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COL1A2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol COL1A2
Entrez Gene ID 1278
Full Name collagen, type I, alpha 2
Synonyms OI4
General protein information
Preferred Names
collagen alpha-2(I) chain
Names
collagen alpha-2(I) chain
type I procollagen
alpha 2(I)-collagen
alpha-2 type I collagen
collagen I, alpha-2 polypeptide
collagen of skin, tendon and bone, alpha-2 chain
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q22.1

Summary This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]. lac of sum
Disorder MIM:

120160

Disorder Html: Ehlers-Danlos syndrome, type VIIB, 130060 (3); Osteogenesis

mRNA and Protein(s)

mRNA Protein Name
NM_000089 NP_000080 collagen alpha-2(I) chain precursor



Homo sapiens (human) COL1A2 NP_000080.2
Pan troglodytes (chimpanzee) COL1A2 XP_001168894.1
Macaca mulatta (Rhesus monkey) COL1A2 XP_001097831.1
Canis lupus familiaris (dog) COL1A2 NP_001003187.1
Bos taurus (cattle) COL1A2 NP_776945.1
Mus musculus (house mouse) Col1a2 NP_031769.2
Rattus norvegicus (Norway rat) Col1a2 NP_445808.1
Gallus gallus (chicken) COL1A2 NP_001073182.2
Danio rerio (zebrafish) col1a2 NP_892013.2
Xenopus (Silurana) tropicalis (western clawed frog) col1a2 NP_001072718.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following COL1A2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COL1A2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19466 NM_000089 Homo sapiens collagen, type I, alpha 2 (COL1A2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 25 $384.30
$549.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19466
Clone ID Related Accession (Same CDS sequence) NM_000089
Accession Version NM_000089.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 4101bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 21-MAY-2015
Organism Homo sapiens (human)
Product collagen alpha-2(I) chain precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from J03464.1, AA457209.1, BC042586.1, CF125721.1, BC054498.1 and Z74616.1. This sequence is a reference standard in the RefSeqGene project. On Jun 16, 2004 this sequence version replaced gi:21536289. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: J03464.1, BC054498.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
ATGCTCAGCT TTGTGGATAC GCGGACTTTG TTGCTGCTTG CAGTAACCTT ATGCCTAGCA 
ACATGCCAAT CTTTACAAGA GGAAACTGTA AGAAAGGGCC CAGCCGGAGA TAGAGGACCA
CGTGGAGAAA GGGGTCCACC AGGCCCCCCA GGCAGAGATG GTGAAGATGG TCCCACAGGC
CCTCCTGGTC CACCTGGTCC TCCTGGCCCC CCTGGTCTCG GTGGGAACTT TGCTGCTCAG
TATGATGGAA AAGGAGTTGG ACTTGGCCCT GGACCAATGG GCTTAATGGG ACCTAGAGGC
CCACCTGGTG CAGCTGGAGC CCCAGGCCCT CAAGGTTTCC AAGGACCTGC TGGTGAGCCT
GGTGAACCTG GTCAAACTGG TCCTGCAGGT GCTCGTGGTC CAGCTGGCCC TCCTGGCAAG
GCTGGTGAAG ATGGTCACCC TGGAAAACCC GGACGACCTG GTGAGAGAGG AGTTGTTGGA
CCACAGGGTG CTCGTGGTTT CCCTGGAACT CCTGGACTTC CTGGCTTCAA AGGCATTAGG
GGACACAATG GTCTGGATGG ATTGAAGGGA CAGCCCGGTG CTCCTGGTGT GAAGGGTGAA
CCTGGTGCCC CTGGTGAAAA TGGAACTCCA GGTCAAACAG GAGCCCGTGG GCTTCCTGGT
GAGAGAGGAC GTGTTGGTGC CCCTGGCCCA GCTGGTGCCC GTGGCAGTGA TGGAAGTGTG
GGTCCCGTGG GTCCTGCTGG TCCCATTGGG TCTGCTGGCC CTCCAGGCTT CCCAGGTGCC
CCTGGCCCCA AGGGTGAAAT TGGAGCTGTT GGTAACGCTG GTCCTGCTGG TCCCGCCGGT
CCCCGTGGTG AAGTGGGTCT TCCAGGCCTC TCCGGCCCCG TTGGACCTCC TGGTAATCCT
GGAGCAAACG GCCTTACTGG TGCCAAGGGT GCTGCTGGCC TTCCCGGCGT TGCTGGGGCT
CCCGGCCTCC CTGGACCCCG CGGTATTCCT GGCCCTGTTG GTGCTGCCGG TGCTACTGGT
GCCAGAGGAC TTGTTGGTGA GCCTGGTCCA GCTGGCTCCA AAGGAGAGAG CGGTAACAAG
GGTGAGCCCG GCTCTGCTGG GCCCCAAGGT CCTCCTGGTC CCAGTGGTGA AGAAGGAAAG
AGAGGCCCTA ATGGGGAAGC TGGATCTGCC GGCCCTCCAG GACCTCCTGG GCTGAGAGGT
AGTCCTGGTT CTCGTGGTCT TCCTGGAGCT GATGGCAGAG CTGGCGTCAT GGGCCCTCCT
GGTAGTCGTG GTGCAAGTGG CCCTGCTGGA GTCCGAGGAC CTAATGGAGA TGCTGGTCGC
CCTGGGGAGC CTGGTCTCAT GGGACCCAGA GGTCTTCCTG GTTCCCCTGG AAATATCGGC
CCCGCTGGAA AAGAAGGTCC TGTCGGCCTC CCTGGCATCG ACGGCAGGCC TGGCCCAATT
GGCCCAGCTG GAGCAAGAGG AGAGCCTGGC AACATTGGAT TCCCTGGACC CAAAGGCCCC
ACTGGTGATC CTGGCAAAAA CGGTGATAAA GGTCATGCTG GTCTTGCTGG TGCTCGGGGT
GCTCCAGGTC CTGATGGAAA CAATGGTGCT CAGGGACCTC CTGGACCACA GGGTGTTCAA
GGTGGAAAAG GTGAACAGGG TCCCCCTGGT CCTCCAGGCT TCCAGGGTCT GCCTGGCCCC
TCAGGTCCCG CTGGTGAAGT TGGCAAACCA GGAGAAAGGG GTCTCCATGG TGAGTTTGGT
CTCCCTGGTC CTGCTGGTCC AAGAGGGGAA CGCGGTCCCC CAGGTGAGAG TGGTGCTGCC
GGTCCTACTG GTCCTATTGG AAGCCGAGGT CCTTCTGGAC CCCCAGGGCC TGATGGAAAC
AAGGGTGAAC CTGGTGTGGT TGGTGCTGTG GGCACTGCTG GTCCATCTGG TCCTAGTGGA
CTCCCAGGAG AGAGGGGTGC TGCTGGCATA CCTGGAGGCA AGGGAGAAAA GGGTGAACCT
GGTCTCAGAG GTGAAATTGG TAACCCTGGC AGAGATGGTG CTCGTGGTGC TCCTGGTGCT
GTAGGTGCCC CTGGTCCTGC TGGAGCCACA GGTGACCGGG GCGAAGCTGG GGCTGCTGGT
CCTGCTGGTC CTGCTGGTCC TCGGGGAAGC CCTGGTGAAC GTGGTGAGGT CGGTCCTGCT
GGCCCCAATG GATTTGCTGG TCCTGCTGGT GCTGCTGGTC AACCTGGTGC TAAAGGAGAA
AGAGGAGCCA AAGGGCCTAA GGGTGAAAAC GGTGTTGTTG GTCCCACAGG CCCCGTTGGA
GCTGCTGGCC CAGCTGGTCC AAATGGTCCC CCCGGTCCTG CTGGAAGTCG TGGTGATGGA
GGCCCCCCTG GTATGACTGG TTTCCCTGGT GCTGCTGGAC GGACTGGTCC CCCAGGACCC
TCTGGTATTT CTGGCCCTCC TGGTCCCCCT GGTCCTGCTG GGAAAGAAGG GCTTCGTGGT
CCTCGTGGTG ACCAAGGTCC AGTTGGCCGA ACTGGAGAAG TAGGTGCAGT TGGTCCCCCT
GGCTTCGCTG GTGAGAAGGG TCCCTCTGGA GAGGCTGGTA CTGCTGGACC TCCTGGCACT
CCAGGTCCTC AGGGTCTTCT TGGTGCTCCT GGTATTCTGG GTCTCCCTGG CTCGAGAGGT
GAACGTGGTC TACCAGGTGT TGCTGGTGCT GTGGGTGAAC CTGGTCCTCT TGGCATTGCC
GGCCCTCCTG GGGCCCGTGG TCCTCCTGGT GCTGTGGGTA GTCCTGGAGT CAACGGTGCT
CCTGGTGAAG CTGGTCGTGA TGGCAACCCT GGGAACGATG GTCCCCCAGG TCGCGATGGT
CAACCCGGAC ACAAGGGAGA GCGCGGTTAC CCTGGCAATA TTGGTCCCGT TGGTGCTGCA
GGTGCACCTG GTCCTCATGG CCCCGTGGGT CCTGCTGGCA AACATGGAAA CCGTGGTGAA
ACTGGTCCTT CTGGTCCTGT TGGTCCTGCT GGTGCTGTTG GCCCAAGAGG TCCTAGTGGC
CCACAAGGCA TTCGTGGCGA TAAGGGAGAG CCCGGTGAAA AGGGGCCCAG AGGTCTTCCT
GGCTTAAAGG GACACAATGG ATTGCAAGGT CTGCCTGGTA TCGCTGGTCA CCATGGTGAT
CAAGGTGCTC CTGGCTCCGT GGGTCCTGCT GGTCCTAGGG GCCCTGCTGG TCCTTCTGGC
CCTGCTGGAA AAGATGGTCG CACTGGACAT CCTGGTACAG TTGGACCTGC TGGCATTCGA
GGCCCTCAGG GTCACCAAGG CCCTGCTGGC CCCCCTGGTC CCCCTGGCCC TCCTGGACCT
CCAGGTGTAA GCGGTGGTGG TTATGACTTT GGTTACGATG GAGACTTCTA CAGGGCTGAC
CAGCCTCGCT CAGCACCTTC TCTCAGACCC AAGGACTATG AAGTTGATGC TACTCTGAAG
TCTCTCAACA ACCAGATTGA GACCCTTCTT ACTCCTGAAG GCTCTAGAAA GAACCCAGCT
CGCACATGCC GTGACTTGAG ACTCAGCCAC CCAGAGTGGA GCAGTGGTTA CTACTGGATT
GACCCTAACC AAGGATGCAC TATGGATGCT ATCAAAGTAT ACTGTGATTT CTCTACTGGC
GAAACCTGTA TCCGGGCCCA ACCTGAAAAC ATCCCAGCCA AGAACTGGTA TAGGAGCTCC
AAGGACAAGA AACACGTCTG GCTAGGAGAA ACTATCAATG CTGGCAGCCA GTTTGAATAT
AATGTAGAAG GAGTGACTTC CAAGGAAATG GCTACCCAAC TTGCCTTCAT GCGCCTGCTG
GCCAACTATG CCTCTCAGAA CATCACCTAC CACTGCAAGA ACAGCATTGC ATACATGGAT
GAGGAGACTG GCAACCTGAA AAAGGCTGTC ATTCTACAGG GCTCTAATGA TGTTGAACTT
GTTGCTGAGG GCAACAGCAG GTTCACTTAC ACTGTTCTTG TAGATGGCTG CTCTAAAAAG
ACAAATGAAT GGGGAAAGAC AATCATTGAA TACAAAACAA ATAAGCCATC ACGCCTGCCC
TTCCTTGATA TTGCACCTTT GGACATCGGT GGTGCTGACC AGGAATTCTT TGTGGACATT
GGCCCAGTCT GTTTCAAATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000080.2
CDS472..4572
Misc Feature(1)460..462(+)
Misc Feature(2)721..723(+)
Misc Feature(3)814..993(+)
Misc Feature(4)913..1092(+)
Misc Feature(5)1030..1209(+)
Misc Feature(6)1273..1452(+)
Misc Feature(7)1729..1731(+)
Misc Feature(8)1777..1962(+)
Misc Feature(9)1792..1794(+)
Misc Feature(10)1801..1803(+)
Misc Feature(11)1876..2055(+)
Misc Feature(12)2209..2418(+)
Misc Feature(13)3226..3390(+)
Misc Feature(14)3334..3510(+)
Misc Feature(15)3865..4569(+)
Exon (1)1..541
Gene:COL1A2
Gene Synonym:
Exon (2)542..552
Gene:COL1A2
Gene Synonym:
Exon (3)553..567
Gene:COL1A2
Gene Synonym:
Exon (4)568..603
Gene:COL1A2
Gene Synonym:
Exon (5)604..696
Gene:COL1A2
Gene Synonym:
Exon (6)697..750
Gene:COL1A2
Gene Synonym:
Exon (7)751..795
Gene:COL1A2
Gene Synonym:
Exon (8)796..849
Gene:COL1A2
Gene Synonym:
Exon (9)850..903
Gene:COL1A2
Gene Synonym:
Exon (10)904..957
Gene:COL1A2
Gene Synonym:
Exon (11)958..1011
Gene:COL1A2
Gene Synonym:
Exon (12)1012..1065
Gene:COL1A2
Gene Synonym:
Exon (13)1066..1110
Gene:COL1A2
Gene Synonym:
Exon (14)1111..1164
Gene:COL1A2
Gene Synonym:
Exon (15)1165..1209
Gene:COL1A2
Gene Synonym:
Exon (16)1210..1263
Gene:COL1A2
Gene Synonym:
Exon (17)1264..1362
Gene:COL1A2
Gene Synonym:
Exon (18)1363..1407
Gene:COL1A2
Gene Synonym:
Exon (19)1408..1506
Gene:COL1A2
Gene Synonym:
Exon (20)1507..1560
Gene:COL1A2
Gene Synonym:
Exon (21)1561..1668
Gene:COL1A2
Gene Synonym:
Exon (22)1669..1722
Gene:COL1A2
Gene Synonym:
Exon (23)1723..1821
Gene:COL1A2
Gene Synonym:
Exon (24)1822..1875
Gene:COL1A2
Gene Synonym:
Exon (25)1876..1974
Gene:COL1A2
Gene Synonym:
Exon (26)1975..2028
Gene:COL1A2
Gene Synonym:
Exon (27)2029..2082
Gene:COL1A2
Gene Synonym:
Exon (28)2083..2136
Gene:COL1A2
Gene Synonym:
Exon (29)2137..2190
Gene:COL1A2
Gene Synonym:
Exon (30)2191..2235
Gene:COL1A2
Gene Synonym:
Exon (31)2236..2334
Gene:COL1A2
Gene Synonym:
Exon (32)2335..2442
Gene:COL1A2
Gene Synonym:
Exon (33)2443..2496
Gene:COL1A2
Gene Synonym:
Exon (34)2497..2550
Gene:COL1A2
Gene Synonym:
Exon (35)2551..2604
Gene:COL1A2
Gene Synonym:
Exon (36)2605..2658
Gene:COL1A2
Gene Synonym:
Exon (37)2659..2766
Gene:COL1A2
Gene Synonym:
Exon (38)2767..2820
Gene:COL1A2
Gene Synonym:
Exon (39)2821..2874
Gene:COL1A2
Gene Synonym:
Exon (40)2875..3036
Gene:COL1A2
Gene Synonym:
Exon (41)3037..3144
Gene:COL1A2
Gene Synonym:
Exon (42)3145..3252
Gene:COL1A2
Gene Synonym:
Exon (43)3253..3306
Gene:COL1A2
Gene Synonym:
Exon (44)3307..3414
Gene:COL1A2
Gene Synonym:
Exon (45)3415..3468
Gene:COL1A2
Gene Synonym:
Exon (46)3469..3576
Gene:COL1A2
Gene Synonym:
Exon (47)3577..3630
Gene:COL1A2
Gene Synonym:
Exon (48)3631..3738
Gene:COL1A2
Gene Synonym:
Exon (49)3739..3997
Gene:COL1A2
Gene Synonym:
Exon (50)3998..4182
Gene:COL1A2
Gene Synonym:
Exon (51)4183..4425
Gene:COL1A2
Gene Synonym:
Exon (52)4426..5411
Gene:COL1A2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000089
Organism Homo sapiens (human)
Definition Homo sapiens collagen, type I, alpha 2 (COL1A2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000089

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
ATGCTCAGCT TTGTGGATAC GCGGACTTTG TTGCTGCTTG CAGTAACCTT ATGCCTAGCA 
ACATGCCAAT CTTTACAAGA GGAAACTGTA AGAAAGGGCC CAGCCGGAGA TAGAGGACCA
CGTGGAGAAA GGGGTCCACC AGGCCCCCCA GGCAGAGATG GTGAAGATGG TCCCACAGGC
CCTCCTGGTC CACCTGGTCC TCCTGGCCCC CCTGGTCTCG GTGGGAACTT TGCTGCTCAG
TATGATGGAA AAGGAGTTGG ACTTGGCCCT GGACCAATGG GCTTAATGGG ACCTAGAGGC
CCACCTGGTG CAGCTGGAGC CCCAGGCCCT CAAGGTTTCC AAGGACCTGC TGGTGAGCCT
GGTGAACCTG GTCAAACTGG TCCTGCAGGT GCTCGTGGTC CAGCTGGCCC TCCTGGCAAG
GCTGGTGAAG ATGGTCACCC TGGAAAACCC GGACGACCTG GTGAGAGAGG AGTTGTTGGA
CCACAGGGTG CTCGTGGTTT CCCTGGAACT CCTGGACTTC CTGGCTTCAA AGGCATTAGG
GGACACAATG GTCTGGATGG ATTGAAGGGA CAGCCCGGTG CTCCTGGTGT GAAGGGTGAA
CCTGGTGCCC CTGGTGAAAA TGGAACTCCA GGTCAAACAG GAGCCCGTGG GCTTCCTGGT
GAGAGAGGAC GTGTTGGTGC CCCTGGCCCA GCTGGTGCCC GTGGCAGTGA TGGAAGTGTG
GGTCCCGTGG GTCCTGCTGG TCCCATTGGG TCTGCTGGCC CTCCAGGCTT CCCAGGTGCC
CCTGGCCCCA AGGGTGAAAT TGGAGCTGTT GGTAACGCTG GTCCTGCTGG TCCCGCCGGT
CCCCGTGGTG AAGTGGGTCT TCCAGGCCTC TCCGGCCCCG TTGGACCTCC TGGTAATCCT
GGAGCAAACG GCCTTACTGG TGCCAAGGGT GCTGCTGGCC TTCCCGGCGT TGCTGGGGCT
CCCGGCCTCC CTGGACCCCG CGGTATTCCT GGCCCTGTTG GTGCTGCCGG TGCTACTGGT
GCCAGAGGAC TTGTTGGTGA GCCTGGTCCA GCTGGCTCCA AAGGAGAGAG CGGTAACAAG
GGTGAGCCCG GCTCTGCTGG GCCCCAAGGT CCTCCTGGTC CCAGTGGTGA AGAAGGAAAG
AGAGGCCCTA ATGGGGAAGC TGGATCTGCC GGCCCTCCAG GACCTCCTGG GCTGAGAGGT
AGTCCTGGTT CTCGTGGTCT TCCTGGAGCT GATGGCAGAG CTGGCGTCAT GGGCCCTCCT
GGTAGTCGTG GTGCAAGTGG CCCTGCTGGA GTCCGAGGAC CTAATGGAGA TGCTGGTCGC
CCTGGGGAGC CTGGTCTCAT GGGACCCAGA GGTCTTCCTG GTTCCCCTGG AAATATCGGC
CCCGCTGGAA AAGAAGGTCC TGTCGGCCTC CCTGGCATCG ACGGCAGGCC TGGCCCAATT
GGCCCAGCTG GAGCAAGAGG AGAGCCTGGC AACATTGGAT TCCCTGGACC CAAAGGCCCC
ACTGGTGATC CTGGCAAAAA CGGTGATAAA GGTCATGCTG GTCTTGCTGG TGCTCGGGGT
GCTCCAGGTC CTGATGGAAA CAATGGTGCT CAGGGACCTC CTGGACCACA GGGTGTTCAA
GGTGGAAAAG GTGAACAGGG TCCCCCTGGT CCTCCAGGCT TCCAGGGTCT GCCTGGCCCC
TCAGGTCCCG CTGGTGAAGT TGGCAAACCA GGAGAAAGGG GTCTCCATGG TGAGTTTGGT
CTCCCTGGTC CTGCTGGTCC AAGAGGGGAA CGCGGTCCCC CAGGTGAGAG TGGTGCTGCC
GGTCCTACTG GTCCTATTGG AAGCCGAGGT CCTTCTGGAC CCCCAGGGCC TGATGGAAAC
AAGGGTGAAC CTGGTGTGGT TGGTGCTGTG GGCACTGCTG GTCCATCTGG TCCTAGTGGA
CTCCCAGGAG AGAGGGGTGC TGCTGGCATA CCTGGAGGCA AGGGAGAAAA GGGTGAACCT
GGTCTCAGAG GTGAAATTGG TAACCCTGGC AGAGATGGTG CTCGTGGTGC TCCTGGTGCT
GTAGGTGCCC CTGGTCCTGC TGGAGCCACA GGTGACCGGG GCGAAGCTGG GGCTGCTGGT
CCTGCTGGTC CTGCTGGTCC TCGGGGAAGC CCTGGTGAAC GTGGTGAGGT CGGTCCTGCT
GGCCCCAATG GATTTGCTGG TCCTGCTGGT GCTGCTGGTC AACCTGGTGC TAAAGGAGAA
AGAGGAGCCA AAGGGCCTAA GGGTGAAAAC GGTGTTGTTG GTCCCACAGG CCCCGTTGGA
GCTGCTGGCC CAGCTGGTCC AAATGGTCCC CCCGGTCCTG CTGGAAGTCG TGGTGATGGA
GGCCCCCCTG GTATGACTGG TTTCCCTGGT GCTGCTGGAC GGACTGGTCC CCCAGGACCC
TCTGGTATTT CTGGCCCTCC TGGTCCCCCT GGTCCTGCTG GGAAAGAAGG GCTTCGTGGT
CCTCGTGGTG ACCAAGGTCC AGTTGGCCGA ACTGGAGAAG TAGGTGCAGT TGGTCCCCCT
GGCTTCGCTG GTGAGAAGGG TCCCTCTGGA GAGGCTGGTA CTGCTGGACC TCCTGGCACT
CCAGGTCCTC AGGGTCTTCT TGGTGCTCCT GGTATTCTGG GTCTCCCTGG CTCGAGAGGT
GAACGTGGTC TACCAGGTGT TGCTGGTGCT GTGGGTGAAC CTGGTCCTCT TGGCATTGCC
GGCCCTCCTG GGGCCCGTGG TCCTCCTGGT GCTGTGGGTA GTCCTGGAGT CAACGGTGCT
CCTGGTGAAG CTGGTCGTGA TGGCAACCCT GGGAACGATG GTCCCCCAGG TCGCGATGGT
CAACCCGGAC ACAAGGGAGA GCGCGGTTAC CCTGGCAATA TTGGTCCCGT TGGTGCTGCA
GGTGCACCTG GTCCTCATGG CCCCGTGGGT CCTGCTGGCA AACATGGAAA CCGTGGTGAA
ACTGGTCCTT CTGGTCCTGT TGGTCCTGCT GGTGCTGTTG GCCCAAGAGG TCCTAGTGGC
CCACAAGGCA TTCGTGGCGA TAAGGGAGAG CCCGGTGAAA AGGGGCCCAG AGGTCTTCCT
GGCTTAAAGG GACACAATGG ATTGCAAGGT CTGCCTGGTA TCGCTGGTCA CCATGGTGAT
CAAGGTGCTC CTGGCTCCGT GGGTCCTGCT GGTCCTAGGG GCCCTGCTGG TCCTTCTGGC
CCTGCTGGAA AAGATGGTCG CACTGGACAT CCTGGTACAG TTGGACCTGC TGGCATTCGA
GGCCCTCAGG GTCACCAAGG CCCTGCTGGC CCCCCTGGTC CCCCTGGCCC TCCTGGACCT
CCAGGTGTAA GCGGTGGTGG TTATGACTTT GGTTACGATG GAGACTTCTA CAGGGCTGAC
CAGCCTCGCT CAGCACCTTC TCTCAGACCC AAGGACTATG AAGTTGATGC TACTCTGAAG
TCTCTCAACA ACCAGATTGA GACCCTTCTT ACTCCTGAAG GCTCTAGAAA GAACCCAGCT
CGCACATGCC GTGACTTGAG ACTCAGCCAC CCAGAGTGGA GCAGTGGTTA CTACTGGATT
GACCCTAACC AAGGATGCAC TATGGATGCT ATCAAAGTAT ACTGTGATTT CTCTACTGGC
GAAACCTGTA TCCGGGCCCA ACCTGAAAAC ATCCCAGCCA AGAACTGGTA TAGGAGCTCC
AAGGACAAGA AACACGTCTG GCTAGGAGAA ACTATCAATG CTGGCAGCCA GTTTGAATAT
AATGTAGAAG GAGTGACTTC CAAGGAAATG GCTACCCAAC TTGCCTTCAT GCGCCTGCTG
GCCAACTATG CCTCTCAGAA CATCACCTAC CACTGCAAGA ACAGCATTGC ATACATGGAT
GAGGAGACTG GCAACCTGAA AAAGGCTGTC ATTCTACAGG GCTCTAATGA TGTTGAACTT
GTTGCTGAGG GCAACAGCAG GTTCACTTAC ACTGTTCTTG TAGATGGCTG CTCTAAAAAG
ACAAATGAAT GGGGAAAGAC AATCATTGAA TACAAAACAA ATAAGCCATC ACGCCTGCCC
TTCCTTGATA TTGCACCTTT GGACATCGGT GGTGCTGACC AGGAATTCTT TGTGGACATT
GGCCCAGTCT GTTTCAAATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Genetic screening of a pedigree with osteogenesis imperfecta type and identification of a novel mutation in COL1A2 pathogenic gene
Yi Chuan 37 (1), 41-47 (2015)
Rong L, Yuanping G, Jingxin P and Yibin G.


book

Notch signaling regulates col1alpha1 and col1alpha2 expression in airway fibroblasts
Exp. Biol. Med. (Maywood) 239 (12), 1589-1596 (2014)
Hu M, Ou-Yang HF, Wu CG, Qu SY, Xu XT and Wang P.


book

[IL-33/ST2 promotes airway remodeling in asthma by activating the expression of fibronectin 1 and type 1 collagen in human lung fibroblasts]
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 30 (9), 975-979 (2014)
Guo Z, Wu J, Zhao J, Liu F, Chen Y, Bi L and Dong L.


book

Sin3B mediates collagen type I gene repression by interferon gamma in vascular smooth muscle cells
Biochem. Biophys. Res. Commun. 447 (2), 263-270 (2014)
Weng X, Cheng X, Wu X, Xu H, Fang M and Xu Y.


book

Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line
Biomed Res Int 2014, 365867 (2014)
Januchowski R, Zawierucha P, Rucinski M, Nowicki M and Zabel M.


book

COL1A1/2-Related Osteogenesis Imperfecta
(in) Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Steiner,R.D., Adsit,J. and Basel,D.


book

Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis
Nat. Genet. 1 (3), 214-217 (1992)
Nusgens BV, Verellen-Dumoulin C, Hermanns-Le T, De Paepe A, Nuytinck L, Pierard GE and Lapiere CM.


book

Defective folding and stable association with protein disulfide isomerase/prolyl hydroxylase of type I procollagen with a deletion in the pro alpha 2(I) chain that preserves the Gly-X-Y repeat pattern
J. Biol. Chem. 267 (11), 7751-7757 (1992)
Chessler SD and Byers PH.


book

Recurrence of lethal osteogenesis imperfecta due to parental mosaicism for a mutation in the COL1A2 gene of type I collagen. The mosaic parent exhibits phenotypic features of a mild form of the disease
Hum. Mutat. 1 (1), 47-54 (1992)
Edwards MJ, Wenstrup RJ, Byers PH and Cohn DH.


book

Lethal perinatal osteogenesis imperfecta due to a type I collagen alpha 2(I) Gly to Arg substitution detected by chemical cleavage of an mRNA:cDNA sequence mismatch
Hum. Mutat. 1 (1), 55-62 (1992)
Bateman JF, Moeller I, Hannagan M, Chan D and Cole WG.


 
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