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DPYD cDNA ORF clone, Homo sapiens (human)

Gene Symbol DPYD
Entrez Gene ID 1806
Full Name dihydropyrimidine dehydrogenase
Synonyms DHP, DHPDHASE, DPD
General protein information
Preferred Names
dihydropyrimidine dehydrogenase [NADP(+)]
Names
dihydropyrimidine dehydrogenase [NADP(+)]
dihydrouracil dehydrogenase
dihydrothymine dehydrogenase
NP_000101.2
NP_001153773.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p22

Summary The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. lac of sum
Disorder MIM:

612779

Disorder Html: Dihydropyrimidine dehydrogenase deficiency, 274270 (3);

mRNA and Protein(s)

mRNA Protein Name
XM_005270562 XP_005270619 dihydropyrimidine dehydrogenase [NADP(+)] isoform X1
XM_006710397 XP_006710460 dihydropyrimidine dehydrogenase [NADP(+)] isoform X2
NM_000110 NP_000101 dihydropyrimidine dehydrogenase [NADP(+)] isoform 1
NM_001160301 NP_001153773 dihydropyrimidine dehydrogenase [NADP(+)] isoform 2



Homo sapiens (human) DPYD NP_000101.2
Pan troglodytes (chimpanzee) DPYD XP_513583.3
Macaca mulatta (Rhesus monkey) DPYD XP_001106007.1
Canis lupus familiaris (dog) DPYD XP_005621932.1
Bos taurus (cattle) DPYD NP_776466.1
Mus musculus (house mouse) Dpyd NP_740748.1
Rattus norvegicus (Norway rat) Dpyd NP_112289.1
Gallus gallus (chicken) DPYD XP_426639.3
Danio rerio (zebrafish) dpydb NP_998058.1
Drosophila melanogaster (fruit fly) su(r) NP_572538.1
Caenorhabditis elegans dpyd-1 NP_508927.2
Xenopus (Silurana) tropicalis (western clawed frog) dpyd XP_002933845.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DPYD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DPYD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu33082 XM_005270562 PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $475.30
$679.00
OHu33083 XM_006710397 PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $475.30
$679.00
OHu19551
NM_000110 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$274.50-$384.30
$549.00
OHu21185
NM_001160301 Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu33082
Clone ID Related Accession (Same CDS sequence) XM_005270562
Accession Version XM_005270562.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2862bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product dihydropyrimidine dehydrogenase [NADP(+)] isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_032977.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578798493. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
ATGGCCCCTG TGCTCAGTAA GGACTCGGCG GACATCGAGA GTATCCTGGC TTTAAATCCT 
CGAACACAAA CTCATGCAAC TCTGTGTTCC ACTTCGGCCA AGAAATTAGA CAAGAAACAT
TGGAAAAGAA ATCCTGATAA GAACTGCTTT AATTGTGAGA AGCTGGAGAA TAATTTTGAT
GACATCAAGC ACACGACTCT TGGTGAGCGA GGAGCTCTCC GAGAAGCAAT GAGATGCCTG
AAATGTGCAG ATGCCCCGTG TCAGAAGAGC TGTCCAACTA ATCTTGATAT TAAATCATTC
ATCACAAGTA TTGCAAACAA GAACTATTAT GGAGCTGCTA AGATGATATT TTCTGACAAC
CCACTTGGTC TGACTTGTGG AATGGTATGT CCAACCTCTG ATCTTTGTGT AGGTGGATGC
AATTTATATG CCACTGAAGA GGGACCCATT AATATTGGTG GATTGCAGCA ATTTGCTACT
GAGGTATTCA AAGCAATGAG TATCCCACAG ATCAGAAATC CTTCGCTGCC TCCCCCAGAA
AAAATGTCTG AAGCCTATTC TGCAAAGATT GCTCTTTTTG GTGCTGGGCC TGCAAGTATA
AGTTGTGCTT CCTTTTTGGC TCGATTGGGG TACTCTGACA TCACTATATT TGAAAAACAA
GAATATGTTG GTGGTTTAAG TACTTCTGAA ATTCCTCAGT TCCGGCTGCC GTATGATGTA
GTGAATTTTG AGATTGAGCT AATGAAGGAC CTTGGTGTAA AGATAATTTG CGGTAAAAGC
CTTTCAGTGA ATGAAATGAC TCTTAGCACT TTGAAAGAAA AAGGCTACAA AGCTGCTTTC
ATTGGAATAG GTTTGCCAGA ACCCAATAAA GATGCCATCT TCCAAGGCCT GACGCAGGAC
CAGGGGTTTT ATACATCCAA AGACTTTTTG CCACTTGTAG CCAAAGGCAG TAAAGCAGGA
ATGTGCGCCT GTCACTCTCC ATTGCCATCG ATACGGGGAG TCGTGATTGT ACTTGGAGCT
GGAGACACTG CCTTTGACTG TGCAACATCT GCTCTACGTT GTGGAGCTCG CCGTGTGTTC
ATCGTCTTCA GAAAAGGCTT TGTTAATATA AGAGCTGTCC CTGAGGAGAT GGAACTTGCT
AAGGAAGAAA AGTGTGAATT TCTGCCATTC CTGTCCCCAC GGAAGGTTAT AGTAAAAGGT
GGGAGAATTG TTGCTATGCA GTTTGTTCGG ACAGAGCAAG ATGAAACTGG AAAATGGAAT
GAAGATGAAG ATCAGATGGT CCATCTGAAA GCCGATGTGG TCATCAGTGC CTTTGGTTCA
GTTCTGAGTG ATCCTAAAGT AAAAGAAGCC TTGAGCCCTA TAAAATTTAA CAGATGGGGT
CTCCCAGAAG TAGATCCAGA AACTATGCAA ACTAGTGAAG CATGGGTATT TGCAGGTGGT
GATGTCGTTG GTTTGGCTAA CACTACAGTG GAATCGGTGA ATGATGGAAA GCAAGCTTCT
TGGTACATTC ACAAATACGT ACAGGACATT GTGACAAATG TTTCCCCCAG AATCATCCGG
GGAACCACCT CTGGCCCCAT GTATGGCCCT GGACAAAGCT CCTTTCTGAA TATTGAGCTC
ATCAGTGAGA AAACGGCTGC ATATTGGTGT CAAAGTGTCA CTGAACTAAA GGCTGACTTT
CCAGACAACA TTGTGATTGC TAGCATTATG TGCAGTTACA ATAAAAATGA CTGGACGGAA
CTTGCCAAGA AGTCTGAGGA TTCTGGAGCA GATGCCCTGG AGTTAAATTT ATCATGTCCA
CATGGCATGG GAGAAAGAGG AATGGGCCTG GCCTGTGGGC AGGATCCAGA GCTGGTGCGG
AACATCTGCC GCTGGGTTAG GCAAGCTGTT CAGATTCCTT TTTTTGCCAA GCTGACCCCA
AATGTCACTG ATATTGTGAG CATCGCAAGA GCTGCAAAGG AAGGTGGTGC CAATGGCGTT
ACAGCCACCA ACACTGTCTC AGGTCTGATG GGATTAAAAT CTGATGGCAC ACCTTGGCCA
GCAGTGGGGA TTGCAAAGCG AACTACATAT GGAGGAGTGT CTGGGACAGC AATCAGACCT
ATTGCTTTGA GAGCTGTGAC CTCCATTGCT CGTGCTCTGC CTGGATTTCC CATTTTGGCT
ACTGGTGGAA TTGACTCTGC TGAAAGTGGT CTTCAGTTTC TCCATAGTGG TGCTTCCGTC
CTCCAGGTAT GCAGTGCCAT TCAGAATCAG GATTTCACTG TGATCGAAGA CTACTGCACT
GGCCTCAAAG CCCTGCTTTA TCTGAAAAGC ATTGAAGAAC TACAAGACTG GGATGGACAG
AGTCCAGCTA CTGTGAGTCA CCAGAAAGGG AAACCAGTTC CACGTATAGC TGAACTCATG
GACAAGAAAC TGCCAAGTTT TGGACCTTAT CTGGAACAGC GCAAGAAAAT CATAGCAGAA
AACAAGATTA GACTGAAAGA ACAAAATGTA GCTTTTTCAC CACTTAAGAG AAACTGTTTT
ATCCCCAAAA GGCCTATTCC TACCATCAAG GATGTAATAG GAAAAGCACT GCAGTACCTT
GGAACATTTG GTGAATTGAG CAACGTAGAG CAAGTTGTGG CTATGATTGA TGAAGAAATG
TGTATCAACT GTGGTAAATG CTACATGACC TGTAATGATT CTGGCTACCA GGCTATACAG
TTTGATCCAG AAACCCACCT GCCCACCATA ACCGACACTT GTACAGGCTG TACTCTGTGT
CTCAGTGTTT GCCCTATTGT CGACTGCATC AAAATGGTTT CCAGGACAAC ACCTTATGAA
CCAAAGAGAG GCGTACCCTT ATCTGTGAAT CCGGTGTGTT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005270619.2
CDS138..2999
Misc Feature(1)294..1661(+)
Misc Feature(2)309..635(+)
Misc Feature(3)717..>851(+)
Misc Feature(4)1662..2423(+)
Misc Feature(5)1668..2396(+)
Misc Feature(6)1689..2132(+)
Misc Feature(7)1689..2132(+)
Misc Feature(8)1746..2132(+)
Misc Feature(9)2757..2933(+)
Misc Feature(10)2772..2912(+)
Translation

Target ORF information:

RefSeq Version XM_005270562
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_005270562

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
ATGGCCCCTG TGCTCAGTAA GGACTCGGCG GACATCGAGA GTATCCTGGC TTTAAATCCT 
CGAACACAAA CTCATGCAAC TCTGTGTTCC ACTTCGGCCA AGAAATTAGA CAAGAAACAT
TGGAAAAGAA ATCCTGATAA GAACTGCTTT AATTGTGAGA AGCTGGAGAA TAATTTTGAT
GACATCAAGC ACACGACTCT TGGTGAGCGA GGAGCTCTCC GAGAAGCAAT GAGATGCCTG
AAATGTGCAG ATGCCCCGTG TCAGAAGAGC TGTCCAACTA ATCTTGATAT TAAATCATTC
ATCACAAGTA TTGCAAACAA GAACTATTAT GGAGCTGCTA AGATGATATT TTCTGACAAC
CCACTTGGTC TGACTTGTGG AATGGTATGT CCAACCTCTG ATCTTTGTGT AGGTGGATGC
AATTTATATG CCACTGAAGA GGGACCCATT AATATTGGTG GATTGCAGCA ATTTGCTACT
GAGGTATTCA AAGCAATGAG TATCCCACAG ATCAGAAATC CTTCGCTGCC TCCCCCAGAA
AAAATGTCTG AAGCCTATTC TGCAAAGATT GCTCTTTTTG GTGCTGGGCC TGCAAGTATA
AGTTGTGCTT CCTTTTTGGC TCGATTGGGG TACTCTGACA TCACTATATT TGAAAAACAA
GAATATGTTG GTGGTTTAAG TACTTCTGAA ATTCCTCAGT TCCGGCTGCC GTATGATGTA
GTGAATTTTG AGATTGAGCT AATGAAGGAC CTTGGTGTAA AGATAATTTG CGGTAAAAGC
CTTTCAGTGA ATGAAATGAC TCTTAGCACT TTGAAAGAAA AAGGCTACAA AGCTGCTTTC
ATTGGAATAG GTTTGCCAGA ACCCAATAAA GATGCCATCT TCCAAGGCCT GACGCAGGAC
CAGGGGTTTT ATACATCCAA AGACTTTTTG CCACTTGTAG CCAAAGGCAG TAAAGCAGGA
ATGTGCGCCT GTCACTCTCC ATTGCCATCG ATACGGGGAG TCGTGATTGT ACTTGGAGCT
GGAGACACTG CCTTTGACTG TGCAACATCT GCTCTACGTT GTGGAGCTCG CCGTGTGTTC
ATCGTCTTCA GAAAAGGCTT TGTTAATATA AGAGCTGTCC CTGAGGAGAT GGAACTTGCT
AAGGAAGAAA AGTGTGAATT TCTGCCATTC CTGTCCCCAC GGAAGGTTAT AGTAAAAGGT
GGGAGAATTG TTGCTATGCA GTTTGTTCGG ACAGAGCAAG ATGAAACTGG AAAATGGAAT
GAAGATGAAG ATCAGATGGT CCATCTGAAA GCCGATGTGG TCATCAGTGC CTTTGGTTCA
GTTCTGAGTG ATCCTAAAGT AAAAGAAGCC TTGAGCCCTA TAAAATTTAA CAGATGGGGT
CTCCCAGAAG TAGATCCAGA AACTATGCAA ACTAGTGAAG CATGGGTATT TGCAGGTGGT
GATGTCGTTG GTTTGGCTAA CACTACAGTG GAATCGGTGA ATGATGGAAA GCAAGCTTCT
TGGTACATTC ACAAATACGT ACAGGACATT GTGACAAATG TTTCCCCCAG AATCATCCGG
GGAACCACCT CTGGCCCCAT GTATGGCCCT GGACAAAGCT CCTTTCTGAA TATTGAGCTC
ATCAGTGAGA AAACGGCTGC ATATTGGTGT CAAAGTGTCA CTGAACTAAA GGCTGACTTT
CCAGACAACA TTGTGATTGC TAGCATTATG TGCAGTTACA ATAAAAATGA CTGGACGGAA
CTTGCCAAGA AGTCTGAGGA TTCTGGAGCA GATGCCCTGG AGTTAAATTT ATCATGTCCA
CATGGCATGG GAGAAAGAGG AATGGGCCTG GCCTGTGGGC AGGATCCAGA GCTGGTGCGG
AACATCTGCC GCTGGGTTAG GCAAGCTGTT CAGATTCCTT TTTTTGCCAA GCTGACCCCA
AATGTCACTG ATATTGTGAG CATCGCAAGA GCTGCAAAGG AAGGTGGTGC CAATGGCGTT
ACAGCCACCA ACACTGTCTC AGGTCTGATG GGATTAAAAT CTGATGGCAC ACCTTGGCCA
GCAGTGGGGA TTGCAAAGCG AACTACATAT GGAGGAGTGT CTGGGACAGC AATCAGACCT
ATTGCTTTGA GAGCTGTGAC CTCCATTGCT CGTGCTCTGC CTGGATTTCC CATTTTGGCT
ACTGGTGGAA TTGACTCTGC TGAAAGTGGT CTTCAGTTTC TCCATAGTGG TGCTTCCGTC
CTCCAGGTAT GCAGTGCCAT TCAGAATCAG GATTTCACTG TGATCGAAGA CTACTGCACT
GGCCTCAAAG CCCTGCTTTA TCTGAAAAGC ATTGAAGAAC TACAAGACTG GGATGGACAG
AGTCCAGCTA CTGTGAGTCA CCAGAAAGGG AAACCAGTTC CACGTATAGC TGAACTCATG
GACAAGAAAC TGCCAAGTTT TGGACCTTAT CTGGAACAGC GCAAGAAAAT CATAGCAGAA
AACAAGATTA GACTGAAAGA ACAAAATGTA GCTTTTTCAC CACTTAAGAG AAACTGTTTT
ATCCCCAAAA GGCCTATTCC TACCATCAAG GATGTAATAG GAAAAGCACT GCAGTACCTT
GGAACATTTG GTGAATTGAG CAACGTAGAG CAAGTTGTGG CTATGATTGA TGAAGAAATG
TGTATCAACT GTGGTAAATG CTACATGACC TGTAATGATT CTGGCTACCA GGCTATACAG
TTTGATCCAG AAACCCACCT GCCCACCATA ACCGACACTT GTACAGGCTG TACTCTGTGT
CTCAGTGTTT GCCCTATTGT CGACTGCATC AAAATGGTTT CCAGGACAAC ACCTTATGAA
CCAAAGAGAG GCGTACCCTT ATCTGTGAAT CCGGTGTGTT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu33083
Clone ID Related Accession (Same CDS sequence) XM_006710397
Accession Version XM_006710397.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2670bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product dihydropyrimidine dehydrogenase [NADP(+)] isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_032977.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced gi:578798495. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGGCCCCTG TGCTCAGTAA GGACTCGGCG GACATCGAGA GTATCCTGGC TTTAAATCCT 
CGAACACAAA CTCATGCAAC TCTGTGTTCC ACTTCGGCCA AGAAATTAGA CAAGAAACAT
TGGAAAAGAA ATCCTGATAA GAACTGCTTT AATTGTGAGA AGCTGGAGAA TAATTTTGAT
GACATCAAGC ACACGACTCT TGGTGAGCGA GGAGCTCTCC GAGAAGCAAT GAGATGCCTG
AAATGTGCAG ATGCCCCGTG TCAGAAGAGC TGTCCAACTA ATCTTGATAT TAAATCATTC
ATCACAAGTA TTGCAAACAA GAACTATTAT GGAGCTGCTA AGATGATATT TTCTGACAAC
CCACTTGGTC TGACTTGTGG AATGGTATGT CCAACCTCTG ATCTTTGTGT AGGTGGATGC
AATTTATATG CCACTGAAGA GGGACCCATT AATATTGGTG GATTGCAGCA ATTTGCTACT
GAGGTATTCA AAGCAATGAG TATCCCACAG ATCAGAAATC CTTCGCTGCC TCCCCCAGAA
AAAATGTCTG AAGCCTATTC TGCAAAGATT GCTCTTTTTG GTGCTGGGCC TGCAAGTATA
AGTTGTGCTT CCTTTTTGGC TCGATTGGGG TACTCTGACA TCACTATATT TGAAAAACAA
GAATATGTTG GTGGTTTAAG TACTTCTGAA ATTCCTCAGT TCCGGCTGCC GTATGATGTA
GTGAATTTTG AGATTGAGCT AATGAAGGAC CTTGGTGTAA AGATAATTTG CGGTAAAAGC
CTTTCAGTGA ATGAAATGAC TCTTAGCACT TTGAAAGAAA AAGGCTACAA AGCTGCTTTC
ATTGGAATAG GTTTGCCAGA ACCCAATAAA GATGCCATCT TCCAAGGCCT GACGCAGGAC
CAGGGGTTTT ATACATCCAA AGACTTTTTG CCACTTGTAG CCAAAGGCAG TAAAGCAGGA
ATGTGCGCCT GTCACTCTCC ATTGCCATCG ATACGGGGAG TCGTGATTGT ACTTGGAGCT
GGAGACACTG CCTTTGACTG TGCAACATCT GCTCTACGTT GTGGAGCTCG CCGTGTGTTC
ATCGTCTTCA GAAAAGGCTT TGTTAATATA AGAGCTGTCC CTGAGGAGAT GGAACTTGCT
AAGGAAGAAA AGTGTGAATT TCTGCCATTC CTGTCCCCAC GGAAGGTTAT AGTAAAAGGT
GGGAGAATTG TTGCTATGCA GTTTGTTCGG ACAGAGCAAG ATGAAACTGG AAAATGGAAT
GAAGATGAAG ATCAGATGGT CCATCTGAAA GCCGATGTGG TCATCAGTGC CTTTGGTTCA
GTTCTGAGTG ATCCTAAAGT AAAAGAAGCC TTGAGCCCTA TAAAATTTAA CAGATGGGGT
CTCCCAGAAG TAGATCCAGA AACTATGCAA ACTAGTGAAG CATGGGTATT TGCAGGTGGT
GATGTCGTTG GTTTGGCTAA CACTACAGTG GAATCGGTGA ATGATGGAAA GCAAGCTTCT
TGGTACATTC ACAAATACGT ACAGTCACAA TATGGAGCTT CCGTTTCTGC CAAGCCTGAA
CTACCCCTCT TTTACACTCC TATTGATCTG GTGGACATTA GTGTAGAAAT GGCCGGATTG
AAGTTTATAA ATCCTTTTGG TCTTGCTAGC GCAACTCCAG CCACCAGCAC ATCAATGATT
CGAAGAGCTT TTGAAGCTGG ATGGGGTTTT GCCCTCACCA AAACTTTCTC TCTTGATAAG
GACATTGTGA CAAATGTTTC CCCCAGAATC ATCCGGGGAA CCACCTCTGG CCCCATGTAT
GGCCCTGGAC AAAGCTCCTT TCTGAATATT GAGCTCATCA GTGAGAAAAC GGCTGCATAT
TGGTGTCAAA GTGTCACTGA ACTAAAGGCT GACTTTCCAG ACAACATTGT GATTGCTAGC
ATTATGTGCA GTTACAATAA AAATGACTGG ACGGAACTTG CCAAGAAGTC TGAGGATTCT
GGAGCAGATG CCCTGGAGTT AAATTTATCA TGTCCACATG GCATGGGAGA AAGAGGAATG
GGCCTGGCCT GTGGGCAGGA TCCAGAGCTG GTGCGGAACA TCTGCCGCTG GGTTAGGCAA
GCTGTTCAGA TTCCTTTTTT TGCCAAGCTG ACCCCAAATG TCACTGATAT TGTGAGCATC
GCAAGAGCTG CAAAGGAAGG TGGTGCCAAT GGCGTTACAG CCACCAACAC TGTCTCAGGT
CTGATGGGAT TAAAATCTGA TGGCACACCT TGGCCAGCAG TGGGGATTGC AAAGCGAACT
ACATATGGAG GAGTGTCTGG GACAGCAATC AGACCTATTG CTTTGAGAGC TGTGACCTCC
ATTGCTCGTG CTCTGCCTGG ATTTCCCATT TTGGCTACTG GTGGAATTGA CTCTGCTGAA
AGTGGTCTTC AGTTTCTCCA TAGTGGTGCT TCCGTCCTCC AGGTATGCAG TGCCATTCAG
AATCAGGATT TCACTGTGAT CGAAGACTAC TGCACTGGCC TCAAAGCCCT GCTTTATCTG
AAAAGCATTG AAGAACTACA AGACTGGGAT GGACAGAGTC CAGCTACTGT GAGTCACCAG
AAAGGGAAAC CAGTTCCACG TATAGCTGAA CTCATGGACA AGGAAACACA GTGCCTCCTG
GATGTGATTT CTTCAGTGGA CTCTTTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006710460.1
CDS138..2807
Misc Feature(1)294..1676(+)
Misc Feature(2)309..635(+)
Misc Feature(3)717..>851(+)
Misc Feature(4)1731..2639(+)
Misc Feature(5)1734..2675(+)
Misc Feature(6)1791..2612(+)
Misc Feature(7)1857..2348(+)
Misc Feature(8)1857..2348(+)
Misc Feature(9)1962..2348(+)
Translation

Target ORF information:

RefSeq Version XM_006710397
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_006710397

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGGCCCCTG TGCTCAGTAA GGACTCGGCG GACATCGAGA GTATCCTGGC TTTAAATCCT 
CGAACACAAA CTCATGCAAC TCTGTGTTCC ACTTCGGCCA AGAAATTAGA CAAGAAACAT
TGGAAAAGAA ATCCTGATAA GAACTGCTTT AATTGTGAGA AGCTGGAGAA TAATTTTGAT
GACATCAAGC ACACGACTCT TGGTGAGCGA GGAGCTCTCC GAGAAGCAAT GAGATGCCTG
AAATGTGCAG ATGCCCCGTG TCAGAAGAGC TGTCCAACTA ATCTTGATAT TAAATCATTC
ATCACAAGTA TTGCAAACAA GAACTATTAT GGAGCTGCTA AGATGATATT TTCTGACAAC
CCACTTGGTC TGACTTGTGG AATGGTATGT CCAACCTCTG ATCTTTGTGT AGGTGGATGC
AATTTATATG CCACTGAAGA GGGACCCATT AATATTGGTG GATTGCAGCA ATTTGCTACT
GAGGTATTCA AAGCAATGAG TATCCCACAG ATCAGAAATC CTTCGCTGCC TCCCCCAGAA
AAAATGTCTG AAGCCTATTC TGCAAAGATT GCTCTTTTTG GTGCTGGGCC TGCAAGTATA
AGTTGTGCTT CCTTTTTGGC TCGATTGGGG TACTCTGACA TCACTATATT TGAAAAACAA
GAATATGTTG GTGGTTTAAG TACTTCTGAA ATTCCTCAGT TCCGGCTGCC GTATGATGTA
GTGAATTTTG AGATTGAGCT AATGAAGGAC CTTGGTGTAA AGATAATTTG CGGTAAAAGC
CTTTCAGTGA ATGAAATGAC TCTTAGCACT TTGAAAGAAA AAGGCTACAA AGCTGCTTTC
ATTGGAATAG GTTTGCCAGA ACCCAATAAA GATGCCATCT TCCAAGGCCT GACGCAGGAC
CAGGGGTTTT ATACATCCAA AGACTTTTTG CCACTTGTAG CCAAAGGCAG TAAAGCAGGA
ATGTGCGCCT GTCACTCTCC ATTGCCATCG ATACGGGGAG TCGTGATTGT ACTTGGAGCT
GGAGACACTG CCTTTGACTG TGCAACATCT GCTCTACGTT GTGGAGCTCG CCGTGTGTTC
ATCGTCTTCA GAAAAGGCTT TGTTAATATA AGAGCTGTCC CTGAGGAGAT GGAACTTGCT
AAGGAAGAAA AGTGTGAATT TCTGCCATTC CTGTCCCCAC GGAAGGTTAT AGTAAAAGGT
GGGAGAATTG TTGCTATGCA GTTTGTTCGG ACAGAGCAAG ATGAAACTGG AAAATGGAAT
GAAGATGAAG ATCAGATGGT CCATCTGAAA GCCGATGTGG TCATCAGTGC CTTTGGTTCA
GTTCTGAGTG ATCCTAAAGT AAAAGAAGCC TTGAGCCCTA TAAAATTTAA CAGATGGGGT
CTCCCAGAAG TAGATCCAGA AACTATGCAA ACTAGTGAAG CATGGGTATT TGCAGGTGGT
GATGTCGTTG GTTTGGCTAA CACTACAGTG GAATCGGTGA ATGATGGAAA GCAAGCTTCT
TGGTACATTC ACAAATACGT ACAGTCACAA TATGGAGCTT CCGTTTCTGC CAAGCCTGAA
CTACCCCTCT TTTACACTCC TATTGATCTG GTGGACATTA GTGTAGAAAT GGCCGGATTG
AAGTTTATAA ATCCTTTTGG TCTTGCTAGC GCAACTCCAG CCACCAGCAC ATCAATGATT
CGAAGAGCTT TTGAAGCTGG ATGGGGTTTT GCCCTCACCA AAACTTTCTC TCTTGATAAG
GACATTGTGA CAAATGTTTC CCCCAGAATC ATCCGGGGAA CCACCTCTGG CCCCATGTAT
GGCCCTGGAC AAAGCTCCTT TCTGAATATT GAGCTCATCA GTGAGAAAAC GGCTGCATAT
TGGTGTCAAA GTGTCACTGA ACTAAAGGCT GACTTTCCAG ACAACATTGT GATTGCTAGC
ATTATGTGCA GTTACAATAA AAATGACTGG ACGGAACTTG CCAAGAAGTC TGAGGATTCT
GGAGCAGATG CCCTGGAGTT AAATTTATCA TGTCCACATG GCATGGGAGA AAGAGGAATG
GGCCTGGCCT GTGGGCAGGA TCCAGAGCTG GTGCGGAACA TCTGCCGCTG GGTTAGGCAA
GCTGTTCAGA TTCCTTTTTT TGCCAAGCTG ACCCCAAATG TCACTGATAT TGTGAGCATC
GCAAGAGCTG CAAAGGAAGG TGGTGCCAAT GGCGTTACAG CCACCAACAC TGTCTCAGGT
CTGATGGGAT TAAAATCTGA TGGCACACCT TGGCCAGCAG TGGGGATTGC AAAGCGAACT
ACATATGGAG GAGTGTCTGG GACAGCAATC AGACCTATTG CTTTGAGAGC TGTGACCTCC
ATTGCTCGTG CTCTGCCTGG ATTTCCCATT TTGGCTACTG GTGGAATTGA CTCTGCTGAA
AGTGGTCTTC AGTTTCTCCA TAGTGGTGCT TCCGTCCTCC AGGTATGCAG TGCCATTCAG
AATCAGGATT TCACTGTGAT CGAAGACTAC TGCACTGGCC TCAAAGCCCT GCTTTATCTG
AAAAGCATTG AAGAACTACA AGACTGGGAT GGACAGAGTC CAGCTACTGT GAGTCACCAG
AAAGGGAAAC CAGTTCCACG TATAGCTGAA CTCATGGACA AGGAAACACA GTGCCTCCTG
GATGTGATTT CTTCAGTGGA CTCTTTCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19551
Clone ID Related Accession (Same CDS sequence) NM_000110
Accession Version NM_000110.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3078bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product dihydropyrimidine dehydrogenase [NADP(+)] isoform 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA721123.1, U20938.1 and AI124948.1. This sequence is a reference standard in the RefSeqGene project. On Dec 25, 2006 this sequence version replaced gi:4557874. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U20938.1, U09178.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
ATGGCCCCTG TGCTCAGTAA GGACTCGGCG GACATCGAGA GTATCCTGGC TTTAAATCCT 
CGAACACAAA CTCATGCAAC TCTGTGTTCC ACTTCGGCCA AGAAATTAGA CAAGAAACAT
TGGAAAAGAA ATCCTGATAA GAACTGCTTT AATTGTGAGA AGCTGGAGAA TAATTTTGAT
GACATCAAGC ACACGACTCT TGGTGAGCGA GGAGCTCTCC GAGAAGCAAT GAGATGCCTG
AAATGTGCAG ATGCCCCGTG TCAGAAGAGC TGTCCAACTA ATCTTGATAT TAAATCATTC
ATCACAAGTA TTGCAAACAA GAACTATTAT GGAGCTGCTA AGATGATATT TTCTGACAAC
CCACTTGGTC TGACTTGTGG AATGGTATGT CCAACCTCTG ATCTTTGTGT AGGTGGATGC
AATTTATATG CCACTGAAGA GGGACCCATT AATATTGGTG GATTGCAGCA ATTTGCTACT
GAGGTATTCA AAGCAATGAG TATCCCACAG ATCAGAAATC CTTCGCTGCC TCCCCCAGAA
AAAATGTCTG AAGCCTATTC TGCAAAGATT GCTCTTTTTG GTGCTGGGCC TGCAAGTATA
AGTTGTGCTT CCTTTTTGGC TCGATTGGGG TACTCTGACA TCACTATATT TGAAAAACAA
GAATATGTTG GTGGTTTAAG TACTTCTGAA ATTCCTCAGT TCCGGCTGCC GTATGATGTA
GTGAATTTTG AGATTGAGCT AATGAAGGAC CTTGGTGTAA AGATAATTTG CGGTAAAAGC
CTTTCAGTGA ATGAAATGAC TCTTAGCACT TTGAAAGAAA AAGGCTACAA AGCTGCTTTC
ATTGGAATAG GTTTGCCAGA ACCCAATAAA GATGCCATCT TCCAAGGCCT GACGCAGGAC
CAGGGGTTTT ATACATCCAA AGACTTTTTG CCACTTGTAG CCAAAGGCAG TAAAGCAGGA
ATGTGCGCCT GTCACTCTCC ATTGCCATCG ATACGGGGAG TCGTGATTGT ACTTGGAGCT
GGAGACACTG CCTTTGACTG TGCAACATCT GCTCTACGTT GTGGAGCTCG CCGTGTGTTC
ATCGTCTTCA GAAAAGGCTT TGTTAATATA AGAGCTGTCC CTGAGGAGAT GGAACTTGCT
AAGGAAGAAA AGTGTGAATT TCTGCCATTC CTGTCCCCAC GGAAGGTTAT AGTAAAAGGT
GGGAGAATTG TTGCTATGCA GTTTGTTCGG ACAGAGCAAG ATGAAACTGG AAAATGGAAT
GAAGATGAAG ATCAGATGGT CCATCTGAAA GCCGATGTGG TCATCAGTGC CTTTGGTTCA
GTTCTGAGTG ATCCTAAAGT AAAAGAAGCC TTGAGCCCTA TAAAATTTAA CAGATGGGGT
CTCCCAGAAG TAGATCCAGA AACTATGCAA ACTAGTGAAG CATGGGTATT TGCAGGTGGT
GATGTCGTTG GTTTGGCTAA CACTACAGTG GAATCGGTGA ATGATGGAAA GCAAGCTTCT
TGGTACATTC ACAAATACGT ACAGTCACAA TATGGAGCTT CCGTTTCTGC CAAGCCTGAA
CTACCCCTCT TTTACACTCC TATTGATCTG GTGGACATTA GTGTAGAAAT GGCCGGATTG
AAGTTTATAA ATCCTTTTGG TCTTGCTAGC GCAACTCCAG CCACCAGCAC ATCAATGATT
CGAAGAGCTT TTGAAGCTGG ATGGGGTTTT GCCCTCACCA AAACTTTCTC TCTTGATAAG
GACATTGTGA CAAATGTTTC CCCCAGAATC ATCCGGGGAA CCACCTCTGG CCCCATGTAT
GGCCCTGGAC AAAGCTCCTT TCTGAATATT GAGCTCATCA GTGAGAAAAC GGCTGCATAT
TGGTGTCAAA GTGTCACTGA ACTAAAGGCT GACTTTCCAG ACAACATTGT GATTGCTAGC
ATTATGTGCA GTTACAATAA AAATGACTGG ACGGAACTTG CCAAGAAGTC TGAGGATTCT
GGAGCAGATG CCCTGGAGTT AAATTTATCA TGTCCACATG GCATGGGAGA AAGAGGAATG
GGCCTGGCCT GTGGGCAGGA TCCAGAGCTG GTGCGGAACA TCTGCCGCTG GGTTAGGCAA
GCTGTTCAGA TTCCTTTTTT TGCCAAGCTG ACCCCAAATG TCACTGATAT TGTGAGCATC
GCAAGAGCTG CAAAGGAAGG TGGTGCCAAT GGCGTTACAG CCACCAACAC TGTCTCAGGT
CTGATGGGAT TAAAATCTGA TGGCACACCT TGGCCAGCAG TGGGGATTGC AAAGCGAACT
ACATATGGAG GAGTGTCTGG GACAGCAATC AGACCTATTG CTTTGAGAGC TGTGACCTCC
ATTGCTCGTG CTCTGCCTGG ATTTCCCATT TTGGCTACTG GTGGAATTGA CTCTGCTGAA
AGTGGTCTTC AGTTTCTCCA TAGTGGTGCT TCCGTCCTCC AGGTATGCAG TGCCATTCAG
AATCAGGATT TCACTGTGAT CGAAGACTAC TGCACTGGCC TCAAAGCCCT GCTTTATCTG
AAAAGCATTG AAGAACTACA AGACTGGGAT GGACAGAGTC CAGCTACTGT GAGTCACCAG
AAAGGGAAAC CAGTTCCACG TATAGCTGAA CTCATGGACA AGAAACTGCC AAGTTTTGGA
CCTTATCTGG AACAGCGCAA GAAAATCATA GCAGAAAACA AGATTAGACT GAAAGAACAA
AATGTAGCTT TTTCACCACT TAAGAGAAAC TGTTTTATCC CCAAAAGGCC TATTCCTACC
ATCAAGGATG TAATAGGAAA AGCACTGCAG TACCTTGGAA CATTTGGTGA ATTGAGCAAC
GTAGAGCAAG TTGTGGCTAT GATTGATGAA GAAATGTGTA TCAACTGTGG TAAATGCTAC
ATGACCTGTA ATGATTCTGG CTACCAGGCT ATACAGTTTG ATCCAGAAAC CCACCTGCCC
ACCATAACCG ACACTTGTAC AGGCTGTACT CTGTGTCTCA GTGTTTGCCC TATTGTCGAC
TGCATCAAAA TGGTTTCCAG GACAACACCT TATGAACCAA AGAGAGGCGT ACCCTTATCT
GTGAATCCGG TGTGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000101.2
CDS138..3215
Misc Feature(1)37..37(+)
Misc Feature(2)294..1676(+)
Misc Feature(3)309..635(+)
Misc Feature(4)717..>851(+)
Misc Feature(5)1287..1289(+)
Misc Feature(6)1731..3158(+)
Misc Feature(7)1731..2639(+)
Misc Feature(8)1791..2612(+)
Misc Feature(9)1857..2348(+)
Misc Feature(10)1857..2348(+)
Misc Feature(11)1962..2348(+)
Misc Feature(12)2139..2147(+)
Misc Feature(13)2343..2348(+)
Misc Feature(14)2988..3128(+)
Exon (1)1..176
Gene:DPYD
Gene Synonym:
Exon (2)177..287
Gene:DPYD
Gene Synonym:
Exon (3)288..370
Gene:DPYD
Gene Synonym:
Exon (4)371..458
Gene:DPYD
Gene Synonym:
Exon (5)459..620
Gene:DPYD
Gene Synonym:
Exon (6)621..817
Gene:DPYD
Gene Synonym:
Exon (7)818..899
Gene:DPYD
Gene Synonym:
Exon (8)900..987
Gene:DPYD
Gene Synonym:
Exon (9)988..1095
Gene:DPYD
Gene Synonym:
Exon (10)1096..1265
Gene:DPYD
Gene Synonym:
Exon (11)1266..1476
Gene:DPYD
Gene Synonym:
Exon (12)1477..1661
Gene:DPYD
Gene Synonym:
Exon (13)1662..1877
Gene:DPYD
Gene Synonym:
Exon (14)1878..2042
Gene:DPYD
Gene Synonym:
Exon (15)2043..2111
Gene:DPYD
Gene Synonym:
Exon (16)2112..2195
Gene:DPYD
Gene Synonym:
Exon (17)2196..2316
Gene:DPYD
Gene Synonym:
Exon (18)2317..2436
Gene:DPYD
Gene Synonym:
Exon (19)2437..2579
Gene:DPYD
Gene Synonym:
Exon (20)2580..2759
Gene:DPYD
Gene Synonym:
Exon (21)2760..2903
Gene:DPYD
Gene Synonym:
Exon (22)2904..3044
Gene:DPYD
Gene Synonym:
Exon (23)3045..4448
Gene:DPYD
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000110
Organism Homo sapiens (human)
Definition Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000110

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
ATGGCCCCTG TGCTCAGTAA GGACTCGGCG GACATCGAGA GTATCCTGGC TTTAAATCCT 
CGAACACAAA CTCATGCAAC TCTGTGTTCC ACTTCGGCCA AGAAATTAGA CAAGAAACAT
TGGAAAAGAA ATCCTGATAA GAACTGCTTT AATTGTGAGA AGCTGGAGAA TAATTTTGAT
GACATCAAGC ACACGACTCT TGGTGAGCGA GGAGCTCTCC GAGAAGCAAT GAGATGCCTG
AAATGTGCAG ATGCCCCGTG TCAGAAGAGC TGTCCAACTA ATCTTGATAT TAAATCATTC
ATCACAAGTA TTGCAAACAA GAACTATTAT GGAGCTGCTA AGATGATATT TTCTGACAAC
CCACTTGGTC TGACTTGTGG AATGGTATGT CCAACCTCTG ATCTTTGTGT AGGTGGATGC
AATTTATATG CCACTGAAGA GGGACCCATT AATATTGGTG GATTGCAGCA ATTTGCTACT
GAGGTATTCA AAGCAATGAG TATCCCACAG ATCAGAAATC CTTCGCTGCC TCCCCCAGAA
AAAATGTCTG AAGCCTATTC TGCAAAGATT GCTCTTTTTG GTGCTGGGCC TGCAAGTATA
AGTTGTGCTT CCTTTTTGGC TCGATTGGGG TACTCTGACA TCACTATATT TGAAAAACAA
GAATATGTTG GTGGTTTAAG TACTTCTGAA ATTCCTCAGT TCCGGCTGCC GTATGATGTA
GTGAATTTTG AGATTGAGCT AATGAAGGAC CTTGGTGTAA AGATAATTTG CGGTAAAAGC
CTTTCAGTGA ATGAAATGAC TCTTAGCACT TTGAAAGAAA AAGGCTACAA AGCTGCTTTC
ATTGGAATAG GTTTGCCAGA ACCCAATAAA GATGCCATCT TCCAAGGCCT GACGCAGGAC
CAGGGGTTTT ATACATCCAA AGACTTTTTG CCACTTGTAG CCAAAGGCAG TAAAGCAGGA
ATGTGCGCCT GTCACTCTCC ATTGCCATCG ATACGGGGAG TCGTGATTGT ACTTGGAGCT
GGAGACACTG CCTTTGACTG TGCAACATCT GCTCTACGTT GTGGAGCTCG CCGTGTGTTC
ATCGTCTTCA GAAAAGGCTT TGTTAATATA AGAGCTGTCC CTGAGGAGAT GGAACTTGCT
AAGGAAGAAA AGTGTGAATT TCTGCCATTC CTGTCCCCAC GGAAGGTTAT AGTAAAAGGT
GGGAGAATTG TTGCTATGCA GTTTGTTCGG ACAGAGCAAG ATGAAACTGG AAAATGGAAT
GAAGATGAAG ATCAGATGGT CCATCTGAAA GCCGATGTGG TCATCAGTGC CTTTGGTTCA
GTTCTGAGTG ATCCTAAAGT AAAAGAAGCC TTGAGCCCTA TAAAATTTAA CAGATGGGGT
CTCCCAGAAG TAGATCCAGA AACTATGCAA ACTAGTGAAG CATGGGTATT TGCAGGTGGT
GATGTCGTTG GTTTGGCTAA CACTACAGTG GAATCGGTGA ATGATGGAAA GCAAGCTTCT
TGGTACATTC ACAAATACGT ACAGTCACAA TATGGAGCTT CCGTTTCTGC CAAGCCTGAA
CTACCCCTCT TTTACACTCC TATTGATCTG GTGGACATTA GTGTAGAAAT GGCCGGATTG
AAGTTTATAA ATCCTTTTGG TCTTGCTAGC GCAACTCCAG CCACCAGCAC ATCAATGATT
CGAAGAGCTT TTGAAGCTGG ATGGGGTTTT GCCCTCACCA AAACTTTCTC TCTTGATAAG
GACATTGTGA CAAATGTTTC CCCCAGAATC ATCCGGGGAA CCACCTCTGG CCCCATGTAT
GGCCCTGGAC AAAGCTCCTT TCTGAATATT GAGCTCATCA GTGAGAAAAC GGCTGCATAT
TGGTGTCAAA GTGTCACTGA ACTAAAGGCT GACTTTCCAG ACAACATTGT GATTGCTAGC
ATTATGTGCA GTTACAATAA AAATGACTGG ACGGAACTTG CCAAGAAGTC TGAGGATTCT
GGAGCAGATG CCCTGGAGTT AAATTTATCA TGTCCACATG GCATGGGAGA AAGAGGAATG
GGCCTGGCCT GTGGGCAGGA TCCAGAGCTG GTGCGGAACA TCTGCCGCTG GGTTAGGCAA
GCTGTTCAGA TTCCTTTTTT TGCCAAGCTG ACCCCAAATG TCACTGATAT TGTGAGCATC
GCAAGAGCTG CAAAGGAAGG TGGTGCCAAT GGCGTTACAG CCACCAACAC TGTCTCAGGT
CTGATGGGAT TAAAATCTGA TGGCACACCT TGGCCAGCAG TGGGGATTGC AAAGCGAACT
ACATATGGAG GAGTGTCTGG GACAGCAATC AGACCTATTG CTTTGAGAGC TGTGACCTCC
ATTGCTCGTG CTCTGCCTGG ATTTCCCATT TTGGCTACTG GTGGAATTGA CTCTGCTGAA
AGTGGTCTTC AGTTTCTCCA TAGTGGTGCT TCCGTCCTCC AGGTATGCAG TGCCATTCAG
AATCAGGATT TCACTGTGAT CGAAGACTAC TGCACTGGCC TCAAAGCCCT GCTTTATCTG
AAAAGCATTG AAGAACTACA AGACTGGGAT GGACAGAGTC CAGCTACTGT GAGTCACCAG
AAAGGGAAAC CAGTTCCACG TATAGCTGAA CTCATGGACA AGAAACTGCC AAGTTTTGGA
CCTTATCTGG AACAGCGCAA GAAAATCATA GCAGAAAACA AGATTAGACT GAAAGAACAA
AATGTAGCTT TTTCACCACT TAAGAGAAAC TGTTTTATCC CCAAAAGGCC TATTCCTACC
ATCAAGGATG TAATAGGAAA AGCACTGCAG TACCTTGGAA CATTTGGTGA ATTGAGCAAC
GTAGAGCAAG TTGTGGCTAT GATTGATGAA GAAATGTGTA TCAACTGTGG TAAATGCTAC
ATGACCTGTA ATGATTCTGG CTACCAGGCT ATACAGTTTG ATCCAGAAAC CCACCTGCCC
ACCATAACCG ACACTTGTAC AGGCTGTACT CTGTGTCTCA GTGTTTGCCC TATTGTCGAC
TGCATCAAAA TGGTTTCCAG GACAACACCT TATGAACCAA AGAGAGGCGT ACCCTTATCT
GTGAATCCGG TGTGTTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu21185
Clone ID Related Accession (Same CDS sequence) NM_001160301
Accession Version NM_001160301.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 522bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product dihydropyrimidine dehydrogenase [NADP(+)] isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA721123.1, BC008379.1 and AC138135.2. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC064027.1, BC108742.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
ATGGCCCCTG TGCTCAGTAA GGACTCGGCG GACATCGAGA GTATCCTGGC TTTAAATCCT 
CGAACACAAA CTCATGCAAC TCTGTGTTCC ACTTCGGCCA AGAAATTAGA CAAGAAACAT
TGGAAAAGAA ATCCTGATAA GAACTGCTTT AATTGTGAGA AGCTGGAGAA TAATTTTGAT
GACATCAAGC ACACGACTCT TGGTGAGCGA GGAGCTCTCC GAGAAGCAAT GAGATGCCTG
AAATGTGCAG ATGCCCCGTG TCAGAAGAGC TGTCCAACTA ATCTTGATAT TAAATCATTC
ATCACAAGTA TTGCAAACAA GAACTATTAT GGAGCTGCTA AGATGATATT TTCTGACAAC
CCACTTGGTC TGACTTGTGG AATGGTATGT CCAACCTCTG ATCTTTGTGT AGGTGGATGC
AATTTATATG CCACTGAAGA GGGACCCATT AATATTGGTG GATTGCAGCA ATTTGCTACT
GAGACTTTGA TCCTGGCTTT CTCTTTAATG AATCATTTGT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001153773.1
CDS138..659
Misc Feature(1)309..623(+)
Exon (1)1..176
Gene:DPYD
Gene Synonym:
Exon (2)177..287
Gene:DPYD
Gene Synonym:
Exon (3)288..370
Gene:DPYD
Gene Synonym:
Exon (4)371..458
Gene:DPYD
Gene Synonym:
Exon (5)459..620
Gene:DPYD
Gene Synonym:
Exon (6)621..1789
Gene:DPYD
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001160301
Organism Homo sapiens (human)
Definition Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001160301

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGCCCCTG TGCTCAGTAA GGACTCGGCG GACATCGAGA GTATCCTGGC TTTAAATCCT 
CGAACACAAA CTCATGCAAC TCTGTGTTCC ACTTCGGCCA AGAAATTAGA CAAGAAACAT
TGGAAAAGAA ATCCTGATAA GAACTGCTTT AATTGTGAGA AGCTGGAGAA TAATTTTGAT
GACATCAAGC ACACGACTCT TGGTGAGCGA GGAGCTCTCC GAGAAGCAAT GAGATGCCTG
AAATGTGCAG ATGCCCCGTG TCAGAAGAGC TGTCCAACTA ATCTTGATAT TAAATCATTC
ATCACAAGTA TTGCAAACAA GAACTATTAT GGAGCTGCTA AGATGATATT TTCTGACAAC
CCACTTGGTC TGACTTGTGG AATGGTATGT CCAACCTCTG ATCTTTGTGT AGGTGGATGC
AATTTATATG CCACTGAAGA GGGACCCATT AATATTGGTG GATTGCAGCA ATTTGCTACT
GAGACTTTGA TCCTGGCTTT CTCTTTAATG AATCATTTGT AA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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