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CORT cortistatin [Homo sapiens (human)]

Gene Symbol CORT
Entrez Gene ID 1325
Full Name cortistatin
Synonyms CST-14, CST-17, CST-29
General protein information
Preferred Names
cortistatin
Names
cortistatin
cortistatin-14
cortistatin-17
cortistatin-29
preprocortistatin
prepro-cortistatin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p36.22

Summary This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]. lac of sum
Disorder MIM:

602784

Disorder Html:





The following CORT gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CORT gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu08513 NM_001302 Homo sapiens cortistatin (CORT), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu08513
Accession Version NM_001302.4
Sequence Information ORF Nucleotide Sequence (Length: 318bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cortistatin preproprotein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY358561.1, BC119724.1, BC040034.1, BF590359.1 and AL354956.13. On Nov 11, 2010 this sequence version replaced gi:56121821. Summary: This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: downstream AUG is associated with N-terminal localization signal (PMID:11011067) ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: AY358561.1, AF013252.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
ATGCCATTGT CCCCCGGCCT CCTGCTGCTG CTGCTCTCCG GGGCCACGGC CACCGCTGCC 
CTGCCCCTGG AGGGTGGCCC CACCGGCCGA GACAGCGAGC ATATGCAGGA AGCGGCAGGA
ATAAGGAAAA GCAGCCTCCT GACTTTCCTC GCTTGGTGGT TTGAGTGGAC CTCCCAGGCC
AGTGCCGGGC CCCTCATAGG AGAGGAAGCC CGGGAGGTGG CCAGGCGGCA GGAAGGCGCA
CCCCCCCAGC AATCTGCGCG CCGGGACAGA ATGCCCTGCA GGAACTTCTT CTGGAAGACC
TTCTCCTCCT GCAAATAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001293.3
CDS506..823
Misc Feature(1)254..256(+)
Misc Feature(2)764..817(+)
Exon (1)1..604
Gene:CORT
Gene Synonym:
Exon (2)605..1231
Gene:CORT
Gene Synonym:
Translation
Position Chain Variation Link
8 8 a, g dbSNP:748149074
30 30 c, g dbSNP:139460129
84 84 c, t dbSNP:181602804
105 105 c, t dbSNP:567454488
113 113 c, g dbSNP:531444597
119 119 c, t dbSNP:759714090
122 122 -, ttg dbSNP:563965530
191 191 a, c dbSNP:767635888
214 214 a, c dbSNP:779573126
219 219 c, t dbSNP:549652789
257 257 a, g dbSNP:571238631
279 279 c, t dbSNP:538220294
288 288 g, t dbSNP:185532953
299 299 a, g, t dbSNP:189899917
307 307 c, t dbSNP:753179420
309 309 a, c dbSNP:763344643
312 312 c, t dbSNP:200789768
313 313 a, g dbSNP:369706158
320 320 c, t dbSNP:372771717
321 321 a, g dbSNP:780645425
323 323 -, gagggaa dbSNP:777360908
323 323 a, g dbSNP:749984934
328 328 a, g dbSNP:755533538
331 331 a, c dbSNP:780089892
332 332 a, g dbSNP:749206441
339 339 a, g, t dbSNP:768641510
342 342 g, t dbSNP:201903837
349 349 a, g dbSNP:747883035
351 351 c, t dbSNP:771214827
355 355 c, g dbSNP:536349877
358 358 a, g dbSNP:759710175
360 360 a, g dbSNP:769727511
366 366 a, g dbSNP:776039862
367 367 c, t dbSNP:763434278
370 370 a, g dbSNP:764523716
391 391 a, g dbSNP:751929665
393 393 a, g dbSNP:762046604
397 397 c, t dbSNP:767225736
399 399 c, t dbSNP:775638493
405 405 a, g dbSNP:377214659
406 406 c, t dbSNP:554414328
411 411 -, aag dbSNP:758193275
411 411 a, g dbSNP:779426632
413 413 c, g dbSNP:753886185
418 418 g, t dbSNP:754981461
420 420 a, c dbSNP:778952757
424 424 a, c dbSNP:760933460
427 427 c, t dbSNP:747977320
436 436 a, g, t dbSNP:142020907
441 441 c, t dbSNP:764412437
446 446 a, g dbSNP:746069598
447 447 c, g dbSNP:769970397
451 451 g, t dbSNP:746163861
454 454 a, g dbSNP:775559314
462 462 a, g dbSNP:749301910
464 464 -, agc dbSNP:763863000
466 466 c, t dbSNP:769185888
475 475 c, g dbSNP:370073315
476 476 a, g dbSNP:762291116
480 480 a, g dbSNP:767743207
486 486 a, c dbSNP:772985649
499 499 c, t dbSNP:760232306
510 510 c, t dbSNP:766073481
516 516 c, t dbSNP:753428581
518 518 c, g dbSNP:754487841
520 520 c, t dbSNP:375806455
521 521 a, g dbSNP:142755741
525 525 g, t dbSNP:758276462
526 526 -, ctg dbSNP:751279638
526 526 c, g, t dbSNP:565298894
542 542 a, t dbSNP:756292279
544 544 c, t dbSNP:780211807
545 545 a, c, g dbSNP:374605608
546 546 g, t dbSNP:368245686
552 552 c, t dbSNP:774882640
553 553 a, g dbSNP:574274425
558 558 c, t dbSNP:772545408
559 559 c, t dbSNP:182159138
560 560 a, g dbSNP:761036242
563 563 a, g dbSNP:766149209
569 569 c, t dbSNP:368651066
571 571 c, t dbSNP:759156889
573 573 g, t dbSNP:556873478
588 588 a, c dbSNP:752733385
589 589 c, t dbSNP:758278055
590 590 a, g dbSNP:764022669
593 593 c, t dbSNP:751345586
594 594 a, g dbSNP:756999760
596 596 a, g dbSNP:780307279
601 601 c, t dbSNP:370903835
610 610 a, g dbSNP:755207510
618 618 c, t dbSNP:373837353
627 627 g, t dbSNP:752753240
632 632 a, g dbSNP:547659978
636 636 c, g dbSNP:778182842
638 638 a, g dbSNP:747513324
652 652 c, g dbSNP:771479464
656 656 a, g dbSNP:781697531
658 658 c, t dbSNP:746165625
671 671 a, t dbSNP:769598738
688 688 c, t dbSNP:775156999
691 691 c, t dbSNP:375132033
692 692 a, g dbSNP:201158337
693 693 c, g dbSNP:774224705
698 698 c, g dbSNP:375844912
702 702 a, c, t dbSNP:767385934
705 705 g, t dbSNP:201163116
709 709 a, g dbSNP:765425169
715 715 c, t dbSNP:628462
716 716 c, t dbSNP:200835553
717 717 a, g dbSNP:544551198
721 721 g, t dbSNP:367676737
731 731 c, t dbSNP:751627080
732 732 a, g, t dbSNP:199777356
739 739 a, g dbSNP:746254364
740 740 a, g dbSNP:756481798
742 742 c, t dbSNP:779616729
745 745 -, c dbSNP:755613959
746 746 -, c dbSNP:779570883
746 746 c, t dbSNP:748969228
747 747 c, t dbSNP:768113640
748 748 a, c dbSNP:773865457
749 749 c, t dbSNP:747591951
750 750 c, t dbSNP:772029734
751 751 c, g dbSNP:773086446
752 752 a, c dbSNP:75501939
753 753 a, g dbSNP:760500441
758 758 c, t dbSNP:766189277
759 759 c, t dbSNP:41376048
760 760 c, t dbSNP:666103
761 761 a, g dbSNP:550348685
762 762 a, c dbSNP:764155114
763 763 a, g dbSNP:751718989
765 765 a, g dbSNP:757361401
766 766 a, c dbSNP:768186124
767 767 c, g, t dbSNP:145148065
768 768 a, g dbSNP:780453865
770 770 a, g dbSNP:749561966
772 772 a, c, g dbSNP:754668122
775 775 a, g dbSNP:747682104
777 777 c, t dbSNP:571865438
780 780 c, t dbSNP:773198534
791 791 a, t dbSNP:746947877
792 792 a, t dbSNP:770711751
798 798 -, g dbSNP:748612792
806 806 a, t dbSNP:776489624
807 807 c, t dbSNP:759210368
808 808 -, ctc dbSNP:772618348
820 820 a, g dbSNP:764397874
826 826 c, t dbSNP:774690087
832 832 c, t dbSNP:146456778
835 835 a, t dbSNP:554425969
836 836 a, g dbSNP:751029582
839 839 g, t dbSNP:375360298
845 845 c, t dbSNP:766732752
846 846 a, g dbSNP:192809834
847 847 c, t dbSNP:755252731
848 848 a, g dbSNP:778587456
852 852 a, g dbSNP:752339274
860 860 a, g dbSNP:757958192
927 927 -, tgtt dbSNP:766307113
929 929 -, tt dbSNP:751370893
960 960 c, g dbSNP:184922802
964 964 c, t dbSNP:554553942
1001 1001 c, t dbSNP:76990442
1045 1045 a, g dbSNP:76343728
1073 1073 c, t dbSNP:541272987
1091 1091 c, t dbSNP:560492454
1093 1093 a, g dbSNP:377518871
1107 1107 a, g dbSNP:558667685
1146 1146 a, g dbSNP:147076752
1176 1176 g, t dbSNP:540895114
1183 1183 c, g dbSNP:559569899
1185 1185 a, g dbSNP:529960906
1207 1207 c, t dbSNP:138494067
1227 1227 c, t dbSNP:1307497

Target ORF information:

RefSeq Version NM_001302
Organism Homo sapiens (human)
Definition Homo sapiens cortistatin (CORT), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001302

ORF Insert Sequence:

1
61
121
181
241
301
ATGCCATTGT CCCCCGGCCT CCTGCTGCTG CTGCTCTCCG GGGCCACGGC CACCGCTGCC 
CTGCCCCTGG AGGGTGGCCC CACCGGCCGA GACAGCGAGC ATATGCAGGA AGCGGCAGGA
ATAAGGAAAA GCAGCCTCCT GACTTTCCTC GCTTGGTGGT TTGAGTGGAC CTCCCAGGCC
AGTGCCGGGC CCCTCATAGG AGAGGAAGCC CGGGAGGTGG CCAGGCGGCA GGAAGGCGCA
CCCCCCCAGC AATCTGCGCG CCGGGACAGA ATGCCCTGCA GGAACTTCTT CTGGAAGACC
TTCTCCTCCT GCAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.