||ORF Nucleotide Sequence (Length: 1398bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||alpha-2A adrenergic receptor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AL158163.11, AF284095.1 and
This sequence is a reference standard in the RefSeqGene project.
On Jul 22, 2008 this sequence version replaced gi:15718669.
Summary: Alpha-2-adrenergic receptors are members of the G
protein-coupled receptor superfamily. They include 3 highly
homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors
have a critical role in regulating neurotransmitter release from
sympathetic nerves and from adrenergic neurons in the central
nervous system. Studies in mouse revealed that both the alpha2A and
alpha2C subtypes were required for normal presynaptic control of
transmitter release from sympathetic nerves in the heart and from
central noradrenergic neurons; the alpha2A subtype inhibited
transmitter release at high stimulation frequencies, whereas the
alpha2C subtype modulated neurotransmission at lower levels of
nerve activity. This gene encodes alpha2A subtype and it contains
no introns in either its coding or untranslated sequences.
[provided by RefSeq, Jul 2008].
Sequence Note: The 5'-most in-frame translation initiation codon is
selected for this RefSeq based on good conservation across
mammalian species. A possible downstream start codon would result
in a protein that is 15 aa shorter at the N-terminus. The
literature, including PMIDs:2823383, 2568356, 1354394 and 1678390,
assumes the use of the downstream start codon based on initial
cloning reports, but there is no experimental evidence indicating
which start codon is preferentially used in vivo.
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
COMPLETENESS: full length.