The following CRYGD gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CRYGD gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||Documents for ORF clone product in dufault vector
||ORF Nucleotide Sequence (Length: 525bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BC117338.1, U66583.1,
EL946552.1 and CD674533.1.
This sequence is a reference standard in the RefSeqGene project.
On Apr 2, 2008 this sequence version replaced gi:13377001.
Summary: Crystallins are separated into two classes:
taxon-specific, or enzyme, and ubiquitous. The latter class
constitutes the major proteins of vertebrate eye lens and maintains
the transparency and refractive index of the lens. Since lens
central fiber cells lose their nuclei during development, these
crystallins are made and then retained throughout life, making them
extremely stable proteins. Mammalian lens crystallins are divided
into alpha, beta, and gamma families; beta and gamma crystallins
are also considered as a superfamily. Alpha and beta families are
further divided into acidic and basic groups. Seven protein regions
exist in crystallins: four homologous motifs, a connecting peptide,
and N- and C-terminal extensions. Gamma-crystallins are a
homogeneous group of highly symmetrical, monomeric proteins
typically lacking connecting peptides and terminal extensions. They
are differentially regulated after early development. Four
gamma-crystallin genes (gamma-A through gamma-D) and three
pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a
genomic segment as a gene cluster. Whether due to aging or
mutations in specific genes, gamma-crystallins have been involved
in cataract formation. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC117338.1, CD676210.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.