||ORF Nucleotide Sequence (Length: 330bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||cytochrome c oxidase subunit 6A1, mitochondrial
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK312009.1, BC107861.1 and
This sequence is a reference standard in the RefSeqGene project.
On Dec 31, 2011 this sequence version replaced gi:17999527.
Summary: Cytochrome c oxidase (COX), the terminal enzyme of the
mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. It is a heteromeric complex
consisting of 3 catalytic subunits encoded by mitochondrial genes
and multiple structural subunits encoded by nuclear genes. The
mitochondrially-encoded subunits function in the electron transfer
and the nuclear-encoded subunits may function in the regulation and
assembly of the complex. This nuclear gene encodes polypeptide 1
(liver isoform) of subunit VIa, and polypeptide 1 is found in all
non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit
VIa is encoded by a different gene, and is present only in striated
muscles. These two polypeptides share 66% amino acid sequence
identity. It has been reported that there may be several
pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However,
only one pseudogene (COX6A1P) on chromosome 1p31.1 has been
documented. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
gene product(s) localized to mito. :: reported by MitoCarta
Transcript exon combination :: BP378295.1, BP342628.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: full length.