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CALR3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CALR3
Entrez Gene ID 125972
Full Name calreticulin 3
Synonyms CMH19, CRT2, CT93
General protein information
Preferred Names
calreticulin-3
Names
calreticulin-3
calsperin
calreticulin-2
cancer/testis antigen 93
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.11

Summary The protein encoded by this gene belongs to the calreticulin family, members of which are calcium-binding chaperones localized mainly in the endoplasmic reticulum. This protein is also localized to the endoplasmic reticulum lumen, however, its capacity for calcium-binding may be absent or much lower than other family members. This gene is specifically expressed in the testis, and may be required for sperm fertility. Mutation in this gene has been associated with familial hypertrophic cardiomyopathy. [provided by RefSeq, Dec 2011]. lac of sum
Disorder MIM:

611414


mRNA and Protein(s)

mRNA Protein Name
NM_145046 NP_659483 calreticulin-3 precursor


Homo sapiens (human) CALR3 NP_659483.2
Pan troglodytes (chimpanzee) CALR3 XP_003316226.1
Canis lupus familiaris (dog) CALR3 XP_533885.1
Bos taurus (cattle) CALR3 NP_001033603.1
Mus musculus (house mouse) Calr3 NP_082776.2
Rattus norvegicus (Norway rat) Calr3 NP_001012212.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CALR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CALR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19764
NM_145046 Homo sapiens calreticulin 3 (CALR3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19764
Clone ID Related Accession (Same CDS sequence) NM_145046
Accession Version NM_145046.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1155bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product calreticulin-3 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC014595.2, DB459545.1, AB576176.1, BP370084.1, AA910019.1 and AA724299.1. This sequence is a reference standard in the RefSeqGene project. On Dec 20, 2011 this sequence version replaced gi:187608347. ##Evidence-Data-START## Transcript exon combination :: BC014595.2, AK058084.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGCCCGGG CTTTGGTCCA GCTCTGGGCC ATATGCATGC TGCGAGTGGC GCTGGCTACC 
GTCTATTTCC AAGAGGAATT TCTAGACGGA GAGCATTGGA GAAACCGATG GTTGCAGTCC
ACCAATGACT CCCGATTTGG GCATTTTAGA CTTTCGTCGG GCAAGTTTTA TGGTCATAAA
GAGAAAGATA AAGGTCTGCA AACCACTCAG AATGGCCGAT TCTATGCCAT CTCTGCACGC
TTCAAACCGT TCAGCAATAA AGGGAAAACT CTGGTTATTC AGTACACAGT AAAACATGAG
CAGAAGATGG ACTGTGGAGG GGGCTACATT AAGGTCTTTC CTGCAGACAT TGACCAGAAG
AACCTGAATG GAAAATCGCA GTACTATATT ATGTTTGGAC CCGATATTTG TGGATTTGAT
ATCAAGAAAG TTCATGTTAT TTTACATTTC AAGAATAAGT ATCACGAAAA CAAGAAACTG
ATCAGGTGTA AGGTTGATGG CTTCACACAC CTGTACACTC TAATTTTAAG ACCAGATCTT
TCTTATGATG TGAAAATTGA TGGTCAGTCA ATTGAATCCG GCAGCATAGA GTACGACTGG
AACTTAACAT CACTCAAGAA GGAAACGTCC CCGGCAGAAT CGAAGGATTG GGAACAGACT
AAAGACAACA AAGCCCAGGA CTGGGAGAAG CATTTTCTGG ACGCCAGCAC CAGCAAGCAG
AGCGACTGGA ACGGTGACCT GGATGGGGAC TGGCCAGCGC CGATGCTCCA GAAGCCCCCG
TACCAGGATG GCCTGAAACC AGAAGGTATT CATAAAGACG TCTGGCTCCA CCGTAAGATG
AAGAATACCG ACTATTTGAC GCAGTATGAC CTCTCAGAAT TTGAGAACAT TGGTGCCATT
GGCCTGGAGC TTTGGCAGGT GAGATCTGGA ACCATTTTTG ATAACTTTCT GATCACAGAT
GATGAAGAGT ACGCAGATAA TTTTGGCAAG GCCACCTGGG GCGAAACCAA GGGTCCAGAA
AGGGAGATGG ATGCCATACA GGCCAAGGAG GAAATGAAGA AGGCCCGCGA GGAAGAGGAG
GAAGAGCTGC TGTCGGGAAA AATTAACAGG CACGAACATT ACTTCAATCA ATTTCACAGA
AGGAATGAAC TTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_659483.2
CDS64..1218
Misc Feature(1)25..27(+)
Misc Feature(2)121..654(+)
Misc Feature(3)124..1017(+)
Misc Feature(4)634..798(+)
Misc Feature(5)655..945(+)
Misc Feature(6)808..912(+)
Misc Feature(7)946..1215(+)
Misc Feature(8)1204..1215(+)
Exon (1)1..154
Gene:CALR3
Gene Synonym:
Exon (2)155..256
Gene:CALR3
Gene Synonym:
Exon (3)257..460
Gene:CALR3
Gene Synonym:
Exon (4)461..555
Gene:CALR3
Gene Synonym:
Exon (5)556..741
Gene:CALR3
Gene Synonym:
Exon (6)742..849
Gene:CALR3
Gene Synonym:
Exon (7)850..981
Gene:CALR3
Gene Synonym:
Exon (8)982..1074
Gene:CALR3
Gene Synonym:
Exon (9)1075..1292
Gene:CALR3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_145046
Organism Homo sapiens (human)
Definition Homo sapiens calreticulin 3 (CALR3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_145046

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGCCCGGG CTTTGGTCCA GCTCTGGGCC ATATGCATGC TGCGAGTGGC GCTGGCTACC 
GTCTATTTCC AAGAGGAATT TCTAGACGGA GAGCATTGGA GAAACCGATG GTTGCAGTCC
ACCAATGACT CCCGATTTGG GCATTTTAGA CTTTCGTCGG GCAAGTTTTA TGGTCATAAA
GAGAAAGATA AAGGTCTGCA AACCACTCAG AATGGCCGAT TCTATGCCAT CTCTGCACGC
TTCAAACCGT TCAGCAATAA AGGGAAAACT CTGGTTATTC AGTACACAGT AAAACATGAG
CAGAAGATGG ACTGTGGAGG GGGCTACATT AAGGTCTTTC CTGCAGACAT TGACCAGAAG
AACCTGAATG GAAAATCGCA GTACTATATT ATGTTTGGAC CCGATATTTG TGGATTTGAT
ATCAAGAAAG TTCATGTTAT TTTACATTTC AAGAATAAGT ATCACGAAAA CAAGAAACTG
ATCAGGTGTA AGGTTGATGG CTTCACACAC CTGTACACTC TAATTTTAAG ACCAGATCTT
TCTTATGATG TGAAAATTGA TGGTCAGTCA ATTGAATCCG GCAGCATAGA GTACGACTGG
AACTTAACAT CACTCAAGAA GGAAACGTCC CCGGCAGAAT CGAAGGATTG GGAACAGACT
AAAGACAACA AAGCCCAGGA CTGGGAGAAG CATTTTCTGG ACGCCAGCAC CAGCAAGCAG
AGCGACTGGA ACGGTGACCT GGATGGGGAC TGGCCAGCGC CGATGCTCCA GAAGCCCCCG
TACCAGGATG GCCTGAAACC AGAAGGTATT CATAAAGACG TCTGGCTCCA CCGTAAGATG
AAGAATACCG ACTATTTGAC GCAGTATGAC CTCTCAGAAT TTGAGAACAT TGGTGCCATT
GGCCTGGAGC TTTGGCAGGT GAGATCTGGA ACCATTTTTG ATAACTTTCT GATCACAGAT
GATGAAGAGT ACGCAGATAA TTTTGGCAAG GCCACCTGGG GCGAAACCAA GGGTCCAGAA
AGGGAGATGG ATGCCATACA GGCCAAGGAG GAAATGAAGA AGGCCCGCGA GGAAGAGGAG
GAAGAGCTGC TGTCGGGAAA AATTAACAGG CACGAACATT ACTTCAATCA ATTTCACAGA
AGGAATGAAC TTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Multiple loci are associated with white blood cell phenotypes
PLoS Genet. 7 (6), E1002113 (2011)
Nalls MA, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, Wood AR, Garcia M, Gasparini P, Liu Y, Lumley T, Folsom AR, Reiner AP, Gieger C, Lagou V, Felix JF, Volzke H, Gouskova NA, Biffi A, Doring A, Volker U, Chong S, Wiggins KL, Rendon A, Dehghan A, Moore M, Taylor K, Wilson JG, Lettre G, Hofman A, Bis JC, Pirastu N, Fox CS, Meisinger C, Sambrook J, Arepalli S, Nauck M, Prokisch H, Stephens J, Glazer NL, Cupples LA, Okada Y, Takahashi A, Kamatani Y, Matsuda K, Tsunoda T, Tanaka T, Kubo M, Nakamura Y, Yamamoto K, Kamatani N, Stumvoll M, Tonjes A, Prokopenko I, Illig T, Patel KV, Garner SF, Kuhnel B, Mangino M, Oostra BA, Thein SL, Coresh J, Wichmann HE, Menzel S, Lin J, Pistis G, Uitterlinden AG, Spector TD, Teumer A, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Ouwehand WH, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Soranzo N, Witteman JC, Psaty BM, Ferrucci L, Harris TB, O'Donnell CJ and Ganesh SK.


book

Calreticulin-2 is localized in the lumen of the endoplasmic reticulum but is not a Ca2+ -binding protein
Histochem. Cell Biol. 135 (6), 531-538 (2011)
Nomura R, Orii M and Senda T.


book

Identification of a novel cancer-testis antigen CRT2 frequently expressed in various cancers using representational differential analysis
Clin. Cancer Res. 13 (21), 6267-6274 (2007)
Hayashi E, Matsuzaki Y, Hasegawa G, Yaguchi T, Kurihara S, Fujita T, Kageshita T, Sano M and Kawakami Y.


book

Identification of a novel calreticulin isoform (Crt2) in human and mouse
Gene 297 (1-2), 151-158 (2002)
Persson S, Rosenquist M and Sommarin M.


 
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