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DRD1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol DRD1
Entrez Gene ID 1812
Full Name dopamine receptor D1
Synonyms DADR, DRD1A
General protein information
Preferred Names
D(1A) dopamine receptor
Names
D(1A) dopamine receptor
dopamine D1 receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.1

Summary This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

126449


mRNA and Protein(s)

mRNA Protein Name
NM_000794 NP_000785 D(1A) dopamine receptor



Homo sapiens (human) DRD1 NP_000785.1
Pan troglodytes (chimpanzee) DRD1 XP_001149473.2
Canis lupus familiaris (dog) DRD1 XP_005619252.1
Bos taurus (cattle) DRD1 NP_776467.1
Mus musculus (house mouse) Drd1a NP_034206.1
Rattus norvegicus (Norway rat) Drd1 NP_036678.2
Gallus gallus (chicken) DRD1 NP_001138320.1
Danio rerio (zebrafish) drd1b NP_001129448.1
Xenopus (Silurana) tropicalis (western clawed frog) drd1 XP_004912926.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DRD1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DRD1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23409
NM_000794 Homo sapiens dopamine receptor D1 (DRD1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23409
Clone ID Related Accession (Same CDS sequence) NM_000794
Accession Version NM_000794.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1341bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product D(1A) dopamine receptor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA249160.1, AC091393.3 and X58987.1. This sequence is a reference standard in the RefSeqGene project. On Feb 23, 2006 this sequence version replaced gi:16445404. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DA249160.1, DA228014.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142363, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 5' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGAGGACTC TGAACACCTC TGCCATGGAC GGGACTGGGC TGGTGGTGGA GAGGGACTTC 
TCTGTTCGTA TCCTCACTGC CTGTTTCCTG TCGCTGCTCA TCCTGTCCAC GCTCCTGGGG
AACACGCTGG TCTGTGCTGC CGTTATCAGG TTCCGACACC TGCGGTCCAA GGTGACCAAC
TTCTTTGTCA TCTCCTTGGC TGTGTCAGAT CTCTTGGTGG CCGTCCTGGT CATGCCCTGG
AAGGCAGTGG CTGAGATTGC TGGCTTCTGG CCCTTTGGGT CCTTCTGTAA CATCTGGGTG
GCCTTTGACA TCATGTGCTC CACTGCATCC ATCCTCAACC TCTGTGTGAT CAGCGTGGAC
AGGTATTGGG CTATCTCCAG CCCTTTCCGG TATGAGAGAA AGATGACCCC CAAGGCAGCC
TTCATCCTGA TCAGTGTGGC ATGGACCTTG TCTGTACTCA TCTCCTTCAT CCCAGTGCAG
CTCAGCTGGC ACAAGGCAAA ACCCACAAGC CCCTCTGATG GAAATGCCAC TTCCCTGGCT
GAGACCATAG ACAACTGTGA CTCCAGCCTC AGCAGGACAT ATGCCATCTC ATCCTCTGTA
ATAAGCTTTT ACATCCCTGT GGCCATCATG ATTGTCACCT ACACCAGGAT CTACAGGATT
GCTCAGAAAC AAATACGGCG CATTGCGGCC TTGGAGAGGG CAGCAGTCCA CGCCAAGAAT
TGCCAGACCA CCACAGGTAA TGGAAAGCCT GTCGAATGTT CTCAACCGGA AAGTTCTTTT
AAGATGTCCT TCAAAAGAGA AACTAAAGTC CTGAAGACTC TGTCGGTGAT CATGGGTGTG
TTTGTGTGCT GTTGGCTACC TTTCTTCATC TTGAACTGCA TTTTGCCCTT CTGTGGGTCT
GGGGAGACGC AGCCCTTCTG CATTGATTCC AACACCTTTG ACGTGTTTGT GTGGTTTGGG
TGGGCTAATT CATCCTTGAA CCCCATCATT TATGCCTTTA ATGCTGATTT TCGGAAGGCA
TTTTCAACCC TCTTAGGATG CTACAGACTT TGCCCTGCGA CGAATAATGC CATAGAGACG
GTGAGTATCA ATAACAATGG GGCCGCGATG TTTTCCAGCC ATCATGAGCC ACGAGGCTCC
ATCTCCAAGG AGTGCAATCT GGTTTACCTG ATCCCACATG CTGTGGGCTC CTCTGAGGAC
CTGAAAAAGG AGGAGGCAGC TGGCATCGCC AGACCCTTGG AGAAGCTGTC CCCAGCCCTA
TCAGTCATAT TGGACTATGA CACTGACGTC TCTCTGGAGA AGATCCAACC CATCACACAA
AACGGTCAGC ACCCAACCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000785.1
CDS946..2286
Misc Feature(1)463..463(+)
Misc Feature(2)805..807(+)
Misc Feature(3)1015..1092(+)
Misc Feature(4)1066..>1419(+)
Misc Feature(5)1081..1938(+)
Misc Feature(6)1126..1206(+)
Misc Feature(7)1234..1302(+)
Misc Feature(8)1360..1434(+)
Misc Feature(9)1522..1599(+)
Misc Feature(10)1762..1842(+)
Misc Feature(11)1882..1956(+)
Misc Feature(12)1984..1986(+)
Misc Feature(13)1996..1998(+)
Misc Feature(14)2023..2025(+)
Exon (1)1..462
Gene:DRD1
Gene Synonym:
Exon (2)463..3373
Gene:DRD1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000794
Organism Homo sapiens (human)
Definition Homo sapiens dopamine receptor D1 (DRD1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000794

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGAGGACTC TGAACACCTC TGCCATGGAC GGGACTGGGC TGGTGGTGGA GAGGGACTTC 
TCTGTTCGTA TCCTCACTGC CTGTTTCCTG TCGCTGCTCA TCCTGTCCAC GCTCCTGGGG
AACACGCTGG TCTGTGCTGC CGTTATCAGG TTCCGACACC TGCGGTCCAA GGTGACCAAC
TTCTTTGTCA TCTCCTTGGC TGTGTCAGAT CTCTTGGTGG CCGTCCTGGT CATGCCCTGG
AAGGCAGTGG CTGAGATTGC TGGCTTCTGG CCCTTTGGGT CCTTCTGTAA CATCTGGGTG
GCCTTTGACA TCATGTGCTC CACTGCATCC ATCCTCAACC TCTGTGTGAT CAGCGTGGAC
AGGTATTGGG CTATCTCCAG CCCTTTCCGG TATGAGAGAA AGATGACCCC CAAGGCAGCC
TTCATCCTGA TCAGTGTGGC ATGGACCTTG TCTGTACTCA TCTCCTTCAT CCCAGTGCAG
CTCAGCTGGC ACAAGGCAAA ACCCACAAGC CCCTCTGATG GAAATGCCAC TTCCCTGGCT
GAGACCATAG ACAACTGTGA CTCCAGCCTC AGCAGGACAT ATGCCATCTC ATCCTCTGTA
ATAAGCTTTT ACATCCCTGT GGCCATCATG ATTGTCACCT ACACCAGGAT CTACAGGATT
GCTCAGAAAC AAATACGGCG CATTGCGGCC TTGGAGAGGG CAGCAGTCCA CGCCAAGAAT
TGCCAGACCA CCACAGGTAA TGGAAAGCCT GTCGAATGTT CTCAACCGGA AAGTTCTTTT
AAGATGTCCT TCAAAAGAGA AACTAAAGTC CTGAAGACTC TGTCGGTGAT CATGGGTGTG
TTTGTGTGCT GTTGGCTACC TTTCTTCATC TTGAACTGCA TTTTGCCCTT CTGTGGGTCT
GGGGAGACGC AGCCCTTCTG CATTGATTCC AACACCTTTG ACGTGTTTGT GTGGTTTGGG
TGGGCTAATT CATCCTTGAA CCCCATCATT TATGCCTTTA ATGCTGATTT TCGGAAGGCA
TTTTCAACCC TCTTAGGATG CTACAGACTT TGCCCTGCGA CGAATAATGC CATAGAGACG
GTGAGTATCA ATAACAATGG GGCCGCGATG TTTTCCAGCC ATCATGAGCC ACGAGGCTCC
ATCTCCAAGG AGTGCAATCT GGTTTACCTG ATCCCACATG CTGTGGGCTC CTCTGAGGAC
CTGAAAAAGG AGGAGGCAGC TGGCATCGCC AGACCCTTGG AGAAGCTGTC CCCAGCCCTA
TCAGTCATAT TGGACTATGA CACTGACGTC TCTCTGGAGA AGATCCAACC CATCACACAA
AACGGTCAGC ACCCAACCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Nonlinear dose-dependent impact of D1 receptor activation on motor cortex plasticity in humans
J. Neurosci. 34 (7), 2744-2753 (2014)
Fresnoza S, Paulus W, Nitsche MA and Kuo MF.


book

Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-N-methyl-D-aspartate receptor coupling
J. Biol. Chem. 288 (48), 34364-34374 (2013)
Sidharthan NP, Minchin RF and Butcher NJ.


book

HIV-related cognitive impairment shows bi-directional association with dopamine receptor DRD1 and DRD2 polymorphisms in substance-dependent and substance-independent populations
J. Neurovirol. 19 (5), 495-504 (2013)
Jacobs,M.M., Murray,J., Byrd,D.A., Hurd,Y.L. and Morgello,S.


book

Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction
PLoS ONE 8 (8), E70805 (2013)
Zhu F, Yan CX, Wen YC, Wang J, Bi J, Zhao YL, Wei L, Gao CG, Jia W and Li SB.


book

Dopamine receptors and the pharmacogenetics of side-effects of stimulant treatment for attention-deficit/hyperactivity disorder
J Child Adolesc Psychopharmacol 23 (6), 423-425 (2013)
Levy,F., Wimalaweera,S., Moul,C., Brennan,J. and Dadds,M.R.


book

Cholera toxin-sensitive 3',5'-cyclic adenosine monophosphate and calcium signals of the human dopamine-D1 receptor: selective potentiation by protein kinase A
Mol. Endocrinol. 6 (11), 1815-1824 (1992)
Liu YF, Civelli O, Zhou QY and Albert PR.


book

Characterization of the 5' flanking region of the human D1A dopamine receptor gene
Proc. Natl. Acad. Sci. U.S.A. 89 (7), 3045-3049 (1992)
Minowa MT, Minowa T, Monsma FJ Jr, Sibley DR and Mouradian MM.


book

Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor
Proc. Natl. Acad. Sci. U.S.A. 88 (17), 7491-7495 (1991)
Tiberi M, Jarvie KR, Silvia C, Falardeau P, Gingrich JA, Godinot N, Bertrand L, Yang-Feng TL, Fremeau RT Jr and Caron MG.


book

A human D1 dopamine receptor gene is located on chromosome 5 at q35.1 and identifies an EcoRI RFLP
Am. J. Hum. Genet. 47 (5), 828-834 (1990)
Grandy DK, Zhou QY, Allen L, Litt R, Magenis RE, Civelli O and Litt M.


book

Human dopamine D1 receptor encoded by an intronless gene on chromosome 5
Nature 347 (6288), 80-83 (1990)
Sunahara RK, Niznik HB, Weiner DM, Stormann TM, Brann MR, Kennedy JL, Gelernter JE, Rozmahel R, Yang YL and Israel Y.


 
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