The following CORT gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CORT gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 318bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AY358561.1, BC119724.1,
BC040034.1, BF590359.1 and AL354956.13.
On Nov 11, 2010 this sequence version replaced gi:56121821.
Summary: This gene encodes a neuropeptide that is structurally
similar to somatostatin. It binds to all known somatostatin
receptors, and shares many pharmacological and functional
properties with somatostatin, including the depression of neuronal
activity. However, it also has many properties distinct from
somatostatin, such as induction of slow-wave sleep, apparently by
antagonism of the excitatory effects of acetylcholine on the
cortex, reduction of locomotor activity, and activation of cation
selective currents not responsive to somatostatin. The
preproprotein undergoes further processing into multiple mature
products. Read-through transcripts exist between this gene and the
upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as
represented in GeneID:100526739. [provided by RefSeq, Nov 2010].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
CDS uses downstream in-frame AUG :: downstream AUG is associated
with N-terminal localization
Transcript exon combination :: AY358561.1, AF013252.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.