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DRD2 cDNA ORF clone, Homo sapiens (human)

Gene Symbol DRD2
Entrez Gene ID 1813
Full Name dopamine receptor D2
Synonyms D2DR, D2R
General protein information
Preferred Names
D(2) dopamine receptor
Names
D(2) dopamine receptor
dopamine D2 receptor
dopamine receptor D2 isoform
seven transmembrane helix receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23

Summary This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

126450

Disorder Html: Dystonia, myoclonic, 159900 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000795 NP_000786 D(2) dopamine receptor isoform long
NM_016574 NP_057658 D(2) dopamine receptor isoform short



Homo sapiens (human) DRD2 NP_000786.1
Pan troglodytes (chimpanzee) DRD2 NP_001029100.1
Macaca mulatta (Rhesus monkey) DRD2 XP_001085571.1
Canis lupus familiaris (dog) DRD2 NP_001003110.1
Bos taurus (cattle) DRD2 NP_776468.1
Mus musculus (house mouse) Drd2 NP_034207.2
Rattus norvegicus (Norway rat) Drd2 NP_036679.1
Gallus gallus (chicken) DRD2 NP_001106761.1
Danio rerio (zebrafish) drd2b NP_922918.1
Danio rerio (zebrafish) drd2a NP_898891.1
Caenorhabditis elegans dop-3 NP_001024908.2
Xenopus (Silurana) tropicalis (western clawed frog) LOC100493063 XP_002937871.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DRD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DRD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu23461
NM_000795 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$189.50-$265.30
$379.00
OHu23557
NM_016574 Homo sapiens dopamine receptor D2 (DRD2), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu23461
Clone ID Related Accession (Same CDS sequence) NM_000795
Accession Version NM_000795.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1332bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product D(2) dopamine receptor isoform long
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA693976.1, BF437994.1, X51362.1 and BC021195.2. This sequence is a reference standard in the RefSeqGene project. On Apr 10, 2008 this sequence version replaced gi:17986271. Transcript Variant: This variant (1) encodes the longer isoform (long). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X51362.1, BC021195.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGATCCAC TGAATCTGTC CTGGTATGAT GATGATCTGG AGAGGCAGAA CTGGAGCCGG 
CCCTTCAACG GGTCAGACGG GAAGGCGGAC AGACCCCACT ACAACTACTA TGCCACACTG
CTCACCCTGC TCATCGCTGT CATCGTCTTC GGCAACGTGC TGGTGTGCAT GGCTGTGTCC
CGCGAGAAGG CGCTGCAGAC CACCACCAAC TACCTGATCG TCAGCCTCGC AGTGGCCGAC
CTCCTCGTCG CCACACTGGT CATGCCCTGG GTTGTCTACC TGGAGGTGGT AGGTGAGTGG
AAATTCAGCA GGATTCACTG TGACATCTTC GTCACTCTGG ACGTCATGAT GTGCACGGCG
AGCATCCTGA ACTTGTGTGC CATCAGCATC GACAGGTACA CAGCTGTGGC CATGCCCATG
CTGTACAATA CGCGCTACAG CTCCAAGCGC CGGGTCACCG TCATGATCTC CATCGTCTGG
GTCCTGTCCT TCACCATCTC CTGCCCACTC CTCTTCGGAC TCAATAACGC AGACCAGAAC
GAGTGCATCA TTGCCAACCC GGCCTTCGTG GTCTACTCCT CCATCGTCTC CTTCTACGTG
CCCTTCATTG TCACCCTGCT GGTCTACATC AAGATCTACA TTGTCCTCCG CAGACGCCGC
AAGCGAGTCA ACACCAAACG CAGCAGCCGA GCTTTCAGGG CCCACCTGAG GGCTCCACTA
AAGGGCAACT GTACTCACCC CGAGGACATG AAACTCTGCA CCGTTATCAT GAAGTCTAAT
GGGAGTTTCC CAGTGAACAG GCGGAGAGTG GAGGCTGCCC GGCGAGCCCA GGAGCTGGAG
ATGGAGATGC TCTCCAGCAC CAGCCCACCC GAGAGGACCC GGTACAGCCC CATCCCACCC
AGCCACCACC AGCTGACTCT CCCCGACCCG TCCCACCATG GTCTCCACAG CACTCCCGAC
AGCCCCGCCA AACCAGAGAA GAATGGGCAT GCCAAAGACC ACCCCAAGAT TGCCAAGATC
TTTGAGATCC AGACCATGCC CAATGGCAAA ACCCGGACCT CCCTCAAGAC CATGAGCCGT
AGGAAGCTCT CCCAGCAGAA GGAGAAGAAA GCCACTCAGA TGCTCGCCAT TGTTCTCGGC
GTGTTCATCA TCTGCTGGCT GCCCTTCTTC ATCACACACA TCCTGAACAT ACACTGTGAC
TGCAACATCC CGCCTGTCCT GTACAGCGCC TTCACGTGGC TGGGCTATGT CAACAGCGCC
GTGAACCCCA TCATCTACAC CACCTTCAAC ATTGAGTTCC GCAAGGCCTT CCTGAAGATC
CTCCACTGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000786.1
CDS236..1567
Misc Feature(1)200..202(+)
Misc Feature(2)347..415(+)
Misc Feature(3)380..>934(+)
Misc Feature(4)404..1513(+)
Misc Feature(5)446..514(+)
Misc Feature(6)554..781(+)
Misc Feature(7)560..625(+)
Misc Feature(8)689..751(+)
Misc Feature(9)800..874(+)
Misc Feature(10)803..826(+)
Misc Feature(11)815..817(+)
Misc Feature(12)824..826(+)
Misc Feature(13)866..1354(+)
Misc Feature(14)1355..1420(+)
Misc Feature(15)1391..1417(+)
Misc Feature(16)1463..1528(+)
Exon (1)1..204
Gene:DRD2
Gene Synonym:
Exon (2)205..520
Gene:DRD2
Gene Synonym:
Exon (3)521..630
Gene:DRD2
Gene Synonym:
Exon (4)631..767
Gene:DRD2
Gene Synonym:
Exon (5)768..958
Gene:DRD2
Gene Synonym:
Exon (6)959..1045
Gene:DRD2
Gene Synonym:
Exon (7)1046..1373
Gene:DRD2
Gene Synonym:
Exon (8)1374..2699
Gene:DRD2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000795
Organism Homo sapiens (human)
Definition Homo sapiens dopamine receptor D2 (DRD2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000795

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGATCCAC TGAATCTGTC CTGGTATGAT GATGATCTGG AGAGGCAGAA CTGGAGCCGG 
CCCTTCAACG GGTCAGACGG GAAGGCGGAC AGACCCCACT ACAACTACTA TGCCACACTG
CTCACCCTGC TCATCGCTGT CATCGTCTTC GGCAACGTGC TGGTGTGCAT GGCTGTGTCC
CGCGAGAAGG CGCTGCAGAC CACCACCAAC TACCTGATCG TCAGCCTCGC AGTGGCCGAC
CTCCTCGTCG CCACACTGGT CATGCCCTGG GTTGTCTACC TGGAGGTGGT AGGTGAGTGG
AAATTCAGCA GGATTCACTG TGACATCTTC GTCACTCTGG ACGTCATGAT GTGCACGGCG
AGCATCCTGA ACTTGTGTGC CATCAGCATC GACAGGTACA CAGCTGTGGC CATGCCCATG
CTGTACAATA CGCGCTACAG CTCCAAGCGC CGGGTCACCG TCATGATCTC CATCGTCTGG
GTCCTGTCCT TCACCATCTC CTGCCCACTC CTCTTCGGAC TCAATAACGC AGACCAGAAC
GAGTGCATCA TTGCCAACCC GGCCTTCGTG GTCTACTCCT CCATCGTCTC CTTCTACGTG
CCCTTCATTG TCACCCTGCT GGTCTACATC AAGATCTACA TTGTCCTCCG CAGACGCCGC
AAGCGAGTCA ACACCAAACG CAGCAGCCGA GCTTTCAGGG CCCACCTGAG GGCTCCACTA
AAGGGCAACT GTACTCACCC CGAGGACATG AAACTCTGCA CCGTTATCAT GAAGTCTAAT
GGGAGTTTCC CAGTGAACAG GCGGAGAGTG GAGGCTGCCC GGCGAGCCCA GGAGCTGGAG
ATGGAGATGC TCTCCAGCAC CAGCCCACCC GAGAGGACCC GGTACAGCCC CATCCCACCC
AGCCACCACC AGCTGACTCT CCCCGACCCG TCCCACCATG GTCTCCACAG CACTCCCGAC
AGCCCCGCCA AACCAGAGAA GAATGGGCAT GCCAAAGACC ACCCCAAGAT TGCCAAGATC
TTTGAGATCC AGACCATGCC CAATGGCAAA ACCCGGACCT CCCTCAAGAC CATGAGCCGT
AGGAAGCTCT CCCAGCAGAA GGAGAAGAAA GCCACTCAGA TGCTCGCCAT TGTTCTCGGC
GTGTTCATCA TCTGCTGGCT GCCCTTCTTC ATCACACACA TCCTGAACAT ACACTGTGAC
TGCAACATCC CGCCTGTCCT GTACAGCGCC TTCACGTGGC TGGGCTATGT CAACAGCGCC
GTGAACCCCA TCATCTACAC CACCTTCAAC ATTGAGTTCC GCAAGGCCTT CCTGAAGATC
CTCCACTGCT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu23557
Clone ID Related Accession (Same CDS sequence) NM_016574
Accession Version NM_016574.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1245bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product D(2) dopamine receptor isoform short
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA693976.1, BF437994.1, S69899.1, BC021195.2 and X51362.1. On Apr 10, 2008 this sequence version replaced gi:17986269. Transcript Variant: This variant (2) lacks an internal exon, as compared to variant 1, but maintains the same reading frame. It encodes an isoform (short), which is 29 aa shorter than isoform long. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: S69899.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA2145544, SAMEA2146411 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGATCCAC TGAATCTGTC CTGGTATGAT GATGATCTGG AGAGGCAGAA CTGGAGCCGG 
CCCTTCAACG GGTCAGACGG GAAGGCGGAC AGACCCCACT ACAACTACTA TGCCACACTG
CTCACCCTGC TCATCGCTGT CATCGTCTTC GGCAACGTGC TGGTGTGCAT GGCTGTGTCC
CGCGAGAAGG CGCTGCAGAC CACCACCAAC TACCTGATCG TCAGCCTCGC AGTGGCCGAC
CTCCTCGTCG CCACACTGGT CATGCCCTGG GTTGTCTACC TGGAGGTGGT AGGTGAGTGG
AAATTCAGCA GGATTCACTG TGACATCTTC GTCACTCTGG ACGTCATGAT GTGCACGGCG
AGCATCCTGA ACTTGTGTGC CATCAGCATC GACAGGTACA CAGCTGTGGC CATGCCCATG
CTGTACAATA CGCGCTACAG CTCCAAGCGC CGGGTCACCG TCATGATCTC CATCGTCTGG
GTCCTGTCCT TCACCATCTC CTGCCCACTC CTCTTCGGAC TCAATAACGC AGACCAGAAC
GAGTGCATCA TTGCCAACCC GGCCTTCGTG GTCTACTCCT CCATCGTCTC CTTCTACGTG
CCCTTCATTG TCACCCTGCT GGTCTACATC AAGATCTACA TTGTCCTCCG CAGACGCCGC
AAGCGAGTCA ACACCAAACG CAGCAGCCGA GCTTTCAGGG CCCACCTGAG GGCTCCACTA
AAGGAGGCTG CCCGGCGAGC CCAGGAGCTG GAGATGGAGA TGCTCTCCAG CACCAGCCCA
CCCGAGAGGA CCCGGTACAG CCCCATCCCA CCCAGCCACC ACCAGCTGAC TCTCCCCGAC
CCGTCCCACC ATGGTCTCCA CAGCACTCCC GACAGCCCCG CCAAACCAGA GAAGAATGGG
CATGCCAAAG ACCACCCCAA GATTGCCAAG ATCTTTGAGA TCCAGACCAT GCCCAATGGC
AAAACCCGGA CCTCCCTCAA GACCATGAGC CGTAGGAAGC TCTCCCAGCA GAAGGAGAAG
AAAGCCACTC AGATGCTCGC CATTGTTCTC GGCGTGTTCA TCATCTGCTG GCTGCCCTTC
TTCATCACAC ACATCCTGAA CATACACTGT GACTGCAACA TCCCGCCTGT CCTGTACAGC
GCCTTCACGT GGCTGGGCTA TGTCAACAGC GCCGTGAACC CCATCATCTA CACCACCTTC
AACATTGAGT TCCGCAAGGC CTTCCTGAAG ATCCTCCACT GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_057658.2
CDS236..1480
Misc Feature(1)200..202(+)
Misc Feature(2)380..>934(+)
Misc Feature(3)404..1426(+)
Misc Feature(4)554..781(+)
Exon (1)1..204
Gene:DRD2
Gene Synonym:
Exon (2)205..520
Gene:DRD2
Gene Synonym:
Exon (3)521..630
Gene:DRD2
Gene Synonym:
Exon (4)631..767
Gene:DRD2
Gene Synonym:
Exon (5)768..958
Gene:DRD2
Gene Synonym:
Exon (6)959..1286
Gene:DRD2
Gene Synonym:
Exon (7)1287..2612
Gene:DRD2
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_016574
Organism Homo sapiens (human)
Definition Homo sapiens dopamine receptor D2 (DRD2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_016574

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGATCCAC TGAATCTGTC CTGGTATGAT GATGATCTGG AGAGGCAGAA CTGGAGCCGG 
CCCTTCAACG GGTCAGACGG GAAGGCGGAC AGACCCCACT ACAACTACTA TGCCACACTG
CTCACCCTGC TCATCGCTGT CATCGTCTTC GGCAACGTGC TGGTGTGCAT GGCTGTGTCC
CGCGAGAAGG CGCTGCAGAC CACCACCAAC TACCTGATCG TCAGCCTCGC AGTGGCCGAC
CTCCTCGTCG CCACACTGGT CATGCCCTGG GTTGTCTACC TGGAGGTGGT AGGTGAGTGG
AAATTCAGCA GGATTCACTG TGACATCTTC GTCACTCTGG ACGTCATGAT GTGCACGGCG
AGCATCCTGA ACTTGTGTGC CATCAGCATC GACAGGTACA CAGCTGTGGC CATGCCCATG
CTGTACAATA CGCGCTACAG CTCCAAGCGC CGGGTCACCG TCATGATCTC CATCGTCTGG
GTCCTGTCCT TCACCATCTC CTGCCCACTC CTCTTCGGAC TCAATAACGC AGACCAGAAC
GAGTGCATCA TTGCCAACCC GGCCTTCGTG GTCTACTCCT CCATCGTCTC CTTCTACGTG
CCCTTCATTG TCACCCTGCT GGTCTACATC AAGATCTACA TTGTCCTCCG CAGACGCCGC
AAGCGAGTCA ACACCAAACG CAGCAGCCGA GCTTTCAGGG CCCACCTGAG GGCTCCACTA
AAGGAGGCTG CCCGGCGAGC CCAGGAGCTG GAGATGGAGA TGCTCTCCAG CACCAGCCCA
CCCGAGAGGA CCCGGTACAG CCCCATCCCA CCCAGCCACC ACCAGCTGAC TCTCCCCGAC
CCGTCCCACC ATGGTCTCCA CAGCACTCCC GACAGCCCCG CCAAACCAGA GAAGAATGGG
CATGCCAAAG ACCACCCCAA GATTGCCAAG ATCTTTGAGA TCCAGACCAT GCCCAATGGC
AAAACCCGGA CCTCCCTCAA GACCATGAGC CGTAGGAAGC TCTCCCAGCA GAAGGAGAAG
AAAGCCACTC AGATGCTCGC CATTGTTCTC GGCGTGTTCA TCATCTGCTG GCTGCCCTTC
TTCATCACAC ACATCCTGAA CATACACTGT GACTGCAACA TCCCGCCTGT CCTGTACAGC
GCCTTCACGT GGCTGGGCTA TGTCAACAGC GCCGTGAACC CCATCATCTA CACCACCTTC
AACATTGAGT TCCGCAAGGC CTTCCTGAAG ATCCTCCACT GCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells
Hypertension 63 (3), E74-E80 (2014)
Jiang X, Konkalmatt P, Yang Y, Gildea J, Jones JE, Cuevas S, Felder RA, Jose PA and Armando I.


book

Combined insular and striatal dopamine dysfunction are associated with executive deficits in Parkinson's disease with mild cognitive impairment
Brain 137 (PT 2), 565-575 (2014)
Christopher L, Marras C, Duff-Canning S, Koshimori Y, Chen R, Boileau I, Segura B, Monchi O, Lang AE, Rusjan P, Houle S and Strafella AP.


book

Initial responses to the first dose of nicotine in novel smokers: the role of exposure to environmental smoking and genetic predisposition
Psychol Health 29 (6), 698-716 (2014)
Schuck K, Otten R, Engels RC and Kleinjan M.


book

The effect of selected polymorphisms of the dopamine receptor gene DRD2 and the ANKK-1 on the preference of concentrations of sucrose solutions in men with alcohol dependence
Psychiatr Danub 25 (4), 371-378 (2013)
Jablonski M, Jasiewicz A, Kucharska-Mazur J, Samochowiec J, Bienkowski P, Mierzejewski P and Samochowiec A.


book

Functional connectivity in healthy subjects is nonlinearly modulated by the COMT and DRD2 polymorphisms in a functional system-dependent manner
J. Neurosci. 33 (44), 17519-17526 (2013)
Tian T, Qin W, Liu B, Jiang T and Yu C.


book

Myoclonus-Dystonia
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Raymond,D. and Ozelius,L.


book

Structure and linkage of the D2 dopamine receptor and neural cell adhesion molecule genes on human chromosome 11q23
Genomics 14 (4), 1010-1018 (1992)
Eubanks JH, Djabali M, Selleri L, Grandy DK, Civelli O, McElligott DL and Evans GA.


book

Differential sensitivity of the short and long human dopamine D2 receptor subtypes to protein kinase C
J. Neurochem. 59 (6), 2311-2317 (1992)
Liu YF, Civelli O, Grandy DK and Albert PR.


book

Structure and expression of human and rat D2 dopamine receptor genes
Neurochem. Int. 21 (1), 91-98 (1992)
Araki K, Kuwano R, Morii K, Hayashi S, Minoshima S, Shimizu N, Katagiri T, Usui H, Kumanishi T and Takahashi Y.


book

D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA
Cell. Mol. Neurobiol. 11 (5), 437-453 (1991)
Dearry A, Falardeau P, Shores C and Caron MG.


 
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