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MESP2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol MESP2
Entrez Gene ID 145873
Full Name mesoderm posterior bHLH transcription factor 2
Synonyms SCDO2, bHLHc6
General protein information
Preferred Names
mesoderm posterior protein 2
Names
mesoderm posterior protein 2
class C basic helix-loop-helix protein 6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

15

15q26.1

Summary This gene encodes a member of the bHLH family of transcription factors and plays a key role in defining the rostrocaudal patterning of somites via interactions with multiple Notch signaling pathways. This gene is expressed in the anterior presomitic mesoderm and is downregulated immediately after the formation of segmented somites. This gene also plays a role in the formation of epithelial somitic mesoderm and cardiac mesoderm. Mutations in the MESP2 gene cause autosomal recessive spondylocostal dystosis 2 (SCD02). [provided by RefSeq, Oct 2008]. lac of sum
Disorder MIM:

605195

Disorder Html: Spondylocostal dysostosis, autosomal recessive 2, 608681 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001039958 NP_001035047 mesoderm posterior protein 2



Homo sapiens (human) MESP2 NP_001035047.1
Pan troglodytes (chimpanzee) MESP2 XP_523152.2
Macaca mulatta (Rhesus monkey) MESP2 XP_001093605.1
Canis lupus familiaris (dog) MESP2 XP_003434391.1
Bos taurus (cattle) MESP2 XP_002696623.1
Mus musculus (house mouse) Mesp2 NP_032615.2
Rattus norvegicus (Norway rat) Mesp2 NP_001099743.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MESP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MESP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu28715
NM_001039958 Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu28715
Clone ID Related Accession (Same CDS sequence) NM_001039958
Accession Version NM_001039958.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1194bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 18-JUN-2015
Organism Homo sapiens (human)
Product mesoderm posterior protein 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BK000142.1 and AC079075.6. This sequence is a reference standard in the RefSeqGene project. On or before Mar 25, 2006 this sequence version replaced gi:89038660, gi:89039287. ##Evidence-Data-START## Transcript exon combination :: BC111413.1, BQ431918.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGCCCAGT CGCCTCCTCC GCAGAGCCTC CTCGGCCACG ACCACTGGAT CTTCGCCCAG 
GGCTGGGGCT GGGCCGGCCA CTGGGACTCC ACGTCCCCGG CCTCCTCCTC CGATTCGTCG
GGTTCGTGCC CCTGCGACGG CGCCCGCGGA CTCCCGCAGC CACAGCCTCC GAGCTGCAGC
TCCCGAGCCG CAGAGGCAGC CGCGACGACG CCCAGACGAG CGCGCACCGG ACCAGCGGGC
GGACAGCGGC AGAGCGCCAG CGAGCGGGAG AAACTGCGCA TGCGCACGCT GGCCCGCGCC
CTGCACGAGT TGCGCCGCTT TCTGCCTCCC TCCTTGGCGC CGGCCGGCCA GAGCCTGACC
AAGATCGAGA CGCTGCGCCT GGCCATCCGC TACATCGGCC ACCTATCGGC CGTGCTGGGT
CTCAGCGAGG AGAGTCTGCA GTGCCGGCGC AGGCAGCGCG GGGACGCGGG GTCCCCTTGG
GGCTGCCCGC TGTGCCCCGA CCGTGGCCCC GCAGAGGCGC AGACGCAGGC GGAGGGGCAG
GGGCAAGGGC AGGGGCAGGG GCAGGGGCAA GGGCAGGGGC AAGGACAGGG GCAAGGACAG
GGGCAAGGGC AGGGGCGCAG GCCGGGCCTG GTCTCCGCCG TCCTCGCCGA GGCGTCCTGG
GGATCCCCGT CCGCCTGCCC CGGAGCCCAA GCCGCACCCG AGCGCCTGGG GAGGGGGGTC
CACGACACGG ATCCCTGGGC AACACCCCCT TACTGCCCCA AGATACAGTC GCCCCCGTAT
TCGTCCCAAG GGACAACCTC CGACGCGTCT CTTTGGACGC CACCCCAAGG CTGTCCCTGG
ACGCAGTCGT CCCCAGAGCC CCGGAACCCA CCAGTGCCCT GGACGGCGGC CCCAGCAACT
TTGGAGCTGG CCGCAGTGTA CCAGGGTCTC TCTGTGTCTC CAGAGCCCTG TCTGTCGCTG
GGAGCTCCAT CTCTCCTGCC CCACCCATCA TGCCAGAGAC TGCAGCCTCA GACCCCCGGG
AGGTGCTGGA GCCACAGTGC AGAGGTGGTG CCCAACTCAG AGGACCAGGG ACCGGGCGCC
GCCTTCCAGC TCAGTGAAGC AAGCCCTCCC CAGAGCTCAG GCCTGCGGTT CAGTGGCTGC
CCTGAACTTT GGCAAGAAGA TCTGGAGGGG GCCCGCCTGG GCATCTTCTA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001035047.1
CDS1..1194
Misc Feature(1)244..417(+)
Misc Feature(2)244..363(+)
Misc Feature(3)268..270(+)
Misc Feature(4)286..417(+)
Misc Feature(5)535..612(+)
Exon (1)1..924
Gene:MESP2
Gene Synonym:
Exon (2)925..1614
Gene:MESP2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001039958
Organism Homo sapiens (human)
Definition Homo sapiens mesoderm posterior bHLH transcription factor 2 (MESP2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001039958

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGCCCAGT CGCCTCCTCC GCAGAGCCTC CTCGGCCACG ACCACTGGAT CTTCGCCCAG 
GGCTGGGGCT GGGCCGGCCA CTGGGACTCC ACGTCCCCGG CCTCCTCCTC CGATTCGTCG
GGTTCGTGCC CCTGCGACGG CGCCCGCGGA CTCCCGCAGC CACAGCCTCC GAGCTGCAGC
TCCCGAGCCG CAGAGGCAGC CGCGACGACG CCCAGACGAG CGCGCACCGG ACCAGCGGGC
GGACAGCGGC AGAGCGCCAG CGAGCGGGAG AAACTGCGCA TGCGCACGCT GGCCCGCGCC
CTGCACGAGT TGCGCCGCTT TCTGCCTCCC TCCTTGGCGC CGGCCGGCCA GAGCCTGACC
AAGATCGAGA CGCTGCGCCT GGCCATCCGC TACATCGGCC ACCTATCGGC CGTGCTGGGT
CTCAGCGAGG AGAGTCTGCA GTGCCGGCGC AGGCAGCGCG GGGACGCGGG GTCCCCTTGG
GGCTGCCCGC TGTGCCCCGA CCGTGGCCCC GCAGAGGCGC AGACGCAGGC GGAGGGGCAG
GGGCAAGGGC AGGGGCAGGG GCAGGGGCAA GGGCAGGGGC AAGGACAGGG GCAAGGACAG
GGGCAAGGGC AGGGGCGCAG GCCGGGCCTG GTCTCCGCCG TCCTCGCCGA GGCGTCCTGG
GGATCCCCGT CCGCCTGCCC CGGAGCCCAA GCCGCACCCG AGCGCCTGGG GAGGGGGGTC
CACGACACGG ATCCCTGGGC AACACCCCCT TACTGCCCCA AGATACAGTC GCCCCCGTAT
TCGTCCCAAG GGACAACCTC CGACGCGTCT CTTTGGACGC CACCCCAAGG CTGTCCCTGG
ACGCAGTCGT CCCCAGAGCC CCGGAACCCA CCAGTGCCCT GGACGGCGGC CCCAGCAACT
TTGGAGCTGG CCGCAGTGTA CCAGGGTCTC TCTGTGTCTC CAGAGCCCTG TCTGTCGCTG
GGAGCTCCAT CTCTCCTGCC CCACCCATCA TGCCAGAGAC TGCAGCCTCA GACCCCCGGG
AGGTGCTGGA GCCACAGTGC AGAGGTGGTG CCCAACTCAG AGGACCAGGG ACCGGGCGCC
GCCTTCCAGC TCAGTGAAGC AAGCCCTCCC CAGAGCTCAG GCCTGCGGTT CAGTGGCTGC
CCTGAACTTT GGCAAGAAGA TCTGGAGGGG GCCCGCCTGG GCATCTTCTA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine
J Proteomics 82, 193-229 (2013)
Prunotto M, Farina A, Lane L, Pernin A, Schifferli J, Hochstrasser DF, Lescuyer P and Moll S.


book

Mutation analysis of MESP2, HES7 and DUSP6 gene exons in patients with congenital scoliosis
Stud Health Technol Inform 176, 52-55 (2012)
Qiu XS, Zhou S, Jiang H, Ji ML, Ding Q, Lv F, Liu Z, Tang N, Cheng JC and Qiu Y.


book

Mutations in the MESP2 gene cause spondylothoracic dysostosis/Jarcho-Levin syndrome
Am. J. Hum. Genet. 82 (6), 1334-1341 (2008)
Cornier AS, Staehling-Hampton K, Delventhal KM, Saga Y, Caubet JF, Sasaki N, Ellard S, Young E, Ramirez N, Carlo SE, Torres J, Emans JB, Turnpenny PD and Pourquie O.


book

Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
Dev. Biol. 300 (2), 687-698 (2006)
Morimoto M, Kiso M, Sasaki N and Saga Y.


book

Mutated MESP2 causes spondylocostal dysostosis in humans
Am. J. Hum. Genet. 74 (6), 1249-1254 (2004)
Whittock NV, Sparrow DB, Wouters MA, Sillence D, Ellard S, Dunwoodie SL and Turnpenny PD.


book

Exhaustive identification of human class II basic helix-loop-helix proteins by virtual library screening
Mech. Dev. 119 (SUPPL 1), S285-S291 (2002)
McLellan AS, Langlands K and Kealey T.


book

Transcriptional regulation of Mesp1 and Mesp2 genes: differential usage of enhancers during development
Mech. Dev. 108 (1-2), 59-69 (2001)
Haraguchi S, Kitajima S, Takagi A, Takeda H, Inoue T and Saga Y.


book

Spondylocostal Dysostosis, Autosomal Recessive
(in) Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Turnpenny,P.D. and Young,E.


book

Congenital Diaphragmatic Hernia Overview
(in) Pagon RA, Adam MP, Ardinger HH, Wallace SE, Amemiya A, Bean LJH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Pober,B.R., Russell,M.K. and Ackerman,K.G.


 
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