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DDB2 damage-specific DNA binding protein 2, 48kDa [Homo sapiens (human)]

Gene Symbol DDB2
Entrez Gene ID 1643
Full Name damage-specific DNA binding protein 2, 48kDa
Synonyms DDBB, UV-DDB2
General protein information
Preferred Names
DNA damage-binding protein 2
Names
DNA damage-binding protein 2
UV-DDB 2
DDB p48 subunit
UV-damaged DNA-binding protein 2
damage-specific DNA-binding protein 2
xeroderma pigmentosum group E protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p12-p11

Summary This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]. lac of sum
Disorder MIM:

600811

Disorder Html: Xeroderma pigmentosum, group E, DDB-negative subtype, 278740 (3)
CloneID RefSeq Accession Definition **Vector *Turnaround time Price
OHu19345 NM_000107 Homo sapiens damage-specific DNA binding protein 2, 48kDa (DDB2), mRNA. pcDNA3.1-C-(k)DYK In stock 5-7 Starting from $99.00
OHu44784 NM_001300734 Homo sapiens damage-specific DNA binding protein 2, 48kDa (DDB2), transcript variant D1, mRNA. pcDNA3.1-C-(k)DYK Not in stock 7-9 Starting from $99.00

*Business Day
**You may select a custom vector to replace pcDNA3.1-C-(k)DYK after clone is added to cart.



CloneID OHu19345D
Sequence Information ORF Nucleotide Sequence (Length: 1284bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product DNA damage-binding protein 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB053816.1, U18300.1 and AA278953.1. This sequence is a reference standard in the RefSeqGene project. On Jan 2, 2008 this sequence version replaced gi:4557514. Summary: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U18300.1, BC000093.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGCTCCCA AGAAACGCCC AGAAACCCAG AAGACCTCCG AGATTGTATT ACGCCCCAGG 
AACAAGAGGA GCAGGAGTCC CCTGGAGCTG GAGCCCGAGG CCAAGAAGCT CTGTGCGAAG
GGCTCCGGTC CTAGCAGAAG ATGTGACTCA GACTGCCTCT GGGTGGGGCT GGCTGGCCCA
CAGATCCTGC CACCATGCCG CAGCATCGTC AGGACCCTCC ACCAGCATAA GCTGGGCAGA
GCTTCCTGGC CATCTGTCCA GCAGGGGCTC CAGCAGTCCT TTTTGCACAC TCTGGATTCT
TACCGGATAT TACAAAAGGC TGCCCCCTTT GACAGGAGGG CTACATCCTT GGCGTGGCAC
CCAACTCACC CCAGCACCGT GGCTGTGGGT TCCAAAGGGG GAGATATCAT GCTCTGGAAT
TTTGGCATCA AGGACAAACC CACCTTCATC AAAGGGATTG GAGCTGGAGG GAGCATCACT
GGGCTGAAGT TTAACCCTCT CAATACCAAC CAGTTTTACG CCTCCTCAAT GGAGGGAACA
ACTAGGCTGC AAGACTTTAA AGGCAACATT CTACGAGTTT TTGCCAGCTC AGACACCATC
AACATCTGGT TTTGTAGCCT GGATGTGTCT GCTAGTAGCC GAATGGTGGT CACAGGAGAC
AACGTGGGGA ACGTGATCCT GCTGAACATG GACGGCAAAG AGCTTTGGAA TCTCAGAATG
CACAAAAAGA AAGTGACGCA TGTGGCCCTG AACCCATGCT GTGATTGGTT CCTGGCCACA
GCCTCCGTAG ATCAAACAGT GAAAATTTGG GACCTGCGCC AGGTTAGAGG GAAAGCCAGC
TTCCTCTACT CGCTGCCGCA CAGGCATCCT GTCAACGCAG CTTGTTTCAG TCCCGATGGA
GCCCGGCTCC TGACCACGGA CCAGAAGAGC GAGATCCGAG TTTACTCTGC TTCCCAGTGG
GACTGCCCCC TGGGCCTGAT CCCGCACCCT CACCGTCACT TCCAGCACCT CACACCCATC
AAGGCAGCCT GGCATCCTCG CTACAACCTC ATTGTTGTGG GCCGATACCC AGATCCTAAT
TTCAAAAGTT GTACCCCTTA TGAATTGAGG ACGATCGACG TGTTCGATGG AAACTCAGGG
AAGATGATGT GTCAGCTCTA TGACCCAGAA TCTTCTGGCA TCAGTTCGCT TAATGAATTC
AATCCCATGG GGGACACGCT GGCCTCTGCA ATGGGTTACC ACATTCTCAT CTGGAGCCAG
GAGGAAGCCA GGACACGGAA GTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_000098.1
CDS196..1479
Misc Feature(1)163..165(+)
Misc Feature(2)265..267(+)
Misc Feature(3)265..267(+)
Misc Feature(4)271..273(+)
Misc Feature(5)271..273(+)
Misc Feature(6)397..>1452(+)
Misc Feature(7)397..432(+)
Misc Feature(8)454..489(+)
Misc Feature(9)538..1452(+)
Misc Feature(10)541..648(+)
Misc Feature(11)580..1452(+)
Misc Feature(12)670..777(+)
Misc Feature(13)802..909(+)
Misc Feature(14)925..1056(+)
Misc Feature(15)961..1017(+)
Misc Feature(16)1063..1182(+)
Misc Feature(17)1195..1203(+)
Misc Feature(18)1222..1353(+)
Misc Feature(19)1381..1455(+)
Exon (1)1..322
Gene:DDB2
Gene Synonym:
Exon (2)323..459
Gene:DDB2
Gene Synonym:
Exon (3)460..651
Gene:DDB2
Gene Synonym:
Exon (4)652..797
Gene:DDB2
Gene Synonym:
Exon (5)798..897
Gene:DDB2
Gene Synonym:
Exon (6)898..1075
Gene:DDB2
Gene Synonym:
Exon (7)1076..1218
Gene:DDB2
Gene Synonym:
Exon (8)1219..1383
Gene:DDB2
Gene Synonym:
Exon (9)1384..1429
Gene:DDB2
Gene Synonym:
Exon (10)1430..1848
Gene:DDB2
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, g dbSNP:137929910
15 15 c, g dbSNP:575126747
36 36 g, t dbSNP:188348077
47 47 c, t dbSNP:554411192
73 73 g, t dbSNP:565058800
76 76 a, g dbSNP:4647707
86 86 c, t dbSNP:559929930
88 88 a, g dbSNP:532229410
90 90 a, g dbSNP:545940200
117 117 a, t dbSNP:747323543
131 131 a, g dbSNP:768981688
140 140 a, t dbSNP:777159854
149 149 c, g, t dbSNP:4647708
151 151 a, g dbSNP:180861241
159 159 c, t dbSNP:758089001
160 160 a, g, t dbSNP:201317629
165 165 c, g dbSNP:375840702
167 167 -, ca dbSNP:764220947
167 167 g, t dbSNP:780921271
171 171 a, g dbSNP:748147583
174 174 a, t dbSNP:769425973
175 175 c, t dbSNP:367717420
181 181 c, t dbSNP:759835280
182 182 -, gaag dbSNP:561846496
182 182 a, g dbSNP:772481534
183 183 -, c dbSNP:757228612
186 186 c, g dbSNP:371281878
187 187 a, g dbSNP:376193077
202 202 c, t dbSNP:760606007
215 215 c, t dbSNP:369110013
224 224 a, g dbSNP:754254385
226 226 a, g dbSNP:762435826
247 247 c, t dbSNP:201229167
248 248 a, g dbSNP:765557363
249 249 c, t dbSNP:750851705
250 250 c, t dbSNP:568689968
252 252 a, c dbSNP:779621308
254 254 a, g dbSNP:373622283
258 258 c, g dbSNP:754405766
272 272 a, g, t dbSNP:780776638
274 274 a, c dbSNP:148175447
276 276 c, t dbSNP:777698820
278 278 a, t dbSNP:749034260
292 292 a, g dbSNP:770855579
298 298 a, g dbSNP:775814662
299 299 a, g dbSNP:530733334
307 307 c, g, t dbSNP:368073045
316 316 a, g dbSNP:772542105
317 317 a, g dbSNP:776815495
324 324 c, t dbSNP:749763301
325 325 c, g dbSNP:141990819
333 333 a, g dbSNP:771533958
337 337 c, t dbSNP:535591210
342 342 c, t dbSNP:759879517
353 353 c, t dbSNP:772355051
361 361 g, t dbSNP:150620642
378 378 a, g dbSNP:760456614
384 384 g, t dbSNP:191773047
387 387 a, c dbSNP:753467757
392 392 a, g dbSNP:568187738
394 394 c, t dbSNP:765161300
395 395 a, g dbSNP:139674102
402 402 c, g dbSNP:758168272
403 403 a, g dbSNP:779731799
413 413 a, t dbSNP:199630230
418 418 a, c dbSNP:756368265
419 419 a, g dbSNP:777824005
432 432 c, t dbSNP:749426163
449 449 a, c, g dbSNP:770922074
465 465 c, t dbSNP:764682019
469 469 c, g dbSNP:750322138
472 472 c, t dbSNP:762843794
476 476 g, t dbSNP:144729572
493 493 c, t dbSNP:751422435
499 499 c, t dbSNP:756313355
500 500 a, g dbSNP:201842334
508 508 c, g dbSNP:754091903
513 513 c, g, t dbSNP:541629437
514 514 a, g, t dbSNP:11537594
516 516 a, t dbSNP:758898579
518 518 c, g dbSNP:78651238
524 524 c, t dbSNP:780555193
531 531 a, g dbSNP:747323146
548 548 c, t dbSNP:769144378
549 549 a, g dbSNP:776380322
552 552 g, t dbSNP:747774067
560 560 c, t dbSNP:769321481
564 564 a, c dbSNP:772637982
565 565 c, g dbSNP:762943470
571 571 a, g dbSNP:766359606
573 573 a, c, g, t dbSNP:326212
574 574 a, g dbSNP:767324814
593 593 c, g dbSNP:139968905
595 595 a, g dbSNP:200856208
603 603 a, c dbSNP:757461854
630 630 c, g dbSNP:765357628
638 638 c, g dbSNP:750530703
645 645 a, c dbSNP:145264146
669 669 c, t dbSNP:370540741
691 691 c, t dbSNP:748993672
697 697 a, g dbSNP:770406867
703 703 a, c, g dbSNP:778435738
706 706 c, g dbSNP:201703288
724 724 a, g dbSNP:775515178
728 728 a, c dbSNP:760322280
757 757 a, g dbSNP:768530307
769 769 c, t dbSNP:199822504
770 770 a, g dbSNP:763313431
772 772 a, g dbSNP:200406558
780 780 c, t dbSNP:751753400
782 782 a, g dbSNP:760106847
791 791 a, c dbSNP:767854150
813 813 c, t dbSNP:759622121
814 814 c, t dbSNP:753070223
835 835 c, t dbSNP:144989465
836 836 a, g dbSNP:370654581
837 837 a, t dbSNP:761285630
839 839 c, t dbSNP:4647750
847 847 a, g dbSNP:754261384
858 858 c, t dbSNP:530983301
859 859 c, g dbSNP:764805641
867 867 a, c, t dbSNP:201525567
869 869 c, t dbSNP:202083037
883 883 a, c dbSNP:779659936
884 884 c, t dbSNP:139325563
885 885 a, g dbSNP:755006840
886 886 a, g dbSNP:781117402
888 888 c, g, t dbSNP:149583624
889 889 a, c, g dbSNP:774675310
890 890 a, g dbSNP:772015549
891 891 c, t dbSNP:142203542
896 896 a, g dbSNP:775705405
913 913 a, g dbSNP:762496558
918 918 c, t dbSNP:765996055
919 919 -, a dbSNP:774449547
925 925 a, g dbSNP:121434639
932 932 a, c, t dbSNP:151146343
933 933 a, g dbSNP:144266685
941 941 c, t dbSNP:767157750
943 943 c, t dbSNP:752658655
946 946 -, c dbSNP:35644155
962 962 g, t dbSNP:756188946
981 981 c, t dbSNP:200094631
982 982 a, g dbSNP:540888883
988 988 a, c, g dbSNP:201259165
993 993 a, g dbSNP:780286263
1002 1002 c, t dbSNP:749806545
1012 1012 c, t dbSNP:747222465
1013 1013 a, g dbSNP:121434640
1021 1021 a, g dbSNP:781286785
1022 1022 c, g dbSNP:748644904
1038 1038 c, g dbSNP:770341238
1046 1046 a, c dbSNP:773602928
1050 1050 a, g dbSNP:763308575
1052 1052 c, t dbSNP:373044335
1053 1053 a, g dbSNP:774005293
1057 1057 a, g dbSNP:145241266
1063 1063 c, g dbSNP:767131311
1065 1065 c, t dbSNP:376783024
1071 1071 c, t dbSNP:778504979
1072 1072 a, g dbSNP:4647751
1089 1089 c, t dbSNP:137958929
1092 1092 c, t dbSNP:763722415
1099 1099 c, t dbSNP:776612511
1100 1100 a, c, g dbSNP:761699363
1102 1102 -, c dbSNP:761833288
1104 1104 c, g dbSNP:750238940
1110 1110 c, t dbSNP:758199547
1113 1113 a, g dbSNP:140886714
1114 1114 g, t dbSNP:121434642
1119 1119 c, g dbSNP:752946218
1125 1125 c, t dbSNP:549041558
1132 1132 c, t dbSNP:121434641
1140 1140 c, t dbSNP:777763167
1142 1142 c, t dbSNP:375788966
1146 1146 c, t dbSNP:757762991
1148 1148 c, t dbSNP:779489467
1151 1151 a, g dbSNP:370130760
1159 1159 c, t dbSNP:764224665
1161 1161 c, t dbSNP:775237497
1162 1162 a, c dbSNP:746711900
1172 1172 c, t dbSNP:768184938
1174 1174 a, t dbSNP:776075728
1178 1178 c, t dbSNP:145822896
1179 1179 a, g dbSNP:138255134
1190 1190 a, g dbSNP:760495922
1191 1191 c, t dbSNP:762693320
1209 1209 a, t dbSNP:766181715
1212 1212 c, t dbSNP:17849262
1213 1213 a, g dbSNP:752893080
1230 1230 g, t dbSNP:764157011
1234 1234 c, t dbSNP:376083611
1235 1235 a, g dbSNP:761752334
1238 1238 a, g dbSNP:765459672
1243 1243 c, t dbSNP:750932875
1248 1248 c, t dbSNP:61741581
1254 1254 g, t dbSNP:780557154
1259 1259 a, g dbSNP:751910498
1263 1263 c, g dbSNP:755370586
1265 1265 c, t dbSNP:780665825
1292 1292 c, g dbSNP:747856764
1293 1293 g, t dbSNP:769162543
1297 1297 c, g dbSNP:777303306
1307 1307 c, t dbSNP:753931064
1308 1308 a, g dbSNP:144368453
1311 1311 c, t dbSNP:774277740
1312 1312 a, g dbSNP:567082210
1315 1315 a, g dbSNP:148299549
1320 1320 c, t dbSNP:185380045
1321 1321 a, g dbSNP:375649516
1326 1326 a, g dbSNP:765406938
1340 1340 a, t dbSNP:750593401
1350 1350 g, t dbSNP:763142457
1351 1351 c, t dbSNP:766922655
1356 1356 c, t dbSNP:752136193
1362 1362 a, g dbSNP:199920301
1379 1379 a, g dbSNP:755246751
1382 1382 a, c dbSNP:781655324
1383 1383 a, g dbSNP:752258696
1392 1392 a, g dbSNP:763083097
1419 1419 c, g, t dbSNP:766586298
1423 1423 a, g dbSNP:143049891
1426 1426 a, g dbSNP:767767775
1442 1442 -, tca dbSNP:760526475
1443 1443 c, t dbSNP:765513314
1445 1445 -, ctc dbSNP:766244670
1455 1455 c, g dbSNP:760979102
1472 1472 a, g dbSNP:773828524
1473 1473 g, t dbSNP:369378109
1476 1476 c, g dbSNP:77897070
1486 1486 c, t dbSNP:763312773
1492 1492 a, g dbSNP:774235977
1496 1496 c, t dbSNP:756968720
1502 1502 c, t dbSNP:200353341
1514 1514 a, t dbSNP:749887036
1523 1523 a, c dbSNP:568791616
1529 1529 a, g dbSNP:373315783
1530 1530 a, g dbSNP:780005436
1556 1556 c, t dbSNP:1050244
1604 1604 a, g dbSNP:751030002
1605 1605 c, t dbSNP:554676341
1630 1630 a, c dbSNP:4647760
1667 1667 c, t dbSNP:749540520
1729 1729 a, g dbSNP:534375494
1764 1764 -, a dbSNP:36044881
1766 1766 g, t dbSNP:554393001
1787 1787 a, g dbSNP:577459290
1788 1788 -, c dbSNP:768815758
1812 1812 -, ca dbSNP:4647761
1844 1844 c, t dbSNP:767210223

Target ORF information:

RefSeq Version NM_000107
Organism Homo sapiens (human)
Definition Homo sapiens damage-specific DNA binding protein 2, 48kDa (DDB2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_000107

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGCTCCCA AGAAACGCCC AGAAACCCAG AAGACCTCCG AGATTGTATT ACGCCCCAGG 
AACAAGAGGA GCAGGAGTCC CCTGGAGCTG GAGCCCGAGG CCAAGAAGCT CTGTGCGAAG
GGCTCCGGTC CTAGCAGAAG ATGTGACTCA GACTGCCTCT GGGTGGGGCT GGCTGGCCCA
CAGATCCTGC CACCATGCCG CAGCATCGTC AGGACCCTCC ACCAGCATAA GCTGGGCAGA
GCTTCCTGGC CATCTGTCCA GCAGGGGCTC CAGCAGTCCT TTTTGCACAC TCTGGATTCT
TACCGGATAT TACAAAAGGC TGCCCCCTTT GACAGGAGGG CTACATCCTT GGCGTGGCAC
CCAACTCACC CCAGCACCGT GGCTGTGGGT TCCAAAGGGG GAGATATCAT GCTCTGGAAT
TTTGGCATCA AGGACAAACC CACCTTCATC AAAGGGATTG GAGCTGGAGG GAGCATCACT
GGGCTGAAGT TTAACCCTCT CAATACCAAC CAGTTTTACG CCTCCTCAAT GGAGGGAACA
ACTAGGCTGC AAGACTTTAA AGGCAACATT CTACGAGTTT TTGCCAGCTC AGACACCATC
AACATCTGGT TTTGTAGCCT GGATGTGTCT GCTAGTAGCC GAATGGTGGT CACAGGAGAC
AACGTGGGGA ACGTGATCCT GCTGAACATG GACGGCAAAG AGCTTTGGAA TCTCAGAATG
CACAAAAAGA AAGTGACGCA TGTGGCCCTG AACCCATGCT GTGATTGGTT CCTGGCCACA
GCCTCCGTAG ATCAAACAGT GAAAATTTGG GACCTGCGCC AGGTTAGAGG GAAAGCCAGC
TTCCTCTACT CGCTGCCGCA CAGGCATCCT GTCAACGCAG CTTGTTTCAG TCCCGATGGA
GCCCGGCTCC TGACCACGGA CCAGAAGAGC GAGATCCGAG TTTACTCTGC TTCCCAGTGG
GACTGCCCCC TGGGCCTGAT CCCGCACCCT CACCGTCACT TCCAGCACCT CACACCCATC
AAGGCAGCCT GGCATCCTCG CTACAACCTC ATTGTTGTGG GCCGATACCC AGATCCTAAT
TTCAAAAGTT GTACCCCTTA TGAATTGAGG ACGATCGACG TGTTCGATGG AAACTCAGGG
AAGATGATGT GTCAGCTCTA TGACCCAGAA TCTTCTGGCA TCAGTTCGCT TAATGAATTC
AATCCCATGG GGGACACGCT GGCCTCTGCA ATGGGTTACC ACATTCTCAT CTGGAGCCAG
GAGGAAGCCA GGACACGGAA GTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.


CloneID OHu44784D
Sequence Information ORF Nucleotide Sequence (Length: 717bp)
Protein sequence
SNP
Vector pcDNA3.1-C-(k)DYK or customized vector
Clone information Clone Map
Tag on pcDNA3.1-C-(k)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product DNA damage-binding protein 2 isoform D1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB053816.1, AB107037.1 and AA278953.1. On Jul 11, 2014 this sequence version replaced gi:578820369. Summary: This gene encodes a protein that is necessary for the repair of ultraviolet light-damaged DNA. This protein is the smaller subunit of a heterodimeric protein complex that participates in nucleotide excision repair, and this complex mediates the ubiquitylation of histones H3 and H4, which facilitates the cellular response to DNA damage. This subunit appears to be required for DNA binding. Mutations in this gene cause xeroderma pigmentosum complementation group E, a recessive disease that is characterized by an increased sensitivity to UV light and a high predisposition for skin cancer development, in some cases accompanied by neurological abnormalities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]. Transcript Variant: This variant (D1) lacks four consecutive alternate exons compared to variant WT, without a reading frame change. The resulting isoform (D1) has the same N- and C-termini but is shorter compared to isoform WT. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB107037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCTCCCA AGAAACGCCC AGAAACCCAG AAGACCTCCG AGATTGTATT ACGCCCCAGG 
AACAAGAGGA GCAGGAGTCC CCTGGAGCTG GAGCCCGAGG CCAAGAAGCT CTGTGCGAAG
GGCTCCGGTC CTAGCAGAAG ATGTGACTCA GACTGCCTCT GGGTGGGGCT GGCTGGCCCA
CAGATCCTGC CACCATGCCG CAGCATCGTC AGGACCCTCC ACCAGCATAA GCTGGGCAGA
GCTTCCTGGC CATCTGTCCA GCAGGGGCTC CAGCAGTCCT TTTTGCACAC TCTGGATTCT
TACCGGATAT TACAAAAGGC TGCCCCCTTT GACAGGAGGG CTACATCCTT GGCGTGGCAC
CCAACTCACC CCAGCACCGT GGCTGTGGGT TCCAAAGGGG GAGATATCAT GCTCTGGAAT
TTTGGCATCA AGGACAAACC CACCTTCATC AAAGGGGCAG CCTGGCATCC TCGCTACAAC
CTCATTGTTG TGGGCCGATA CCCAGATCCT AATTTCAAAA GTTGTACCCC TTATGAATTG
AGGACGATCG ACGTGTTCGA TGGAAACTCA GGGAAGATGA TGTGTCAGCT CTATGACCCA
GAATCTTCTG GCATCAGTTC GCTTAATGAA TTCAATCCCA TGGGGGACAC GCTGGCCTCT
GCAATGGGTT ACCACATTCT CATCTGGAGC CAGGAGGAAG CCAGGACACG GAAGTGA
The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.
RefSeqNP_001287663.1
CDS196..912
Misc Feature(1)163..165(+)
Misc Feature(2)265..267(+)
Misc Feature(3)271..273(+)
Misc Feature(4)397..432(+)
Misc Feature(5)454..489(+)
Misc Feature(6)538..>885(+)
Misc Feature(7)541..648(+)
Exon (1)1..322
Gene:DDB2
Gene Synonym:
Exon (2)323..459
Gene:DDB2
Gene Synonym:
Exon (3)460..651
Gene:DDB2
Gene Synonym:
Exon (4)652..816
Gene:DDB2
Gene Synonym:
Exon (5)817..862
Gene:DDB2
Gene Synonym:
Exon (6)863..1281
Gene:DDB2
Gene Synonym:
Translation
Position Chain Variation Link
10 10 c, g dbSNP:137929910
15 15 c, g dbSNP:575126747
36 36 g, t dbSNP:188348077
47 47 c, t dbSNP:554411192
73 73 g, t dbSNP:565058800
76 76 a, g dbSNP:4647707
86 86 c, t dbSNP:559929930
88 88 a, g dbSNP:532229410
90 90 a, g dbSNP:545940200
117 117 a, t dbSNP:747323543
131 131 a, g dbSNP:768981688
140 140 a, t dbSNP:777159854
149 149 c, g, t dbSNP:4647708
151 151 a, g dbSNP:180861241
159 159 c, t dbSNP:758089001
160 160 a, g, t dbSNP:201317629
165 165 c, g dbSNP:375840702
167 167 -, ca dbSNP:764220947
167 167 g, t dbSNP:780921271
171 171 a, g dbSNP:748147583
174 174 a, t dbSNP:769425973
175 175 c, t dbSNP:367717420
181 181 c, t dbSNP:759835280
182 182 -, gaag dbSNP:561846496
182 182 a, g dbSNP:772481534
183 183 -, c dbSNP:757228612
186 186 c, g dbSNP:371281878
187 187 a, g dbSNP:376193077
202 202 c, t dbSNP:760606007
215 215 c, t dbSNP:369110013
224 224 a, g dbSNP:754254385
226 226 a, g dbSNP:762435826
247 247 c, t dbSNP:201229167
248 248 a, g dbSNP:765557363
249 249 c, t dbSNP:750851705
250 250 c, t dbSNP:568689968
252 252 a, c dbSNP:779621308
254 254 a, g dbSNP:373622283
258 258 c, g dbSNP:754405766
272 272 a, g, t dbSNP:780776638
274 274 a, c dbSNP:148175447
276 276 c, t dbSNP:777698820
278 278 a, t dbSNP:749034260
292 292 a, g dbSNP:770855579
298 298 a, g dbSNP:775814662
299 299 a, g dbSNP:530733334
307 307 c, g, t dbSNP:368073045
316 316 a, g dbSNP:772542105
317 317 a, g dbSNP:776815495
324 324 c, t dbSNP:749763301
325 325 c, g dbSNP:141990819
333 333 a, g dbSNP:771533958
337 337 c, t dbSNP:535591210
342 342 c, t dbSNP:759879517
353 353 c, t dbSNP:772355051
361 361 g, t dbSNP:150620642
378 378 a, g dbSNP:760456614
384 384 g, t dbSNP:191773047
387 387 a, c dbSNP:753467757
392 392 a, g dbSNP:568187738
394 394 c, t dbSNP:765161300
395 395 a, g dbSNP:139674102
402 402 c, g dbSNP:758168272
403 403 a, g dbSNP:779731799
413 413 a, t dbSNP:199630230
418 418 a, c dbSNP:756368265
419 419 a, g dbSNP:777824005
432 432 c, t dbSNP:749426163
449 449 a, c, g dbSNP:770922074
465 465 c, t dbSNP:764682019
469 469 c, g dbSNP:750322138
472 472 c, t dbSNP:762843794
476 476 g, t dbSNP:144729572
493 493 c, t dbSNP:751422435
499 499 c, t dbSNP:756313355
500 500 a, g dbSNP:201842334
508 508 c, g dbSNP:754091903
513 513 c, g, t dbSNP:541629437
514 514 a, g, t dbSNP:11537594
516 516 a, t dbSNP:758898579
518 518 c, g dbSNP:78651238
524 524 c, t dbSNP:780555193
531 531 a, g dbSNP:747323146
548 548 c, t dbSNP:769144378
549 549 a, g dbSNP:776380322
552 552 g, t dbSNP:747774067
560 560 c, t dbSNP:769321481
564 564 a, c dbSNP:772637982
565 565 c, g dbSNP:762943470
571 571 a, g dbSNP:766359606
573 573 a, c, g, t dbSNP:326212
574 574 a, g dbSNP:767324814
593 593 c, g dbSNP:139968905
595 595 a, g dbSNP:200856208
603 603 a, c dbSNP:757461854
630 630 c, g dbSNP:765357628
638 638 c, g dbSNP:750530703
645 645 a, c dbSNP:145264146
663 663 g, t dbSNP:764157011
667 667 c, t dbSNP:376083611
668 668 a, g dbSNP:761752334
671 671 a, g dbSNP:765459672
676 676 c, t dbSNP:750932875
681 681 c, t dbSNP:61741581
687 687 g, t dbSNP:780557154
692 692 a, g dbSNP:751910498
696 696 c, g dbSNP:755370586
698 698 c, t dbSNP:780665825
725 725 c, g dbSNP:747856764
726 726 g, t dbSNP:769162543
730 730 c, g dbSNP:777303306
740 740 c, t dbSNP:753931064
741 741 a, g dbSNP:144368453
744 744 c, t dbSNP:774277740
745 745 a, g dbSNP:567082210
748 748 a, g dbSNP:148299549
753 753 c, t dbSNP:185380045
754 754 a, g dbSNP:375649516
759 759 a, g dbSNP:765406938
773 773 a, t dbSNP:750593401
783 783 g, t dbSNP:763142457
784 784 c, t dbSNP:766922655
789 789 c, t dbSNP:752136193
795 795 a, g dbSNP:199920301
812 812 a, g dbSNP:755246751
815 815 a, c dbSNP:781655324
816 816 a, g dbSNP:752258696
825 825 a, g dbSNP:763083097
852 852 c, g, t dbSNP:766586298
856 856 a, g dbSNP:143049891
859 859 a, g dbSNP:767767775
875 875 -, tca dbSNP:760526475
876 876 c, t dbSNP:765513314
878 878 -, ctc dbSNP:766244670
888 888 c, g dbSNP:760979102
905 905 a, g dbSNP:773828524
906 906 g, t dbSNP:369378109
909 909 c, g dbSNP:77897070
919 919 c, t dbSNP:763312773
925 925 a, g dbSNP:774235977
929 929 c, t dbSNP:756968720
935 935 c, t dbSNP:200353341
947 947 a, t dbSNP:749887036
956 956 a, c dbSNP:568791616
962 962 a, g dbSNP:373315783
963 963 a, g dbSNP:780005436
989 989 c, t dbSNP:1050244
1037 1037 a, g dbSNP:751030002
1038 1038 c, t dbSNP:554676341
1063 1063 a, c dbSNP:4647760
1100 1100 c, t dbSNP:749540520
1162 1162 a, g dbSNP:534375494
1197 1197 -, a dbSNP:36044881
1199 1199 g, t dbSNP:554393001
1220 1220 a, g dbSNP:577459290
1221 1221 -, c dbSNP:768815758
1245 1245 -, ca dbSNP:4647761
1277 1277 c, t dbSNP:767210223

Target ORF information:

RefSeq Version NM_001300734
Organism Homo sapiens (human)
Definition Homo sapiens damage-specific DNA binding protein 2, 48kDa (DDB2), transcript variant D1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1-C-(k)DYK
NM_001300734

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGGCTCCCA AGAAACGCCC AGAAACCCAG AAGACCTCCG AGATTGTATT ACGCCCCAGG 
AACAAGAGGA GCAGGAGTCC CCTGGAGCTG GAGCCCGAGG CCAAGAAGCT CTGTGCGAAG
GGCTCCGGTC CTAGCAGAAG ATGTGACTCA GACTGCCTCT GGGTGGGGCT GGCTGGCCCA
CAGATCCTGC CACCATGCCG CAGCATCGTC AGGACCCTCC ACCAGCATAA GCTGGGCAGA
GCTTCCTGGC CATCTGTCCA GCAGGGGCTC CAGCAGTCCT TTTTGCACAC TCTGGATTCT
TACCGGATAT TACAAAAGGC TGCCCCCTTT GACAGGAGGG CTACATCCTT GGCGTGGCAC
CCAACTCACC CCAGCACCGT GGCTGTGGGT TCCAAAGGGG GAGATATCAT GCTCTGGAAT
TTTGGCATCA AGGACAAACC CACCTTCATC AAAGGGGCAG CCTGGCATCC TCGCTACAAC
CTCATTGTTG TGGGCCGATA CCCAGATCCT AATTTCAAAA GTTGTACCCC TTATGAATTG
AGGACGATCG ACGTGTTCGA TGGAAACTCA GGGAAGATGA TGTGTCAGCT CTATGACCCA
GAATCTTCTG GCATCAGTTC GCTTAATGAA TTCAATCCCA TGGGGGACAC GCTGGCCTCT
GCAATGGGTT ACCACATTCT CATCTGGAGC CAGGAGGAAG CCAGGACACG GAAGTGA

The stop codons will be deleted if pcDNA3.1-C-(k)DYK vector is selected.