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COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 [Homo sapiens (human)]

Gene Symbol COX6A1
Entrez Gene ID 1337
Full Name cytochrome c oxidase subunit VIa polypeptide 1
Synonyms CMTRID, COX6A, COX6AL
General protein information
Preferred Names
cytochrome c oxidase subunit 6A1, mitochondrial
Names
cytochrome c oxidase subunit 6A1, mitochondrial
COX VIa-L
cytochrome c oxidase subunit VIA-liver
cytochrome C oxidase subunit VIa homolog
cytochrome c oxidase polypeptide VIa-liver
NP_004364.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q24.2|12q24.2

Summary Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602072

Disorder Html:





The following COX6A1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX6A1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu55939 NM_004373 Homo sapiens cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$99

*Business Day
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CloneID OHu55939
Accession Version NM_004373.3
Sequence Information ORF Nucleotide Sequence (Length: 330bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cytochrome c oxidase subunit 6A1, mitochondrial
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312009.1, BC107861.1 and BP378295.1. This sequence is a reference standard in the RefSeqGene project. On Dec 31, 2011 this sequence version replaced gi:17999527. Summary: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BP378295.1, BP342628.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
ATGGCGGTAG TTGGTGTGTC CTCGGTTTCT CGGCTGCTGG GTCGGTCCCG CCCACAGCTG 
GGGCGGCCTA TGTCGAGTGG CGCCCATGGC GAAGAGGGCT CAGCTCGCAT GTGGAAGACT
CTCACCTTCT TCGTCGCGCT CCCCGGGGTG GCAGTCAGCA TGCTGAATGT GTACCTGAAG
TCGCACCACG GAGAGCACGA GAGACCCGAG TTCATCGCCT ACCCCCATCT CCGCATCAGG
ACCAAGCCGT TTCCCTGGGG AGATGGTAAC CATACTCTAT TCCATAACCC TCATGTGAAT
CCACTTCCAA CTGGCTACGA AGATGAATAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_004364.2
CDS38..367
Misc Feature(1)101..358(+)
Misc Feature(2)107..169(+)
Misc Feature(3)137..337(+)
Misc Feature(4)152..154(+)
Misc Feature(5)251..262(+)
Misc Feature(6)263..289(+)
Exon (1)1..140
Gene:COX6A1
Gene Synonym:
Exon (2)141..283
Gene:COX6A1
Gene Synonym:
Exon (3)284..572
Gene:COX6A1
Gene Synonym:
Translation
Position Chain Variation Link
5 5 a, c, t dbSNP:551025182
6 6 c, t dbSNP:768718959
8 8 c, t dbSNP:776793031
15 15 c, t dbSNP:374848276
16 16 g, t dbSNP:765164058
17 17 c, t dbSNP:750423568
19 19 g, t dbSNP:762861046
22 22 a, g dbSNP:766208343
24 24 a, c dbSNP:751278378
25 25 c, g dbSNP:754693121
27 27 a, c, g dbSNP:191333802
28 28 c, g dbSNP:367968830
29 29 a, g, t dbSNP:755516912
33 33 a, c, g dbSNP:746436073
36 36 a, g dbSNP:780608037
37 37 a, g dbSNP:747286086
41 41 g, t dbSNP:768935203
42 42 c, t dbSNP:200221639
45 45 c, t dbSNP:371574963
46 46 a, g dbSNP:762086520
49 49 c, t dbSNP:372420548
53 53 a, g, t dbSNP:780327129
56 56 a, t dbSNP:567294603
57 57 c, g, t dbSNP:375856274
58 58 -, ctcggttt dbSNP:754588549
58 58 c, t dbSNP:751396273
59 59 a, t dbSNP:759197876
60 60 c, g dbSNP:767207473
61 61 c, g, t dbSNP:752358822
63 63 g, t dbSNP:777475898
64 64 g, t dbSNP:753369445
66 66 c, g dbSNP:369319975
69 69 c, g dbSNP:746723756
73 73 c, g, t dbSNP:146320405
76 76 -, g dbSNP:760164633
81 81 c, g dbSNP:768968190
84 84 c, t dbSNP:373513642
87 87 a, g dbSNP:139069733
88 88 -, c dbSNP:767076829
90 90 c, g, t dbSNP:748364941
91 91 a, g dbSNP:773309070
96 96 c, t dbSNP:749320086
98 98 a, g dbSNP:745397763
100 100 g, t dbSNP:774093378
101 101 c, t dbSNP:759518079
102 102 a, g dbSNP:767273412
105 105 c, g dbSNP:775333422
107 107 a, g dbSNP:148951026
111 111 c, t dbSNP:763801945
118 118 a, c dbSNP:753410217
127 127 c, t dbSNP:556029536
130 130 a, t dbSNP:12828701
131 131 c, g dbSNP:756759502
133 133 c, g dbSNP:375697683
135 135 a, g dbSNP:752060150
138 138 c, t dbSNP:755484880
141 141 c, g dbSNP:756407289
143 143 c, t dbSNP:778110803
144 144 g, t dbSNP:749573412
146 146 a, g dbSNP:757479032
147 147 a, t dbSNP:143732226
149 149 g, t dbSNP:745923380
160 160 a, c dbSNP:771927851
162 162 c, g, t dbSNP:148139529
164 164 c, t dbSNP:201293121
166 166 c, t dbSNP:776541523
173 173 c, g dbSNP:761593677
174 174 c, t dbSNP:573978401
179 179 c, t dbSNP:772617717
181 181 c, t dbSNP:762468993
183 183 g, t dbSNP:767917472
193 193 a, c dbSNP:753273273
197 197 a, g dbSNP:141919390
200 200 c, t dbSNP:566337235
202 202 c, g dbSNP:764491049
220 220 g, t dbSNP:754171628
221 221 c, t dbSNP:757837742
224 224 c, t dbSNP:779149316
233 233 c, t dbSNP:750471573
235 235 c, g dbSNP:758570135
242 242 c, t dbSNP:780266939
250 250 a, c dbSNP:201634491
253 253 c, t dbSNP:746992069
256 256 c, t dbSNP:768678691
258 258 a, c dbSNP:781161214
259 259 c, t dbSNP:747925967
260 260 -, ccccatct dbSNP:778153798
261 261 c, t dbSNP:769342311
262 262 c, t dbSNP:772857750
263 263 a, c dbSNP:140243339
264 264 a, g dbSNP:762510923
266 266 c, g dbSNP:202037015
271 271 c, t dbSNP:773833020
278 278 a, g dbSNP:761211615
285 285 c, t dbSNP:773886058
286 286 a, g dbSNP:146125922
291 291 a, c dbSNP:377211866
292 292 a, c dbSNP:138997341
300 300 a, g dbSNP:762210259
302 302 a, g dbSNP:765679027
306 306 a, g dbSNP:773414676
309 309 a, g dbSNP:556385005
316 316 a, g dbSNP:142268151
319 319 c, g dbSNP:751700637
325 325 a, c, t dbSNP:755039018
329 329 c, t dbSNP:145932304
336 336 a, c dbSNP:755983285
339 339 c, t dbSNP:777663466
344 344 -, c dbSNP:745931204
346 346 a, g dbSNP:749000821
347 347 a, g dbSNP:200936136
349 349 c, t dbSNP:373626484
351 351 a, g dbSNP:538664861
352 352 a, c dbSNP:771626656
355 355 c, t dbSNP:139479998
356 356 a, g dbSNP:200045442
357 357 a, t dbSNP:149689691
366 366 -, aa dbSNP:772251366
366 366 a, c dbSNP:376655800
380 380 c, g dbSNP:763350351
381 381 c, t dbSNP:766711093
384 384 g, t dbSNP:774783726
387 387 c, g dbSNP:759821114
388 388 c, t dbSNP:140777141
389 389 a, g, t dbSNP:372792047
393 393 a, g dbSNP:756112059
407 407 c, t dbSNP:763892942
417 417 c, g dbSNP:753683592
420 420 c, t dbSNP:571988378
449 449 a, g dbSNP:549902402
512 512 a, g dbSNP:142326243
527 527 a, g dbSNP:114944041
557 557 c, g, t dbSNP:8903

Target ORF information:

RefSeq Version NM_004373
Organism Homo sapiens (human)
Definition Homo sapiens cytochrome c oxidase subunit VIa polypeptide 1 (COX6A1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004373

ORF Insert Sequence:

1
61
121
181
241
301
ATGGCGGTAG TTGGTGTGTC CTCGGTTTCT CGGCTGCTGG GTCGGTCCCG CCCACAGCTG 
GGGCGGCCTA TGTCGAGTGG CGCCCATGGC GAAGAGGGCT CAGCTCGCAT GTGGAAGACT
CTCACCTTCT TCGTCGCGCT CCCCGGGGTG GCAGTCAGCA TGCTGAATGT GTACCTGAAG
TCGCACCACG GAGAGCACGA GAGACCCGAG TTCATCGCCT ACCCCCATCT CCGCATCAGG
ACCAAGCCGT TTCCCTGGGG AGATGGTAAC CATACTCTAT TCCATAACCC TCATGTGAAT
CCACTTCCAA CTGGCTACGA AGATGAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.