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COMP cDNA ORF clone, Homo sapiens (human)

Gene Symbol COMP
Entrez Gene ID 1311
Full Name cartilage oligomeric matrix protein
Synonyms EDM1, EPD1, MED, PSACH, THBS5
General protein information
Preferred Names
cartilage oligomeric matrix protein
Names
cartilage oligomeric matrix protein
TSP5
thrombospondin-5
pseudoachondroplasia (epiphyseal dysplasia 1, multiple)
cartilage oligomeric matrix protein(pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19p13.1

Summary The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Mutations can cause the osteochondrodysplasias pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

600310

Disorder Html: Pseudoachondroplasia, 177170 (3); Epiphyseal dysplasia, multiple 1,

mRNA and Protein(s)

mRNA Protein Name
NM_000095 NP_000086 cartilage oligomeric matrix protein precursor



Homo sapiens (human) COMP NP_000086.2
Pan troglodytes (chimpanzee) COMP NP_001092035.1
Macaca mulatta (Rhesus monkey) COMP XP_001115565.1
Canis lupus familiaris (dog) COMP XP_533869.2
Bos taurus (cattle) COMP NP_001159989.1
Mus musculus (house mouse) Comp NP_057894.2
Rattus norvegicus (Norway rat) Comp NP_036966.1
Gallus gallus (chicken) COMP XP_418238.2
Danio rerio (zebrafish) im:7154332 XP_002663752.3
Drosophila melanogaster (fruit fly) Tsp NP_523495.2
Xenopus (Silurana) tropicalis (western clawed frog) comp XP_002940251.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following COMP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu19189
NM_000095 Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19189
Clone ID Related Accession (Same CDS sequence) NM_000095
Accession Version NM_000095.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2274bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cartilage oligomeric matrix protein precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU120397.1, BC033676.1 and L32137.1. This sequence is a reference standard in the RefSeqGene project. On Dec 19, 2003 this sequence version replaced gi:4557482. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK223216.1, L32137.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA962337 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGGTCCCCG ACACCGCCTG CGTTCTTCTG CTCACCCTGG CTGCCCTCGG CGCGTCCGGA 
CAGGGCCAGA GCCCGTTGGG CTCAGACCTG GGCCCGCAGA TGCTTCGGGA ACTGCAGGAA
ACCAACGCGG CGCTGCAGGA CGTGCGGGAG CTGCTGCGGC AGCAGGTCAG GGAGATCACG
TTCCTGAAAA ACACGGTGAT GGAGTGTGAC GCGTGCGGGA TGCAGCAGTC AGTACGCACC
GGCCTACCCA GCGTGCGGCC CCTGCTCCAC TGCGCGCCCG GCTTCTGCTT CCCCGGCGTG
GCCTGCATCC AGACGGAGAG CGGCGCGCGC TGCGGCCCCT GCCCCGCGGG CTTCACGGGC
AACGGCTCGC ACTGCACCGA CGTCAACGAG TGCAACGCCC ACCCCTGCTT CCCCCGAGTC
CGCTGTATCA ACACCAGCCC GGGGTTCCGC TGCGAGGCTT GCCCGCCGGG GTACAGCGGC
CCCACCCACC AGGGCGTGGG GCTGGCTTTC GCCAAGGCCA ACAAGCAGGT TTGCACGGAC
ATCAACGAGT GTGAGACCGG GCAACATAAC TGCGTCCCCA ACTCCGTGTG CATCAACACC
CGGGGCTCCT TCCAGTGCGG CCCGTGCCAG CCCGGCTTCG TGGGCGACCA GGCGTCCGGC
TGCCAGCGGC GCGCACAGCG CTTCTGCCCC GACGGCTCGC CCAGCGAGTG CCACGAGCAT
GCAGACTGCG TCCTAGAGCG CGATGGCTCG CGGTCGTGCG TGTGTGCCGT TGGCTGGGCC
GGCAACGGGA TCCTCTGTGG TCGCGACACT GACCTAGACG GCTTCCCGGA CGAGAAGCTG
CGCTGCCCGG AGCGCCAGTG CCGTAAGGAC AACTGCGTGA CTGTGCCCAA CTCAGGGCAG
GAGGATGTGG ACCGCGATGG CATCGGAGAC GCCTGCGATC CGGATGCCGA CGGGGACGGG
GTCCCCAATG AAAAGGACAA CTGCCCGCTG GTGCGGAACC CAGACCAGCG CAACACGGAC
GAGGACAAGT GGGGCGATGC GTGCGACAAC TGCCGGTCCC AGAAGAACGA CGACCAAAAG
GACACAGACC AGGACGGCCG GGGCGATGCG TGCGACGACG ACATCGACGG CGACCGGATC
CGCAACCAGG CCGACAACTG CCCTAGGGTA CCCAACTCAG ACCAGAAGGA CAGTGATGGC
GATGGTATAG GGGATGCCTG TGACAACTGT CCCCAGAAGA GCAACCCGGA TCAGGCGGAT
GTGGACCACG ACTTTGTGGG AGATGCTTGT GACAGCGATC AAGACCAGGA TGGAGACGGA
CATCAGGACT CTCGGGACAA CTGTCCCACG GTGCCTAACA GTGCCCAGGA GGACTCAGAC
CACGATGGCC AGGGTGATGC CTGCGACGAC GACGACGACA ATGACGGAGT CCCTGACAGT
CGGGACAACT GCCGCCTGGT GCCTAACCCC GGCCAGGAGG ACGCGGACAG GGACGGCGTG
GGCGACGTGT GCCAGGACGA CTTTGATGCA GACAAGGTGG TAGACAAGAT CGACGTGTGT
CCGGAGAACG CTGAAGTCAC GCTCACCGAC TTCAGGGCCT TCCAGACAGT CGTGCTGGAC
CCGGAGGGTG ACGCGCAGAT TGACCCCAAC TGGGTGGTGC TCAACCAGGG AAGGGAGATC
GTGCAGACAA TGAACAGCGA CCCAGGCCTG GCTGTGGGTT ACACTGCCTT CAATGGCGTG
GACTTCGAGG GCACGTTCCA TGTGAACACG GTCACGGATG ACGACTATGC GGGCTTCATC
TTTGGCTACC AGGACAGCTC CAGCTTCTAC GTGGTCATGT GGAAGCAGAT GGAGCAAACG
TATTGGCAGG CGAACCCCTT CCGTGCTGTG GCCGAGCCTG GCATCCAACT CAAGGCTGTG
AAGTCTTCCA CAGGCCCCGG GGAACAGCTG CGGAACGCTC TGTGGCATAC AGGAGACACA
GAGTCCCAGG TGCGGCTGCT GTGGAAGGAC CCGCGAAACG TGGGTTGGAA GGACAAGAAG
TCCTATCGTT GGTTCCTGCA GCACCGGCCC CAAGTGGGCT ACATCAGGGT GCGATTCTAT
GAGGGCCCTG AGCTGGTGGC CGACAGCAAC GTGGTCTTGG ACACAACCAT GCGGGGTGGC
CGCCTGGGGG TCTTCTGCTT CTCCCAGGAG AACATCATCT GGGCCAACCT GCGTTACCGC
TGCAATGACA CCATCCCAGA GGACTATGAG ACCCATCAGC TGCGGCAAGC CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000086.2
CDS37..2310
Misc Feature(1)100..294(+)
Misc Feature(2)121..255(+)
Misc Feature(3)415..522(+)
Misc Feature(4)415..468(+)
Misc Feature(5)574..684(+)
Misc Feature(6)574..633(+)
Misc Feature(7)817..936(+)
Misc Feature(8)838..936(+)
Misc Feature(9)841..927(+)
Misc Feature(10)937..1044(+)
Misc Feature(11)937..1044(+)
Misc Feature(12)937..1044(+)
Misc Feature(13)940..1044(+)
Misc Feature(14)940..1035(+)
Misc Feature(15)940..975(+)
Misc Feature(16)979..1035(+)
Misc Feature(17)1045..1113(+)
Misc Feature(18)1045..1113(+)
Misc Feature(19)1045..1113(+)
Misc Feature(20)1048..1104(+)
Misc Feature(21)1048..1104(+)
Misc Feature(22)1114..1221(+)
Misc Feature(23)1114..1221(+)
Misc Feature(24)1117..1152(+)
Misc Feature(25)1135..1143(+)
Misc Feature(26)1156..1212(+)
Misc Feature(27)1222..1290(+)
Misc Feature(28)1222..1290(+)
Misc Feature(29)1225..1404(+)
Misc Feature(30)1225..1281(+)
Misc Feature(31)1291..1404(+)
Misc Feature(32)1291..1404(+)
Misc Feature(33)1294..1335(+)
Misc Feature(34)1339..1395(+)
Misc Feature(35)1405..1512(+)
Misc Feature(36)1513..1620(+)
Misc Feature(37)1513..1608(+)
Misc Feature(38)1516..1620(+)
Misc Feature(39)1516..1551(+)
Misc Feature(40)1555..1590(+)
Misc Feature(41)1615..2307(+)
Misc Feature(42)1672..2274(+)
Exon (1)1..115
Gene:COMP
Gene Synonym:
Exon (2)116..201
Gene:COMP
Gene Synonym:
Exon (3)202..253
Gene:COMP
Gene Synonym:
Exon (4)254..426
Gene:COMP
Gene Synonym:
Exon (5)427..564
Gene:COMP
Gene Synonym:
Exon (6)565..639
Gene:COMP
Gene Synonym:
Exon (7)640..798
Gene:COMP
Gene Synonym:
Exon (8)799..903
Gene:COMP
Gene Synonym:
Exon (9)904..1011
Gene:COMP
Gene Synonym:
Exon (10)1012..1171
Gene:COMP
Gene Synonym:
Exon (11)1172..1290
Gene:COMP
Gene Synonym:
Exon (12)1291..1343
Gene:COMP
Gene Synonym:
Exon (13)1344..1525
Gene:COMP
Gene Synonym:
Exon (14)1526..1704
Gene:COMP
Gene Synonym:
Exon (15)1705..1753
Gene:COMP
Gene Synonym:
Exon (16)1754..1950
Gene:COMP
Gene Synonym:
Exon (17)1951..2123
Gene:COMP
Gene Synonym:
Exon (18)2124..2263
Gene:COMP
Gene Synonym:
Exon (19)2264..2452
Gene:COMP
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000095
Organism Homo sapiens (human)
Definition Homo sapiens cartilage oligomeric matrix protein (COMP), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000095

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGGTCCCCG ACACCGCCTG CGTTCTTCTG CTCACCCTGG CTGCCCTCGG CGCGTCCGGA 
CAGGGCCAGA GCCCGTTGGG CTCAGACCTG GGCCCGCAGA TGCTTCGGGA ACTGCAGGAA
ACCAACGCGG CGCTGCAGGA CGTGCGGGAG CTGCTGCGGC AGCAGGTCAG GGAGATCACG
TTCCTGAAAA ACACGGTGAT GGAGTGTGAC GCGTGCGGGA TGCAGCAGTC AGTACGCACC
GGCCTACCCA GCGTGCGGCC CCTGCTCCAC TGCGCGCCCG GCTTCTGCTT CCCCGGCGTG
GCCTGCATCC AGACGGAGAG CGGCGCGCGC TGCGGCCCCT GCCCCGCGGG CTTCACGGGC
AACGGCTCGC ACTGCACCGA CGTCAACGAG TGCAACGCCC ACCCCTGCTT CCCCCGAGTC
CGCTGTATCA ACACCAGCCC GGGGTTCCGC TGCGAGGCTT GCCCGCCGGG GTACAGCGGC
CCCACCCACC AGGGCGTGGG GCTGGCTTTC GCCAAGGCCA ACAAGCAGGT TTGCACGGAC
ATCAACGAGT GTGAGACCGG GCAACATAAC TGCGTCCCCA ACTCCGTGTG CATCAACACC
CGGGGCTCCT TCCAGTGCGG CCCGTGCCAG CCCGGCTTCG TGGGCGACCA GGCGTCCGGC
TGCCAGCGGC GCGCACAGCG CTTCTGCCCC GACGGCTCGC CCAGCGAGTG CCACGAGCAT
GCAGACTGCG TCCTAGAGCG CGATGGCTCG CGGTCGTGCG TGTGTGCCGT TGGCTGGGCC
GGCAACGGGA TCCTCTGTGG TCGCGACACT GACCTAGACG GCTTCCCGGA CGAGAAGCTG
CGCTGCCCGG AGCGCCAGTG CCGTAAGGAC AACTGCGTGA CTGTGCCCAA CTCAGGGCAG
GAGGATGTGG ACCGCGATGG CATCGGAGAC GCCTGCGATC CGGATGCCGA CGGGGACGGG
GTCCCCAATG AAAAGGACAA CTGCCCGCTG GTGCGGAACC CAGACCAGCG CAACACGGAC
GAGGACAAGT GGGGCGATGC GTGCGACAAC TGCCGGTCCC AGAAGAACGA CGACCAAAAG
GACACAGACC AGGACGGCCG GGGCGATGCG TGCGACGACG ACATCGACGG CGACCGGATC
CGCAACCAGG CCGACAACTG CCCTAGGGTA CCCAACTCAG ACCAGAAGGA CAGTGATGGC
GATGGTATAG GGGATGCCTG TGACAACTGT CCCCAGAAGA GCAACCCGGA TCAGGCGGAT
GTGGACCACG ACTTTGTGGG AGATGCTTGT GACAGCGATC AAGACCAGGA TGGAGACGGA
CATCAGGACT CTCGGGACAA CTGTCCCACG GTGCCTAACA GTGCCCAGGA GGACTCAGAC
CACGATGGCC AGGGTGATGC CTGCGACGAC GACGACGACA ATGACGGAGT CCCTGACAGT
CGGGACAACT GCCGCCTGGT GCCTAACCCC GGCCAGGAGG ACGCGGACAG GGACGGCGTG
GGCGACGTGT GCCAGGACGA CTTTGATGCA GACAAGGTGG TAGACAAGAT CGACGTGTGT
CCGGAGAACG CTGAAGTCAC GCTCACCGAC TTCAGGGCCT TCCAGACAGT CGTGCTGGAC
CCGGAGGGTG ACGCGCAGAT TGACCCCAAC TGGGTGGTGC TCAACCAGGG AAGGGAGATC
GTGCAGACAA TGAACAGCGA CCCAGGCCTG GCTGTGGGTT ACACTGCCTT CAATGGCGTG
GACTTCGAGG GCACGTTCCA TGTGAACACG GTCACGGATG ACGACTATGC GGGCTTCATC
TTTGGCTACC AGGACAGCTC CAGCTTCTAC GTGGTCATGT GGAAGCAGAT GGAGCAAACG
TATTGGCAGG CGAACCCCTT CCGTGCTGTG GCCGAGCCTG GCATCCAACT CAAGGCTGTG
AAGTCTTCCA CAGGCCCCGG GGAACAGCTG CGGAACGCTC TGTGGCATAC AGGAGACACA
GAGTCCCAGG TGCGGCTGCT GTGGAAGGAC CCGCGAAACG TGGGTTGGAA GGACAAGAAG
TCCTATCGTT GGTTCCTGCA GCACCGGCCC CAAGTGGGCT ACATCAGGGT GCGATTCTAT
GAGGGCCCTG AGCTGGTGGC CGACAGCAAC GTGGTCTTGG ACACAACCAT GCGGGGTGGC
CGCCTGGGGG TCTTCTGCTT CTCCCAGGAG AACATCATCT GGGCCAACCT GCGTTACCGC
TGCAATGACA CCATCCCAGA GGACTATGAG ACCCATCAGC TGCGGCAAGC CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

[Clinical features and COMP gene mutation in a family with a pseudoachondroplasia child]
Zhongguo Dang Dai Er Ke Za Zhi 15 (11), 937-941 (2013)
Lu CT, Guo L, Zahng ZH, Lin WX, Song YZ and Feng L.


book

Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2
Bone 55 (1), 23-35 (2013)
Ishida K, Acharya C, Christiansen BA, Yik JH, DiCesare PE and Haudenschild DR.


book

A novel COMP mutation in a Chinese patient with pseudoachondroplasia
Gene 522 (1), 102-106 (2013)
Xie X, Liao L, Gao J and Luo X.


book

Early increase in serum-COMP is associated with joint damage progression over the first five years in patients with rheumatoid arthritis
BMC Musculoskelet Disord 14, 229 (2013)
Andersson ML, Svensson B, Petersson IF, Hafstrom I, Albertsson K, Forslind K, Heinegard D and Saxne T.


book

Pseudoachondroplasia and multiple epiphyseal dysplasia due to mutations in the cartilage oligomeric matrix protein gene
Nat. Genet. 10 (3), 330-336 (1995)
Briggs MD, Hoffman SM, King LM, Olsen AS, Mohrenweiser H, Leroy JG, Mortier GR, Rimoin DL, Lachman RS and Gaines ES.


book

Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasia
Nat. Genet. 10 (3), 325-329 (1995)
Hecht JT, Nelson LD, Crowder E, Wang Y, Elder FF, Harrison WR, Francomano CA, Prange CK, Lennon GG and Deere M.


book

Cartilage and bone metabolism in rheumatoid arthritis. Differences between rapid and slow progression of disease identified by serum markers of cartilage metabolism
J. Clin. Invest. 95 (3), 1071-1077 (1995)
Mansson B, Carey D, Alini M, Ionescu M, Rosenberg LC, Poole AR, Heinegard D and Saxne T.


book

Characterization of human and mouse cartilage oligomeric matrix protein
Genomics 24 (3), 435-439 (1994)
Newton G, Weremowicz S, Morton CC, Copeland NG, Gilbert DJ, Jenkins NA and Lawler J.


book

Pseudoachondroplasia
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Briggs,M.D. and Wright,M.J.


book

Multiple Epiphyseal Dysplasia, Dominant
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Briggs,M.D., Wright,M.J. and Mortier,G.R.


 
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