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HIST2H3C histone cluster 2, H3c [Homo sapiens (human)]

Gene Symbol HIST2H3C
Entrez Gene ID 126961
Full Name histone cluster 2, H3c
Synonyms H3, H3.2, H3/M, H3F2, H3FM, H3FN
General protein information
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q21.2

Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]. lac of sum
Disorder MIM:

142780

Disorder Html:





The following HIST2H3C gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HIST2H3C gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu13909 NM_021059 Homo sapiens histone cluster 2, H3c (HIST2H3C), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu13909
Accession Version NM_021059.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 411bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector Document: User manual_GenEZ ORF Clone Products.pdf (pdf)
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags Document: MSDS_GenEZ ORF Clone Products.pdf (pdf)
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-AUG-2015
Organism Homo sapiens (human)
Product histone H3.2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF531307.1. On or before Sep 20, 2006 this sequence version replaced gi:113431186, gi:22748792, gi:19743832. Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## replication-dependent histone :: PMID: 12408966 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
ATGGCCCGTA CTAAGCAGAC TGCTCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCCACCA AGGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC
CGCTACCGGC CCGGCACCGT AGCCCTGCGG GAGATCCGGC GCTACCAGAA GTCCACGGAG
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ACGCCAAGCG CGTGACCATT
ATGCCCAAGG ACATCCAGCT GGCCCGCCGC ATCCGTGGAG AGCGGGCTTA A
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_066403.2
CDS37..447
Misc Feature(1)37..444(+)
Misc Feature(2)37..435(+)
Misc Feature(3)43..45(+)
Misc Feature(4)43..45(+)
Misc Feature(5)46..48(+)
Misc Feature(6)49..51(+)
Misc Feature(7)49..51(+)
Misc Feature(8)49..51(+)
Misc Feature(9)49..51(+)
Misc Feature(10)55..57(+)
Misc Feature(11)61..63(+)
Misc Feature(12)61..63(+)
Misc Feature(13)64..66(+)
Misc Feature(14)64..66(+)
Misc Feature(15)64..66(+)
Misc Feature(16)67..69(+)
Misc Feature(17)70..72(+)
Misc Feature(18)79..81(+)
Misc Feature(19)88..90(+)
Misc Feature(20)88..90(+)
Misc Feature(21)91..93(+)
Misc Feature(22)91..93(+)
Misc Feature(23)91..93(+)
Misc Feature(24)106..108(+)
Misc Feature(25)106..108(+)
Misc Feature(26)106..108(+)
Misc Feature(27)115..117(+)
Misc Feature(28)118..120(+)
Misc Feature(29)118..120(+)
Misc Feature(30)118..120(+)
Misc Feature(31)121..123(+)
Misc Feature(32)142..144(+)
Misc Feature(33)145..147(+)
Misc Feature(34)145..147(+)
Misc Feature(35)148..150(+)
Misc Feature(36)160..162(+)
Misc Feature(37)205..207(+)
Misc Feature(38)205..207(+)
Misc Feature(39)205..207(+)
Misc Feature(40)208..210(+)
Misc Feature(41)229..231(+)
Misc Feature(42)274..276(+)
Misc Feature(43)274..276(+)
Misc Feature(44)277..279(+)
Misc Feature(45)295..297(+)
Misc Feature(46)358..360(+)
Misc Feature(47)382..384(+)
Misc Feature(48)403..405(+)
Misc Feature(49)403..405(+)
Exon (1)1..507
Gene:HIST2H3C
Gene Synonym:
Translation
Position Chain Variation Link
201 201 c, t dbSNP:584378
234 234 a, g dbSNP:7524039
308 308 c, t dbSNP:2664732
327 327 a, c dbSNP:584902
351 351 c, t dbSNP:58712756

Target ORF information:

RefSeq Version NM_021059
Organism Homo sapiens (human)
Definition Homo sapiens histone cluster 2, H3c (HIST2H3C), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_021059

ORF Insert Sequence:

1
61
121
181
241
301
361
ATGGCCCGTA CTAAGCAGAC TGCTCGCAAG TCGACCGGCG GCAAGGCCCC GAGGAAGCAG 
CTGGCCACCA AGGCGGCCCG CAAGAGCGCG CCGGCCACGG GCGGGGTGAA GAAGCCGCAC
CGCTACCGGC CCGGCACCGT AGCCCTGCGG GAGATCCGGC GCTACCAGAA GTCCACGGAG
CTGCTGATCC GCAAGCTGCC CTTCCAGCGG CTGGTACGCG AGATCGCGCA GGACTTTAAG
ACGGACCTGC GCTTCCAGAG CTCGGCCGTG ATGGCGCTGC AGGAGGCCAG CGAGGCCTAC
CTGGTGGGGC TGTTCGAAGA CACGAACCTG TGCGCCATCC ACGCCAAGCG CGTGACCATT
ATGCCCAAGG ACATCCAGCT GGCCCGCCGC ATCCGTGGAG AGCGGGCTTA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.