:199979207
1539 1539 a, c dbSNP:142958639
1559 1559 a, g dbSNP:751235567
1580 1580 c, t dbSNP:113845299
1590 1590 c, t dbSNP:777406780
1591 1591 c, g dbSNP:532573871
1623 1623 g, t dbSNP:755606047
1625 1625 a, g dbSNP:184662946
1630 1630 c, t dbSNP:145698326
1636 1636 a, c dbSNP:113112766
1681 1681 a, g dbSNP:561135374
1686 1686 a, g dbSNP:757923800
1691 1691 a, g dbSNP:1064912
1717 1717 g, t dbSNP:370999518

Target ORF information:

RefSeq Version NM_001286105
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001286105

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGGACCC AGGCCCAACG CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT 
CTGTCTCTAC GGCTCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27575
Accession Version NM_001286109.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1083bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP252176.1, DA869025.1 and BC111068.1. Summary: This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence, the 3' UTR, and lacks an alternate in-frame exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (d) with a shorter N-terminus and missing an alternate internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## NMD candidate :: translation inferred ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC111068.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTGAGTG CCGCCCACGA CATCCTTAGC CACAAGAGGA CATCGGGAAA CCAGAGCCAT 
GCTGTGCTCC TGGCGGACAT CCTCCCCACA CTCGTCATCA AATTGTTGGC TCCTCTTGGC
CTTCACCTGC TGCCCTACAG CCCCCGGGTT CTCGTCAGTG GGATTTGTGC TGCTGGAAGC
TTCGTCCTGG TTGCCTTTTC TCATTCTGTG GGGACCAGCC TGTGTGGTGT GGTCTTCGCT
AGCATCTCAT CAGGCCTTGG GGAGGTCACC TTCCTCTCCC TCACTGCCTT CTACCCCAGG
GCCGTGATCT CCTGGTGGTC CTCAGGGACT GGGGGAGCTG GGCTGCTGGG GGCCCTGTCC
TACCTGGGCC TCACCCAGGC CGGCCTCTCC CCTCAGCAGA CCCTGCTGTC CATGCTGGGT
ATCCCTGCCC TGCTGCTGGC CAGCTATTTC TTGTTGCTCA CATCTCCTGA GGCCCAGGAC
CCTGGAGGGG AAGAAGAAGC AGAGAGCGCA GCCCGGCAGC CCCTCATAAG AACCGAGGCC
CCGGAGTCGA AGCCAGGCTC CAGCTCCAGC CTCTCCCTTC GGGAAAGGTG GACAGTGTTC
AAGGGTCTGC TGTGGTACAT TGTTCCCTTG GTCGTAGTTT ACTTTGCCGA GTATTTCATT
AACCAGGGAC TTTTTGAACT CCTCTTTTTC TGGAACACTT CCCTGAGTCA CGCTCAGCAA
TACCGCTGGT ACCAGATGCT GTACCAGGCT GGCGTCTTTG CCTCCCGCTC TTCTCTCCGC
TGCTGTCGCA TCCGTTTCAC CTGGGCCCTG GCCCTGCTGC AGTGCCTCAA CCTGGTGTTC
CTGCTGGCAG ACGTGTGGTT CGGCTTTCTG CCAAGCATCT ACCTCGTCTT CCTGATCATT
CTGTATGAGG GGCTCCTGGG AGGCGCAGCC TACGTGAACA CCTTCCACAA CATCGCCCTG
GAGACCAGTG ATGAGCACCG GGAGTTTGCA ATGGCGGCCA CCTGCATCTC TGACACACTG
GGGATCTCCC TGTCGGGGCT CCTGGCTTTG CCTCTGCATG ACTTCCTCTG CCAGCTCTCC
TGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001273038.1
CDS407..1489
Misc Feature(1)317..319(+)
Misc Feature(2)407..1486(+)
Exon (1)1..369
Gene:CLN3
Gene Synonym:
Exon (2)370..466
Gene:CLN3
Gene Synonym:
Exon (3)467..546
Gene:CLN3
Gene Synonym:
Exon (4)547..632
Gene:CLN3
Gene Synonym:
Exon (5)633..705
Gene:CLN3
Gene Synonym:
Exon (6)706..849
Gene:CLN3
Gene Synonym:
Exon (7)850..962
Gene:CLN3
Gene Synonym:
Exon (8)963..1009
Gene:CLN3
Gene Synonym:
Exon (9)1010..1078
Gene:CLN3
Gene Synonym:
Exon (10)1079..1134
Gene:CLN3
Gene Synonym:
Exon (11)1135..1228
Gene:CLN3
Gene Synonym:
Exon (12)1229..1369
Gene:CLN3
Gene Synonym:
Exon (13)1370..1541
Gene:CLN3
Gene Synonym:
Exon (14)1542..1791
Gene:CLN3
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:574775208
11 11 c, g dbSNP:141305257
26 26 a, g dbSNP:369500373
28 28 c, t dbSNP:572212180
35 35 a, t dbSNP:73533476
46 46 a, t dbSNP:565767570
83 83 c, t dbSNP:374400500
97 97 c, t dbSNP:574173550
118 118 a, g dbSNP:538884310
134 134 a, g dbSNP:370165217
148 148 a, g dbSNP:28612835
178 178 a, g dbSNP:372566364
187 187 a, g dbSNP:148025951
234 234 a, g dbSNP:368542813
250 250 c, t dbSNP:534657200
273 273 c, t dbSNP:767141815
274 274 -, ggagccccc dbSNP:760562597
274 274 c, t dbSNP:759135845
283 283 a, c dbSNP:370217726
286 286 -, t dbSNP:775483589
287 287 a, g dbSNP:766826715
291 291 a, c dbSNP:368494637
307 307 a, c, g dbSNP:770428655
311 311 g, t dbSNP:555894979
318 318 c, g dbSNP:776594074
319 319 a, g dbSNP:768881655
322 322 c, g dbSNP:747169563
323 323 c, g, t dbSNP:201274333
324 324 a, c, g dbSNP:386833708
325 325 c, t dbSNP:777625354
331 331 a, g dbSNP:756062000
352 352 -, g dbSNP:374055075
355 355 c, t dbSNP:752205710
360 360 a, g, t dbSNP:754562266
365 365 c, t dbSNP:751155598
368 368 a, g dbSNP:201824641
370 370 a, g dbSNP:781617143
373 373 a, g dbSNP:755493834
391 391 c, t dbSNP:571216643
396 396 c, t dbSNP:780151271
400 400 c, t dbSNP:758454511
401 401 a, g dbSNP:750643595
407 407 a, g, t dbSNP:760481173
410 410 a, c, g dbSNP:767513559
412 412 a, g dbSNP:759581122
418 418 c, t dbSNP:138433617
419 419 a, g dbSNP:765893479
424 424 c, t dbSNP:150120797
425 425 a, g dbSNP:772851701
438 438 a, g dbSNP:574261896
441 441 a, g dbSNP:769447444
449 449 c, t dbSNP:748458737
450 450 c, t dbSNP:769840061
451 451 a, g dbSNP:551476103
453 453 a, g dbSNP:747526330
458 458 c, t dbSNP:386833709
459 459 a, t dbSNP:780482162
460 460 c, g dbSNP:758501983
464 464 c, t dbSNP:745941670
466 466 c, t dbSNP:201225986
474 474 c, t dbSNP:386833714
480 480 c, t dbSNP:760039703
481 481 a, g dbSNP:774996613
485 485 a, g dbSNP:11552531
490 490 c, t dbSNP:148248159
491 491 c, t dbSNP:149095062
495 495 c, t dbSNP:769953653
499 499 c, t dbSNP:748293490
500 500 a, g dbSNP:781534624
507 507 a, g dbSNP:771758062
509 509 c, t dbSNP:745665200
510 510 c, t dbSNP:778765250
511 511 a, g dbSNP:200356262
525 525 a, g dbSNP:753305901
530 530 a, c dbSNP:145749864
533 533 a, c, g dbSNP:752282954
538 538 a, g dbSNP:376960425
542 542 -, t dbSNP:386833715
543 543 -, t dbSNP:587779397
543 543 a, g dbSNP:546862372
544 544 c, t dbSNP:755330966
546 546 a, g dbSNP:386833716
547 547 c, t dbSNP:146076617
551 551 -, cc dbSNP:386833717
551 551 -, c dbSNP:386833718
551 551 c, t dbSNP:201168980
552 552 a, g dbSNP:780776829
553 553 c, g dbSNP:750889321
559 559 c, t dbSNP:765776873
560 560 a, c, g, t dbSNP:764261700
564 564 a, g dbSNP:144770450
565 565 c, t dbSNP:794727850
571 571 c, t dbSNP:775739498
572 572 c, t dbSNP:386833719
576 576 c, t dbSNP:770702932
580 580 c, t dbSNP:749176223
586 586 c, t dbSNP:772960606
590 590 a, g dbSNP:373034150
592 592 c, g dbSNP:544119921
596 596 -, g dbSNP:386833720
605 605 c, t dbSNP:780814580
608 608 c, t dbSNP:371590088
615 615 -, tgg dbSNP:752130042
615 615 g, t dbSNP:746644433
619 619 g, t dbSNP:779918787
620 620 a, c dbSNP:758767565
630 630 a, g dbSNP:750813350
633 633 c, g dbSNP:746178854
636 636 g, t dbSNP:779304920
643 643 c, t dbSNP:140670783
644 644 c, g dbSNP:386833723
646 646 c, t dbSNP:551927665
648 648 c, g dbSNP:754331166
654 654 c, g dbSNP:386833724
655 655 a, g dbSNP:778321651
657 657 c, g dbSNP:386833725
662 662 c, t dbSNP:758342160
664 664 -, g dbSNP:35832901
666 666 a, g dbSNP:786201028
681 681 c, t dbSNP:386833727
682 682 c, t dbSNP:756123046
688 688 c, t dbSNP:148846795
694 694 c, t dbSNP:371467190
695 695 c, t dbSNP:759769158
703 703 c, t dbSNP:751773646
706 706 c, g dbSNP:756640405
709 709 c, t dbSNP:147667964
710 710 a, g dbSNP:202215629
730 730 -, ag dbSNP:386833729
732 732 c, g dbSNP:386833730
737 737 c, g dbSNP:386833731
741 741 -, g dbSNP:763096461
741 741 -, g dbSNP:386833732
747 747 a, g dbSNP:386833733
748 748 a, g, t dbSNP:566516380
753 753 c, t dbSNP:751799615
754 754 g, t dbSNP:386833734
758 758 -, g dbSNP:386833735
759 759 c, t dbSNP:757018330
761 761 c, t dbSNP:753705869
763 763 a, g dbSNP:764082661
769 769 a, c dbSNP:267606737
770 770 c, g dbSNP:768149446
774 774 g, t dbSNP:775618174
787 787 c, t dbSNP:145631076
788 788 a, g dbSNP:370603922
794 794 -, t dbSNP:386833736
798 798 c, t dbSNP:139417824
803 803 c, t dbSNP:386833737
810 810 c, t dbSNP:554746072
813 813 c, t dbSNP:749609898
819 819 a, t dbSNP:773602052
821 821 a, c dbSNP:150913606
833 833 a, g dbSNP:748636727
837 837 c, t dbSNP:781613318
841 841 a, g dbSNP:755016673
842 842 c, t dbSNP:141508632
844 844 a, g dbSNP:747071263
853 853 c, t dbSNP:747068998
857 857 c, t dbSNP:779965094
859 859 a, g dbSNP:772327361
860 860 c, t dbSNP:746075287
865 865 c, t dbSNP:376590377
866 866 a, t dbSNP:755908083
867 867 c, t dbSNP:752450798
875 875 g, t dbSNP:781138637
879 879 c, t dbSNP:754906598
896 896 c, g dbSNP:751560016
901 901 -, a dbSNP:762192561
906 906 -, cag dbSNP:776966610
911 911 a, c dbSNP:765857735
913 913 c, t dbSNP:148782327
914 914 a, g dbSNP:750008067
920 920 c, t dbSNP:764881080
921 921 a, g dbSNP:374217931
924 924 a, c dbSNP:776890506
926 926 c, t dbSNP:769104531
927 927 c, t dbSNP:761065339
929 929 c, g dbSNP:776122422
931 931 a, c dbSNP:772274552
933 933 c, t dbSNP:745948575
940 940 c, t dbSNP:145967477
941 941 a, g dbSNP:771303379
943 943 a, g dbSNP:73533466
945 945 c, t dbSNP:780823167
948 948 c, t dbSNP:137858807
949 949 a, g dbSNP:751443804
954 954 c, t dbSNP:199627744
955 955 a, g dbSNP:752632879
961 961 a, c dbSNP:574450787
966 966 c, t dbSNP:749453498
976 976 a, c dbSNP:773546150
986 986 c, t dbSNP:113041302
987 987 a, g dbSNP:145270402
996 996 a, g dbSNP:779914525
1000 1000 -, ag dbSNP:755465037
1001 1001 a, g dbSNP:758360941
1003 1003 a, g dbSNP:1142183
1022 1022 c, t dbSNP:201090501
1025 1025 a, g dbSNP:748844685
1034 1034 g, t dbSNP:777244248
1037 1037 a, g dbSNP:755824692
1040 1040 a, g, t dbSNP:369008702
1047 1047 a, g dbSNP:755402909
1052 1052 a, g dbSNP:752112708
1054 1054 c, t dbSNP:766972077
1055 1055 a, g, t dbSNP:121434286
1058 1058 a, t dbSNP:750558528
1066 1066 c, t dbSNP:747222268
1069 1069 c, g dbSNP:765265208
1075 1075 a, g dbSNP:761976112
1077 1077 c, t dbSNP:776853352
1087 1087 c, g dbSNP:759304422
1088 1088 c, t dbSNP:774239875
1103 1103 a, g dbSNP:770660659
1108 1108 c, t dbSNP:762896453
1110 1110 c, t dbSNP:141816714
1113 1113 a, g dbSNP:769358990
1116 1116 -, a dbSNP:386833740
1117 1117 c, t dbSNP:747723206
1118 1118 a, g dbSNP:780974004
1130 1130 c, t dbSNP:768466445
1131 1131 a, g dbSNP:138636923
1142 1142 a, g dbSNP:779370547
1147 1147 a, g dbSNP:150174473
1151 1151 c, t dbSNP:386833743
1159 1159 c, t dbSNP:777779035
1160 1160 a, g, t dbSNP:386833744
1167 1167 c, t dbSNP:752894528
1172 1172 c, t dbSNP:386833694
1173 1173 a, g dbSNP:386833695
1174 1174 c, t dbSNP:140828382
1176 1176 c, g dbSNP:765157752
1179 1179 c, t dbSNP:761795794
1184 1184 c, t dbSNP:776725094
1185 1185 a, g dbSNP:557870972
1186 1186 c, t dbSNP:774284416
1189 1189 c, t dbSNP:768479701
1193 1193 c, t dbSNP:775195638
1194 1194 a, g dbSNP:201271341
1197 1197 a, t dbSNP:746211816
1199 1199 c, t dbSNP:201407601
1200 1200 a, g dbSNP:771305783
1204 1204 c, t dbSNP:749734787
1205 1205 a, c, t dbSNP:150986176
1220 1220 -, c dbSNP:386833696
1226 1226 c, t dbSNP:386833697
1228 1228 c, g dbSNP:386833699
1234 1234 c, t dbSNP:781086870
1243 1243 g, t dbSNP:146467602
1258 1258 c, g, t dbSNP:376907245
1259 1259 a, g dbSNP:370963882
1267 1267 c, t dbSNP:757106140
1268 1268 a, g dbSNP:772209464
1269 1269 a, g dbSNP:371214018
1270 1270 a, c dbSNP:367780407
1288 1288 c, t dbSNP:142456044
1289 1289 c, t dbSNP:752700529
1291 1291 c, t dbSNP:376478363
1292 1292 a, g dbSNP:759049027
1294 1294 c, t dbSNP:751205979
1300 1300 c, g dbSNP:766074736
1304 1304 a, c, g dbSNP:147658282
1323 1323 c, t dbSNP:770221497
1324 1324 c, g dbSNP:762171432
1330 1330 c, t dbSNP:145340637
1331 1331 a, g dbSNP:768614719
1334 1334 a, g dbSNP:747145427
1335 1335 c, t dbSNP:148514847
1336 1336 a, c dbSNP:772463617
1339 1339 c, t dbSNP:371025471
1340 1340 a, g dbSNP:777383109
1351 1351 c, t dbSNP:755948129
1357 1357 a, c dbSNP:747968377
1358 1358 a, g dbSNP:781253826
1361 1361 a, g dbSNP:754468227
1363 1363 c, t dbSNP:779338007
1364 1364 c, g dbSNP:751114018
1367 1367 g, t dbSNP:386833701
1372 1372 c, t dbSNP:754270222
1375 1375 a, t dbSNP:764585366
1381 1381 a, g dbSNP:377369610
1382 1382 a, c, t dbSNP:146610181
1383 1383 a, g dbSNP:77595156
1385 1385 c, g, t dbSNP:139842473
1386 1386 a, g dbSNP:747861558
1397 1397 a, g dbSNP:776443981
1401 1401 c, t dbSNP:369801432
1402 1402 a, g dbSNP:201206239
1412 1412 a, c, g dbSNP:146124686
1414 1414 a, g dbSNP:1064886
1419 1419 a, g dbSNP:386833703
1421 1421 a, g dbSNP:570472210
1424 1424 c, g dbSNP:778399559
1429 1429 g, t dbSNP:756893993
1432 1432 c, g dbSNP:753454206
1434 1434 c, t dbSNP:778225078
1440 1440 a, c, t dbSNP:386833706
1441 1441 a, g dbSNP:200719311
1443 1443 a, g dbSNP:753251101
1444 1444 -, g dbSNP:386833707
1452 1452 c, t dbSNP:768194285
1463 1463 c, t dbSNP:759510380
1464 1464 a, t dbSNP:751697176
1492 1492 a, c dbSNP:116985567
1496 1496 a, g dbSNP:763180323
1506 1506 a, g dbSNP:773432104
1508 1508 c, t dbSNP:768437444
1509 1509 a, g, t dbSNP:369540789
1513 1513 a, g dbSNP:772089665
1515 1515 a, c dbSNP:201685501
1518 1518 a, g dbSNP:778438984
1519 1519 c, t dbSNP:770360224
1529 1529 g, t dbSNP:748903907
1539 1539 c, t dbSNP:777635234
1606 1606 a, t dbSNP:572751662
1655 1655 a, g dbSNP:774331738
1666 1666 c, t dbSNP:111502097
1668 1668 -, att dbSNP:754999804
1670 1670 g, t dbSNP:766276012
1676 1676 c, t dbSNP:762517397
1687 1687 -, a dbSNP:752093755
1697 1697 c, t dbSNP:772804323
1762 1762 c, t dbSNP:769448985

Target ORF information:

RefSeq Version NM_001286109
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001286109

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTGAGTG CCGCCCACGA CATCCTTAGC CACAAGAGGA CATCGGGAAA CCAGAGCCAT 
GCTGTGCTCC TGGCGGACAT CCTCCCCACA CTCGTCATCA AATTGTTGGC TCCTCTTGGC
CTTCACCTGC TGCCCTACAG CCCCCGGGTT CTCGTCAGTG GGATTTGTGC TGCTGGAAGC
TTCGTCCTGG TTGCCTTTTC TCATTCTGTG GGGACCAGCC TGTGTGGTGT GGTCTTCGCT
AGCATCTCAT CAGGCCTTGG GGAGGTCACC TTCCTCTCCC TCACTGCCTT CTACCCCAGG
GCCGTGATCT CCTGGTGGTC CTCAGGGACT GGGGGAGCTG GGCTGCTGGG GGCCCTGTCC
TACCTGGGCC TCACCCAGGC CGGCCTCTCC CCTCAGCAGA CCCTGCTGTC CATGCTGGGT
ATCCCTGCCC TGCTGCTGGC CAGCTATTTC TTGTTGCTCA CATCTCCTGA GGCCCAGGAC
CCTGGAGGGG AAGAAGAAGC AGAGAGCGCA GCCCGGCAGC CCCTCATAAG AACCGAGGCC
CCGGAGTCGA AGCCAGGCTC CAGCTCCAGC CTCTCCCTTC GGGAAAGGTG GACAGTGTTC
AAGGGTCTGC TGTGGTACAT TGTTCCCTTG GTCGTAGTTT ACTTTGCCGA GTATTTCATT
AACCAGGGAC TTTTTGAACT CCTCTTTTTC TGGAACACTT CCCTGAGTCA CGCTCAGCAA
TACCGCTGGT ACCAGATGCT GTACCAGGCT GGCGTCTTTG CCTCCCGCTC TTCTCTCCGC
TGCTGTCGCA TCCGTTTCAC CTGGGCCCTG GCCCTGCTGC AGTGCCTCAA CCTGGTGTTC
CTGCTGGCAG ACGTGTGGTT CGGCTTTCTG CCAAGCATCT ACCTCGTCTT CCTGATCATT
CTGTATGAGG GGCTCCTGGG AGGCGCAGCC TACGTGAACA CCTTCCACAA CATCGCCCTG
GAGACCAGTG ATGAGCACCG GGAGTTTGCA ATGGCGGCCA CCTGCATCTC TGACACACTG
GGGATCTCCC TGTCGGGGCT CCTGGCTTTG CCTCTGCATG ACTTCCTCTG CCAGCTCTCC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16865
Accession Version NM_001286110.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1155bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform e
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP252176.1, DA869025.1 and AK294070.1. Summary: This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (e) with a shorter N-terminus and missing an alternate internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294070.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCTGAGTG CCGCCCACGA CATCCTTAGC CACAAGAGGA CATCGGGAAA CCAGAGCCAT 
GTGGACCCAG GCCCAACGCC GATCCCCCAC AACAGCTCAT CACGATTTGA CTGCAACTCT
GTCTCTACGG CTGCTGTGCT CCTGGCGGAC ATCCTCCCCA CACTCGTCAT CAAATTGTTG
GCTCCTCTTG GCCTTCACCT GCTGCCCTAC AGCCCCCGGG TTCTCGTCAG TGGGATTTGT
GCTGCTGGAA GCTTCGTCCT GGTTGCCTTT TCTCATTCTG TGGGGACCAG CCTGTGTGGT
GTGGTCTTCG CTAGCATCTC ATCAGGCCTT GGGGAGGTCA CCTTCCTCTC CCTCACTGCC
TTCTACCCCA GGGCCGTGAT CTCCTGGTGG TCCTCAGGGA CTGGGGGAGC TGGGCTGCTG
GGGGCCCTGT CCTACCTGGG CCTCACCCAG GCCGGCCTCT CCCCTCAGCA GACCCTGCTG
TCCATGCTGG GTATCCCTGC CCTGCTGCTG GCCAGCTATT TCTTGTTGCT CACATCTCCT
GAGGCCCAGG ACCCTGGAGG GGAAGAAGAA GCAGAGAGCG CAGCCCGGCA GCCCCTCATA
AGAACCGAGG CCCCGGAGTC GAAGCCAGGC TCCAGCTCCA GCCTCTCCCT TCGGGAAAGG
TGGACAGTGT TCAAGGGTCT GCTGTGGTAC ATTGTTCCCT TGGTCGTAGT TTACTTTGCC
GAGTATTTCA TTAACCAGGG ACTTTTTGAA CTCCTCTTTT TCTGGAACAC TTCCCTGAGT
CACGCTCAGC AATACCGCTG GTACCAGATG CTGTACCAGG CTGGCGTCTT TGCCTCCCGC
TCTTCTCTCC GCTGCTGTCG CATCCGTTTC ACCTGGGCCC TGGCCCTGCT GCAGTGCCTC
AACCTGGTGT TCCTGCTGGC AGACGTGTGG TTCGGCTTTC TGCCAAGCAT CTACCTCGTC
TTCCTGATCA TTCTGTATGA GGGGCTCCTG GGAGGCGCAG CCTACGTGAA CACCTTCCAC
AACATCGCCC TGGAGACCAG TGATGAGCAC CGGGAGTTTG CAATGGCGGC CACCTGCATC
TCTGACACAC TGGGGATCTC CCTGTCGGGG CTCCTGGCTT TGCCTCTGCA TGACTTCCTC
TGCCAGCTCT CCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001273039.1
CDS407..1561
Misc Feature(1)317..319(+)
Misc Feature(2)407..1558(+)
Exon (1)1..369
Gene:CLN3
Gene Synonym:
Exon (2)370..466
Gene:CLN3
Gene Synonym:
Exon (3)467..538
Gene:CLN3
Gene Synonym:
Exon (4)539..618
Gene:CLN3
Gene Synonym:
Exon (5)619..704
Gene:CLN3
Gene Synonym:
Exon (6)705..777
Gene:CLN3
Gene Synonym:
Exon (7)778..921
Gene:CLN3
Gene Synonym:
Exon (8)922..1034
Gene:CLN3
Gene Synonym:
Exon (9)1035..1081
Gene:CLN3
Gene Synonym:
Exon (10)1082..1150
Gene:CLN3
Gene Synonym:
Exon (11)1151..1206
Gene:CLN3
Gene Synonym:
Exon (12)1207..1300
Gene:CLN3
Gene Synonym:
Exon (13)1301..1441
Gene:CLN3
Gene Synonym:
Exon (14)1442..1797
Gene:CLN3
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:574775208
11 11 c, g dbSNP:141305257
26 26 a, g dbSNP:369500373
28 28 c, t dbSNP:572212180
35 35 a, t dbSNP:73533476
46 46 a, t dbSNP:565767570
83 83 c, t dbSNP:374400500
97 97 c, t dbSNP:574173550
118 118 a, g dbSNP:538884310
134 134 a, g dbSNP:370165217
148 148 a, g dbSNP:28612835
178 178 a, g dbSNP:372566364
187 187 a, g dbSNP:148025951
234 234 a, g dbSNP:368542813
250 250 c, t dbSNP:534657200
273 273 c, t dbSNP:767141815
274 274 -, ggagccccc dbSNP:760562597
274 274 c, t dbSNP:759135845
283 283 a, c dbSNP:370217726
286 286 -, t dbSNP:775483589
287 287 a, g dbSNP:766826715
291 291 a, c dbSNP:368494637
307 307 a, c, g dbSNP:770428655
311 311 g, t dbSNP:555894979
318 318 c, g dbSNP:776594074
319 319 a, g dbSNP:768881655
322 322 c, g dbSNP:747169563
323 323 c, g, t dbSNP:201274333
324 324 a, c, g dbSNP:386833708
325 325 c, t dbSNP:777625354
331 331 a, g dbSNP:756062000
352 352 -, g dbSNP:374055075
355 355 c, t dbSNP:752205710
360 360 a, g, t dbSNP:754562266
365 365 c, t dbSNP:751155598
368 368 a, g dbSNP:201824641
370 370 a, g dbSNP:781617143
373 373 a, g dbSNP:755493834
391 391 c, t dbSNP:571216643
396 396 c, t dbSNP:780151271
400 400 c, t dbSNP:758454511
401 401 a, g dbSNP:750643595
407 407 a, g, t dbSNP:760481173
410 410 a, c, g dbSNP:767513559
412 412 a, g dbSNP:759581122
418 418 c, t dbSNP:138433617
419 419 a, g dbSNP:765893479
424 424 c, t dbSNP:150120797
425 425 a, g dbSNP:772851701
438 438 a, g dbSNP:574261896
441 441 a, g dbSNP:769447444
449 449 c, t dbSNP:748458737
450 450 c, t dbSNP:769840061
451 451 a, g dbSNP:551476103
453 453 a, g dbSNP:747526330
458 458 c, t dbSNP:386833709
459 459 a, t dbSNP:780482162
460 460 c, g dbSNP:758501983
464 464 c, t dbSNP:745941670
466 466 c, t dbSNP:201225986
477 477 -, g dbSNP:386833712
477 477 a, g dbSNP:768993577
482 482 a, t dbSNP:150348015
483 483 c, t dbSNP:775999656
484 484 a, g dbSNP:373911322
484 484 -, g dbSNP:748710466
486 486 c, t dbSNP:137906617
487 487 a, g dbSNP:779165392
488 488 a, t dbSNP:370020452
492 492 c, t dbSNP:749503213
494 494 a, c dbSNP:201329358
506 506 a, t dbSNP:754801166
508 508 a, c dbSNP:751321507
509 509 c, t dbSNP:386833713
510 510 a, g dbSNP:766287694
514 514 c, g, t dbSNP:145520962
521 521 a, c, g dbSNP:761369095
522 522 a, g dbSNP:140409296
527 527 c, g dbSNP:763659524
534 534 c, t dbSNP:376421578
535 535 a, g dbSNP:367945307
546 546 c, t dbSNP:386833714
552 552 c, t dbSNP:760039703
553 553 a, g dbSNP:774996613
557 557 a, g dbSNP:11552531
562 562 c, t dbSNP:148248159
563 563 c, t dbSNP:149095062
567 567 c, t dbSNP:769953653
571 571 c, t dbSNP:748293490
572 572 a, g dbSNP:781534624
579 579 a, g dbSNP:771758062
581 581 c, t dbSNP:745665200
582 582 c, t dbSNP:778765250
583 583 a, g dbSNP:200356262
597 597 a, g dbSNP:753305901
602 602 a, c dbSNP:145749864
605 605 a, c, g dbSNP:752282954
610 610 a, g dbSNP:376960425
614 614 -, t dbSNP:386833715
615 615 -, t dbSNP:587779397
615 615 a, g dbSNP:546862372
616 616 c, t dbSNP:755330966
618 618 a, g dbSNP:386833716
619 619 c, t dbSNP:146076617
623 623 -, cc dbSNP:386833717
623 623 -, c dbSNP:386833718
623 623 c, t dbSNP:201168980
624 624 a, g dbSNP:780776829
625 625 c, g dbSNP:750889321
631 631 c, t dbSNP:765776873
632 632 a, c, g, t dbSNP:764261700
636 636 a, g dbSNP:144770450
637 637 c, t dbSNP:794727850
643 643 c, t dbSNP:775739498
644 644 c, t dbSNP:386833719
648 648 c, t dbSNP:770702932
652 652 c, t dbSNP:749176223
658 658 c, t dbSNP:772960606
662 662 a, g dbSNP:373034150
664 664 c, g dbSNP:544119921
668 668 -, g dbSNP:386833720
677 677 c, t dbSNP:780814580
680 680 c, t dbSNP:371590088
687 687 -, tgg dbSNP:752130042
687 687 g, t dbSNP:746644433
691 691 g, t dbSNP:779918787
692 692 a, c dbSNP:758767565
702 702 a, g dbSNP:750813350
705 705 c, g dbSNP:746178854
708 708 g, t dbSNP:779304920
715 715 c, t dbSNP:140670783
716 716 c, g dbSNP:386833723
718 718 c, t dbSNP:551927665
720 720 c, g dbSNP:754331166
726 726 c, g dbSNP:386833724
727 727 a, g dbSNP:778321651
729 729 c, g dbSNP:386833725
734 734 c, t dbSNP:758342160
736 736 -, g dbSNP:35832901
738 738 a, g dbSNP:786201028
753 753 c, t dbSNP:386833727
754 754 c, t dbSNP:756123046
760 760 c, t dbSNP:148846795
766 766 c, t dbSNP:371467190
767 767 c, t dbSNP:759769158
775 775 c, t dbSNP:751773646
778 778 c, g dbSNP:756640405
781 781 c, t dbSNP:147667964
782 782 a, g dbSNP:202215629
802 802 -, ag dbSNP:386833729
804 804 c, g dbSNP:386833730
809 809 c, g dbSNP:386833731
813 813 -, g dbSNP:763096461
813 813 -, g dbSNP:386833732
819 819 a, g dbSNP:386833733
820 820 a, g, t dbSNP:566516380
825 825 c, t dbSNP:751799615
826 826 g, t dbSNP:386833734
830 830 -, g dbSNP:386833735
831 831 c, t dbSNP:757018330
833 833 c, t dbSNP:753705869
835 835 a, g dbSNP:764082661
841 841 a, c dbSNP:267606737
842 842 c, g dbSNP:768149446
846 846 g, t dbSNP:775618174
859 859 c, t dbSNP:145631076
860 860 a, g dbSNP:370603922
866 866 -, t dbSNP:386833736
870 870 c, t dbSNP:139417824
875 875 c, t dbSNP:386833737
882 882 c, t dbSNP:554746072
885 885 c, t dbSNP:749609898
891 891 a, t dbSNP:773602052
893 893 a, c dbSNP:150913606
905 905 a, g dbSNP:748636727
909 909 c, t dbSNP:781613318
913 913 a, g dbSNP:755016673
914 914 c, t dbSNP:141508632
916 916 a, g dbSNP:747071263
925 925 c, t dbSNP:747068998
929 929 c, t dbSNP:779965094
931 931 a, g dbSNP:772327361
932 932 c, t dbSNP:746075287
937 937 c, t dbSNP:376590377
938 938 a, t dbSNP:755908083
939 939 c, t dbSNP:752450798
947 947 g, t dbSNP:781138637
951 951 c, t dbSNP:754906598
968 968 c, g dbSNP:751560016
973 973 -, a dbSNP:762192561
978 978 -, cag dbSNP:776966610
983 983 a, c dbSNP:765857735
985 985 c, t dbSNP:148782327
986 986 a, g dbSNP:750008067
992 992 c, t dbSNP:764881080
993 993 a, g dbSNP:374217931
996 996 a, c dbSNP:776890506
998 998 c, t dbSNP:769104531
999 999 c, t dbSNP:761065339
1001 1001 c, g dbSNP:776122422
1003 1003 a, c dbSNP:772274552
1005 1005 c, t dbSNP:745948575
1012 1012 c, t dbSNP:145967477
1013 1013 a, g dbSNP:771303379
1015 1015 a, g dbSNP:73533466
1017 1017 c, t dbSNP:780823167
1020 1020 c, t dbSNP:137858807
1021 1021 a, g dbSNP:751443804
1026 1026 c, t dbSNP:199627744
1027 1027 a, g dbSNP:752632879
1033 1033 a, c dbSNP:574450787
1038 1038 c, t dbSNP:749453498
1048 1048 a, c dbSNP:773546150
1058 1058 c, t dbSNP:113041302
1059 1059 a, g dbSNP:145270402
1068 1068 a, g dbSNP:779914525
1072 1072 -, ag dbSNP:755465037
1073 1073 a, g dbSNP:758360941
1075 1075 a, g dbSNP:1142183
1094 1094 c, t dbSNP:201090501
1097 1097 a, g dbSNP:748844685
1106 1106 g, t dbSNP:777244248
1109 1109 a, g dbSNP:755824692
1112 1112 a, g, t dbSNP:369008702
1119 1119 a, g dbSNP:755402909
1124 1124 a, g dbSNP:752112708
1126 1126 c, t dbSNP:766972077
1127 1127 a, g, t dbSNP:121434286
1130 1130 a, t dbSNP:750558528
1138 1138 c, t dbSNP:747222268
1141 1141 c, g dbSNP:765265208
1147 1147 a, g dbSNP:761976112
1149 1149 c, t dbSNP:776853352
1159 1159 c, g dbSNP:759304422
1160 1160 c, t dbSNP:774239875
1175 1175 a, g dbSNP:770660659
1180 1180 c, t dbSNP:762896453
1182 1182 c, t dbSNP:141816714
1185 1185 a, g dbSNP:769358990
1188 1188 -, a dbSNP:386833740
1189 1189 c, t dbSNP:747723206
1190 1190 a, g dbSNP:780974004
1202 1202 c, t dbSNP:768466445
1203 1203 a, g dbSNP:138636923
1214 1214 a, g dbSNP:779370547
1219 1219 a, g dbSNP:150174473
1223 1223 c, t dbSNP:386833743
1231 1231 c, t dbSNP:777779035
1232 1232 a, g, t dbSNP:386833744
1239 1239 c, t dbSNP:752894528
1244 1244 c, t dbSNP:386833694
1245 1245 a, g dbSNP:386833695
1246 1246 c, t dbSNP:140828382
1248 1248 c, g dbSNP:765157752
1251 1251 c, t dbSNP:761795794
1256 1256 c, t dbSNP:776725094
1257 1257 a, g dbSNP:557870972
1258 1258 c, t dbSNP:774284416
1261 1261 c, t dbSNP:768479701
1265 1265 c, t dbSNP:775195638
1266 1266 a, g dbSNP:201271341
1269 1269 a, t dbSNP:746211816
1271 1271 c, t dbSNP:201407601
1272 1272 a, g dbSNP:771305783
1276 1276 c, t dbSNP:749734787
1277 1277 a, c, t dbSNP:150986176
1292 1292 -, c dbSNP:386833696
1298 1298 c, t dbSNP:386833697
1300 1300 c, g dbSNP:386833699
1306 1306 c, t dbSNP:781086870
1315 1315 g, t dbSNP:146467602
1330 1330 c, g, t dbSNP:376907245
1331 1331 a, g dbSNP:370963882
1339 1339 c, t dbSNP:757106140
1340 1340 a, g dbSNP:772209464
1341 1341 a, g dbSNP:371214018
1342 1342 a, c dbSNP:367780407
1360 1360 c, t dbSNP:142456044
1361 1361 c, t dbSNP:752700529
1363 1363 c, t dbSNP:376478363
1364 1364 a, g dbSNP:759049027
1366 1366 c, t dbSNP:751205979
1372 1372 c, g dbSNP:766074736
1376 1376 a, c, g dbSNP:147658282
1395 1395 c, t dbSNP:770221497
1396 1396 c, g dbSNP:762171432
1402 1402 c, t dbSNP:145340637
1403 1403 a, g dbSNP:768614719
1406 1406 a, g dbSNP:747145427
1407 1407 c, t dbSNP:148514847
1408 1408 a, c dbSNP:772463617
1411 1411 c, t dbSNP:371025471
1412 1412 a, g dbSNP:777383109
1423 1423 c, t dbSNP:755948129
1429 1429 a, c dbSNP:747968377
1430 1430 a, g dbSNP:781253826
1433 1433 a, g dbSNP:754468227
1435 1435 c, t dbSNP:779338007
1436 1436 c, g dbSNP:751114018
1439 1439 g, t dbSNP:386833701
1444 1444 c, t dbSNP:754270222
1447 1447 a, t dbSNP:764585366
1453 1453 a, g dbSNP:377369610
1454 1454 a, c, t dbSNP:146610181
1455 1455 a, g dbSNP:77595156
1457 1457 c, g, t dbSNP:139842473
1458 1458 a, g dbSNP:747861558
1469 1469 a, g dbSNP:776443981
1473 1473 c, t dbSNP:369801432
1474 1474 a, g dbSNP:201206239
1484 1484 a, c, g dbSNP:146124686
1486 1486 a, g dbSNP:1064886
1491 1491 a, g dbSNP:386833703
1493 1493 a, g dbSNP:570472210
1496 1496 c, g dbSNP:778399559
1501 1501 g, t dbSNP:756893993
1504 1504 c, g dbSNP:753454206
1506 1506 c, t dbSNP:778225078
1512 1512 a, c, t dbSNP:386833706
1513 1513 a, g dbSNP:200719311
1515 1515 a, g dbSNP:753251101
1516 1516 -, g dbSNP:386833707
1524 1524 c, t dbSNP:768194285
1535 1535 c, t dbSNP:759510380
1536 1536 a, t dbSNP:751697176
1564 1564 a, c dbSNP:116985567
1568 1568 a, g dbSNP:763180323
1578 1578 a, g dbSNP:773432104
1580 1580 c, t dbSNP:768437444
1581 1581 a, g, t dbSNP:369540789
1585 1585 a, g dbSNP:772089665
1587 1587 a, c dbSNP:201685501
1590 1590 a, g dbSNP:778438984
1591 1591 c, t dbSNP:770360224
1601 1601 g, t dbSNP:748903907
1611 1611 c, t dbSNP:777635234
1616 1616 a, c dbSNP:199979207
1619 1619 a, c dbSNP:142958639
1639 1639 a, g dbSNP:751235567
1660 1660 c, t dbSNP:113845299
1670 1670 c, t dbSNP:777406780
1671 1671 c, g dbSNP:532573871
1703 1703 g, t dbSNP:755606047
1705 1705 a, g dbSNP:184662946
1710 1710 c, t dbSNP:145698326
1716 1716 a, c dbSNP:113112766
1761 1761 a, g dbSNP:561135374
1766 1766 a, g dbSNP:757923800
1771 1771 a, g dbSNP:1064912
1797 1797 g, t dbSNP:370999518

Target ORF information:

RefSeq Version NM_001286110
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001286110

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCTGAGTG CCGCCCACGA CATCCTTAGC CACAAGAGGA CATCGGGAAA CCAGAGCCAT 
GTGGACCCAG GCCCAACGCC GATCCCCCAC AACAGCTCAT CACGATTTGA CTGCAACTCT
GTCTCTACGG CTGCTGTGCT CCTGGCGGAC ATCCTCCCCA CACTCGTCAT CAAATTGTTG
GCTCCTCTTG GCCTTCACCT GCTGCCCTAC AGCCCCCGGG TTCTCGTCAG TGGGATTTGT
GCTGCTGGAA GCTTCGTCCT GGTTGCCTTT TCTCATTCTG TGGGGACCAG CCTGTGTGGT
GTGGTCTTCG CTAGCATCTC ATCAGGCCTT GGGGAGGTCA CCTTCCTCTC CCTCACTGCC
TTCTACCCCA GGGCCGTGAT CTCCTGGTGG TCCTCAGGGA CTGGGGGAGC TGGGCTGCTG
GGGGCCCTGT CCTACCTGGG CCTCACCCAG GCCGGCCTCT CCCCTCAGCA GACCCTGCTG
TCCATGCTGG GTATCCCTGC CCTGCTGCTG GCCAGCTATT TCTTGTTGCT CACATCTCCT
GAGGCCCAGG ACCCTGGAGG GGAAGAAGAA GCAGAGAGCG CAGCCCGGCA GCCCCTCATA
AGAACCGAGG CCCCGGAGTC GAAGCCAGGC TCCAGCTCCA GCCTCTCCCT TCGGGAAAGG
TGGACAGTGT TCAAGGGTCT GCTGTGGTAC ATTGTTCCCT TGGTCGTAGT TTACTTTGCC
GAGTATTTCA TTAACCAGGG ACTTTTTGAA CTCCTCTTTT TCTGGAACAC TTCCCTGAGT
CACGCTCAGC AATACCGCTG GTACCAGATG CTGTACCAGG CTGGCGTCTT TGCCTCCCGC
TCTTCTCTCC GCTGCTGTCG CATCCGTTTC ACCTGGGCCC TGGCCCTGCT GCAGTGCCTC
AACCTGGTGT TCCTGCTGGC AGACGTGTGG TTCGGCTTTC TGCCAAGCAT CTACCTCGTC
TTCCTGATCA TTCTGTATGA GGGGCTCCTG GGAGGCGCAG CCTACGTGAA CACCTTCCAC
AACATCGCCC TGGAGACCAG TGATGAGCAC CGGGAGTTTG CAATGGCGGC CACCTGCATC
TCTGACACAC TGGGGATCTC CCTGTCGGGG CTCCTGGCTT TGCCTCTGCA TGACTTCCTC
TGCCAGCTCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25863
Accession Version NM_001042432.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1317bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA552461.1, DB101039.1, AF077957.1 and AI138575.1. This sequence is a reference standard in the RefSeqGene project. Summary: This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002394.2, AK313002.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGTGGACCC AGGCCCAACG
CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT CTGTCTCTAC GGCTGCTGTG
CTCCTGGCGG ACATCCTCCC CACACTCGTC ATCAAATTGT TGGCTCCTCT TGGCCTTCAC
CTGCTGCCCT ACAGCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001035897.1
CDS360..1676
Misc Feature(1)324..326(+)
Misc Feature(2)393..395(+)
Misc Feature(3)393..395(+)
Misc Feature(4)399..401(+)
Misc Feature(5)399..401(+)
Misc Feature(6)468..1673(+)
Misc Feature(7)471..533(+)
Misc Feature(8)654..716(+)
Misc Feature(9)741..803(+)
Misc Feature(10)897..959(+)
Misc Feature(11)993..1055(+)
Misc Feature(12)1191..1253(+)
Misc Feature(13)1431..1493(+)
Misc Feature(14)1578..1640(+)
Exon (1)1..283
Gene:CLN3
Gene Synonym:
Exon (2)284..405
Gene:CLN3
Gene Synonym:
Exon (3)406..484
Gene:CLN3
Gene Synonym:
Exon (4)485..581
Gene:CLN3
Gene Synonym:
Exon (5)582..653
Gene:CLN3
Gene Synonym:
Exon (6)654..733
Gene:CLN3
Gene Synonym:
Exon (7)734..819
Gene:CLN3
Gene Synonym:
Exon (8)820..892
Gene:CLN3
Gene Synonym:
Exon (9)893..1036
Gene:CLN3
Gene Synonym:
Exon (10)1037..1149
Gene:CLN3
Gene Synonym:
Exon (11)1150..1196
Gene:CLN3
Gene Synonym:
Exon (12)1197..1265
Gene:CLN3
Gene Synonym:
Exon (13)1266..1321
Gene:CLN3
Gene Synonym:
Exon (14)1322..1415
Gene:CLN3
Gene Synonym:
Exon (15)1416..1556
Gene:CLN3
Gene Synonym:
Exon (16)1557..1913
Gene:CLN3
Gene Synonym:
Translation
Position Chain Variation Link
18 18 c, g dbSNP:528209961
80 80 a, c dbSNP:559560438
96 96 c, g dbSNP:187163584
104 104 c, t dbSNP:532405948
113 113 a, t dbSNP:563482688
156 156 a, c dbSNP:543778792
181 181 a, g dbSNP:544844147
213 213 -, a dbSNP:547169357
219 219 a, g, t dbSNP:760565039
230 230 c, t dbSNP:574775208
231 231 c, g dbSNP:141305257
246 246 a, g dbSNP:369500373
248 248 c, t dbSNP:572212180
255 255 a, t dbSNP:73533476
266 266 a, t dbSNP:565767570
286 286 c, t dbSNP:534657200
309 309 c, t dbSNP:767141815
310 310 -, ggagccccc dbSNP:760562597
310 310 c, t dbSNP:759135845
319 319 a, c dbSNP:370217726
322 322 -, t dbSNP:775483589
323 323 a, g dbSNP:766826715
327 327 a, c dbSNP:368494637
343 343 a, c, g dbSNP:770428655
347 347 g, t dbSNP:555894979
354 354 c, g dbSNP:776594074
355 355 a, g dbSNP:768881655
358 358 c, g dbSNP:747169563
359 359 c, g, t dbSNP:201274333
360 360 a, c, g dbSNP:386833708
361 361 c, t dbSNP:777625354
367 367 a, g dbSNP:756062000
388 388 -, g dbSNP:374055075
391 391 c, t dbSNP:752205710
396 396 a, g, t dbSNP:754562266
401 401 c, t dbSNP:751155598
404 404 a, g dbSNP:201824641
408 408 a, g, t dbSNP:386833726
415 415 c, t dbSNP:758020045
421 421 c, g, t dbSNP:562525993
426 426 c, t dbSNP:757558651
428 428 c, t dbSNP:754235288
430 430 a, g dbSNP:764455367
431 431 g, t dbSNP:756670390
432 432 a, c dbSNP:752737552
460 460 a, g, t dbSNP:759668300
461 461 c, t dbSNP:774549218
464 464 a, g dbSNP:386833700
467 467 a, g dbSNP:761453819
470 470 c, t dbSNP:776507846
471 471 a, g dbSNP:565082957
475 475 c, t dbSNP:760656860
485 485 a, g dbSNP:781617143
488 488 a, g dbSNP:755493834
506 506 c, t dbSNP:571216643
511 511 c, t dbSNP:780151271
515 515 c, t dbSNP:758454511
516 516 a, g dbSNP:750643595
522 522 a, g, t dbSNP:760481173
525 525 a, c, g dbSNP:767513559
527 527 a, g dbSNP:759581122
533 533 c, t dbSNP:138433617
534 534 a, g dbSNP:765893479
539 539 c, t dbSNP:150120797
540 540 a, g dbSNP:772851701
553 553 a, g dbSNP:574261896
556 556 a, g dbSNP:769447444
564 564 c, t dbSNP:748458737
565 565 c, t dbSNP:769840061
566 566 a, g dbSNP:551476103
568 568 a, g dbSNP:747526330
573 573 c, t dbSNP:386833709
574 574 a, t dbSNP:780482162
575 575 c, g dbSNP:758501983
579 579 c, t dbSNP:745941670
581 581 c, t dbSNP:201225986
592 592 -, g dbSNP:386833712
592 592 a, g dbSNP:768993577
597 597 a, t dbSNP:150348015
598 598 c, t dbSNP:775999656
599 599 a, g dbSNP:373911322
599 599 -, g dbSNP:748710466
601 601 c, t dbSNP:137906617
602 602 a, g dbSNP:779165392
603 603 a, t dbSNP:370020452
607 607 c, t dbSNP:749503213
609 609 a, c dbSNP:201329358
621 621 a, t dbSNP:754801166
623 623 a, c dbSNP:751321507
624 624 c, t dbSNP:386833713
625 625 a, g dbSNP:766287694
629 629 c, g, t dbSNP:145520962
636 636 a, c, g dbSNP:761369095
637 637 a, g dbSNP:140409296
642 642 c, g dbSNP:763659524
649 649 c, t dbSNP:376421578
650 650 a, g dbSNP:367945307
661 661 c, t dbSNP:386833714
667 667 c, t dbSNP:760039703
668 668 a, g dbSNP:774996613
672 672 a, g dbSNP:11552531
677 677 c, t dbSNP:148248159
678 678 c, t dbSNP:149095062
682 682 c, t dbSNP:769953653
686 686 c, t dbSNP:748293490
687 687 a, g dbSNP:781534624
694 694 a, g dbSNP:771758062
696 696 c, t dbSNP:745665200
697 697 c, t dbSNP:778765250
698 698 a, g dbSNP:200356262
712 712 a, g dbSNP:753305901
717 717 a, c dbSNP:145749864
720 720 a, c, g dbSNP:752282954
725 725 a, g dbSNP:376960425
729 729 -, t dbSNP:386833715
730 730 -, t dbSNP:587779397
730 730 a, g dbSNP:546862372
731 731 c, t dbSNP:755330966
733 733 a, g dbSNP:386833716
734 734 c, t dbSNP:146076617
738 738 -, cc dbSNP:386833717
738 738 -, c dbSNP:386833718
738 738 c, t dbSNP:201168980
739 739 a, g dbSNP:780776829
740 740 c, g dbSNP:750889321
746 746 c, t dbSNP:765776873
747 747 a, c, g, t dbSNP:764261700
751 751 a, g dbSNP:144770450
752 752 c, t dbSNP:794727850
758 758 c, t dbSNP:775739498
759 759 c, t dbSNP:386833719
763 763 c, t dbSNP:770702932
767 767 c, t dbSNP:749176223
773 773 c, t dbSNP:772960606
777 777 a, g dbSNP:373034150
779 779 c, g dbSNP:544119921
783 783 -, g dbSNP:386833720
792 792 c, t dbSNP:780814580
795 795 c, t dbSNP:371590088
802 802 -, tgg dbSNP:752130042
802 802 g, t dbSNP:746644433
806 806 g, t dbSNP:779918787
807 807 a, c dbSNP:758767565
817 817 a, g dbSNP:750813350
820 820 c, g dbSNP:746178854
823 823 g, t dbSNP:779304920
830 830 c, t dbSNP:140670783
831 831 c, g dbSNP:386833723
833 833 c, t dbSNP:551927665
835 835 c, g dbSNP:754331166
841 841 c, g dbSNP:386833724
842 842 a, g dbSNP:778321651
844 844 c, g dbSNP:386833725
849 849 c, t dbSNP:758342160
851 851 -, g dbSNP:35832901
853 853 a, g dbSNP:786201028
868 868 c, t dbSNP:386833727
869 869 c, t dbSNP:756123046
875 875 c, t dbSNP:148846795
881 881 c, t dbSNP:371467190
882 882 c, t dbSNP:759769158
890 890 c, t dbSNP:751773646
893 893 c, g dbSNP:756640405
896 896 c, t dbSNP:147667964
897 897 a, g dbSNP:202215629
917 917 -, ag dbSNP:386833729
919 919 c, g dbSNP:386833730
924 924 c, g dbSNP:386833731
928 928 -, g dbSNP:763096461
928 928 -, g dbSNP:386833732
934 934 a, g dbSNP:386833733
935 935 a, g, t dbSNP:566516380
940 940 c, t dbSNP:751799615
941 941 g, t dbSNP:386833734
945 945 -, g dbSNP:386833735
946 946 c, t dbSNP:757018330
948 948 c, t dbSNP:753705869
950 950 a, g dbSNP:764082661
956 956 a, c dbSNP:267606737
957 957 c, g dbSNP:768149446
961 961 g, t dbSNP:775618174
974 974 c, t dbSNP:145631076
975 975 a, g dbSNP:370603922
981 981 -, t dbSNP:386833736
985 985 c, t dbSNP:139417824
990 990 c, t dbSNP:386833737
997 997 c, t dbSNP:554746072
1000 1000 c, t dbSNP:749609898
1006 1006 a, t dbSNP:773602052
1008 1008 a, c dbSNP:150913606
1020 1020 a, g dbSNP:748636727
1024 1024 c, t dbSNP:781613318
1028 1028 a, g dbSNP:755016673
1029 1029 c, t dbSNP:141508632
1031 1031 a, g dbSNP:747071263
1040 1040 c, t dbSNP:747068998
1044 1044 c, t dbSNP:779965094
1046 1046 a, g dbSNP:772327361
1047 1047 c, t dbSNP:746075287
1052 1052 c, t dbSNP:376590377
1053 1053 a, t dbSNP:755908083
1054 1054 c, t dbSNP:752450798
1062 1062 g, t dbSNP:781138637
1066 1066 c, t dbSNP:754906598
1083 1083 c, g dbSNP:751560016
1088 1088 -, a dbSNP:762192561
1093 1093 -, cag dbSNP:776966610
1098 1098 a, c dbSNP:765857735
1100 1100 c, t dbSNP:148782327
1101 1101 a, g dbSNP:750008067
1107 1107 c, t dbSNP:764881080
1108 1108 a, g dbSNP:374217931
1111 1111 a, c dbSNP:776890506
1113 1113 c, t dbSNP:769104531
1114 1114 c, t dbSNP:761065339
1116 1116 c, g dbSNP:776122422
1118 1118 a, c dbSNP:772274552
1120 1120 c, t dbSNP:745948575
1127 1127 c, t dbSNP:145967477
1128 1128 a, g dbSNP:771303379
1130 1130 a, g dbSNP:73533466
1132 1132 c, t dbSNP:780823167
1135 1135 c, t dbSNP:137858807
1136 1136 a, g dbSNP:751443804
1141 1141 c, t dbSNP:199627744
1142 1142 a, g dbSNP:752632879
1148 1148 a, c dbSNP:574450787
1153 1153 c, t dbSNP:749453498
1163 1163 a, c dbSNP:773546150
1173 1173 c, t dbSNP:113041302
1174 1174 a, g dbSNP:145270402
1183 1183 a, g dbSNP:779914525
1187 1187 -, ag dbSNP:755465037
1188 1188 a, g dbSNP:758360941
1190 1190 a, g dbSNP:1142183
1209 1209 c, t dbSNP:201090501
1212 1212 a, g dbSNP:748844685
1221 1221 g, t dbSNP:777244248
1224 1224 a, g dbSNP:755824692
1227 1227 a, g, t dbSNP:369008702
1234 1234 a, g dbSNP:755402909
1239 1239 a, g dbSNP:752112708
1241 1241 c, t dbSNP:766972077
1242 1242 a, g, t dbSNP:121434286
1245 1245 a, t dbSNP:750558528
1253 1253 c, t dbSNP:747222268
1256 1256 c, g dbSNP:765265208
1262 1262 a, g dbSNP:761976112
1264 1264 c, t dbSNP:776853352
1274 1274 c, g dbSNP:759304422
1275 1275 c, t dbSNP:774239875
1290 1290 a, g dbSNP:770660659
1295 1295 c, t dbSNP:762896453
1297 1297 c, t dbSNP:141816714
1300 1300 a, g dbSNP:769358990
1303 1303 -, a dbSNP:386833740
1304 1304 c, t dbSNP:747723206
1305 1305 a, g dbSNP:780974004
1317 1317 c, t dbSNP:768466445
1318 1318 a, g dbSNP:138636923
1329 1329 a, g dbSNP:779370547
1334 1334 a, g dbSNP:150174473
1338 1338 c, t dbSNP:386833743
1346 1346 c, t dbSNP:777779035
1347 1347 a, g, t dbSNP:386833744
1354 1354 c, t dbSNP:752894528
1359 1359 c, t dbSNP:386833694
1360 1360 a, g dbSNP:386833695
1361 1361 c, t dbSNP:140828382
1363 1363 c, g dbSNP:765157752
1366 1366 c, t dbSNP:761795794
1371 1371 c, t dbSNP:776725094
1372 1372 a, g dbSNP:557870972
1373 1373 c, t dbSNP:774284416
1376 1376 c, t dbSNP:768479701
1380 1380 c, t dbSNP:775195638
1381 1381 a, g dbSNP:201271341
1384 1384 a, t dbSNP:746211816
1386 1386 c, t dbSNP:201407601
1387 1387 a, g dbSNP:771305783
1391 1391 c, t dbSNP:749734787
1392 1392 a, c, t dbSNP:150986176
1407 1407 -, c dbSNP:386833696
1413 1413 c, t dbSNP:386833697
1415 1415 c, g dbSNP:386833699
1421 1421 c, t dbSNP:781086870
1430 1430 g, t dbSNP:146467602
1445 1445 c, g, t dbSNP:376907245
1446 1446 a, g dbSNP:370963882
1454 1454 c, t dbSNP:757106140
1455 1455 a, g dbSNP:772209464
1456 1456 a, g dbSNP:371214018
1457 1457 a, c dbSNP:367780407
1475 1475 c, t dbSNP:142456044
1476 1476 c, t dbSNP:752700529
1478 1478 c, t dbSNP:376478363
1479 1479 a, g dbSNP:759049027
1481 1481 c, t dbSNP:751205979
1487 1487 c, g dbSNP:766074736
1491 1491 a, c, g dbSNP:147658282
1510 1510 c, t dbSNP:770221497
1511 1511 c, g dbSNP:762171432
1517 1517 c, t dbSNP:145340637
1518 1518 a, g dbSNP:768614719
1521 1521 a, g dbSNP:747145427
1522 1522 c, t dbSNP:148514847
1523 1523 a, c dbSNP:772463617
1526 1526 c, t dbSNP:371025471
1527 1527 a, g dbSNP:777383109
1538 1538 c, t dbSNP:755948129
1544 1544 a, c dbSNP:747968377
1545 1545 a, g dbSNP:781253826
1548 1548 a, g dbSNP:754468227
1550 1550 c, t dbSNP:779338007
1551 1551 c, g dbSNP:751114018
1554 1554 g, t dbSNP:386833701
1559 1559 c, t dbSNP:754270222
1562 1562 a, t dbSNP:764585366
1568 1568 a, g dbSNP:377369610
1569 1569 a, c, t dbSNP:146610181
1570 1570 a, g dbSNP:77595156
1572 1572 c, g, t dbSNP:139842473
1573 1573 a, g dbSNP:747861558
1584 1584 a, g dbSNP:776443981
1588 1588 c, t dbSNP:369801432
1589 1589 a, g dbSNP:201206239
1599 1599 a, c, g dbSNP:146124686
1601 1601 a, g dbSNP:1064886
1606 1606 a, g dbSNP:386833703
1608 1608 a, g dbSNP:570472210
1611 1611 c, g dbSNP:778399559
1616 1616 g, t dbSNP:756893993
1619 1619 c, g dbSNP:753454206
1621 1621 c, t dbSNP:778225078
1627 1627 a, c, t dbSNP:386833706
1628 1628 a, g dbSNP:200719311
1630 1630 a, g dbSNP:753251101
1631 1631 -, g dbSNP:386833707
1639 1639 c, t dbSNP:768194285
1650 1650 c, t dbSNP:759510380
1651 1651 a, t dbSNP:751697176
1679 1679 a, c dbSNP:116985567
1683 1683 a, g dbSNP:763180323
1693 1693 a, g dbSNP:773432104
1695 1695 c, t dbSNP:768437444
1696 1696 a, g, t dbSNP:369540789
1700 1700 a, g dbSNP:772089665
1702 1702 a, c dbSNP:201685501
1705 1705 a, g dbSNP:778438984
1706 1706 c, t dbSNP:770360224
1716 1716 g, t dbSNP:748903907
1726 1726 c, t dbSNP:777635234
1731 1731 a, c dbSNP:199979207
1734 1734 a, c dbSNP:142958639
1754 1754 a, g dbSNP:751235567
1775 1775 c, t dbSNP:113845299
1785 1785 c, t dbSNP:777406780
1786 1786 c, g dbSNP:532573871
1818 1818 g, t dbSNP:755606047
1820 1820 a, g dbSNP:184662946
1825 1825 c, t dbSNP:145698326
1831 1831 a, c dbSNP:113112766
1876 1876 a, g dbSNP:561135374
1881 1881 a, g dbSNP:757923800
1886 1886 a, g dbSNP:1064912
1912 1912 g, t dbSNP:370999518

Target ORF information:

RefSeq Version NM_001042432
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001042432

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGTGGACCC AGGCCCAACG
CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT CTGTCTCTAC GGCTGCTGTG
CTCCTGGCGG ACATCCTCCC CACACTCGTC ATCAAATTGT TGGCTCCTCT TGGCCTTCAC
CTGCTGCCCT ACAGCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25863
Accession Version NM_000086.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1317bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU105965.1, DA869025.1, U32680.1, AF077962.1 and AI138575.1. This sequence is a reference standard in the RefSeqGene project. On Jun 28, 2006 this sequence version replaced gi:4502888. Summary: This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U32680.1, AF015593.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGTGGACCC AGGCCCAACG
CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT CTGTCTCTAC GGCTGCTGTG
CTCCTGGCGG ACATCCTCCC CACACTCGTC ATCAAATTGT TGGCTCCTCT TGGCCTTCAC
CTGCTGCCCT ACAGCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000077.1
CDS324..1640
Misc Feature(1)288..290(+)
Misc Feature(2)357..359(+)
Misc Feature(3)357..359(+)
Misc Feature(4)363..365(+)
Misc Feature(5)363..365(+)
Misc Feature(6)432..1637(+)
Misc Feature(7)435..497(+)
Misc Feature(8)618..680(+)
Misc Feature(9)705..767(+)
Misc Feature(10)861..923(+)
Misc Feature(11)957..1019(+)
Misc Feature(12)1155..1217(+)
Misc Feature(13)1395..1457(+)
Misc Feature(14)1542..1604(+)
Exon (1)1..369
Gene:CLN3
Gene Synonym:
Exon (2)370..448
Gene:CLN3
Gene Synonym:
Exon (3)449..545
Gene:CLN3
Gene Synonym:
Exon (4)546..617
Gene:CLN3
Gene Synonym:
Exon (5)618..697
Gene:CLN3
Gene Synonym:
Exon (6)698..783
Gene:CLN3
Gene Synonym:
Exon (7)784..856
Gene:CLN3
Gene Synonym:
Exon (8)857..1000
Gene:CLN3
Gene Synonym:
Exon (9)1001..1113
Gene:CLN3
Gene Synonym:
Exon (10)1114..1160
Gene:CLN3
Gene Synonym:
Exon (11)1161..1229
Gene:CLN3
Gene Synonym:
Exon (12)1230..1285
Gene:CLN3
Gene Synonym:
Exon (13)1286..1379
Gene:CLN3
Gene Synonym:
Exon (14)1380..1520
Gene:CLN3
Gene Synonym:
Exon (15)1521..1877
Gene:CLN3
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, t dbSNP:574775208
11 11 c, g dbSNP:141305257
26 26 a, g dbSNP:369500373
28 28 c, t dbSNP:572212180
35 35 a, t dbSNP:73533476
46 46 a, t dbSNP:565767570
83 83 c, t dbSNP:374400500
97 97 c, t dbSNP:574173550
118 118 a, g dbSNP:538884310
134 134 a, g dbSNP:370165217
148 148 a, g dbSNP:28612835
178 178 a, g dbSNP:372566364
187 187 a, g dbSNP:148025951
234 234 a, g dbSNP:368542813
250 250 c, t dbSNP:534657200
273 273 c, t dbSNP:767141815
274 274 -, ggagccccc dbSNP:760562597
274 274 c, t dbSNP:759135845
283 283 a, c dbSNP:370217726
286 286 -, t dbSNP:775483589
287 287 a, g dbSNP:766826715
291 291 a, c dbSNP:368494637
307 307 a, c, g dbSNP:770428655
311 311 g, t dbSNP:555894979
318 318 c, g dbSNP:776594074
319 319 a, g dbSNP:768881655
322 322 c, g dbSNP:747169563
323 323 c, g, t dbSNP:201274333
324 324 a, c, g dbSNP:386833708
325 325 c, t dbSNP:777625354
331 331 a, g dbSNP:756062000
352 352 -, g dbSNP:374055075
355 355 c, t dbSNP:752205710
360 360 a, g, t dbSNP:754562266
365 365 c, t dbSNP:751155598
368 368 a, g dbSNP:201824641
372 372 a, g, t dbSNP:386833726
379 379 c, t dbSNP:758020045
385 385 c, g, t dbSNP:562525993
390 390 c, t dbSNP:757558651
392 392 c, t dbSNP:754235288
394 394 a, g dbSNP:764455367
395 395 g, t dbSNP:756670390
396 396 a, c dbSNP:752737552
424 424 a, g, t dbSNP:759668300
425 425 c, t dbSNP:774549218
428 428 a, g dbSNP:386833700
431 431 a, g dbSNP:761453819
434 434 c, t dbSNP:776507846
435 435 a, g dbSNP:565082957
439 439 c, t dbSNP:760656860
449 449 a, g dbSNP:781617143
452 452 a, g dbSNP:755493834
470 470 c, t dbSNP:571216643
475 475 c, t dbSNP:780151271
479 479 c, t dbSNP:758454511
480 480 a, g dbSNP:750643595
486 486 a, g, t dbSNP:760481173
489 489 a, c, g dbSNP:767513559
491 491 a, g dbSNP:759581122
497 497 c, t dbSNP:138433617
498 498 a, g dbSNP:765893479
503 503 c, t dbSNP:150120797
504 504 a, g dbSNP:772851701
517 517 a, g dbSNP:574261896
520 520 a, g dbSNP:769447444
528 528 c, t dbSNP:748458737
529 529 c, t dbSNP:769840061
530 530 a, g dbSNP:551476103
532 532 a, g dbSNP:747526330
537 537 c, t dbSNP:386833709
538 538 a, t dbSNP:780482162
539 539 c, g dbSNP:758501983
543 543 c, t dbSNP:745941670
545 545 c, t dbSNP:201225986
556 556 -, g dbSNP:386833712
556 556 a, g dbSNP:768993577
561 561 a, t dbSNP:150348015
562 562 c, t dbSNP:775999656
563 563 a, g dbSNP:373911322
563 563 -, g dbSNP:748710466
565 565 c, t dbSNP:137906617
566 566 a, g dbSNP:779165392
567 567 a, t dbSNP:370020452
571 571 c, t dbSNP:749503213
573 573 a, c dbSNP:201329358
585 585 a, t dbSNP:754801166
587 587 a, c dbSNP:751321507
588 588 c, t dbSNP:386833713
589 589 a, g dbSNP:766287694
593 593 c, g, t dbSNP:145520962
600 600 a, c, g dbSNP:761369095
601 601 a, g dbSNP:140409296
606 606 c, g dbSNP:763659524
613 613 c, t dbSNP:376421578
614 614 a, g dbSNP:367945307
625 625 c, t dbSNP:386833714
631 631 c, t dbSNP:760039703
632 632 a, g dbSNP:774996613
636 636 a, g dbSNP:11552531
641 641 c, t dbSNP:148248159
642 642 c, t dbSNP:149095062
646 646 c, t dbSNP:769953653
650 650 c, t dbSNP:748293490
651 651 a, g dbSNP:781534624
658 658 a, g dbSNP:771758062
660 660 c, t dbSNP:745665200
661 661 c, t dbSNP:778765250
662 662 a, g dbSNP:200356262
676 676 a, g dbSNP:753305901
681 681 a, c dbSNP:145749864
684 684 a, c, g dbSNP:752282954
689 689 a, g dbSNP:376960425
693 693 -, t dbSNP:386833715
694 694 -, t dbSNP:587779397
694 694 a, g dbSNP:546862372
695 695 c, t dbSNP:755330966
697 697 a, g dbSNP:386833716
698 698 c, t dbSNP:146076617
702 702 -, cc dbSNP:386833717
702 702 -, c dbSNP:386833718
702 702 c, t dbSNP:201168980
703 703 a, g dbSNP:780776829
704 704 c, g dbSNP:750889321
710 710 c, t dbSNP:765776873
711 711 a, c, g, t dbSNP:764261700
715 715 a, g dbSNP:144770450
716 716 c, t dbSNP:794727850
722 722 c, t dbSNP:775739498
723 723 c, t dbSNP:386833719
727 727 c, t dbSNP:770702932
731 731 c, t dbSNP:749176223
737 737 c, t dbSNP:772960606
741 741 a, g dbSNP:373034150
743 743 c, g dbSNP:544119921
747 747 -, g dbSNP:386833720
756 756 c, t dbSNP:780814580
759 759 c, t dbSNP:371590088
766 766 -, tgg dbSNP:752130042
766 766 g, t dbSNP:746644433
770 770 g, t dbSNP:779918787
771 771 a, c dbSNP:758767565
781 781 a, g dbSNP:750813350
784 784 c, g dbSNP:746178854
787 787 g, t dbSNP:779304920
794 794 c, t dbSNP:140670783
795 795 c, g dbSNP:386833723
797 797 c, t dbSNP:551927665
799 799 c, g dbSNP:754331166
805 805 c, g dbSNP:386833724
806 806 a, g dbSNP:778321651
808 808 c, g dbSNP:386833725
813 813 c, t dbSNP:758342160
815 815 -, g dbSNP:35832901
817 817 a, g dbSNP:786201028
832 832 c, t dbSNP:386833727
833 833 c, t dbSNP:756123046
839 839