The following COX6A1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the COX6A1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 330bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||cytochrome c oxidase subunit 6A1, mitochondrial
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AK312009.1, BC107861.1 and
This sequence is a reference standard in the RefSeqGene project.
On Dec 31, 2011 this sequence version replaced gi:17999527.
Summary: Cytochrome c oxidase (COX), the terminal enzyme of the
mitochondrial respiratory chain, catalyzes the electron transfer
from reduced cytochrome c to oxygen. It is a heteromeric complex
consisting of 3 catalytic subunits encoded by mitochondrial genes
and multiple structural subunits encoded by nuclear genes. The
mitochondrially-encoded subunits function in the electron transfer
and the nuclear-encoded subunits may function in the regulation and
assembly of the complex. This nuclear gene encodes polypeptide 1
(liver isoform) of subunit VIa, and polypeptide 1 is found in all
non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit
VIa is encoded by a different gene, and is present only in striated
muscles. These two polypeptides share 66% amino acid sequence
identity. It has been reported that there may be several
pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However,
only one pseudogene (COX6A1P) on chromosome 1p31.1 has been
documented. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
gene product(s) localized to mito. :: reported by MitoCarta
Transcript exon combination :: BP378295.1, BP342628.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: full length.