The following CYP2E1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CYP2E1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 1482bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||cytochrome P450 2E1 precursor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BX951478.1, J02625.1 and
This sequence is a reference standard in the RefSeqGene project.
On Sep 15, 2005 this sequence version replaced gi:13699837.
Summary: This gene encodes a member of the cytochrome P450
superfamily of enzymes. The cytochrome P450 proteins are
monooxygenases which catalyze many reactions involved in drug
metabolism and synthesis of cholesterol, steroids and other lipids.
This protein localizes to the endoplasmic reticulum and is induced
by ethanol, the diabetic state, and starvation. The enzyme
metabolizes both endogenous substrates, such as ethanol, acetone,
and acetal, as well as exogenous substrates including benzene,
carbon tetrachloride, ethylene glycol, and nitrosamines which are
premutagens found in cigarette smoke. Due to its many substrates,
this enzyme may be involved in such varied processes as
gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided
by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: J02625.1, AF182276.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: full length.