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CRX cDNA ORF clone, Homo sapiens (human)

Gene Symbol CRX
Entrez Gene ID 1406
Full Name cone-rod homeobox
Synonyms CORD2, CRD, LCA7, OTX3
General protein information
Preferred Names
cone-rod homeobox protein
Names
cone-rod homeobox protein
orthodenticle homeobox 3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.3

Summary The protein encoded by this gene is a photoreceptor-specific transcription factor which plays a role in the differentiation of photoreceptor cells. This homeodomain protein is necessary for the maintenance of normal cone and rod function. Mutations in this gene are associated with photoreceptor degeneration, Leber congenital amaurosis type III and the autosomal dominant cone-rod dystrophy 2. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602225

Disorder Html: Cone-rod retinal dystrophy-2, 120970 (3); Leber congenital

mRNA and Protein(s)

mRNA Protein Name
NM_000554 NP_000545 cone-rod homeobox protein


Homo sapiens (human) CRX NP_000545.1
Pan troglodytes (chimpanzee) CRX XP_524319.3
Macaca mulatta (Rhesus monkey) CRX XP_001113415.2
Canis lupus familiaris (dog) CRX NP_001003049.1
Bos taurus (cattle) CRX NP_776329.1
Mus musculus (house mouse) Crx NP_001106801.1
Rattus norvegicus (Norway rat) Crx NP_068627.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CRX gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRX cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18946
NM_000554 Homo sapiens cone-rod homeobox (CRX), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18946
Clone ID Related Accession (Same CDS sequence) NM_000554
Accession Version NM_000554.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 900bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product cone-rod homeobox protein
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL711350.1, BT007364.1, AF335249.1, AC008745.7 and BU736672.1. This sequence is a reference standard in the RefSeqGene project. On May 28, 2008 this sequence version replaced gi:87196337. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL711350.1, BC016664.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGGCGT ATATGAACCC GGGGCCCCAC TATTCTGTCA ACGCCTTGGC CCTAAGTGGC 
CCCAGTGTGG ATCTGATGCA CCAGGCTGTG CCCTACCCAA GCGCCCCCAG GAAGCAGCGG
CGGGAGCGCA CCACCTTCAC CCGGAGCCAA CTGGAGGAGC TGGAGGCACT GTTTGCCAAG
ACCCAGTACC CAGACGTCTA TGCCCGTGAG GAGGTGGCTC TGAAGATCAA TCTGCCTGAG
TCCAGGGTTC AGGTTTGGTT CAAGAACCGG AGGGCTAAAT GCAGGCAGCA GCGACAGCAG
CAGAAACAGC AGCAGCAGCC CCCAGGGGGC CAGGCCAAGG CCCGGCCTGC CAAGAGGAAG
GCGGGCACGT CCCCAAGACC CTCCACAGAT GTGTGTCCAG ACCCTCTGGG CATCTCAGAT
TCCTACAGTC CCCCTCTGCC CGGCCCCTCA GGCTCCCCAA CCACGGCAGT GGCCACTGTG
TCCATCTGGA GCCCAGCCTC AGAGTCCCCT TTGCCTGAGG CGCAGCGGGC TGGGCTGGTG
GCCTCAGGGC CGTCTCTGAC CTCCGCCCCC TATGCCATGA CCTACGCCCC GGCCTCCGCT
TTCTGCTCTT CCCCCTCCGC CTATGGGTCT CCGAGCTCCT ATTTCAGCGG CCTAGACCCC
TACCTTTCTC CCATGGTGCC CCAGCTAGGG GGCCCGGCTC TTAGCCCCCT CTCTGGCCCC
TCCGTGGGAC CTTCCCTGGC CCAGTCCCCC ACCTCCCTAT CAGGCCAGAG CTATGGCGCC
TACAGCCCCG TGGATAGCTT GGAATTCAAG GACCCCACGG GCACCTGGAA ATTCACCTAC
AATCCCATGG ACCCTCTGGA CTACAAGGAT CAGAGTGCCT GGAAGTTTCA GATCTTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000545.1
CDS205..1104
Misc Feature(1)127..129(+)
Misc Feature(2)322..486(+)
Misc Feature(3)322..483(+)
Misc Feature(4)328..480(+)
Misc Feature(5)694..954(+)
Exon (1)1..169
Gene:CRX
Gene Synonym:
Exon (2)170..304
Gene:CRX
Gene Synonym:
Exon (3)305..456
Gene:CRX
Gene Synonym:
Exon (4)457..4467
Gene:CRX
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000554
Organism Homo sapiens (human)
Definition Homo sapiens cone-rod homeobox (CRX), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000554

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGATGGCGT ATATGAACCC GGGGCCCCAC TATTCTGTCA ACGCCTTGGC CCTAAGTGGC 
CCCAGTGTGG ATCTGATGCA CCAGGCTGTG CCCTACCCAA GCGCCCCCAG GAAGCAGCGG
CGGGAGCGCA CCACCTTCAC CCGGAGCCAA CTGGAGGAGC TGGAGGCACT GTTTGCCAAG
ACCCAGTACC CAGACGTCTA TGCCCGTGAG GAGGTGGCTC TGAAGATCAA TCTGCCTGAG
TCCAGGGTTC AGGTTTGGTT CAAGAACCGG AGGGCTAAAT GCAGGCAGCA GCGACAGCAG
CAGAAACAGC AGCAGCAGCC CCCAGGGGGC CAGGCCAAGG CCCGGCCTGC CAAGAGGAAG
GCGGGCACGT CCCCAAGACC CTCCACAGAT GTGTGTCCAG ACCCTCTGGG CATCTCAGAT
TCCTACAGTC CCCCTCTGCC CGGCCCCTCA GGCTCCCCAA CCACGGCAGT GGCCACTGTG
TCCATCTGGA GCCCAGCCTC AGAGTCCCCT TTGCCTGAGG CGCAGCGGGC TGGGCTGGTG
GCCTCAGGGC CGTCTCTGAC CTCCGCCCCC TATGCCATGA CCTACGCCCC GGCCTCCGCT
TTCTGCTCTT CCCCCTCCGC CTATGGGTCT CCGAGCTCCT ATTTCAGCGG CCTAGACCCC
TACCTTTCTC CCATGGTGCC CCAGCTAGGG GGCCCGGCTC TTAGCCCCCT CTCTGGCCCC
TCCGTGGGAC CTTCCCTGGC CCAGTCCCCC ACCTCCCTAT CAGGCCAGAG CTATGGCGCC
TACAGCCCCG TGGATAGCTT GGAATTCAAG GACCCCACGG GCACCTGGAA ATTCACCTAC
AATCCCATGG ACCCTCTGGA CTACAAGGAT CAGAGTGCCT GGAAGTTTCA GATCTTGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

CRX/OTX3: a useful marker in the differential diagnosis of tumors of the pineal region and indicator of photoreceptor differentiation in medulloblastomas and atypical teratoid rhabdoid tumors
Appl. Immunohistochem. Mol. Morphol. 21 (3), 248-253 (2013)
Gielen GH, Gessi M, Denkhaus D and Pietsch T.


book

Sterile alpha motif containing 7 (samd7) is a novel crx-regulated transcriptional repressor in the retina
PLoS ONE 8 (4), E60633 (2013)
Hlawatsch J, Karlstetter M, Aslanidis A, Luckoff A, Walczak Y, Plank M, Bock J and Langmann T.


book

CRX variants in cone-rod dystrophy and mutation overview
Biochem. Biophys. Res. Commun. 426 (4), 498-503 (2012)
Huang L, Xiao X, Li S, Jia X, Wang P, Guo X and Zhang Q.


book

Immunohistochemical expression of CRX in extracranial malignant small round cell tumors
Am. J. Surg. Pathol. 36 (8), 1165-1169 (2012)
Terry J, Calicchio ML, Rodriguez-Galindo C and Perez-Atayde AR.


book

De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis
Nat. Genet. 18 (4), 311-312 (1998)
Freund,C.L., Wang,Q.L., Chen,S., Muskat,B.L., Wiles,C.D., Sheffield,V.C., Jacobson,S.G., McInnes,R.R., Zack,D.J. and Stone,E.M.


book

Mutations in the cone-rod homeobox gene are associated with the cone-rod dystrophy photoreceptor degeneration
Neuron 19 (6), 1329-1336 (1997)
Swain PK, Chen S, Wang QL, Affatigato LM, Coats CL, Brady KD, Fishman GA, Jacobson SG, Swaroop A, Stone E, Sieving PA and Zack DJ.


book

Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor
Cell 91 (4), 543-553 (1997)
Freund CL, Gregory-Evans CY, Furukawa T, Papaioannou M, Looser J, Ploder L, Bellingham J, Ng D, Herbrick JA, Duncan A, Scherer SW, Tsui LC, Loutradis-Anagnostou A, Jacobson SG, Cepko CL, Bhattacharya SS and McInnes RR.


book

Genetic linkage of cone-rod retinal dystrophy to chromosome 19q and evidence for segregation distortion
Nat. Genet. 6 (2), 210-213 (1994)
Evans K, Fryer A, Inglehearn C, Duvall-Young J, Whittaker JL, Gregory CY, Butler R, Ebenezer N, Hunt DM and Bhattacharya S.


book

Retinitis Pigmentosa Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Fahim,A.T., Daiger,S.P. and Weleber,R.G.


book

Leber Congenital Amaurosis
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Weleber,R.G., Francis,P.J., Trzupek,K.M. and Beattie,C.


 
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