||ORF Nucleotide Sequence (Length: 1260bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||D(4) dopamine receptor
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from EU432112.1, AP006284.2,
L12398.1 and BM674709.1.
This sequence is a reference standard in the RefSeqGene project.
On May 13, 2010 this sequence version replaced gi:32483396.
Summary: This gene encodes the D4 subtype of the dopamine receptor.
The D4 subtype is a G-protein coupled receptor which inhibits
adenylyl cyclase. It is a target for drugs which treat
schizophrenia and Parkinson disease. Mutations in this gene have
been associated with various behavioral phenotypes, including
autonomic nervous system dysfunction, attention
deficit/hyperactivity disorder, and the personality trait of
novelty seeking. This gene contains a polymorphic number (2-10
copies) of tandem 48 nt repeats; the sequence shown contains four
repeats. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: EU432112.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.