The following COMP gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COMP gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 2274bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||cartilage oligomeric matrix protein precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AU120397.1, BC033676.1 and
This sequence is a reference standard in the RefSeqGene project.
On Dec 19, 2003 this sequence version replaced gi:4557482.
Summary: The protein encoded by this gene is a noncollagenous
extracellular matrix (ECM) protein. It consists of five identical
glycoprotein subunits, each with EGF-like and calcium-binding
(thrombospondin-like) domains. Oligomerization results from
formation of a five-stranded coiled coil and disulfides. Binding to
other ECM proteins such as collagen appears to depend on divalent
cations. Mutations can cause the osteochondrodysplasias
pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia
(MED). [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: AK223216.1, L32137.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.