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DRD1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol DRD1
Entrez Gene ID 1812
Full Name dopamine receptor D1
Synonyms DADR, DRD1A
General protein information
Preferred Names
D(1A) dopamine receptor
Names
D(1A) dopamine receptor
dopamine D1 receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.1

Summary This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

126449

Disorder Html:

mRNA and Protein(s)

mRNA Protein Name
NM_000794 NP_000785 D(1A) dopamine receptor

KEGG
hsa04080 Neuroactive ligand-receptor interaction
hsa04020 Calcium signaling pathway
hsa04540 Gap junction
hsa05012 Parkinson's disease
hsa04728 Dopaminergic synapse
hsa05030 Cocaine addiction
hsa05031 Amphetamine addiction
hsa05032 Morphine addiction
hsa05034 Alcoholism
hsa04024 cAMP signaling pathway
Reactome
R-HSA-162582 Signal Transduction
R-HSA-372790 Signaling by GPCR
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signaling
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-390651 Dopamine receptors
R-HSA-418555 G alpha (s) signalling events
R-HSA-375280 Amine ligand-binding receptors
WikiPathways
WP666 Hypothetical Network for Drug Addiction
WP455 GPCRs, Class A Rhodopsin-like
WP58 Monoamine GPCRs


Homo sapiens (human) DRD1 NP_000785.1
Pan troglodytes (chimpanzee) DRD1 XP_001149473.2
Canis lupus familiaris (dog) DRD1 XP_005619252.1
Bos taurus (cattle) DRD1 NP_776467.1
Mus musculus (house mouse) Drd1a NP_034206.1
Rattus norvegicus (Norway rat) Drd1 NP_036678.2
Gallus gallus (chicken) DRD1 NP_001138320.1
Danio rerio (zebrafish) drd1b NP_001129448.1
Xenopus (Silurana) tropicalis (western clawed frog) drd1 XP_004912926.1

Component

ID Name Evidence
GO:0005624 membrane fraction IDA
GO:0005634 nucleus IEA
GO:0005783 endoplasmic reticulum IEA
GO:0005789 endoplasmic reticulum membrane IEA
GO:0005886 plasma membrane EXP
GO:0005886 plasma membrane IDA
GO:0005886 plasma membrane TAS
GO:0005887 integral to plasma membrane IC
GO:0005901 caveola IEA
GO:0030424 axon IEA
GO:0043025 neuronal cell body IEA
GO:0043197 dendritic spine IEA

Function

ID Name Evidence
GO:0001588 dopamine receptor activity, coupled via Gs IDA
GO:0001588 dopamine receptor activity, coupled via Gs IMP
GO:0001590 dopamine D1 receptor activity IEA
GO:0004872 receptor activity IEA
GO:0004930 G-protein coupled receptor activity IEA
GO:0004952 dopamine receptor activity IDA
GO:0005515 protein binding IPI
GO:0008144 drug binding IEA
GO:0035240 dopamine binding IMP

Process

ID Name Evidence
GO:0001659 temperature homeostasis IEA
GO:0001661 conditioned taste aversion IEA
GO:0001662 behavioral fear response IEA
GO:0001963 synaptic transmission, dopaminergic IEA
GO:0001975 response to amphetamine IEA
GO:0006469 negative regulation of protein kinase activity IEA
GO:0006606 protein import into nucleus IEA
GO:0006886 intracellular protein transport IEA
GO:0006936 muscle contraction IEA
GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger IDA
GO:0007189 activation of adenylate cyclase activity by G-protein signaling pathway IDA
GO:0007190 activation of adenylate cyclase activity IDA
GO:0007191 activation of adenylate cyclase activity by dopamine receptor signaling pathway IDA
GO:0007416 synapse assembly ISS
GO:0007613 memory IEA
GO:0007617 mating behavior ISS
GO:0007625 grooming behavior IEA
GO:0007626 locomotory behavior IEA
GO:0007628 adult walking behavior ISS
GO:0008542 visual learning ISS
GO:0014002 astrocyte development IEA
GO:0015872 dopamine transport IEA
GO:0019226 transmission of nerve impulse ISS
GO:0019228 regulation of action potential in neuron IEA
GO:0019722 calcium-mediated signaling IEA
GO:0021542 dentate gyrus development IEA
GO:0021756 striatum development IEA
GO:0021853 cerebral cortex GABAergic interneuron migration ISS
GO:0030335 positive regulation of cell migration ISS
GO:0030336 negative regulation of cell migration IEA
GO:0030432 peristalsis IEA
GO:0030819 positive regulation of cAMP biosynthetic process IDA
GO:0031161 phosphatidylinositol catabolic process IEA
GO:0032869 cellular response to insulin stimulus IEA
GO:0035106 operant conditioning IEA
GO:0042053 regulation of dopamine metabolic process IEA
GO:0042321 negative regulation of circadian sleep/wake cycle, sleep IEA
GO:0042417 dopamine metabolic process IC
GO:0042493 response to drug ISS
GO:0042755 eating behavior IEA
GO:0043268 positive regulation of potassium ion transport ISS
GO:0043269 regulation of ion transport IEA
GO:0046323 glucose import IEA
GO:0046960 sensitization IEA
GO:0048148 behavioral response to cocaine IEA
GO:0048169 regulation of long-term neuronal synaptic plasticity IEA
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA
GO:0051482 elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger IDA
GO:0051584 regulation of dopamine uptake IC
GO:0051968 positive regulation of synaptic transmission, glutamatergic ISS
GO:0060134 prepulse inhibition ISS
GO:0060158 activation of phospholipase C activity by dopamine receptor signaling pathway IDA
GO:0060158 activation of phospholipase C activity by dopamine receptor signaling pathway IGI
GO:0060291 long-term synaptic potentiation IEA
GO:0060292 long term synaptic depression IEA

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DRD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DRD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23409
NM_000794 Homo sapiens dopamine receptor D1 (DRD1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$223.30
$319.00

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).


CloneID OHu23409
Accession Version NM_000794.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1341bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product D(1A) dopamine receptor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA249160.1, AC091393.3 and X58987.1. This sequence is a reference standard in the RefSeqGene project. On Feb 23, 2006 this sequence version replaced gi:16445404. Summary: This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA249160.1, DA228014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142363, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGAGGACTC TGAACACCTC TGCCATGGAC GGGACTGGGC TGGTGGTGGA GAGGGACTTC 
TCTGTTCGTA TCCTCACTGC CTGTTTCCTG TCGCTGCTCA TCCTGTCCAC GCTCCTGGGG
AACACGCTGG TCTGTGCTGC CGTTATCAGG TTCCGACACC TGCGGTCCAA GGTGACCAAC
TTCTTTGTCA TCTCCTTGGC TGTGTCAGAT CTCTTGGTGG CCGTCCTGGT CATGCCCTGG
AAGGCAGTGG CTGAGATTGC TGGCTTCTGG CCCTTTGGGT CCTTCTGTAA CATCTGGGTG
GCCTTTGACA TCATGTGCTC CACTGCATCC ATCCTCAACC TCTGTGTGAT CAGCGTGGAC
AGGTATTGGG CTATCTCCAG CCCTTTCCGG TATGAGAGAA AGATGACCCC CAAGGCAGCC
TTCATCCTGA TCAGTGTGGC ATGGACCTTG TCTGTACTCA TCTCCTTCAT CCCAGTGCAG
CTCAGCTGGC ACAAGGCAAA ACCCACAAGC CCCTCTGATG GAAATGCCAC TTCCCTGGCT
GAGACCATAG ACAACTGTGA CTCCAGCCTC AGCAGGACAT ATGCCATCTC ATCCTCTGTA
ATAAGCTTTT ACATCCCTGT GGCCATCATG ATTGTCACCT ACACCAGGAT CTACAGGATT
GCTCAGAAAC AAATACGGCG CATTGCGGCC TTGGAGAGGG CAGCAGTCCA CGCCAAGAAT
TGCCAGACCA CCACAGGTAA TGGAAAGCCT GTCGAATGTT CTCAACCGGA AAGTTCTTTT
AAGATGTCCT TCAAAAGAGA AACTAAAGTC CTGAAGACTC TGTCGGTGAT CATGGGTGTG
TTTGTGTGCT GTTGGCTACC TTTCTTCATC TTGAACTGCA TTTTGCCCTT CTGTGGGTCT
GGGGAGACGC AGCCCTTCTG CATTGATTCC AACACCTTTG ACGTGTTTGT GTGGTTTGGG
TGGGCTAATT CATCCTTGAA CCCCATCATT TATGCCTTTA ATGCTGATTT TCGGAAGGCA
TTTTCAACCC TCTTAGGATG CTACAGACTT TGCCCTGCGA CGAATAATGC CATAGAGACG
GTGAGTATCA ATAACAATGG GGCCGCGATG TTTTCCAGCC ATCATGAGCC ACGAGGCTCC
ATCTCCAAGG AGTGCAATCT GGTTTACCTG ATCCCACATG CTGTGGGCTC CTCTGAGGAC
CTGAAAAAGG AGGAGGCAGC TGGCATCGCC AGACCCTTGG AGAAGCTGTC CCCAGCCCTA
TCAGTCATAT TGGACTATGA CACTGACGTC TCTCTGGAGA AGATCCAACC CATCACACAA
AACGGTCAGC ACCCAACCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_000785.1
CDS946..2286
Misc Feature(1)463..463(+)
Misc Feature(2)805..807(+)
Misc Feature(3)1015..1092(+)
Misc Feature(4)1066..>1419(+)
Misc Feature(5)1081..1938(+)
Misc Feature(6)1126..1206(+)
Misc Feature(7)1234..1302(+)
Misc Feature(8)1360..1434(+)
Misc Feature(9)1522..1599(+)
Misc Feature(10)1762..1842(+)
Misc Feature(11)1882..1956(+)
Misc Feature(12)1984..1986(+)
Misc Feature(13)1996..1998(+)
Misc Feature(14)2023..2025(+)
Exon (1)1..462
Gene:DRD1
Gene Synonym:
Exon (2)463..3373
Gene:DRD1
Gene Synonym:
Translation
Position Chain Variation Link
16 16 a, g dbSNP:202230826
77 77 c, t dbSNP:370393332
103 103 c, g dbSNP:566124813
109 109 a, g, t dbSNP:10061709
118 118 c, t dbSNP:536150357
174 174 c, t dbSNP:189073284
179 179 c, g dbSNP:773372266
182 182 a, g dbSNP:550522813
202 202 a, g dbSNP:56000379
205 205 c, t dbSNP:564459543
245 245 a, t dbSNP:552619913
246 246 a, c dbSNP:527732040
251 251 a, g dbSNP:372160361
262 262 c, t dbSNP:265981
279 279 a, g dbSNP:542207570
302 302 c, t dbSNP:780710382
320 320 c, t dbSNP:575215390
357 357 a, g dbSNP:758917277
359 359 c, t dbSNP:201089398
365 365 a, g dbSNP:544511033
371 371 g, t dbSNP:11742764
425 425 a, t dbSNP:577344141
476 476 c, t dbSNP:554147045
495 495 c, t dbSNP:749920467
506 506 c, g dbSNP:535817442
558 558 c, t dbSNP:749661152
573 573 c, t dbSNP:568825406
576 576 c, t dbSNP:775070467
612 612 c, g dbSNP:557207143
640 640 a, g dbSNP:185064274
643 643 c, t dbSNP:571417062
690 690 a, g dbSNP:111805057
730 730 a, t dbSNP:371698970
757 757 c, g dbSNP:778443115
766 766 c, t dbSNP:527799137
783 783 c, t dbSNP:192224189
808 808 a, g dbSNP:769511379
809 809 a, g dbSNP:745333001
842 842 a, c dbSNP:79985405
852 852 a, g dbSNP:5326
883 883 a, c dbSNP:563201214
893 893 c, t dbSNP:756772351
898 898 a, g dbSNP:4532
914 914 a, t dbSNP:774034163
924 924 a, t dbSNP:187630543
924 924 -, t dbSNP:758790202
927 927 a, c, t dbSNP:369445409
928 928 a, g dbSNP:773243062
937 937 c, g dbSNP:565482170
939 939 g, t dbSNP:747717004
948 948 a, g dbSNP:780843388
950 950 a, g dbSNP:754681988
968 968 c, t dbSNP:763856000
970 970 a, g dbSNP:760461607
976 976 a, g dbSNP:146816422
984 984 a, g dbSNP:369853177
995 995 a, t dbSNP:780300179
999 999 g, t dbSNP:758745722
1002 1002 a, c dbSNP:750719811
1005 1005 a, c dbSNP:752426861
1008 1008 g, t dbSNP:145032403
1012 1012 a, c dbSNP:757759969
1013 1013 a, c, g, t dbSNP:572625837
1025 1025 c, g dbSNP:775742033
1032 1032 c, g dbSNP:767604497
1035 1035 a, g dbSNP:1042768
1038 1038 a, g dbSNP:767459799
1054 1054 a, c, g dbSNP:5327
1056 1056 g, t dbSNP:372040450
1059 1059 a, c dbSNP:769918422
1065 1065 a, g dbSNP:748030620
1070 1070 c, t dbSNP:777853990
1071 1071 g, t dbSNP:768227443
1072 1072 c, t dbSNP:554208539
1074 1074 a, g, t dbSNP:369288437
1086 1086 a, c, g dbSNP:5329
1087 1087 a, g dbSNP:746313806
1094 1094 a, g dbSNP:779186397
1095 1095 a, g, t dbSNP:5330
1101 1101 a, c dbSNP:754298471
1111 1111 g, t dbSNP:764190400
1122 1122 c, t dbSNP:756259088
1129 1129 g, t dbSNP:555464688
1134 1134 c, t dbSNP:752698175
1140 1140 c, t dbSNP:141052935
1143 1143 a, g dbSNP:1799914
1160 1160 c, t dbSNP:759671921
1167 1167 a, c, t dbSNP:1042770
1168 1168 a, g dbSNP:367761486
1182 1182 c, t dbSNP:776666364
1188 1188 a, g dbSNP:768680344
1196 1196 a, c dbSNP:549712601
1227 1227 c, t dbSNP:760278176
1232 1232 a, g dbSNP:774846844
1233 1233 c, t dbSNP:771762936
1245 1245 a, g dbSNP:745456137
1266 1266 c, t dbSNP:779276408
1274 1274 c, t dbSNP:767856135
1287 1287 c, g dbSNP:771244904
1298 1298 a, g dbSNP:749622213
1299 1299 c, t dbSNP:191953032
1300 1300 a, g dbSNP:756568052
1323 1323 c, t dbSNP:752886523
1326 1326 c, t dbSNP:149673312
1333 1333 c, t dbSNP:755241449
1334 1334 a, g dbSNP:751782298
1347 1347 c, g dbSNP:765151364
1354 1354 c, t dbSNP:761736618
1355 1355 c, t dbSNP:753660657
1358 1358 a, c dbSNP:764182655
1362 1362 a, c dbSNP:374437918
1366 1366 c, t dbSNP:372262906
1377 1377 a, c, t dbSNP:116072750
1378 1378 a, g dbSNP:775081512
1384 1384 a, g dbSNP:368319023
1387 1387 c, t dbSNP:759268810
1401 1401 a, g dbSNP:774032796
1404 1404 c, t dbSNP:770549660
1437 1437 c, g dbSNP:749712205
1465 1465 a, g dbSNP:778108888
1467 1467 a, c dbSNP:770336294
1488 1488 g, t dbSNP:748544904
1489 1489 a, g dbSNP:781350753
1492 1492 a, g dbSNP:754968722
1497 1497 c, t dbSNP:148899064
1498 1498 a, g dbSNP:780471405
1500 1500 a, c dbSNP:187573912
1507 1507 a, t dbSNP:374427471
1509 1509 c, t dbSNP:148681593
1510 1510 a, t dbSNP:113146177
1516 1516 a, g dbSNP:753750657
1540 1540 g, t dbSNP:5331
1544 1544 c, t dbSNP:763741028
1545 1545 a, g dbSNP:145599956
1560 1560 a, c dbSNP:756099884
1566 1566 g, t dbSNP:752538302
1568 1568 c, t dbSNP:767462851
1578 1578 c, t dbSNP:200975855
1594 1594 a, g dbSNP:773841109
1596 1596 c, t dbSNP:766089357
1621 1621 c, g, t dbSNP:773577315
1622 1622 a, g dbSNP:564042116
1624 1624 a, c, t dbSNP:777044090
1625 1625 a, g dbSNP:769184130
1627 1627 a, g dbSNP:747143134
1629 1629 c, t dbSNP:144226767
1630 1630 a, g dbSNP:13306309
1631 1631 c, t dbSNP:758710148
1646 1646 c, t dbSNP:140250188
1656 1656 a, c, t dbSNP:777655360
1657 1657 a, g dbSNP:755902762
1666 1666 c, t dbSNP:752518690
1693 1693 c, t dbSNP:200037245
1695 1695 c, t dbSNP:754908065
1698 1698 c, g dbSNP:147169569
1699 1699 a, g dbSNP:548677242
1712 1712 c, t dbSNP:182894202
1713 1713 a, g, t dbSNP:752562538
1721 1721 a, c dbSNP:74414188
1728 1728 g, t dbSNP:777039128
1753 1753 c, g dbSNP:139908345
1770 1770 a, c, g dbSNP:201944827
1797 1797 c, t dbSNP:772239676
1809 1809 a, c dbSNP:745912042
1836 1836 c, t dbSNP:370118588
1843 1843 c, t dbSNP:191808405
1846 1846 a, g dbSNP:771174351
1853 1853 c, t dbSNP:550657704
1854 1854 a, g dbSNP:780977005
1860 1860 c, t dbSNP:377005366
1861 1861 c, g, t dbSNP:150662348
1862 1862 g, t dbSNP:757939714
1869 1869 c, t dbSNP:759420920
1873 1873 c, t dbSNP:764855525
1881 1881 c, g dbSNP:761520910
1887 1887 c, t dbSNP:373400500
1914 1914 c, t dbSNP:764505741
1917 1917 a, c dbSNP:750662551
1929 1929 c, t dbSNP:141925440
1932 1932 a, c dbSNP:776180680
1957 1957 c, t dbSNP:532843195
1971 1971 a, c dbSNP:772685461
1974 1974 a, c, g dbSNP:774488532
1987 1987 c, t dbSNP:771065562
1989 1989 c, t dbSNP:6272
1990 1990 a, g dbSNP:780868574
1991 1991 c, g dbSNP:768398169
1992 1992 a, t dbSNP:370098478
2003 2003 c, g, t dbSNP:144813919
2004 2004 a, g dbSNP:749967573
2006 2006 c, t dbSNP:778418674
2007 2007 a, g dbSNP:756872143
2024 2024 c, t dbSNP:753491559
2025 2025 -, gg dbSNP:753165553
2025 2025 a, g dbSNP:763809199
2030 2030 a, g dbSNP:761172175
2032 2032 a, g dbSNP:528645013
2034 2034 c, g dbSNP:768208899
2043 2043 a, t dbSNP:760024652
2049 2049 c, t dbSNP:373118849
2050 2050 a, g, t dbSNP:763112127
2051 2051 c, t dbSNP:201076076
2052 2052 a, g dbSNP:374239045
2059 2059 c, t dbSNP:746864254
2066 2066 a, g dbSNP:775260576
2078 2078 a, g dbSNP:771907312
2080 2080 a, g dbSNP:745758211
2081 2081 g, t dbSNP:778319909
2094 2094 a, g dbSNP:756834255
2098 2098 c, t dbSNP:748726799
2099 2099 a, g dbSNP:777626977
2107 2107 a, g dbSNP:755827909
2123 2123 a, g dbSNP:753120440
2125 2125 -, gctgtggg dbSNP:765528098
2128 2128 a, g dbSNP:767938936
2133 2133 c, t dbSNP:755465400
2134 2134 -, t dbSNP:759873198
2139 2139 c, t dbSNP:141964738
2143 2143 a, g dbSNP:766763026
2154 2154 c, g dbSNP:763137374
2159 2159 a, g dbSNP:773263928
2160 2160 a, g dbSNP:774776350
2171 2171 c, t dbSNP:761955823
2172 2172 c, t dbSNP:187504751
2173 2173 a, g, t dbSNP:201057716
2181 2181 c, t dbSNP:774397165
2185 2185 a, g dbSNP:574934486
2196 2196 c, g dbSNP:748874679
2202 2202 a, c dbSNP:556926199
2205 2205 a, g dbSNP:199860205
2207 2207 c, t dbSNP:747757924
2208 2208 a, g dbSNP:155417
2211 2211 a, c dbSNP:577893445
2215 2215 c, t dbSNP:751844856
2217 2217 g, t dbSNP:763257219
2218 2218 g, t dbSNP:766964125
2232 2232 a, c, t dbSNP:200809329
2233 2233 a, g dbSNP:145080397
2234 2234 c, t dbSNP:765241799
2235 2235 c, t dbSNP:762043655
2255 2255 a, c dbSNP:776880092
2262 2262 a, g dbSNP:202050642
2266 2266 a, g dbSNP:759434354
2268 2268 c, t dbSNP:774013750
2273 2273 a, g dbSNP:62636575
2277 2277 c, t dbSNP:762930285
2281 2281 a, g dbSNP:775956849
2282 2282 c, t dbSNP:182759154
2290 2290 c, t dbSNP:375177269
2291 2291 a, g, t dbSNP:768176917
2297 2297 a, g dbSNP:5332
2311 2311 a, g, t dbSNP:555138780
2320 2320 c, t dbSNP:368890959
2322 2322 a, g dbSNP:778994047
2325 2325 -, a dbSNP:753850773
2336 2336 a, g dbSNP:757377403
2348 2348 c, t dbSNP:686
2349 2349 c, t dbSNP:1799961
2385 2385 a, g dbSNP:759211459
2430 2430 c, t dbSNP:41275335
2446 2446 a, c dbSNP:770403637
2476 2476 a, g dbSNP:541639846
2491 2491 c, t dbSNP:550974788
2500 2500 a, g dbSNP:144821512
2505 2505 g, t dbSNP:371818668
2506 2506 c, t dbSNP:538621545
2512 2512 a, g dbSNP:140926690
2566 2566 g, t dbSNP:368180983
2598 2598 a, c dbSNP:546866266
2630 2630 -, g dbSNP:142247949
2714 2714 a, c dbSNP:190425059
2903 2903 c, t dbSNP:200058591
2918 2918 c, t dbSNP:62388319
2919 2919 c, t dbSNP:780513987
2941 2941 g, t dbSNP:748134867
2964 2964 a, g dbSNP:549126059
2976 2976 -, ct dbSNP:148869003
2991 2991 a, g, t dbSNP:530634440
3045 3045 a, g dbSNP:563211988
3061 3061 a, c dbSNP:754787886
3096 3096 c, t dbSNP:545006138
3097 3097 a, t dbSNP:372631082
3149 3149 a, g dbSNP:4867798
3177 3177 c, t dbSNP:559730208
3178 3178 a, g dbSNP:147261878
3191 3191 a, g dbSNP:578026532
3261 3261 c, t dbSNP:781277406
3264 3264 c, t dbSNP:768411676
3294 3294 g, t dbSNP:746352624
3299 3299 c, t dbSNP:116555419
3345 3345 c, t dbSNP:557947365
3362 3362 c, t dbSNP:575707624

Target ORF information:

RefSeq Version NM_000794
Organism Homo sapiens (human)
Definition Homo sapiens dopamine receptor D1 (DRD1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000794

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGAGGACTC TGAACACCTC TGCCATGGAC GGGACTGGGC TGGTGGTGGA GAGGGACTTC 
TCTGTTCGTA TCCTCACTGC CTGTTTCCTG TCGCTGCTCA TCCTGTCCAC GCTCCTGGGG
AACACGCTGG TCTGTGCTGC CGTTATCAGG TTCCGACACC TGCGGTCCAA GGTGACCAAC
TTCTTTGTCA TCTCCTTGGC TGTGTCAGAT CTCTTGGTGG CCGTCCTGGT CATGCCCTGG
AAGGCAGTGG CTGAGATTGC TGGCTTCTGG CCCTTTGGGT CCTTCTGTAA CATCTGGGTG
GCCTTTGACA TCATGTGCTC CACTGCATCC ATCCTCAACC TCTGTGTGAT CAGCGTGGAC
AGGTATTGGG CTATCTCCAG CCCTTTCCGG TATGAGAGAA AGATGACCCC CAAGGCAGCC
TTCATCCTGA TCAGTGTGGC ATGGACCTTG TCTGTACTCA TCTCCTTCAT CCCAGTGCAG
CTCAGCTGGC ACAAGGCAAA ACCCACAAGC CCCTCTGATG GAAATGCCAC TTCCCTGGCT
GAGACCATAG ACAACTGTGA CTCCAGCCTC AGCAGGACAT ATGCCATCTC ATCCTCTGTA
ATAAGCTTTT ACATCCCTGT GGCCATCATG ATTGTCACCT ACACCAGGAT CTACAGGATT
GCTCAGAAAC AAATACGGCG CATTGCGGCC TTGGAGAGGG CAGCAGTCCA CGCCAAGAAT
TGCCAGACCA CCACAGGTAA TGGAAAGCCT GTCGAATGTT CTCAACCGGA AAGTTCTTTT
AAGATGTCCT TCAAAAGAGA AACTAAAGTC CTGAAGACTC TGTCGGTGAT CATGGGTGTG
TTTGTGTGCT GTTGGCTACC TTTCTTCATC TTGAACTGCA TTTTGCCCTT CTGTGGGTCT
GGGGAGACGC AGCCCTTCTG CATTGATTCC AACACCTTTG ACGTGTTTGT GTGGTTTGGG
TGGGCTAATT CATCCTTGAA CCCCATCATT TATGCCTTTA ATGCTGATTT TCGGAAGGCA
TTTTCAACCC TCTTAGGATG CTACAGACTT TGCCCTGCGA CGAATAATGC CATAGAGACG
GTGAGTATCA ATAACAATGG GGCCGCGATG TTTTCCAGCC ATCATGAGCC ACGAGGCTCC
ATCTCCAAGG AGTGCAATCT GGTTTACCTG ATCCCACATG CTGTGGGCTC CTCTGAGGAC
CTGAAAAAGG AGGAGGCAGC TGGCATCGCC AGACCCTTGG AGAAGCTGTC CCCAGCCCTA
TCAGTCATAT TGGACTATGA CACTGACGTC TCTCTGGAGA AGATCCAACC CATCACACAA
AACGGTCAGC ACCCAACCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Nonlinear dose-dependent impact of D1 receptor activation on motor cortex plasticity in humans
J. Neurosci. 34 (7), 2744-2753 (2014)
Fresnoza S, Paulus W, Nitsche MA and Kuo MF.


book

Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling
J. Biol. Chem. 288 (48), 34364-34374 (2013)
Sidharthan NP, Minchin RF and Butcher NJ.


book

HIV-related cognitive impairment shows bi-directional association with dopamine receptor DRD1 and DRD2 polymorphisms in substance-dependent and substance-independent populations
J. Neurovirol. 19 (5), 495-504 (2013)
Jacobs,M.M., Murray,J., Byrd,D.A., Hurd,Y.L. and Morgello,S.


book

Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction
PLoS ONE 8 (8), E70805 (2013)
Zhu F, Yan CX, Wen YC, Wang J, Bi J, Zhao YL, Wei L, Gao CG, Jia W and Li SB.


book

Dopamine receptors and the pharmacogenetics of side-effects of stimulant treatment for attention-deficit/hyperactivity disorder
J Child Adolesc Psychopharmacol 23 (6), 423-425 (2013)
Levy,F., Wimalaweera,S., Moul,C., Brennan,J. and Dadds,M.R.


book

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A
Mol. Endocrinol. 6 (11), 1815-1824 (1992)
Liu YF, Civelli O, Zhou QY and Albert PR.


book

Characterization of the 5' flanking region of the human D1A dopamine receptor gene
Proc. Natl. Acad. Sci. U.S.A. 89 (7), 3045-3049 (1992)
Minowa MT, Minowa T, Monsma FJ Jr, Sibley DR and Mouradian MM.


book

Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor
Proc. Natl. Acad. Sci. U.S.A. 88 (17), 7491-7495 (1991)
Tiberi M, Jarvie KR, Silvia C, Falardeau P, Gingrich JA, Godinot N, Bertrand L, Yang-Feng TL, Fremeau RT Jr and Caron MG.


book

A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP
Am. J. Hum. Genet. 47 (5), 828-834 (1990)
Grandy DK, Zhou QY, Allen L, Litt R, Magenis RE, Civelli O and Litt M.


book

Human dopamine D1 receptor encoded by an intronless gene on chromosome 5
Nature 347 (6288), 80-83 (1990)
Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL and Israel Y.


 
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