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DRD4 cDNA ORF clone, Homo sapiens (human)

Gene Symbol DRD4
Entrez Gene ID 1815
Full Name dopamine receptor D4
Synonyms D4DR
General protein information
Preferred Names
D(4) dopamine receptor
Names
D(4) dopamine receptor
dopamine D4 receptor
D(2C) dopamine receptor
seven transmembrane helix receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

126452

Disorder Html: Autonomic nervous system dysfunction (3); [Novelty seeking

mRNA and Protein(s)

mRNA Protein Name
NM_000797 NP_000788 D(4) dopamine receptor



Homo sapiens (human) DRD4 NP_000788.2
Macaca mulatta (Rhesus monkey) DRD4 XP_001087197.1
Mus musculus (house mouse) Drd4 NP_031904.1
Rattus norvegicus (Norway rat) Drd4 NP_037076.1
Gallus gallus (chicken) DRD4 NP_001136321.1
Danio rerio (zebrafish) drd4b NP_001012636.1
Danio rerio (zebrafish) drd4a NP_001012634.1
Xenopus (Silurana) tropicalis (western clawed frog) drd4 XP_002937535.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DRD4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DRD4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu21038
NM_000797 Homo sapiens dopamine receptor D4 (DRD4), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu21038
Clone ID Related Accession (Same CDS sequence) NM_000797
Accession Version NM_000797.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1260bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product D(4) dopamine receptor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EU432112.1, AP006284.2, L12398.1 and BM674709.1. This sequence is a reference standard in the RefSeqGene project. On May 13, 2010 this sequence version replaced gi:32483396. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: EU432112.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2152568, SAMEA2159931 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGGGAACC GCAGCACCGC GGACGCGGAC GGGCTGCTGG CTGGGCGCGG GCCGGCCGCG 
GGGGCATCTG CGGGGGCATC TGCGGGGCTG GCTGGGCAGG GCGCGGCGGC GCTGGTGGGG
GGCGTGCTGC TCATCGGCGC GGTGCTCGCG GGGAACTCGC TCGTGTGCGT GAGCGTGGCC
ACCGAGCGCG CCCTGCAGAC GCCCACCAAC TCCTTCATCG TGAGCCTGGC GGCCGCCGAC
CTCCTCCTCG CTCTCCTGGT GCTGCCGCTC TTCGTCTACT CCGAGGTCCA GGGTGGCGCG
TGGCTGCTGA GCCCCCGCCT GTGCGACGCC CTCATGGCCA TGGACGTCAT GCTGTGCACC
GCCTCCATCT TCAACCTGTG CGCCATCAGC GTGGACAGGT TCGTGGCCGT GGCCGTGCCG
CTGCGCTACA ACCGGCAGGG TGGGAGCCGC CGGCAGCTGC TGCTCATCGG CGCCACGTGG
CTGCTGTCCG CGGCGGTGGC GGCGCCCGTA CTGTGCGGCC TCAACGACGT GCGCGGCCGC
GACCCCGCCG TGTGCCGCCT GGAGGACCGC GACTACGTGG TCTACTCGTC CGTGTGCTCC
TTCTTCCTAC CCTGCCCGCT CATGCTGCTG CTCTACTGGG CCACGTTCCG CGGCCTGCAG
CGCTGGGAGG TGGCACGTCG CGCCAAGCTG CACGGCCGCG CGCCCCGCCG ACCCAGCGGC
CCTGGCCCGC CTTCCCCCAC GCCACCCGCG CCCCGCCTCC CCCAGGACCC CTGCGGCCCC
GACTGTGCGC CCCCCGCGCC CGGCCTTCCC CGGGGTCCCT GCGGCCCCGA CTGTGCGCCC
GCCGCGCCCA GCCTCCCCCA GGACCCCTGC GGCCCCGACT GTGCGCCCCC CGCGCCCGGC
CTCCCCCCGG ACCCCTGCGG CTCCAACTGT GCTCCCCCCG ACGCCGTCAG AGCCGCCGCG
CTCCCACCCC AGACTCCACC GCAGACCCGC AGGAGGCGGC GTGCCAAGAT CACCGGCCGG
GAGCGCAAGG CCATGAGGGT CCTGCCGGTG GTGGTCGGGG CCTTCCTGCT GTGCTGGACG
CCCTTCTTCG TGGTGCACAT CACGCAGGCG CTGTGTCCTG CCTGCTCCGT GCCCCCGCGG
CTGGTCAGCG CCGTCACCTG GCTGGGCTAC GTCAACAGCG CCCTCAACCC CGTCATCTAC
ACTGTCTTCA ACGCCGAGTT CCGCAACGTC TTCCGCAAGG CCCTGCGTGC CTGCTGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000788.2
CDS1..1260
Misc Feature(1)169..1200(+)
Exon (1)1..285
Gene:DRD4
Gene Synonym:
Exon (2)286..398
Gene:DRD4
Gene Synonym:
Exon (3)399..1057
Gene:DRD4
Gene Synonym:
Exon (4)1058..1363
Gene:DRD4
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000797
Organism Homo sapiens (human)
Definition Homo sapiens dopamine receptor D4 (DRD4), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000797

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGGGAACC GCAGCACCGC GGACGCGGAC GGGCTGCTGG CTGGGCGCGG GCCGGCCGCG 
GGGGCATCTG CGGGGGCATC TGCGGGGCTG GCTGGGCAGG GCGCGGCGGC GCTGGTGGGG
GGCGTGCTGC TCATCGGCGC GGTGCTCGCG GGGAACTCGC TCGTGTGCGT GAGCGTGGCC
ACCGAGCGCG CCCTGCAGAC GCCCACCAAC TCCTTCATCG TGAGCCTGGC GGCCGCCGAC
CTCCTCCTCG CTCTCCTGGT GCTGCCGCTC TTCGTCTACT CCGAGGTCCA GGGTGGCGCG
TGGCTGCTGA GCCCCCGCCT GTGCGACGCC CTCATGGCCA TGGACGTCAT GCTGTGCACC
GCCTCCATCT TCAACCTGTG CGCCATCAGC GTGGACAGGT TCGTGGCCGT GGCCGTGCCG
CTGCGCTACA ACCGGCAGGG TGGGAGCCGC CGGCAGCTGC TGCTCATCGG CGCCACGTGG
CTGCTGTCCG CGGCGGTGGC GGCGCCCGTA CTGTGCGGCC TCAACGACGT GCGCGGCCGC
GACCCCGCCG TGTGCCGCCT GGAGGACCGC GACTACGTGG TCTACTCGTC CGTGTGCTCC
TTCTTCCTAC CCTGCCCGCT CATGCTGCTG CTCTACTGGG CCACGTTCCG CGGCCTGCAG
CGCTGGGAGG TGGCACGTCG CGCCAAGCTG CACGGCCGCG CGCCCCGCCG ACCCAGCGGC
CCTGGCCCGC CTTCCCCCAC GCCACCCGCG CCCCGCCTCC CCCAGGACCC CTGCGGCCCC
GACTGTGCGC CCCCCGCGCC CGGCCTTCCC CGGGGTCCCT GCGGCCCCGA CTGTGCGCCC
GCCGCGCCCA GCCTCCCCCA GGACCCCTGC GGCCCCGACT GTGCGCCCCC CGCGCCCGGC
CTCCCCCCGG ACCCCTGCGG CTCCAACTGT GCTCCCCCCG ACGCCGTCAG AGCCGCCGCG
CTCCCACCCC AGACTCCACC GCAGACCCGC AGGAGGCGGC GTGCCAAGAT CACCGGCCGG
GAGCGCAAGG CCATGAGGGT CCTGCCGGTG GTGGTCGGGG CCTTCCTGCT GTGCTGGACG
CCCTTCTTCG TGGTGCACAT CACGCAGGCG CTGTGTCCTG CCTGCTCCGT GCCCCCGCGG
CTGGTCAGCG CCGTCACCTG GCTGGGCTAC GTCAACAGCG CCCTCAACCC CGTCATCTAC
ACTGTCTTCA ACGCCGAGTT CCGCAACGTC TTCCGCAAGG CCCTGCGTGC CTGCTGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

An historical perspective on 'The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus'
Hum. Genet. 133 (4), 431-433 (2014)
Kidd KK, Pakstis AJ and Yun L.


book

No association between DRD4 gene and SRI treatment response in obsessive compulsive disorder: need for a novel approach
Asian J Psychiatr 6 (4), 347-348 (2013)
Viswanath,B., Taj M,J. RJ, Purushottam,M., Kandavel,T., Shetty,P.H., Reddy,Y.C. and Jain,S.


book

Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence
PLoS ONE 8 (6), E66592 (2013)
Vereczkei A, Demetrovics Z, Szekely A, Sarkozy P, Antal P, Szilagyi A, Sasvari-Szekely M and Barta C.


book

[Genetic markers for trait anxiety as one of the risk factors for cardiovascular diseases (WHO-MONICA program, MONICA-psychosocial subprogram)]
Ter. Arkh. 85 (4), 47-51 (2013)
Gafarov,V.V., Voevoda,M.I., Gromova,E.A., Maksimov,V.N., Gagulin,I.V., Iudin,N.S., Gafarova,A.V. and Mishakova,T.M.


book

D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells
J. Biol. Chem. 269 (16), 11813-11819 (1994)
Chio CL, Drong RF, Riley DT, Gill GS, Slightom JL and Huff RM.


book

Molecular modelling of D2-like dopamine receptors
Biochem. J. 287 (PT 1), 277-282 (1992)
Livingstone CD, Strange PG and Naylor LH.


book

Multiple dopamine D4 receptor variants in the human population
Nature 358 (6382), 149-152 (1992)
Van Tol HH, Wu CM, Guan HC, Ohara K, Bunzow JR, Civelli O, Kennedy J, Seeman P, Niznik HB and Jovanovic V.


book

The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS
Genomics 13 (1), 208-210 (1992)
Gelernter J, Kennedy JL, van Tol HH, Civelli O and Kidd KK.


book

Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine
Nature 350 (6319), 610-614 (1991)
Van Tol HH, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB and Civelli O.


book

Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs
J. Biol. Chem. 263 (14), 6656-6664 (1988)
Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M and Kaziro Y.


 
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