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CCR5 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CCR5
Entrez Gene ID 1234
Full Name chemokine (C-C motif) receptor 5 (gene/pseudogene)
Synonyms CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CKR5, CMKBR5, IDDM22
General protein information
Preferred Names
C-C chemokine receptor type 5
Names
C-C chemokine receptor type 5
chemr13
HIV-1 fusion coreceptor
chemokine receptor CCR5
C-C motif chemokine receptor 5 A159A
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21.31

Summary This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015]. lac of sum
Disorder MIM:

601373

Disorder Html: {HIV infection, susceptibility/resistance to} (3); {West nile virus,

mRNA and Protein(s)

mRNA Protein Name
NM_001100168 NP_001093638 C-C chemokine receptor type 5
NM_000579 NP_000570 C-C chemokine receptor type 5



Homo sapiens (human) CCR5 NP_001093638.1
Pan troglodytes (chimpanzee) CCR5 NP_001009046.1
Macaca mulatta (Rhesus monkey) CCR5 NP_001036238.2
Canis lupus familiaris (dog) CCR5 NP_001012342.2
Bos taurus (cattle) CCR5 NP_001011672.2
Mus musculus (house mouse) Ccr5 NP_034047.2
Rattus norvegicus (Norway rat) Ccr5 NP_446412.2
Danio rerio (zebrafish) LOC100005081 XP_001344220.4
Danio rerio (zebrafish) LOC100004625 XP_001343879.1
Danio rerio (zebrafish) LOC100004988 XP_001344151.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101731980 XP_004915406.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CCR5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCR5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu20119
NM_001100168 Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant B, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu20119
NM_000579 Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant A, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu20119
Clone ID Related Accession (Same CDS sequence) NM_000579 , NM_001100168
Accession Version NM_001100168.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1059bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 29-JUL-2015
Organism Homo sapiens (human)
Product C-C chemokine receptor type 5
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC098613.2, DA818906.1, U54994.1 and BC038398.1. Transcript Variant: This variant (B) differs in the 5' UTR compared to variant A. Both variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by published experimental evidence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: U54994.1, BC038398.1 [ECO:0000331] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 17417600 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGATTATC AAGTGTCAAG TCCAATCTAT GACATCAATT ATTATACATC GGAGCCCTGC 
CAAAAAATCA ATGTGAAGCA AATCGCAGCC CGCCTCCTGC CTCCGCTCTA CTCACTGGTG
TTCATCTTTG GTTTTGTGGG CAACATGCTG GTCATCCTCA TCCTGATAAA CTGCAAAAGG
CTGAAGAGCA TGACTGACAT CTACCTGCTC AACCTGGCCA TCTCTGACCT GTTTTTCCTT
CTTACTGTCC CCTTCTGGGC TCACTATGCT GCCGCCCAGT GGGACTTTGG AAATACAATG
TGTCAACTCT TGACAGGGCT CTATTTTATA GGCTTCTTCT CTGGAATCTT CTTCATCATC
CTCCTGACAA TCGATAGGTA CCTGGCTGTC GTCCATGCTG TGTTTGCTTT AAAAGCCAGG
ACGGTCACCT TTGGGGTGGT GACAAGTGTG ATCACTTGGG TGGTGGCTGT GTTTGCGTCT
CTCCCAGGAA TCATCTTTAC CAGATCTCAA AAAGAAGGTC TTCATTACAC CTGCAGCTCT
CATTTTCCAT ACAGTCAGTA TCAATTCTGG AAGAATTTCC AGACATTAAA GATAGTCATC
TTGGGGCTGG TCCTGCCGCT GCTTGTCATG GTCATCTGCT ACTCGGGAAT CCTAAAAACT
CTGCTTCGGT GTCGAAATGA GAAGAAGAGG CACAGGGCTG TGAGGCTTAT CTTCACCATC
ATGATTGTTT ATTTTCTCTT CTGGGCTCCC TACAACATTG TCCTTCTCCT GAACACCTTC
CAGGAATTCT TTGGCCTGAA TAATTGCAGT AGCTCTAACA GGTTGGACCA AGCTATGCAG
GTGACAGAGA CTCTTGGGAT GACGCACTGC TGCATCAACC CCATCATCTA TGCCTTTGTC
GGGGAGAAGT TCAGAAACTA CCTCTTAGTC TTCTTCCAAA AGCACATTGC CAAACGCTTC
TGCAAATGCT GTTCTATTTT CCAGCAAGAG GCTCCCGAGC GAGCAAGCTC AGTTTACACC
CGATCCACTG GGGAGCAGGA AATATCTGTG GGCTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001093638.1
CDS123..1181
Misc Feature(1)54..56(+)
Misc Feature(2)129..131(+)
Misc Feature(3)150..152(+)
Misc Feature(4)162..164(+)
Misc Feature(5)165..167(+)
Misc Feature(6)213..296(+)
Misc Feature(7)297..1013(+)
Misc Feature(8)327..389(+)
Misc Feature(9)429..494(+)
Misc Feature(10)546..620(+)
Misc Feature(11)717..776(+)
Misc Feature(12)828..902(+)
Misc Feature(13)954..1025(+)
Misc Feature(14)1128..1130(+)
Misc Feature(15)1131..1133(+)
Misc Feature(16)1146..1148(+)
Misc Feature(17)1167..1169(+)
Exon (1)1..57
Gene:CCR5
Gene Synonym:
Exon (2)58..111
Gene:CCR5
Gene Synonym:
Exon (3)112..3426
Gene:CCR5
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001100168
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant B, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001100168

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGATTATC AAGTGTCAAG TCCAATCTAT GACATCAATT ATTATACATC GGAGCCCTGC 
CAAAAAATCA ATGTGAAGCA AATCGCAGCC CGCCTCCTGC CTCCGCTCTA CTCACTGGTG
TTCATCTTTG GTTTTGTGGG CAACATGCTG GTCATCCTCA TCCTGATAAA CTGCAAAAGG
CTGAAGAGCA TGACTGACAT CTACCTGCTC AACCTGGCCA TCTCTGACCT GTTTTTCCTT
CTTACTGTCC CCTTCTGGGC TCACTATGCT GCCGCCCAGT GGGACTTTGG AAATACAATG
TGTCAACTCT TGACAGGGCT CTATTTTATA GGCTTCTTCT CTGGAATCTT CTTCATCATC
CTCCTGACAA TCGATAGGTA CCTGGCTGTC GTCCATGCTG TGTTTGCTTT AAAAGCCAGG
ACGGTCACCT TTGGGGTGGT GACAAGTGTG ATCACTTGGG TGGTGGCTGT GTTTGCGTCT
CTCCCAGGAA TCATCTTTAC CAGATCTCAA AAAGAAGGTC TTCATTACAC CTGCAGCTCT
CATTTTCCAT ACAGTCAGTA TCAATTCTGG AAGAATTTCC AGACATTAAA GATAGTCATC
TTGGGGCTGG TCCTGCCGCT GCTTGTCATG GTCATCTGCT ACTCGGGAAT CCTAAAAACT
CTGCTTCGGT GTCGAAATGA GAAGAAGAGG CACAGGGCTG TGAGGCTTAT CTTCACCATC
ATGATTGTTT ATTTTCTCTT CTGGGCTCCC TACAACATTG TCCTTCTCCT GAACACCTTC
CAGGAATTCT TTGGCCTGAA TAATTGCAGT AGCTCTAACA GGTTGGACCA AGCTATGCAG
GTGACAGAGA CTCTTGGGAT GACGCACTGC TGCATCAACC CCATCATCTA TGCCTTTGTC
GGGGAGAAGT TCAGAAACTA CCTCTTAGTC TTCTTCCAAA AGCACATTGC CAAACGCTTC
TGCAAATGCT GTTCTATTTT CCAGCAAGAG GCTCCCGAGC GAGCAAGCTC AGTTTACACC
CGATCCACTG GGGAGCAGGA AATATCTGTG GGCTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu20119
Clone ID Related Accession (Same CDS sequence) NM_000579 , NM_001100168
Accession Version NM_000579.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1059bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 29-JUL-2015
Organism Homo sapiens (human)
Product C-C chemokine receptor type 5
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC098613.2, DA818906.1, U54994.1 and BC038398.1. This sequence is a reference standard in the RefSeqGene project. On or before Aug 31, 2013 this sequence version replaced gi:530371858, gi:157671960, gi:118572593. Transcript Variant: This variant (A) represents the longer transcript. Both variants encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by published experimental evidence. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: U54994.1, BC038398.1 [ECO:0000331] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 17417600 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGATTATC AAGTGTCAAG TCCAATCTAT GACATCAATT ATTATACATC GGAGCCCTGC 
CAAAAAATCA ATGTGAAGCA AATCGCAGCC CGCCTCCTGC CTCCGCTCTA CTCACTGGTG
TTCATCTTTG GTTTTGTGGG CAACATGCTG GTCATCCTCA TCCTGATAAA CTGCAAAAGG
CTGAAGAGCA TGACTGACAT CTACCTGCTC AACCTGGCCA TCTCTGACCT GTTTTTCCTT
CTTACTGTCC CCTTCTGGGC TCACTATGCT GCCGCCCAGT GGGACTTTGG AAATACAATG
TGTCAACTCT TGACAGGGCT CTATTTTATA GGCTTCTTCT CTGGAATCTT CTTCATCATC
CTCCTGACAA TCGATAGGTA CCTGGCTGTC GTCCATGCTG TGTTTGCTTT AAAAGCCAGG
ACGGTCACCT TTGGGGTGGT GACAAGTGTG ATCACTTGGG TGGTGGCTGT GTTTGCGTCT
CTCCCAGGAA TCATCTTTAC CAGATCTCAA AAAGAAGGTC TTCATTACAC CTGCAGCTCT
CATTTTCCAT ACAGTCAGTA TCAATTCTGG AAGAATTTCC AGACATTAAA GATAGTCATC
TTGGGGCTGG TCCTGCCGCT GCTTGTCATG GTCATCTGCT ACTCGGGAAT CCTAAAAACT
CTGCTTCGGT GTCGAAATGA GAAGAAGAGG CACAGGGCTG TGAGGCTTAT CTTCACCATC
ATGATTGTTT ATTTTCTCTT CTGGGCTCCC TACAACATTG TCCTTCTCCT GAACACCTTC
CAGGAATTCT TTGGCCTGAA TAATTGCAGT AGCTCTAACA GGTTGGACCA AGCTATGCAG
GTGACAGAGA CTCTTGGGAT GACGCACTGC TGCATCAACC CCATCATCTA TGCCTTTGTC
GGGGAGAAGT TCAGAAACTA CCTCTTAGTC TTCTTCCAAA AGCACATTGC CAAACGCTTC
TGCAAATGCT GTTCTATTTT CCAGCAAGAG GCTCCCGAGC GAGCAAGCTC AGTTTACACC
CGATCCACTG GGGAGCAGGA AATATCTGTG GGCTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000570.1
CDS358..1416
Misc Feature(1)277..279(+)
Misc Feature(2)364..366(+)
Misc Feature(3)364..366(+)
Misc Feature(4)373..375(+)
Misc Feature(5)385..387(+)
Misc Feature(6)385..387(+)
Misc Feature(7)397..399(+)
Misc Feature(8)397..399(+)
Misc Feature(9)400..402(+)
Misc Feature(10)400..402(+)
Misc Feature(11)448..531(+)
Misc Feature(12)532..1248(+)
Misc Feature(13)562..624(+)
Misc Feature(14)664..729(+)
Misc Feature(15)781..855(+)
Misc Feature(16)952..1011(+)
Misc Feature(17)1063..1137(+)
Misc Feature(18)1189..1260(+)
Misc Feature(19)1318..1320(+)
Misc Feature(20)1324..1326(+)
Misc Feature(21)1327..1329(+)
Misc Feature(22)1363..1365(+)
Misc Feature(23)1363..1365(+)
Misc Feature(24)1366..1368(+)
Misc Feature(25)1366..1368(+)
Misc Feature(26)1381..1383(+)
Misc Feature(27)1381..1383(+)
Misc Feature(28)1402..1404(+)
Misc Feature(29)1402..1404(+)
Exon (1)1..57
Gene:CCR5
Gene Synonym:
Exon (2)58..346
Gene:CCR5
Gene Synonym:
Exon (3)347..3661
Gene:CCR5
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000579
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) receptor 5 (gene/pseudogene) (CCR5), transcript variant A, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000579

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGATTATC AAGTGTCAAG TCCAATCTAT GACATCAATT ATTATACATC GGAGCCCTGC 
CAAAAAATCA ATGTGAAGCA AATCGCAGCC CGCCTCCTGC CTCCGCTCTA CTCACTGGTG
TTCATCTTTG GTTTTGTGGG CAACATGCTG GTCATCCTCA TCCTGATAAA CTGCAAAAGG
CTGAAGAGCA TGACTGACAT CTACCTGCTC AACCTGGCCA TCTCTGACCT GTTTTTCCTT
CTTACTGTCC CCTTCTGGGC TCACTATGCT GCCGCCCAGT GGGACTTTGG AAATACAATG
TGTCAACTCT TGACAGGGCT CTATTTTATA GGCTTCTTCT CTGGAATCTT CTTCATCATC
CTCCTGACAA TCGATAGGTA CCTGGCTGTC GTCCATGCTG TGTTTGCTTT AAAAGCCAGG
ACGGTCACCT TTGGGGTGGT GACAAGTGTG ATCACTTGGG TGGTGGCTGT GTTTGCGTCT
CTCCCAGGAA TCATCTTTAC CAGATCTCAA AAAGAAGGTC TTCATTACAC CTGCAGCTCT
CATTTTCCAT ACAGTCAGTA TCAATTCTGG AAGAATTTCC AGACATTAAA GATAGTCATC
TTGGGGCTGG TCCTGCCGCT GCTTGTCATG GTCATCTGCT ACTCGGGAAT CCTAAAAACT
CTGCTTCGGT GTCGAAATGA GAAGAAGAGG CACAGGGCTG TGAGGCTTAT CTTCACCATC
ATGATTGTTT ATTTTCTCTT CTGGGCTCCC TACAACATTG TCCTTCTCCT GAACACCTTC
CAGGAATTCT TTGGCCTGAA TAATTGCAGT AGCTCTAACA GGTTGGACCA AGCTATGCAG
GTGACAGAGA CTCTTGGGAT GACGCACTGC TGCATCAACC CCATCATCTA TGCCTTTGTC
GGGGAGAAGT TCAGAAACTA CCTCTTAGTC TTCTTCCAAA AGCACATTGC CAAACGCTTC
TGCAAATGCT GTTCTATTTT CCAGCAAGAG GCTCCCGAGC GAGCAAGCTC AGTTTACACC
CGATCCACTG GGGAGCAGGA AATATCTGTG GGCTTGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Specificity for a CCR5 Inhibitor Is Conferred by a Single Amino Acid Residue: ROLE OF ILE198
J. Biol. Chem. 290 (17), 11041-11051 (2015)
Lau G, Labrecque J, Metz M, Vaz R and Fricker SP.


book

Biased signaling at chemokine receptors
J. Biol. Chem. 290 (15), 9542-9554 (2015)
Corbisier J, Gales C, Huszagh A, Parmentier M and Springael JY.


book

CCR5 receptor antagonists block metastasis to bone of v-Src oncogene-transformed metastatic prostate cancer cell lines
Cancer Res. 74 (23), 7103-7114 (2014)
Sicoli D, Jiao X, Ju X, Velasco-Velazquez M, Ertel A, Addya S, Li Z, Ando S, Fatatis A, Paudyal B, Cristofanilli M, Thakur ML, Lisanti MP and Pestell RG.


book

Relationship between chemokine receptor 5 Delta32/W gene polymorphism and lupus nephritis
Hum. Immunol. 75 (9), 968-972 (2014)
Zhou TB, Jiang ZP, Zhou JF and Su N.


book

Prevalence of CCR5-delta32 mutation in asthmatic and non-asthmatic subjects from department of medicine, JUCM, Cracow
Folia Med Cracov 54 (4), 5-13 (2014)
Gomulska M, Rusin G and Gwiazdak P.


book

Polymorphisms of chemokine and chemokine receptor genes in idiopathic immune-mediated posterior segment uveitis
Mol. Vis. 13, 388-396 (2007)
Ahad MA, Missotten T, Abdallah A, Lympany PA and Lightman S.


book

Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family
Nucleic Acids Res. 18 (6), 1513-1516 (1990)
Madsen HO, Poulsen K, Dahl O, Clark BF and Hjorth JP.


book

Murine elongation factor 1 alpha (EF-1 alpha) is posttranslationally modified by novel amide-linked ethanolamine-phosphoglycerol moieties. Addition of ethanolamine-phosphoglycerol to specific glutamic acid residues on EF-1 alpha
J. Biol. Chem. 264 (24), 14334-14341 (1989)
Whiteheart SW, Shenbagamurthi P, Chen L, Cotter RJ and Hart GW.


book

Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha
J. Biol. Chem. 264 (10), 5791-5798 (1989)
Uetsuki T, Naito A, Nagata S and Kaziro Y.


book

Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs
J. Biol. Chem. 263 (14), 6656-6664 (1988)
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M and Kaziro Y.


 
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