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CYBB cytochrome b-245, beta polypeptide [Homo sapiens (human)]

Gene Symbol CYBB
Entrez Gene ID 1536
Full Name cytochrome b-245, beta polypeptide
Synonyms AMCBX2, CGD, GP91-1, GP91-PHOX, GP91PHOX, IMD34, NOX2, p91-PHOX
General protein information
Preferred Names
cytochrome b-245 heavy chain
Names
cytochrome b-245 heavy chain
CGD91-phox
NADPH oxidase 2
p22 phagocyte B-cytochrome
cytochrome b558 subunit beta
cytochrome b(558) subunit beta
neutrophil cytochrome b 91 kDa polypeptide
heme-binding membrane glycoprotein gp91phox
superoxide-generating NADPH oxidase heavy chain subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

X

Xp21.1

Summary Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

300481

Disorder Html: Chronic granulomatous disease, X-linked, 306400 (3)





The following CYBB gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYBB gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu57140 XM_011543890 PREDICTED: Homo sapiens cytochrome b-245, beta polypeptide (CYBB), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $319
OHu27109 NM_000397 Homo sapiens cytochrome b-245, beta polypeptide (CYBB), mRNA. pcDNA3.1+/C-(K)DYK or customized vector in pcDNA3.1+/C-(K)DYK $379

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu57140
Accession Version XM_011543890.1
Sequence Information ORF Nucleotide Sequence (Length: 1407bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product cytochrome b-245 heavy chain isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_079573.5) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGTGGCAT GGATGATTGC ACTTCACTCT GCGATTCACA CCATTGCACA TCTATTTAAT 
GTGGAATGGT GTGTGAATGC CCGAGTCAAT AATTCTGATC CTTATTCAGT AGCACTCTCT
GAACTTGGAG ACAGGCAAAA TGAAAGTTAT CTCAATTTTG CTCGAAAGAG AATAAAGAAC
CCTGAAGGAG GCCTGTACCT GGCTGTGACC CTGTTGGCAG GCATCACTGG AGTTGTCATC
ACGCTGTGCC TCATATTAAT TATCACTTCC TCCACCAAAA CCATCCGGAG GTCTTACTTT
GAAGTCTTTT GGTACACACA TCATCTCTTT GTGATCTTCT TCATTGGCCT TGCCATCCAT
GGAGCTGAAC GAATTGTACG TGGGCAGACC GCAGAGAGTT TGGCTGTGCA TAATATAACA
GTTTGTGAAC AAAAAATCTC AGAATGGGGA AAAATAAAGG AATGCCCAAT CCCTCAGTTT
GCTGGAAACC CTCCTATGAC TTGGAAATGG ATAGTGGGTC CCATGTTTCT GTATCTCTGT
GAGAGGTTGG TGCGGTTTTG GCGATCTCAA CAGAAGGTGG TCATCACCAA GGTGGTCACT
CACCCTTTCA AAACCATCGA GCTACAGATG AAGAAGAAGG GGTTCAAAAT GGAAGTGGGA
CAATACATTT TTGTCAAGTG CCCAAAGGTG TCCAAGCTGG AGTGGCACCC TTTTACACTG
ACATCCGCCC CTGAGGAAGA CTTCTTTAGT ATCCATATCC GCATCGTTGG GGACTGGACA
GAGGGGCTGT TCAATGCTTG TGGCTGTGAT AAGCAGGAGT TTCAAGATGC GTGGAAACTA
CCTAAGATAG CGGTTGATGG GCCCTTTGGC ACTGCCAGTG AAGATGTGTT CAGCTATGAG
GTGGTGATGT TAGTGGGAGC AGGGATTGGG GTCACACCCT TCGCATCCAT TCTCAAGTCA
GTCTGGTACA AATATTGCAA TAACGCCACC AATCTGAAGC TCAAAAAGAT CTACTTCTAC
TGGCTGTGCC GGGACACACA TGCCTTTGAG TGGTTTGCAG ATCTGCTGCA ACTGCTGGAG
AGCCAGATGC AGGAAAGGAA CAATGCCGGC TTCCTCAGCT ACAACATCTA CCTCACTGGC
TGGGATGAGT CTCAGGCCAA TCACTTTGCT GTGCACCATG ATGAGGAGAA AGATGTGATC
ACAGGCCTGA AACAAAAGAC TTTGTATGGA CGGCCCAACT GGGATAATGA ATTCAAGACA
ATTGCAAGTC AACACCCTAA TACCAGAATA GGAGTTTTCC TCTGTGGACC TGAAGCCTTG
GCTGAAACCC TGAGTAAACA AAGCATCTCC AACTCTGAGT CTGGCCCTCG GGGAGTGCAT
TTCATTTTCA ACAAGGAAAA CTTCTAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqXP_011542192.1
CDS407..1813
Misc Feature(1)407..760(+)
Misc Feature(2)989..1810(+)
Misc Feature(3)1070..1333(+)
Misc Feature(4)1112..1123(+)
Misc Feature(5)1316..1348(+)
Misc Feature(6)1316..1345(+)
Misc Feature(7)1331..1717(+)
Misc Feature(8)1424..1438(+)
Translation
Position Chain Variation Link
34 34 c, g dbSNP:151344455
42 42 c, t dbSNP:193922450
66 66 ccg, ggt dbSNP:387906486
97 97 g, t dbSNP:151344453
137 137 g, t dbSNP:151344479
138 138 c, g dbSNP:151344456
140 140 a, c dbSNP:151344480
146 146 a, c dbSNP:151344481
151 151 c, t dbSNP:151344457
153 153 c, g dbSNP:151344488
193 193 c, t dbSNP:137854588
228 228 a, g, t dbSNP:387906485
401 401 c, t dbSNP:137854594
402 402 a, g dbSNP:137854591
456 456 a, g dbSNP:151344458
489 489 c, g dbSNP:193922448
566 566 a, g dbSNP:137854590
632 632 a, c dbSNP:151344497
635 635 a, g dbSNP:151344491
678 678 c, t dbSNP:151344493
707 707 g, t dbSNP:193922449
713 713 a, t dbSNP:151344496
725 725 c, t dbSNP:137854587
726 726 a, g dbSNP:151344482
727 727 a, t dbSNP:151344459
754 754 a, c dbSNP:35080474
764 764 a, c, t dbSNP:151344460
765 765 a, g dbSNP:151344462
767 767 g, t dbSNP:151344463
768 768 g, t dbSNP:151344464
771 771 c, g dbSNP:151344483
774 774 a, t dbSNP:151344494
776 776 c, t dbSNP:137854592
792 792 a, c dbSNP:151344498
830 830 c, t dbSNP:151344465
831 831 a, c, g dbSNP:137854589
1007 1007 a, c dbSNP:137854595
1011 1011 c, g dbSNP:137854596
1019 1019 a, c dbSNP:151344489
1025 1025 a, g dbSNP:151344466
1065 1065 a, g dbSNP:151344467
1073 1073 a, t dbSNP:151344468
1097 1097 c, t dbSNP:151344469
1098 1098 c, t dbSNP:267606451
1112 1112 c, t dbSNP:151344484
1116 1116 a, c dbSNP:151344470
1125 1125 a, t dbSNP:151344495
1131 1131 c, t dbSNP:151344485
1167 1167 c, g dbSNP:151344471
1190 1190 c, g dbSNP:141756032
1240 1240 -, g dbSNP:193922445
1266 1266 a, c, g dbSNP:137854586
1314 1314 g, t dbSNP:151344472
1322 1322 a, g dbSNP:151344473
1323 1323 a, c, g dbSNP:151344474
1344 1344 a, c, t dbSNP:137854585
1359 1359 c, t dbSNP:151344486
1364 1364 c, t dbSNP:151344475
1457 1457 c, t dbSNP:151344476
1599 1599 a, g dbSNP:137854593
1614 1614 g, t dbSNP:151344490
1646 1646 c, t dbSNP:151344487
1648 1648 g, t dbSNP:151344477
1651 1651 a, t dbSNP:151344452
1701 1701 a, t dbSNP:151344478
1709 1709 c, t dbSNP:151344454
1717 1717 c, t dbSNP:187038548
1734 1734 a, c dbSNP:147991211
1737 1737 c, t dbSNP:151344492
1741 1741 c, t dbSNP:771661205
1748 1748 a, t dbSNP:748092600
1775 1775 c, t dbSNP:760298475
1776 1776 a, g dbSNP:763640811
1778 1778 a, g, t dbSNP:776358735
1781 1781 a, c, g dbSNP:766756667
1782 1782 g, t dbSNP:760011628
1785 1785 a, g dbSNP:768055122
1789 1789 c, t dbSNP:567830215
1801 1801 a, g dbSNP:140774378
1804 1804 a, g dbSNP:200528487
1817 1817 a, g dbSNP:754096410
1830 1830 g, t dbSNP:756962345
1845 1845 c, t dbSNP:778875023
1854 1854 a, c dbSNP:201232380
1955 1955 a, g dbSNP:756804428
1960 1960 a, g dbSNP:780798131
2081 2081 c, t dbSNP:535570203
2165 2165 a, c dbSNP:767755266
2197 2197 c, t dbSNP:192401117
2211 2211 a, t dbSNP:745544033
2270 2270 a, g dbSNP:34407298
2372 2372 g, t dbSNP:5964151
2402 2402 c, g dbSNP:754334687
2411 2411 c, t dbSNP:757821843
2515 2515 c, t dbSNP:779723585
2516 2516 a, g dbSNP:765908758
2547 2547 a, c dbSNP:749109015
2575 2575 a, g dbSNP:148238930
2674 2674 a, g dbSNP:17146280
2804 2804 a, t dbSNP:147429025
2850 2850 a, t dbSNP:779720905
2910 2910 a, g dbSNP:768520501
2914 2914 a, g dbSNP:774253225
2948 2948 a, g dbSNP:746650045
2954 2954 -, ac dbSNP:754748195
2971 2971 c, t dbSNP:184252383
3104 3104 c, g dbSNP:771032050
3127 3127 c, t dbSNP:748004724
3204 3204 c, t dbSNP:372880592
3222 3222 a, g dbSNP:776625919
3245 3245 a, g dbSNP:34920432
3261 3261 a, g dbSNP:773184486
3267 3267 g, t dbSNP:745909408
3346 3346 -, a dbSNP:772074883
3351 3351 -, a dbSNP:35782029
3367 3367 c, g dbSNP:775715250
3430 3430 a, g dbSNP:190415874
3458 3458 a, g dbSNP:35278070
3486 3486 c, t dbSNP:34380982
3502 3502 c, t dbSNP:765482385
3572 3572 c, t dbSNP:41303695
3597 3597 c, t dbSNP:777128323
3654 3654 c, t dbSNP:35621886
3663 3663 a, c dbSNP:763343233
3667 3667 c, t dbSNP:764744919
3852 3852 a, g dbSNP:765792906
3888 3888 a, g dbSNP:184490051
4073 4073 -, g dbSNP:762462467
4103 4103 a, g dbSNP:79650864
4105 4105 -, t dbSNP:11338914
4108 4108 c, t dbSNP:74486909
4127 4127 -, t dbSNP:397895918
4133 4133 g, t dbSNP:547510406
4169 4169 c, t dbSNP:565718269
4188 4188 a, c dbSNP:143812152
4201 4201 a, g dbSNP:752469812
4253 4253 c, t dbSNP:752131308
4262 4262 c, g dbSNP:188865354
4310 4310 c, t dbSNP:537400177
4311 4311 a, g dbSNP:767135388
4321 4321 c, t dbSNP:777646109

Target ORF information:

RefSeq Version XM_011543890
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens cytochrome b-245, beta polypeptide (CYBB), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011543890

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
ATGGTGGCAT GGATGATTGC ACTTCACTCT GCGATTCACA CCATTGCACA TCTATTTAAT 
GTGGAATGGT GTGTGAATGC CCGAGTCAAT AATTCTGATC CTTATTCAGT AGCACTCTCT
GAACTTGGAG ACAGGCAAAA TGAAAGTTAT CTCAATTTTG CTCGAAAGAG AATAAAGAAC
CCTGAAGGAG GCCTGTACCT GGCTGTGACC CTGTTGGCAG GCATCACTGG AGTTGTCATC
ACGCTGTGCC TCATATTAAT TATCACTTCC TCCACCAAAA CCATCCGGAG GTCTTACTTT
GAAGTCTTTT GGTACACACA TCATCTCTTT GTGATCTTCT TCATTGGCCT TGCCATCCAT
GGAGCTGAAC GAATTGTACG TGGGCAGACC GCAGAGAGTT TGGCTGTGCA TAATATAACA
GTTTGTGAAC AAAAAATCTC AGAATGGGGA AAAATAAAGG AATGCCCAAT CCCTCAGTTT
GCTGGAAACC CTCCTATGAC TTGGAAATGG ATAGTGGGTC CCATGTTTCT GTATCTCTGT
GAGAGGTTGG TGCGGTTTTG GCGATCTCAA CAGAAGGTGG TCATCACCAA GGTGGTCACT
CACCCTTTCA AAACCATCGA GCTACAGATG AAGAAGAAGG GGTTCAAAAT GGAAGTGGGA
CAATACATTT TTGTCAAGTG CCCAAAGGTG TCCAAGCTGG AGTGGCACCC TTTTACACTG
ACATCCGCCC CTGAGGAAGA CTTCTTTAGT ATCCATATCC GCATCGTTGG GGACTGGACA
GAGGGGCTGT TCAATGCTTG TGGCTGTGAT AAGCAGGAGT TTCAAGATGC GTGGAAACTA
CCTAAGATAG CGGTTGATGG GCCCTTTGGC ACTGCCAGTG AAGATGTGTT CAGCTATGAG
GTGGTGATGT TAGTGGGAGC AGGGATTGGG GTCACACCCT TCGCATCCAT TCTCAAGTCA
GTCTGGTACA AATATTGCAA TAACGCCACC AATCTGAAGC TCAAAAAGAT CTACTTCTAC
TGGCTGTGCC GGGACACACA TGCCTTTGAG TGGTTTGCAG ATCTGCTGCA ACTGCTGGAG
AGCCAGATGC AGGAAAGGAA CAATGCCGGC TTCCTCAGCT ACAACATCTA CCTCACTGGC
TGGGATGAGT CTCAGGCCAA TCACTTTGCT GTGCACCATG ATGAGGAGAA AGATGTGATC
ACAGGCCTGA AACAAAAGAC TTTGTATGGA CGGCCCAACT GGGATAATGA ATTCAAGACA
ATTGCAAGTC AACACCCTAA TACCAGAATA GGAGTTTTCC TCTGTGGACC TGAAGCCTTG
GCTGAAACCC TGAGTAAACA AAGCATCTCC AACTCTGAGT CTGGCCCTCG GGGAGTGCAT
TTCATTTTCA ACAAGGAAAA CTTCTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27109
Accession Version NM_000397.3
Sequence Information ORF Nucleotide Sequence (Length: 1713bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product cytochrome b-245 heavy chain
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA995835.1 and BC032720.1. This sequence is a reference standard in the RefSeqGene project. On Dec 21, 2007 this sequence version replaced gi:6996020. Summary: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032720.1, AK289753.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGGGAACT GGGCTGTGAA TGAGGGGCTC TCCATTTTTG TCATTCTGGT TTGGCTGGGG 
TTGAACGTCT TCCTCTTTGT CTGGTATTAC CGGGTTTATG ATATTCCACC TAAGTTCTTT
TACACAAGAA AACTTCTTGG GTCAGCACTG GCACTGGCCA GGGCCCCTGC AGCCTGCCTG
AATTTCAACT GCATGCTGAT TCTCTTGCCA GTCTGTCGAA ATCTGCTGTC CTTCCTCAGG
GGTTCCAGTG CGTGCTGCTC AACAAGAGTT CGAAGACAAC TGGACAGGAA TCTCACCTTT
CATAAAATGG TGGCATGGAT GATTGCACTT CACTCTGCGA TTCACACCAT TGCACATCTA
TTTAATGTGG AATGGTGTGT GAATGCCCGA GTCAATAATT CTGATCCTTA TTCAGTAGCA
CTCTCTGAAC TTGGAGACAG GCAAAATGAA AGTTATCTCA ATTTTGCTCG AAAGAGAATA
AAGAACCCTG AAGGAGGCCT GTACCTGGCT GTGACCCTGT TGGCAGGCAT CACTGGAGTT
GTCATCACGC TGTGCCTCAT ATTAATTATC ACTTCCTCCA CCAAAACCAT CCGGAGGTCT
TACTTTGAAG TCTTTTGGTA CACACATCAT CTCTTTGTGA TCTTCTTCAT TGGCCTTGCC
ATCCATGGAG CTGAACGAAT TGTACGTGGG CAGACCGCAG AGAGTTTGGC TGTGCATAAT
ATAACAGTTT GTGAACAAAA AATCTCAGAA TGGGGAAAAA TAAAGGAATG CCCAATCCCT
CAGTTTGCTG GAAACCCTCC TATGACTTGG AAATGGATAG TGGGTCCCAT GTTTCTGTAT
CTCTGTGAGA GGTTGGTGCG GTTTTGGCGA TCTCAACAGA AGGTGGTCAT CACCAAGGTG
GTCACTCACC CTTTCAAAAC CATCGAGCTA CAGATGAAGA AGAAGGGGTT CAAAATGGAA
GTGGGACAAT ACATTTTTGT CAAGTGCCCA AAGGTGTCCA AGCTGGAGTG GCACCCTTTT
ACACTGACAT CCGCCCCTGA GGAAGACTTC TTTAGTATCC ATATCCGCAT CGTTGGGGAC
TGGACAGAGG GGCTGTTCAA TGCTTGTGGC TGTGATAAGC AGGAGTTTCA AGATGCGTGG
AAACTACCTA AGATAGCGGT TGATGGGCCC TTTGGCACTG CCAGTGAAGA TGTGTTCAGC
TATGAGGTGG TGATGTTAGT GGGAGCAGGG ATTGGGGTCA CACCCTTCGC ATCCATTCTC
AAGTCAGTCT GGTACAAATA TTGCAATAAC GCCACCAATC TGAAGCTCAA AAAGATCTAC
TTCTACTGGC TGTGCCGGGA CACACATGCC TTTGAGTGGT TTGCAGATCT GCTGCAACTG
CTGGAGAGCC AGATGCAGGA AAGGAACAAT GCCGGCTTCC TCAGCTACAA CATCTACCTC
ACTGGCTGGG ATGAGTCTCA GGCCAATCAC TTTGCTGTGC ACCATGATGA GGAGAAAGAT
GTGATCACAG GCCTGAAACA AAAGACTTTG TATGGACGGC CCAACTGGGA TAATGAATTC
AAGACAATTG CAAGTCAACA CCCTAATACC AGAATAGGAG TTTTCCTCTG TGGACCTGAA
GCCTTGGCTG AAACCCTGAG TAAACAAAGC ATCTCCAACT CTGAGTCTGG CCCTCGGGGA
GTGCATTTCA TTTTCAACAA GGAAAACTTC TAA
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_000388.2
CDS62..1774
Misc Feature(1)17..19(+)
Misc Feature(2)86..148(+)
Misc Feature(3)254..721(+)
Misc Feature(4)263..265(+)
Misc Feature(5)314..316(+)
Misc Feature(6)368..430(+)
Misc Feature(7)569..631(+)
Misc Feature(8)662..724(+)
Misc Feature(9)845..907(+)
Misc Feature(10)950..1771(+)
Misc Feature(11)1031..1294(+)
Misc Feature(12)1073..1084(+)
Misc Feature(13)1277..1309(+)
Misc Feature(14)1277..1306(+)
Misc Feature(15)1292..1678(+)
Misc Feature(16)1385..1399(+)
Exon (1)1..106
Gene:CYBB
Gene Synonym:
Exon (2)107..202
Gene:CYBB
Gene Synonym:
Exon (3)203..313
Gene:CYBB
Gene Synonym:
Exon (4)314..398
Gene:CYBB
Gene Synonym:
Exon (5)399..544
Gene:CYBB
Gene Synonym:
Exon (6)545..735
Gene:CYBB
Gene Synonym:
Exon (7)736..865
Gene:CYBB
Gene Synonym:
Exon (8)866..958
Gene:CYBB
Gene Synonym:
Exon (9)959..1212
Gene:CYBB
Gene Synonym:
Exon (10)1213..1375
Gene:CYBB
Gene Synonym:
Exon (11)1376..1522
Gene:CYBB
Gene Synonym:
Exon (12)1523..1647
Gene:CYBB
Gene Synonym:
Exon (13)1648..4318
Gene:CYBB
Gene Synonym:
Translation
Position Chain Variation Link
76 76 -, t dbSNP:193922446
119 119 c, g dbSNP:151344455
127 127 c, t dbSNP:193922450
151 151 ccg, ggt dbSNP:387906486
182 182 g, t dbSNP:151344453
222 222 g, t dbSNP:151344479
223 223 c, g dbSNP:151344456
225 225 a, c dbSNP:151344480
231 231 a, c dbSNP:151344481
236 236 c, t dbSNP:151344457
238 238 c, g dbSNP:151344488
278 278 c, t dbSNP:137854588
313 313 a, g, t dbSNP:387906485
362 362 c, t dbSNP:137854594
363 363 a, g dbSNP:137854591
417 417 a, g dbSNP:151344458
450 450 c, g dbSNP:193922448
527 527 a, g dbSNP:137854590
593 593 a, c dbSNP:151344497
596 596 a, g dbSNP:151344491
639 639 c, t dbSNP:151344493
668 668 g, t dbSNP:193922449
674 674 a, t dbSNP:151344496
686 686 c, t dbSNP:137854587
687 687 a, g dbSNP:151344482
688 688 a, t dbSNP:151344459
715 715 a, c dbSNP:35080474
725 725 a, c, t dbSNP:151344460
726 726 a, g dbSNP:151344462
728 728 g, t dbSNP:151344463
729 729 g, t dbSNP:151344464
732 732 c, g dbSNP:151344483
735 735 a, t dbSNP:151344494
737 737 c, t dbSNP:137854592
753 753 a, c dbSNP:151344498
791 791 c, t dbSNP:151344465
792 792 a, c, g dbSNP:137854589
968 968 a, c dbSNP:137854595
972 972 c, g dbSNP:137854596
980 980 a, c dbSNP:151344489
986 986 a, g dbSNP:151344466
1026 1026 a, g dbSNP:151344467
1034 1034 a, t dbSNP:151344468
1058 1058 c, t dbSNP:151344469
1059 1059 c, t dbSNP:267606451
1073 1073 c, t dbSNP:151344484
1077 1077 a, c dbSNP:151344470
1086 1086 a, t dbSNP:151344495
1092 1092 c, t dbSNP:151344485
1128 1128 c, g dbSNP:151344471
1151 1151 c, g dbSNP:141756032
1201 1201 -, g dbSNP:193922445
1227 1227 a, c, g dbSNP:137854586
1275 1275 g, t dbSNP:151344472
1283 1283 a, g dbSNP:151344473
1284 1284 a, c, g dbSNP:151344474
1305 1305 a, c, t dbSNP:137854585
1320 1320 c, t dbSNP:151344486
1325 1325 c, t dbSNP:151344475
1418 1418 c, t dbSNP:151344476
1560 1560 a, g dbSNP:137854593
1575 1575 g, t dbSNP:151344490
1607 1607 c, t dbSNP:151344487
1609 1609 g, t dbSNP:151344477
1612 1612 a, t dbSNP:151344452
1662 1662 a, t dbSNP:151344478
1670 1670 c, t dbSNP:151344454
1678 1678 c, t dbSNP:187038548
1695 1695 a, c dbSNP:147991211
1698 1698 c, t dbSNP:151344492
1702 1702 c, t dbSNP:771661205
1709 1709 a, t dbSNP:748092600
1736 1736 c, t dbSNP:760298475
1737 1737 a, g dbSNP:763640811
1739 1739 a, g, t dbSNP:776358735
1742 1742 a, c, g dbSNP:766756667
1743 1743 g, t dbSNP:760011628
1746 1746 a, g dbSNP:768055122
1750 1750 c, t dbSNP:567830215
1762 1762 a, g dbSNP:140774378
1765 1765 a, g dbSNP:200528487
1778 1778 a, g dbSNP:754096410
1791 1791 g, t dbSNP:756962345
1806 1806 c, t dbSNP:778875023
1815 1815 a, c dbSNP:201232380
1916 1916 a, g dbSNP:756804428
1921 1921 a, g dbSNP:780798131
2042 2042 c, t dbSNP:535570203
2126 2126 a, c dbSNP:767755266
2158 2158 c, t dbSNP:192401117
2172 2172 a, t dbSNP:745544033
2231 2231 a, g dbSNP:34407298
2333 2333 g, t dbSNP:5964151
2363 2363 c, g dbSNP:754334687
2372 2372 c, t dbSNP:757821843
2476 2476 c, t dbSNP:779723585
2477 2477 a, g dbSNP:765908758
2508 2508 a, c dbSNP:749109015
2536 2536 a, g dbSNP:148238930
2635 2635 a, g dbSNP:17146280
2765 2765 a, t dbSNP:147429025
2811 2811 a, t dbSNP:779720905
2871 2871 a, g dbSNP:768520501
2875 2875 a, g dbSNP:774253225
2909 2909 a, g dbSNP:746650045
2915 2915 -, ac dbSNP:754748195
2932 2932 c, t dbSNP:184252383
3065 3065 c, g dbSNP:771032050
3088 3088 c, t dbSNP:748004724
3165 3165 c, t dbSNP:372880592
3183 3183 a, g dbSNP:776625919
3206 3206 a, g dbSNP:34920432
3222 3222 a, g dbSNP:773184486
3228 3228 g, t dbSNP:745909408
3307 3307 -, a dbSNP:772074883
3312 3312 -, a dbSNP:35782029
3328 3328 c, g dbSNP:775715250
3391 3391 a, g dbSNP:190415874
3419 3419 a, g dbSNP:35278070
3447 3447 c, t dbSNP:34380982
3463 3463 c, t dbSNP:765482385
3533 3533 c, t dbSNP:41303695
3558 3558 c, t dbSNP:777128323
3615 3615 c, t dbSNP:35621886
3624 3624 a, c dbSNP:763343233
3628 3628 c, t dbSNP:764744919
3813 3813 a, g dbSNP:765792906
3849 3849 a, g dbSNP:184490051
4034 4034 -, g dbSNP:762462467
4064 4064 a, g dbSNP:79650864
4066 4066 -, t dbSNP:11338914
4069 4069 c, t dbSNP:74486909
4088 4088 -, t dbSNP:397895918
4094 4094 g, t dbSNP:547510406
4130 4130 c, t dbSNP:565718269
4149 4149 a, c dbSNP:143812152
4162 4162 a, g dbSNP:752469812
4214 4214 c, t dbSNP:752131308
4223 4223 c, g dbSNP:188865354
4271 4271 c, t dbSNP:537400177
4272 4272 a, g dbSNP:767135388
4282 4282 c, t dbSNP:777646109

Target ORF information:

RefSeq Version NM_000397
Organism Homo sapiens (human)
Definition Homo sapiens cytochrome b-245, beta polypeptide (CYBB), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000397

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
ATGGGGAACT GGGCTGTGAA TGAGGGGCTC TCCATTTTTG TCATTCTGGT TTGGCTGGGG 
TTGAACGTCT TCCTCTTTGT CTGGTATTAC CGGGTTTATG ATATTCCACC TAAGTTCTTT
TACACAAGAA AACTTCTTGG GTCAGCACTG GCACTGGCCA GGGCCCCTGC AGCCTGCCTG
AATTTCAACT GCATGCTGAT TCTCTTGCCA GTCTGTCGAA ATCTGCTGTC CTTCCTCAGG
GGTTCCAGTG CGTGCTGCTC AACAAGAGTT CGAAGACAAC TGGACAGGAA TCTCACCTTT
CATAAAATGG TGGCATGGAT GATTGCACTT CACTCTGCGA TTCACACCAT TGCACATCTA
TTTAATGTGG AATGGTGTGT GAATGCCCGA GTCAATAATT CTGATCCTTA TTCAGTAGCA
CTCTCTGAAC TTGGAGACAG GCAAAATGAA AGTTATCTCA ATTTTGCTCG AAAGAGAATA
AAGAACCCTG AAGGAGGCCT GTACCTGGCT GTGACCCTGT TGGCAGGCAT CACTGGAGTT
GTCATCACGC TGTGCCTCAT ATTAATTATC ACTTCCTCCA CCAAAACCAT CCGGAGGTCT
TACTTTGAAG TCTTTTGGTA CACACATCAT CTCTTTGTGA TCTTCTTCAT TGGCCTTGCC
ATCCATGGAG CTGAACGAAT TGTACGTGGG CAGACCGCAG AGAGTTTGGC TGTGCATAAT
ATAACAGTTT GTGAACAAAA AATCTCAGAA TGGGGAAAAA TAAAGGAATG CCCAATCCCT
CAGTTTGCTG GAAACCCTCC TATGACTTGG AAATGGATAG TGGGTCCCAT GTTTCTGTAT
CTCTGTGAGA GGTTGGTGCG GTTTTGGCGA TCTCAACAGA AGGTGGTCAT CACCAAGGTG
GTCACTCACC CTTTCAAAAC CATCGAGCTA CAGATGAAGA AGAAGGGGTT CAAAATGGAA
GTGGGACAAT ACATTTTTGT CAAGTGCCCA AAGGTGTCCA AGCTGGAGTG GCACCCTTTT
ACACTGACAT CCGCCCCTGA GGAAGACTTC TTTAGTATCC ATATCCGCAT CGTTGGGGAC
TGGACAGAGG GGCTGTTCAA TGCTTGTGGC TGTGATAAGC AGGAGTTTCA AGATGCGTGG
AAACTACCTA AGATAGCGGT TGATGGGCCC TTTGGCACTG CCAGTGAAGA TGTGTTCAGC
TATGAGGTGG TGATGTTAGT GGGAGCAGGG ATTGGGGTCA CACCCTTCGC ATCCATTCTC
AAGTCAGTCT GGTACAAATA TTGCAATAAC GCCACCAATC TGAAGCTCAA AAAGATCTAC
TTCTACTGGC TGTGCCGGGA CACACATGCC TTTGAGTGGT TTGCAGATCT GCTGCAACTG
CTGGAGAGCC AGATGCAGGA AAGGAACAAT GCCGGCTTCC TCAGCTACAA CATCTACCTC
ACTGGCTGGG ATGAGTCTCA GGCCAATCAC TTTGCTGTGC ACCATGATGA GGAGAAAGAT
GTGATCACAG GCCTGAAACA AAAGACTTTG TATGGACGGC CCAACTGGGA TAATGAATTC
AAGACAATTG CAAGTCAACA CCCTAATACC AGAATAGGAG TTTTCCTCTG TGGACCTGAA
GCCTTGGCTG AAACCCTGAG TAAACAAAGC ATCTCCAACT CTGAGTCTGG CCCTCGGGGA
GTGCATTTCA TTTTCAACAA GGAAAACTTC TAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.