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GSC cDNA ORF clone, Homo sapiens (human)

Gene Symbol GSC
Entrez Gene ID 145258
Full Name goosecoid homeobox
Synonyms SAMS
General protein information
Preferred Names
homeobox protein goosecoid
Names
homeobox protein goosecoid
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

14

14q32.1

Summary This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

138890


mRNA and Protein(s)

mRNA Protein Name
NM_173849 NP_776248 homeobox protein goosecoid



Homo sapiens (human) GSC NP_776248.1
Pan troglodytes (chimpanzee) GSC NP_001074955.1
Macaca mulatta (Rhesus monkey) GSC XP_001100695.1
Canis lupus familiaris (dog) GSC XP_005623984.1
Bos taurus (cattle) GSC NP_001179315.1
Mus musculus (house mouse) Gsc NP_034481.1
Rattus norvegicus (Norway rat) Gsc NP_001178802.1
Gallus gallus (chicken) GSC NP_990662.1
Danio rerio (zebrafish) gsc NP_571092.1
Xenopus (Silurana) tropicalis (western clawed frog) gsc NP_001016704.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GSC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GSC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18704
NM_173849 Homo sapiens goosecoid homeobox (GSC), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18704
Clone ID Related Accession (Same CDS sequence) NM_173849
Accession Version NM_173849.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 774bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein goosecoid
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY177407.1. This sequence is a reference standard in the RefSeqGene project. On Mar 25, 2003 this sequence version replaced gi:27777662. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY177407.1, BC063580.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142680, SAMEA2154125 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGCCCGCCA GCATGTTCAG CATCGACAAC ATCCTAGCCG CCCGGCCGCG CTGCAAGGAC 
TCGGTGTTGC CGGTGGCGCA CAGCGCGGCG GCTCCCGTCG TCTTCCCGGC CCTGCACGGG
GACTCGCTCT ACGGCGCCAG CGGCGGCGCC TCCTCGGACT ATGGCGCCTT CTACCCGCGC
CCCGTGGCCC CCGGCGGCGC GGGCCTCCCG GCCGCGGTCA GCGGCTCCCG CCTCGGCTAC
AACAACTACT TCTACGGGCA GCTGCACGTG CAGGCGGCGC CCGTGGGCCC GGCCTGCTGC
GGGGCCGTGC CGCCGCTGGG CGCCCAGCAG TGCTCCTGCG TCCCGACGCC CCCAGGCTAC
GAGGGCCCCG GTTCGGTGCT GGTGTCCCCG GTACCGCACC AGATGCTGCC CTACATGAAC
GTGGGCACGC TGTCGCGCAC CGAGCTGCAG CTTCTCAACC AGCTGCACTG TCGGCGGAAG
CGGCGGCACC GCACCATCTT CACTGACGAG CAGCTCGAAG CTCTCGAGAA CCTCTTCCAG
GAGACCAAGT ACCCGGACGT GGGCACGCGC GAGCAGCTGG CCCGGAAAGT GCACCTCCGC
GAGGAGAAAG TGGAGGTCTG GTTTAAGAAC CGCCGCGCCA AATGGAGGCG GCAGAAGCGG
TCCTCATCAG AGGAGTCGGA GAACGCGGAG AAGTGGAACA AGACGTCGTC GTCGAAGGCG
TCACCGGAGA AGAGGGAAGA GGAAGGTAAA AGCGATTTGG ACTCGGACAG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_776248.1
CDS148..921
Misc Feature(1)628..804(+)
Misc Feature(2)628..798(+)
Misc Feature(3)634..786(+)
Exon (1)1..502
Gene:GSC
Gene Synonym:
Exon (2)503..762
Gene:GSC
Gene Synonym:
Exon (3)763..1189
Gene:GSC
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_173849
Organism Homo sapiens (human)
Definition Homo sapiens goosecoid homeobox (GSC), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_173849

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGCCCGCCA GCATGTTCAG CATCGACAAC ATCCTAGCCG CCCGGCCGCG CTGCAAGGAC 
TCGGTGTTGC CGGTGGCGCA CAGCGCGGCG GCTCCCGTCG TCTTCCCGGC CCTGCACGGG
GACTCGCTCT ACGGCGCCAG CGGCGGCGCC TCCTCGGACT ATGGCGCCTT CTACCCGCGC
CCCGTGGCCC CCGGCGGCGC GGGCCTCCCG GCCGCGGTCA GCGGCTCCCG CCTCGGCTAC
AACAACTACT TCTACGGGCA GCTGCACGTG CAGGCGGCGC CCGTGGGCCC GGCCTGCTGC
GGGGCCGTGC CGCCGCTGGG CGCCCAGCAG TGCTCCTGCG TCCCGACGCC CCCAGGCTAC
GAGGGCCCCG GTTCGGTGCT GGTGTCCCCG GTACCGCACC AGATGCTGCC CTACATGAAC
GTGGGCACGC TGTCGCGCAC CGAGCTGCAG CTTCTCAACC AGCTGCACTG TCGGCGGAAG
CGGCGGCACC GCACCATCTT CACTGACGAG CAGCTCGAAG CTCTCGAGAA CCTCTTCCAG
GAGACCAAGT ACCCGGACGT GGGCACGCGC GAGCAGCTGG CCCGGAAAGT GCACCTCCGC
GAGGAGAAAG TGGAGGTCTG GTTTAAGAAC CGCCGCGCCA AATGGAGGCG GCAGAAGCGG
TCCTCATCAG AGGAGTCGGA GAACGCGGAG AAGTGGAACA AGACGTCGTC GTCGAAGGCG
TCACCGGAGA AGAGGGAAGA GGAAGGTAAA AGCGATTTGG ACTCGGACAG CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

SAMS, a syndrome of short stature, auditory-canal atresia, mandibular hypoplasia, and skeletal abnormalities is a unique neurocristopathy caused by mutations in Goosecoid
Am. J. Hum. Genet. 93 (6), 1135-1142 (2013)
Parry DA, Logan CV, Stegmann AP, Abdelhamed ZA, Calder A, Khan S, Bonthron DT, Clowes V, Sheridan E, Ghali N, Chudley AE, Dobbie A, Stumpel CT and Johnson CA.


book

EVEN-SKIPPED HOMEOBOX 1 controls human ES cell differentiation by directly repressing GOOSECOID expression
Dev. Biol. 362 (1), 94-103 (2012)
Kalisz M, Winzi M, Bisgaard HC and Serup P.


book

Evaluation of four novel genetic variants affecting hemoglobin A1c levels in a population-based type 2 diabetes cohort (the HUNT2 study)
BMC Med. Genet. 12, 20 (2011)
Hertel JK, Johansson S, Raeder H, Platou CG, Midthjell K, Hveem K, Molven A and Njolstad PR.


book

Pedigree and genetic study of a bilateral congenital microtia family
Plast. Reconstr. Surg. 125 (3), 979-987 (2010)
Zhang Q, Zhang J and Yin W.


book

Environmental and genetic factors associated with congenital microtia: a case-control study in Jiangsu, China, 2004 to 2007
Plast. Reconstr. Surg. 124 (4), 1157-1164 (2009)
Zhang QG, Zhang J, Yu P and Shen H.


book

High-throughput mapping of a dynamic signaling network in mammalian cells
Science 307 (5715), 1621-1625 (2005)
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I and Wrana JL.


book

Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1
Mamm. Genome 15 (3), 162-178 (2004)
Namciu SJ, Friedman RD, Marsden MD, Sarausad LM, Jasoni CL and Fournier RE.


book

Joint regulation of the MAP1B promoter by HNF3beta/Foxa2 and Engrailed is the result of a highly conserved mechanism for direct interaction of homeoproteins and Fox transcription factors
Development 130 (9), 1867-1876 (2003)
Foucher I, Montesinos ML, Volovitch M, Prochiantz A and Trembleau A.


book

Negative autoregulation of the organizer-specific homeobox gene goosecoid
J. Biol. Chem. 273 (1), 627-635 (1998)
Danilov V, Blum M, Schweickert A, Campione M and Steinbeisser H.


book

Molecular cloning of the human homeobox gene goosecoid (GSC) and mapping of the gene to human chromosome 14q32.1
Genomics 21 (2), 388-393 (1994)
Blum M, De Robertis EM, Kojis T, Heinzmann C, Klisak I, Geissert D and Sparkes RS.


 
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