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ATN1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol ATN1
Entrez Gene ID 1822
Full Name atrophin 1
Synonyms B37, D12S755E, DRPLA, HRS, NOD
General protein information
Preferred Names
atrophin-1
Names
atrophin-1
dentatorubral-pallidoluysian atrophy protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p13.31

Summary Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Feb 2010]. lac of sum
Disorder MIM:

607462

Disorder Html: Dentatorubro-pallidoluysian atrophy, 125370 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001940 NP_001931 atrophin-1
NM_001007026 NP_001007027 atrophin-1



Homo sapiens (human) ATN1 NP_001007027.1
Pan troglodytes (chimpanzee) ATN1 NP_001029337.1
Macaca mulatta (Rhesus monkey) ATN1 XP_001118307.2
Canis lupus familiaris (dog) ATN1 XP_003640006.1
Bos taurus (cattle) ATN1 NP_001192677.1
Mus musculus (house mouse) Atn1 NP_031907.2
Rattus norvegicus (Norway rat) Atn1 NP_058924.2
Rattus norvegicus (Norway rat) LOC100911672 XP_003750706.1
Gallus gallus (chicken) ATN1 XP_425518.4

Component

ID Name Evidence
GO:0005634 nucleus TAS
GO:0005737 cytoplasm IEA

Function

ID Name Evidence
GO:0003714 transcription corepressor activity IEA
GO:0005515 protein binding IPI
GO:0008432 JUN kinase binding IEA
GO:0019904 protein domain specific binding IPI
GO:0050827 toxin receptor binding IEA

Process

ID Name Evidence
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA
GO:0007417 central nervous system development TAS
GO:0008219 cell death IEA
GO:0009404 toxin metabolic process IEA
GO:0045664 regulation of neuron differentiation IEA

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following ATN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu25731 NM_001940 Homo sapiens atrophin 1 (ATN1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD Quote Price
OHu25731 NM_001007026 Homo sapiens atrophin 1 (ATN1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD Quote Price

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).


CloneID OHu25731
Accession Version NM_001940.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3573bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product atrophin-1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE142829.1, D31840.1, BQ957462.1, BQ897715.1, AW411230.1 and BQ448220.1. On Nov 15, 2004 this sequence version replaced gi:6005998. Summary: Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Feb 2010]. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D31840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
ATGAAGACAC GACAGAATAA AGACTCGATG TCAATGAGGA GTGGACGGAA GAAAGAGGCC 
CCTGGGCCCC GGGAAGAACT GAGATCGAGG GGCCGGGCCT CCCCTGGAGG GGTCAGCACG
TCCAGCAGTG ATGGCAAAGC TGAGAAGTCC AGGCAGACAG CCAAGAAGGC CCGAGTAGAG
GAAGCCTCCA CCCCAAAGGT CAACAAGCAG GGTCGGAGTG AGGAGATCTC AGAGAGTGAA
AGTGAGGAGA CCAATGCACC AAAAAAGACC AAAACTGAGC AGGAACTCCC TCGGCCACAG
TCTCCCTCCG ATCTGGATAG CTTGGACGGG CGGAGCCTTA ATGATGATGG CAGCAGCGAC
CCTAGGGATA TCGACCAGGA CAACCGAAGC ACGTCCCCCA GTATCTACAG CCCTGGAAGT
GTGGAGAATG ACTCTGACTC ATCTTCTGGC CTGTCCCAGG GCCCAGCCCG CCCCTACCAC
CCACCTCCAC TCTTTCCTCC TTCCCCTCAA CCGCCAGACA GCACCCCTCG ACAGCCAGAG
GCTAGCTTTG AACCCCATCC TTCTGTGACA CCCACTGGAT ATCATGCTCC CATGGAGCCC
CCCACATCTC GAATGTTCCA GGCTCCTCCT GGGGCCCCTC CCCCTCACCC ACAGCTCTAT
CCTGGGGGCA CTGGTGGAGT TTTGTCTGGA CCCCCAATGG GTCCCAAGGG GGGAGGGGCT
GCCTCATCAG TGGGGGGCCC TAATGGGGGT AAGCAGCACC CCCCACCCAC TACTCCCATT
TCAGTATCAA GCTCTGGGGC TAGTGGTGCT CCCCCAACAA AGCCGCCTAC CACTCCAGTG
GGTGGTGGGA ACCTACCTTC TGCTCCACCA CCAGCCAACT TCCCCCATGT GACACCGAAC
CTGCCTCCCC CACCTGCCCT GAGACCCCTC AACAATGCAT CAGCCTCTCC CCCTGGCCTG
GGGGCCCAAC CACTACCTGG TCATCTGCCC TCTCCCCACG CCATGGGACA GGGTATGGGT
GGACTTCCTC CTGGCCCAGA GAAGGGCCCA ACTCTGGCTC CTTCACCCCA CTCTCTGCCT
CCTGCTTCCT CTTCTGCTCC AGCGCCCCCC ATGAGGTTTC CTTATTCATC CTCTAGTAGT
AGCTCTGCAG CAGCCTCCTC TTCCAGTTCT TCCTCCTCTT CCTCTGCCTC CCCCTTCCCA
GCTTCCCAGG CATTGCCCAG CTACCCCCAC TCTTTCCCTC CCCCAACAAG CCTCTCTGTC
TCCAATCAGC CCCCCAAGTA TACTCAGCCT TCTCTCCCAT CCCAGGCTGT GTGGAGCCAG
GGTCCCCCAC CACCTCCTCC CTATGGCCGC CTCTTAGCCA ACAGCAATGC CCATCCAGGC
CCCTTCCCTC CCTCTACTGG GGCCCAGTCC ACCGCCCACC CACCAGTCTC AACACATCAC
CATCACCACC AGCAACAGCA ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG
CAGCAGCATC ACGGAAACTC TGGGCCCCCT CCTCCTGGAG CATTTCCCCA CCCACTGGAG
GGCGGTAGCT CCCACCACGC ACACCCTTAC GCCATGTCTC CCTCCCTGGG GTCTCTGAGG
CCCTACCCAC CAGGGCCAGC ACACCTGCCC CCACCTCACA GCCAGGTGTC CTACAGCCAA
GCAGGCCCCA ATGGCCCTCC AGTCTCTTCC TCTTCCAACT CTTCCTCTTC CACTTCTCAA
GGGTCCTACC CATGTTCACA CCCCTCCCCT TCCCAGGGCC CTCAAGGGGC GCCCTACCCT
TTCCCACCGG TGCCTACGGT CACCACCTCT TCGGCTACCC TTTCCACGGT CATTGCCACC
GTGGCTTCCT CGCCAGCAGG CTACAAAACG GCCTCCCCAC CTGGGCCCCC ACCGTACGGA
AAGAGAGCCC CGTCCCCGGG GGCCTACAAG ACAGCCACCC CACCCGGATA CAAACCCGGG
TCGCCTCCCT CCTTCCGAAC GGGGACCCCA CCGGGCTATC GAGGAACCTC GCCACCTGCA
GGCCCAGGGA CCTTCAAGCC GGGCTCGCCC ACCGTGGGAC CTGGGCCCCT GCCACCTGCG
GGGCCCTCAG GCCTGCCATC GCTGCCACCA CCACCTGCGG CCCCTGCCTC AGGGCCGCCC
CTGAGCGCCA CGCAGATCAA ACAGGAGCCG GCTGAGGAGT ATGAGACCCC CGAGAGCCCG
GTGCCCCCAG CCCGCAGCCC CTCGCCCCCT CCCAAGGTGG TAGATGTACC CAGCCATGCC
AGTCAGTCTG CCAGGTTCAA CAAACACCTG GATCGCGGCT TCAACTCGTG CGCGCGCAGC
GACCTGTACT TCGTGCCACT GGAGGGCTCC AAGCTGGCCA AGAAGCGGGC CGACCTGGTG
GAGAAGGTGC GGCGCGAGGC CGAGCAGCGC GCGCGCGAAG AAAAGGAGCG CGAGCGCGAG
CGGGAACGCG AGAAAGAGCG CGAGCGCGAG AAGGAGCGCG AGCTTGAACG CAGCGTGAAG
TTGGCTCAGG AGGGCCGTGC TCCGGTGGAA TGCCCATCTC TGGGCCCAGT GCCCCATCGC
CCTCCATTTG AACCGGGCAG TGCGGTGGCT ACAGTGCCCC CCTACCTGGG TCCTGACACT
CCAGCCTTGC GCACTCTCAG TGAATATGCC CGGCCTCATG TCATGTCTCC TGGCAATCGC
AACCATCCAT TCTACGTGCC CCTGGGGGCA GTGGACCCGG GGCTCCTGGG TTACAATGTC
CCGGCCCTGT ACAGCAGTGA TCCAGCTGCC CGGGAGAGGG AACGGGAAGC CCGTGAACGA
GACCTCCGTG ACCGCCTCAA GCCTGGCTTT GAGGTGAAGC CTAGTGAGCT GGAACCCCTA
CATGGGGTCC CTGGGCCGGG CTTGGATCCC TTTCCCCGAC ATGGGGGCCT GGCTCTGCAG
CCTGGCCCAC CTGGCCTGCA CCCTTTCCCC TTTCATCCGA GCCTGGGGCC CCTGGAGCGA
GAACGTCTAG CGCTGGCAGC TGGGCCAGCC CTGCGGCCTG ACATGTCCTA TGCTGAGCGG
CTGGCAGCTG AGAGGCAGCA CGCAGAAAGG GTGGCGGCCC TGGGCAATGA CCCACTGGCC
CGGCTGCAGA TGCTCAATGT GACTCCCCAT CACCACCAGC ACTCCCACAT CCACTCGCAC
CTGCACCTGC ACCAGCAAGA TGCTATCCAT GCAGCCTCTG CCTCGGTGCA CCCTCTCATT
GACCCCCTGG CCTCAGGGTC TCACCTTACC CGGATCCCCT ACCCAGCTGG AACTCTCCCT
AACCCCCTGC TTCCTCACCC TCTGCACGAG AACGAAGTTC TTCGTCACCA GCTCTTTGCT
GCCCCTTACC GGGACCTGCC GGCCTCCCTT TCTGCCCCGA TGTCAGCAGC TCATCAGCTG
CAGGCCATGC ACGCACAGTC AGCTGAGCTG CAGCGCTTGG CGCTGGAACA GCAGCAGTGG
CTGCATGCCC ATCACCCGCT GCACAGTGTG CCGCTGCCTG CCCAGGAGGA CTACTACAGT
CACCTGAAGA AGGAAAGCGA CAAGCCACTG TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001931.2
CDS231..3803
Misc Feature(1)225..227(+)
Misc Feature(2)231..3800(+)
Misc Feature(3)276..326(+)
Misc Feature(4)330..332(+)
Misc Feature(5)330..332(+)
Misc Feature(6)459..461(+)
Misc Feature(7)459..461(+)
Misc Feature(8)465..467(+)
Misc Feature(9)465..467(+)
Misc Feature(10)471..473(+)
Misc Feature(11)531..533(+)
Misc Feature(12)531..533(+)
Misc Feature(13)537..539(+)
Misc Feature(14)537..539(+)
Misc Feature(15)549..551(+)
Misc Feature(16)549..551(+)
Misc Feature(17)555..560(+)
Misc Feature(18)555..557(+)
Misc Feature(19)564..566(+)
Misc Feature(20)585..587(+)
Misc Feature(21)1680..1736(+)
Misc Feature(22)1779..1931(+)
Misc Feature(23)2124..2126(+)
Misc Feature(24)2151..2153(+)
Misc Feature(25)2163..2165(+)
Misc Feature(26)2187..2189(+)
Misc Feature(27)2187..2189(+)
Misc Feature(28)2211..2213(+)
Misc Feature(29)2211..2213(+)
Misc Feature(30)2235..2237(+)
Misc Feature(31)2445..2447(+)
Misc Feature(32)2445..2447(+)
Misc Feature(33)2466..2468(+)
Misc Feature(34)2466..2468(+)
Misc Feature(35)2472..2474(+)
Misc Feature(36)2472..2474(+)
Misc Feature(37)2865..2912(+)
Misc Feature(38)3327..3353(+)
Exon (1)1..68
Gene:ATN1
Gene Synonym:
Exon (2)69..257
Gene:ATN1
Gene Synonym:
Exon (3)258..395
Gene:ATN1
Gene Synonym:
Exon (4)396..509
Gene:ATN1
Gene Synonym:
Exon (5)510..2524
Gene:ATN1
Gene Synonym:
Exon (6)2525..2747
Gene:ATN1
Gene Synonym:
Exon (7)2748..3444
Gene:ATN1
Gene Synonym:
Exon (8)3445..3588
Gene:ATN1
Gene Synonym:
Exon (9)3589..3769
Gene:ATN1
Gene Synonym:
Exon (10)3770..4344
Gene:ATN1
Gene Synonym:
Translation
Position Chain Variation Link
219 219 a, g dbSNP:148970839
317 317 a, g, t dbSNP:200869380
558 558 a, g, t dbSNP:201715319
709 709 a, c dbSNP:201263134
783 783 c, g dbSNP:201262663
944 944 a, g dbSNP:200736794
975 975 a, g dbSNP:745377685
1485 1485 c, t dbSNP:200023232
1680 1680 (cag(8_25)) dbSNP:193922934
1692 1692 -, cagcagcagcagcag dbSNP:377147612
1712 1712 a, g dbSNP:144280633
1721 1721 a, g dbSNP:201797204
1730 1730 -, gcagcagca dbSNP:60216939
1877 1877 a, g dbSNP:11547602
2014 2014 a, g dbSNP:112609741
2198 2198 a, c dbSNP:112842935
2340 2340 a, g dbSNP:12315465
2660 2660 a, c dbSNP:7969685
3157 3157 a, g dbSNP:763345965
3410 3410 c, t dbSNP:200797076
3509 3509 c, g dbSNP:759634387
3791 3791 a, c, g dbSNP:113128950
3810 3810 c, t dbSNP:751840812
3868 3868 c, t dbSNP:74057225
3872 3872 a, g dbSNP:762450306
3979 3979 c, g, t dbSNP:753349625
4084 4084 a, c dbSNP:12318608
4156 4156 -, gt dbSNP:146026478
4163 4163 a, g dbSNP:754443549
4307 4307 a, c dbSNP:78561525

Target ORF information:

RefSeq Version NM_001940
Organism Homo sapiens (human)
Definition Homo sapiens atrophin 1 (ATN1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001940

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
ATGAAGACAC GACAGAATAA AGACTCGATG TCAATGAGGA GTGGACGGAA GAAAGAGGCC 
CCTGGGCCCC GGGAAGAACT GAGATCGAGG GGCCGGGCCT CCCCTGGAGG GGTCAGCACG
TCCAGCAGTG ATGGCAAAGC TGAGAAGTCC AGGCAGACAG CCAAGAAGGC CCGAGTAGAG
GAAGCCTCCA CCCCAAAGGT CAACAAGCAG GGTCGGAGTG AGGAGATCTC AGAGAGTGAA
AGTGAGGAGA CCAATGCACC AAAAAAGACC AAAACTGAGC AGGAACTCCC TCGGCCACAG
TCTCCCTCCG ATCTGGATAG CTTGGACGGG CGGAGCCTTA ATGATGATGG CAGCAGCGAC
CCTAGGGATA TCGACCAGGA CAACCGAAGC ACGTCCCCCA GTATCTACAG CCCTGGAAGT
GTGGAGAATG ACTCTGACTC ATCTTCTGGC CTGTCCCAGG GCCCAGCCCG CCCCTACCAC
CCACCTCCAC TCTTTCCTCC TTCCCCTCAA CCGCCAGACA GCACCCCTCG ACAGCCAGAG
GCTAGCTTTG AACCCCATCC TTCTGTGACA CCCACTGGAT ATCATGCTCC CATGGAGCCC
CCCACATCTC GAATGTTCCA GGCTCCTCCT GGGGCCCCTC CCCCTCACCC ACAGCTCTAT
CCTGGGGGCA CTGGTGGAGT TTTGTCTGGA CCCCCAATGG GTCCCAAGGG GGGAGGGGCT
GCCTCATCAG TGGGGGGCCC TAATGGGGGT AAGCAGCACC CCCCACCCAC TACTCCCATT
TCAGTATCAA GCTCTGGGGC TAGTGGTGCT CCCCCAACAA AGCCGCCTAC CACTCCAGTG
GGTGGTGGGA ACCTACCTTC TGCTCCACCA CCAGCCAACT TCCCCCATGT GACACCGAAC
CTGCCTCCCC CACCTGCCCT GAGACCCCTC AACAATGCAT CAGCCTCTCC CCCTGGCCTG
GGGGCCCAAC CACTACCTGG TCATCTGCCC TCTCCCCACG CCATGGGACA GGGTATGGGT
GGACTTCCTC CTGGCCCAGA GAAGGGCCCA ACTCTGGCTC CTTCACCCCA CTCTCTGCCT
CCTGCTTCCT CTTCTGCTCC AGCGCCCCCC ATGAGGTTTC CTTATTCATC CTCTAGTAGT
AGCTCTGCAG CAGCCTCCTC TTCCAGTTCT TCCTCCTCTT CCTCTGCCTC CCCCTTCCCA
GCTTCCCAGG CATTGCCCAG CTACCCCCAC TCTTTCCCTC CCCCAACAAG CCTCTCTGTC
TCCAATCAGC CCCCCAAGTA TACTCAGCCT TCTCTCCCAT CCCAGGCTGT GTGGAGCCAG
GGTCCCCCAC CACCTCCTCC CTATGGCCGC CTCTTAGCCA ACAGCAATGC CCATCCAGGC
CCCTTCCCTC CCTCTACTGG GGCCCAGTCC ACCGCCCACC CACCAGTCTC AACACATCAC
CATCACCACC AGCAACAGCA ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG
CAGCAGCATC ACGGAAACTC TGGGCCCCCT CCTCCTGGAG CATTTCCCCA CCCACTGGAG
GGCGGTAGCT CCCACCACGC ACACCCTTAC GCCATGTCTC CCTCCCTGGG GTCTCTGAGG
CCCTACCCAC CAGGGCCAGC ACACCTGCCC CCACCTCACA GCCAGGTGTC CTACAGCCAA
GCAGGCCCCA ATGGCCCTCC AGTCTCTTCC TCTTCCAACT CTTCCTCTTC CACTTCTCAA
GGGTCCTACC CATGTTCACA CCCCTCCCCT TCCCAGGGCC CTCAAGGGGC GCCCTACCCT
TTCCCACCGG TGCCTACGGT CACCACCTCT TCGGCTACCC TTTCCACGGT CATTGCCACC
GTGGCTTCCT CGCCAGCAGG CTACAAAACG GCCTCCCCAC CTGGGCCCCC ACCGTACGGA
AAGAGAGCCC CGTCCCCGGG GGCCTACAAG ACAGCCACCC CACCCGGATA CAAACCCGGG
TCGCCTCCCT CCTTCCGAAC GGGGACCCCA CCGGGCTATC GAGGAACCTC GCCACCTGCA
GGCCCAGGGA CCTTCAAGCC GGGCTCGCCC ACCGTGGGAC CTGGGCCCCT GCCACCTGCG
GGGCCCTCAG GCCTGCCATC GCTGCCACCA CCACCTGCGG CCCCTGCCTC AGGGCCGCCC
CTGAGCGCCA CGCAGATCAA ACAGGAGCCG GCTGAGGAGT ATGAGACCCC CGAGAGCCCG
GTGCCCCCAG CCCGCAGCCC CTCGCCCCCT CCCAAGGTGG TAGATGTACC CAGCCATGCC
AGTCAGTCTG CCAGGTTCAA CAAACACCTG GATCGCGGCT TCAACTCGTG CGCGCGCAGC
GACCTGTACT TCGTGCCACT GGAGGGCTCC AAGCTGGCCA AGAAGCGGGC CGACCTGGTG
GAGAAGGTGC GGCGCGAGGC CGAGCAGCGC GCGCGCGAAG AAAAGGAGCG CGAGCGCGAG
CGGGAACGCG AGAAAGAGCG CGAGCGCGAG AAGGAGCGCG AGCTTGAACG CAGCGTGAAG
TTGGCTCAGG AGGGCCGTGC TCCGGTGGAA TGCCCATCTC TGGGCCCAGT GCCCCATCGC
CCTCCATTTG AACCGGGCAG TGCGGTGGCT ACAGTGCCCC CCTACCTGGG TCCTGACACT
CCAGCCTTGC GCACTCTCAG TGAATATGCC CGGCCTCATG TCATGTCTCC TGGCAATCGC
AACCATCCAT TCTACGTGCC CCTGGGGGCA GTGGACCCGG GGCTCCTGGG TTACAATGTC
CCGGCCCTGT ACAGCAGTGA TCCAGCTGCC CGGGAGAGGG AACGGGAAGC CCGTGAACGA
GACCTCCGTG ACCGCCTCAA GCCTGGCTTT GAGGTGAAGC CTAGTGAGCT GGAACCCCTA
CATGGGGTCC CTGGGCCGGG CTTGGATCCC TTTCCCCGAC ATGGGGGCCT GGCTCTGCAG
CCTGGCCCAC CTGGCCTGCA CCCTTTCCCC TTTCATCCGA GCCTGGGGCC CCTGGAGCGA
GAACGTCTAG CGCTGGCAGC TGGGCCAGCC CTGCGGCCTG ACATGTCCTA TGCTGAGCGG
CTGGCAGCTG AGAGGCAGCA CGCAGAAAGG GTGGCGGCCC TGGGCAATGA CCCACTGGCC
CGGCTGCAGA TGCTCAATGT GACTCCCCAT CACCACCAGC ACTCCCACAT CCACTCGCAC
CTGCACCTGC ACCAGCAAGA TGCTATCCAT GCAGCCTCTG CCTCGGTGCA CCCTCTCATT
GACCCCCTGG CCTCAGGGTC TCACCTTACC CGGATCCCCT ACCCAGCTGG AACTCTCCCT
AACCCCCTGC TTCCTCACCC TCTGCACGAG AACGAAGTTC TTCGTCACCA GCTCTTTGCT
GCCCCTTACC GGGACCTGCC GGCCTCCCTT TCTGCCCCGA TGTCAGCAGC TCATCAGCTG
CAGGCCATGC ACGCACAGTC AGCTGAGCTG CAGCGCTTGG CGCTGGAACA GCAGCAGTGG
CTGCATGCCC ATCACCCGCT GCACAGTGTG CCGCTGCCTG CCCAGGAGGA CTACTACAGT
CACCTGAAGA AGGAAAGCGA CAAGCCACTG TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25731
Accession Version NM_001007026.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 3573bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product atrophin-1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC051795.2, BQ897715.1, BQ880124.1 and BQ448220.1. This sequence is a reference standard in the RefSeqGene project. Summary: Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-23 copies to 49-75 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Feb 2010]. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC051795.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
ATGAAGACAC GACAGAATAA AGACTCGATG TCAATGAGGA GTGGACGGAA GAAAGAGGCC 
CCTGGGCCCC GGGAAGAACT GAGATCGAGG GGCCGGGCCT CCCCTGGAGG GGTCAGCACG
TCCAGCAGTG ATGGCAAAGC TGAGAAGTCC AGGCAGACAG CCAAGAAGGC CCGAGTAGAG
GAAGCCTCCA CCCCAAAGGT CAACAAGCAG GGTCGGAGTG AGGAGATCTC AGAGAGTGAA
AGTGAGGAGA CCAATGCACC AAAAAAGACC AAAACTGAGC AGGAACTCCC TCGGCCACAG
TCTCCCTCCG ATCTGGATAG CTTGGACGGG CGGAGCCTTA ATGATGATGG CAGCAGCGAC
CCTAGGGATA TCGACCAGGA CAACCGAAGC ACGTCCCCCA GTATCTACAG CCCTGGAAGT
GTGGAGAATG ACTCTGACTC ATCTTCTGGC CTGTCCCAGG GCCCAGCCCG CCCCTACCAC
CCACCTCCAC TCTTTCCTCC TTCCCCTCAA CCGCCAGACA GCACCCCTCG ACAGCCAGAG
GCTAGCTTTG AACCCCATCC TTCTGTGACA CCCACTGGAT ATCATGCTCC CATGGAGCCC
CCCACATCTC GAATGTTCCA GGCTCCTCCT GGGGCCCCTC CCCCTCACCC ACAGCTCTAT
CCTGGGGGCA CTGGTGGAGT TTTGTCTGGA CCCCCAATGG GTCCCAAGGG GGGAGGGGCT
GCCTCATCAG TGGGGGGCCC TAATGGGGGT AAGCAGCACC CCCCACCCAC TACTCCCATT
TCAGTATCAA GCTCTGGGGC TAGTGGTGCT CCCCCAACAA AGCCGCCTAC CACTCCAGTG
GGTGGTGGGA ACCTACCTTC TGCTCCACCA CCAGCCAACT TCCCCCATGT GACACCGAAC
CTGCCTCCCC CACCTGCCCT GAGACCCCTC AACAATGCAT CAGCCTCTCC CCCTGGCCTG
GGGGCCCAAC CACTACCTGG TCATCTGCCC TCTCCCCACG CCATGGGACA GGGTATGGGT
GGACTTCCTC CTGGCCCAGA GAAGGGCCCA ACTCTGGCTC CTTCACCCCA CTCTCTGCCT
CCTGCTTCCT CTTCTGCTCC AGCGCCCCCC ATGAGGTTTC CTTATTCATC CTCTAGTAGT
AGCTCTGCAG CAGCCTCCTC TTCCAGTTCT TCCTCCTCTT CCTCTGCCTC CCCCTTCCCA
GCTTCCCAGG CATTGCCCAG CTACCCCCAC TCTTTCCCTC CCCCAACAAG CCTCTCTGTC
TCCAATCAGC CCCCCAAGTA TACTCAGCCT TCTCTCCCAT CCCAGGCTGT GTGGAGCCAG
GGTCCCCCAC CACCTCCTCC CTATGGCCGC CTCTTAGCCA ACAGCAATGC CCATCCAGGC
CCCTTCCCTC CCTCTACTGG GGCCCAGTCC ACCGCCCACC CACCAGTCTC AACACATCAC
CATCACCACC AGCAACAGCA ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG
CAGCAGCATC ACGGAAACTC TGGGCCCCCT CCTCCTGGAG CATTTCCCCA CCCACTGGAG
GGCGGTAGCT CCCACCACGC ACACCCTTAC GCCATGTCTC CCTCCCTGGG GTCTCTGAGG
CCCTACCCAC CAGGGCCAGC ACACCTGCCC CCACCTCACA GCCAGGTGTC CTACAGCCAA
GCAGGCCCCA ATGGCCCTCC AGTCTCTTCC TCTTCCAACT CTTCCTCTTC CACTTCTCAA
GGGTCCTACC CATGTTCACA CCCCTCCCCT TCCCAGGGCC CTCAAGGGGC GCCCTACCCT
TTCCCACCGG TGCCTACGGT CACCACCTCT TCGGCTACCC TTTCCACGGT CATTGCCACC
GTGGCTTCCT CGCCAGCAGG CTACAAAACG GCCTCCCCAC CTGGGCCCCC ACCGTACGGA
AAGAGAGCCC CGTCCCCGGG GGCCTACAAG ACAGCCACCC CACCCGGATA CAAACCCGGG
TCGCCTCCCT CCTTCCGAAC GGGGACCCCA CCGGGCTATC GAGGAACCTC GCCACCTGCA
GGCCCAGGGA CCTTCAAGCC GGGCTCGCCC ACCGTGGGAC CTGGGCCCCT GCCACCTGCG
GGGCCCTCAG GCCTGCCATC GCTGCCACCA CCACCTGCGG CCCCTGCCTC AGGGCCGCCC
CTGAGCGCCA CGCAGATCAA ACAGGAGCCG GCTGAGGAGT ATGAGACCCC CGAGAGCCCG
GTGCCCCCAG CCCGCAGCCC CTCGCCCCCT CCCAAGGTGG TAGATGTACC CAGCCATGCC
AGTCAGTCTG CCAGGTTCAA CAAACACCTG GATCGCGGCT TCAACTCGTG CGCGCGCAGC
GACCTGTACT TCGTGCCACT GGAGGGCTCC AAGCTGGCCA AGAAGCGGGC CGACCTGGTG
GAGAAGGTGC GGCGCGAGGC CGAGCAGCGC GCGCGCGAAG AAAAGGAGCG CGAGCGCGAG
CGGGAACGCG AGAAAGAGCG CGAGCGCGAG AAGGAGCGCG AGCTTGAACG CAGCGTGAAG
TTGGCTCAGG AGGGCCGTGC TCCGGTGGAA TGCCCATCTC TGGGCCCAGT GCCCCATCGC
CCTCCATTTG AACCGGGCAG TGCGGTGGCT ACAGTGCCCC CCTACCTGGG TCCTGACACT
CCAGCCTTGC GCACTCTCAG TGAATATGCC CGGCCTCATG TCATGTCTCC TGGCAATCGC
AACCATCCAT TCTACGTGCC CCTGGGGGCA GTGGACCCGG GGCTCCTGGG TTACAATGTC
CCGGCCCTGT ACAGCAGTGA TCCAGCTGCC CGGGAGAGGG AACGGGAAGC CCGTGAACGA
GACCTCCGTG ACCGCCTCAA GCCTGGCTTT GAGGTGAAGC CTAGTGAGCT GGAACCCCTA
CATGGGGTCC CTGGGCCGGG CTTGGATCCC TTTCCCCGAC ATGGGGGCCT GGCTCTGCAG
CCTGGCCCAC CTGGCCTGCA CCCTTTCCCC TTTCATCCGA GCCTGGGGCC CCTGGAGCGA
GAACGTCTAG CGCTGGCAGC TGGGCCAGCC CTGCGGCCTG ACATGTCCTA TGCTGAGCGG
CTGGCAGCTG AGAGGCAGCA CGCAGAAAGG GTGGCGGCCC TGGGCAATGA CCCACTGGCC
CGGCTGCAGA TGCTCAATGT GACTCCCCAT CACCACCAGC ACTCCCACAT CCACTCGCAC
CTGCACCTGC ACCAGCAAGA TGCTATCCAT GCAGCCTCTG CCTCGGTGCA CCCTCTCATT
GACCCCCTGG CCTCAGGGTC TCACCTTACC CGGATCCCCT ACCCAGCTGG AACTCTCCCT
AACCCCCTGC TTCCTCACCC TCTGCACGAG AACGAAGTTC TTCGTCACCA GCTCTTTGCT
GCCCCTTACC GGGACCTGCC GGCCTCCCTT TCTGCCCCGA TGTCAGCAGC TCATCAGCTG
CAGGCCATGC ACGCACAGTC AGCTGAGCTG CAGCGCTTGG CGCTGGAACA GCAGCAGTGG
CTGCATGCCC ATCACCCGCT GCACAGTGTG CCGCTGCCTG CCCAGGAGGA CTACTACAGT
CACCTGAAGA AGGAAAGCGA CAAGCCACTG TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeqNP_001007027.1
CDS238..3810
Misc Feature(1)232..234(+)
Misc Feature(2)238..3807(+)
Misc Feature(3)283..333(+)
Misc Feature(4)337..339(+)
Misc Feature(5)337..339(+)
Misc Feature(6)466..468(+)
Misc Feature(7)466..468(+)
Misc Feature(8)472..474(+)
Misc Feature(9)472..474(+)
Misc Feature(10)478..480(+)
Misc Feature(11)538..540(+)
Misc Feature(12)538..540(+)
Misc Feature(13)544..546(+)
Misc Feature(14)544..546(+)
Misc Feature(15)556..558(+)
Misc Feature(16)556..558(+)
Misc Feature(17)562..567(+)
Misc Feature(18)562..564(+)
Misc Feature(19)571..573(+)
Misc Feature(20)592..594(+)
Misc Feature(21)1687..1743(+)
Misc Feature(22)1786..1938(+)
Misc Feature(23)2131..2133(+)
Misc Feature(24)2158..2160(+)
Misc Feature(25)2170..2172(+)
Misc Feature(26)2194..2196(+)
Misc Feature(27)2194..2196(+)
Misc Feature(28)2218..2220(+)
Misc Feature(29)2218..2220(+)
Misc Feature(30)2242..2244(+)
Misc Feature(31)2452..2454(+)
Misc Feature(32)2452..2454(+)
Misc Feature(33)2473..2475(+)
Misc Feature(34)2473..2475(+)
Misc Feature(35)2479..2481(+)
Misc Feature(36)2479..2481(+)
Misc Feature(37)2872..2919(+)
Misc Feature(38)3334..3360(+)
Exon (1)1..75
Gene:ATN1
Gene Synonym:
Exon (2)76..264
Gene:ATN1
Gene Synonym:
Exon (3)265..402
Gene:ATN1
Gene Synonym:
Exon (4)403..516
Gene:ATN1
Gene Synonym:
Exon (5)517..2531
Gene:ATN1
Gene Synonym:
Exon (6)2532..2754
Gene:ATN1
Gene Synonym:
Exon (7)2755..3451
Gene:ATN1
Gene Synonym:
Exon (8)3452..3595
Gene:ATN1
Gene Synonym:
Exon (9)3596..3776
Gene:ATN1
Gene Synonym:
Exon (10)3777..4351
Gene:ATN1
Gene Synonym:
Translation
Position Chain Variation Link
226 226 a, g dbSNP:148970839
324 324 a, g, t dbSNP:200869380
565 565 a, g, t dbSNP:201715319
716 716 a, c dbSNP:201263134
790 790 c, g dbSNP:201262663
951 951 a, g dbSNP:200736794
982 982 a, g dbSNP:745377685
1492 1492 c, t dbSNP:200023232
1687 1687 (cag(8_25)) dbSNP:193922934
1699 1699 -, cagcagcagcagcag dbSNP:377147612
1719 1719 a, g dbSNP:144280633
1728 1728 a, g dbSNP:201797204
1737 1737 -, gcagcagca dbSNP:60216939
1884 1884 a, g dbSNP:11547602
2021 2021 a, g dbSNP:112609741
2205 2205 a, c dbSNP:112842935
2347 2347 a, g dbSNP:12315465
2667 2667 a, c dbSNP:7969685
3164 3164 a, g dbSNP:763345965
3417 3417 c, t dbSNP:200797076
3516 3516 c, g dbSNP:759634387
3798 3798 a, c, g dbSNP:113128950
3817 3817 c, t dbSNP:751840812
3875 3875 c, t dbSNP:74057225
3879 3879 a, g dbSNP:762450306
3986 3986 c, g, t dbSNP:753349625
4091 4091 a, c dbSNP:12318608
4163 4163 -, gt dbSNP:146026478
4170 4170 a, g dbSNP:754443549
4314 4314 a, c dbSNP:78561525

Target ORF information:

RefSeq Version NM_001007026
Organism Homo sapiens (human)
Definition Homo sapiens atrophin 1 (ATN1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001007026

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
ATGAAGACAC GACAGAATAA AGACTCGATG TCAATGAGGA GTGGACGGAA GAAAGAGGCC 
CCTGGGCCCC GGGAAGAACT GAGATCGAGG GGCCGGGCCT CCCCTGGAGG GGTCAGCACG
TCCAGCAGTG ATGGCAAAGC TGAGAAGTCC AGGCAGACAG CCAAGAAGGC CCGAGTAGAG
GAAGCCTCCA CCCCAAAGGT CAACAAGCAG GGTCGGAGTG AGGAGATCTC AGAGAGTGAA
AGTGAGGAGA CCAATGCACC AAAAAAGACC AAAACTGAGC AGGAACTCCC TCGGCCACAG
TCTCCCTCCG ATCTGGATAG CTTGGACGGG CGGAGCCTTA ATGATGATGG CAGCAGCGAC
CCTAGGGATA TCGACCAGGA CAACCGAAGC ACGTCCCCCA GTATCTACAG CCCTGGAAGT
GTGGAGAATG ACTCTGACTC ATCTTCTGGC CTGTCCCAGG GCCCAGCCCG CCCCTACCAC
CCACCTCCAC TCTTTCCTCC TTCCCCTCAA CCGCCAGACA GCACCCCTCG ACAGCCAGAG
GCTAGCTTTG AACCCCATCC TTCTGTGACA CCCACTGGAT ATCATGCTCC CATGGAGCCC
CCCACATCTC GAATGTTCCA GGCTCCTCCT GGGGCCCCTC CCCCTCACCC ACAGCTCTAT
CCTGGGGGCA CTGGTGGAGT TTTGTCTGGA CCCCCAATGG GTCCCAAGGG GGGAGGGGCT
GCCTCATCAG TGGGGGGCCC TAATGGGGGT AAGCAGCACC CCCCACCCAC TACTCCCATT
TCAGTATCAA GCTCTGGGGC TAGTGGTGCT CCCCCAACAA AGCCGCCTAC CACTCCAGTG
GGTGGTGGGA ACCTACCTTC TGCTCCACCA CCAGCCAACT TCCCCCATGT GACACCGAAC
CTGCCTCCCC CACCTGCCCT GAGACCCCTC AACAATGCAT CAGCCTCTCC CCCTGGCCTG
GGGGCCCAAC CACTACCTGG TCATCTGCCC TCTCCCCACG CCATGGGACA GGGTATGGGT
GGACTTCCTC CTGGCCCAGA GAAGGGCCCA ACTCTGGCTC CTTCACCCCA CTCTCTGCCT
CCTGCTTCCT CTTCTGCTCC AGCGCCCCCC ATGAGGTTTC CTTATTCATC CTCTAGTAGT
AGCTCTGCAG CAGCCTCCTC TTCCAGTTCT TCCTCCTCTT CCTCTGCCTC CCCCTTCCCA
GCTTCCCAGG CATTGCCCAG CTACCCCCAC TCTTTCCCTC CCCCAACAAG CCTCTCTGTC
TCCAATCAGC CCCCCAAGTA TACTCAGCCT TCTCTCCCAT CCCAGGCTGT GTGGAGCCAG
GGTCCCCCAC CACCTCCTCC CTATGGCCGC CTCTTAGCCA ACAGCAATGC CCATCCAGGC
CCCTTCCCTC CCTCTACTGG GGCCCAGTCC ACCGCCCACC CACCAGTCTC AACACATCAC
CATCACCACC AGCAACAGCA ACAGCAGCAG CAGCAGCAGC AGCAGCAGCA GCAGCAGCAG
CAGCAGCATC ACGGAAACTC TGGGCCCCCT CCTCCTGGAG CATTTCCCCA CCCACTGGAG
GGCGGTAGCT CCCACCACGC ACACCCTTAC GCCATGTCTC CCTCCCTGGG GTCTCTGAGG
CCCTACCCAC CAGGGCCAGC ACACCTGCCC CCACCTCACA GCCAGGTGTC CTACAGCCAA
GCAGGCCCCA ATGGCCCTCC AGTCTCTTCC TCTTCCAACT CTTCCTCTTC CACTTCTCAA
GGGTCCTACC CATGTTCACA CCCCTCCCCT TCCCAGGGCC CTCAAGGGGC GCCCTACCCT
TTCCCACCGG TGCCTACGGT CACCACCTCT TCGGCTACCC TTTCCACGGT CATTGCCACC
GTGGCTTCCT CGCCAGCAGG CTACAAAACG GCCTCCCCAC CTGGGCCCCC ACCGTACGGA
AAGAGAGCCC CGTCCCCGGG GGCCTACAAG ACAGCCACCC CACCCGGATA CAAACCCGGG
TCGCCTCCCT CCTTCCGAAC GGGGACCCCA CCGGGCTATC GAGGAACCTC GCCACCTGCA
GGCCCAGGGA CCTTCAAGCC GGGCTCGCCC ACCGTGGGAC CTGGGCCCCT GCCACCTGCG
GGGCCCTCAG GCCTGCCATC GCTGCCACCA CCACCTGCGG CCCCTGCCTC AGGGCCGCCC
CTGAGCGCCA CGCAGATCAA ACAGGAGCCG GCTGAGGAGT ATGAGACCCC CGAGAGCCCG
GTGCCCCCAG CCCGCAGCCC CTCGCCCCCT CCCAAGGTGG TAGATGTACC CAGCCATGCC
AGTCAGTCTG CCAGGTTCAA CAAACACCTG GATCGCGGCT TCAACTCGTG CGCGCGCAGC
GACCTGTACT TCGTGCCACT GGAGGGCTCC AAGCTGGCCA AGAAGCGGGC CGACCTGGTG
GAGAAGGTGC GGCGCGAGGC CGAGCAGCGC GCGCGCGAAG AAAAGGAGCG CGAGCGCGAG
CGGGAACGCG AGAAAGAGCG CGAGCGCGAG AAGGAGCGCG AGCTTGAACG CAGCGTGAAG
TTGGCTCAGG AGGGCCGTGC TCCGGTGGAA TGCCCATCTC TGGGCCCAGT GCCCCATCGC
CCTCCATTTG AACCGGGCAG TGCGGTGGCT ACAGTGCCCC CCTACCTGGG TCCTGACACT
CCAGCCTTGC GCACTCTCAG TGAATATGCC CGGCCTCATG TCATGTCTCC TGGCAATCGC
AACCATCCAT TCTACGTGCC CCTGGGGGCA GTGGACCCGG GGCTCCTGGG TTACAATGTC
CCGGCCCTGT ACAGCAGTGA TCCAGCTGCC CGGGAGAGGG AACGGGAAGC CCGTGAACGA
GACCTCCGTG ACCGCCTCAA GCCTGGCTTT GAGGTGAAGC CTAGTGAGCT GGAACCCCTA
CATGGGGTCC CTGGGCCGGG CTTGGATCCC TTTCCCCGAC ATGGGGGCCT GGCTCTGCAG
CCTGGCCCAC CTGGCCTGCA CCCTTTCCCC TTTCATCCGA GCCTGGGGCC CCTGGAGCGA
GAACGTCTAG CGCTGGCAGC TGGGCCAGCC CTGCGGCCTG ACATGTCCTA TGCTGAGCGG
CTGGCAGCTG AGAGGCAGCA CGCAGAAAGG GTGGCGGCCC TGGGCAATGA CCCACTGGCC
CGGCTGCAGA TGCTCAATGT GACTCCCCAT CACCACCAGC ACTCCCACAT CCACTCGCAC
CTGCACCTGC ACCAGCAAGA TGCTATCCAT GCAGCCTCTG CCTCGGTGCA CCCTCTCATT
GACCCCCTGG CCTCAGGGTC TCACCTTACC CGGATCCCCT ACCCAGCTGG AACTCTCCCT
AACCCCCTGC TTCCTCACCC TCTGCACGAG AACGAAGTTC TTCGTCACCA GCTCTTTGCT
GCCCCTTACC GGGACCTGCC GGCCTCCCTT TCTGCCCCGA TGTCAGCAGC TCATCAGCTG
CAGGCCATGC ACGCACAGTC AGCTGAGCTG CAGCGCTTGG CGCTGGAACA GCAGCAGTGG
CTGCATGCCC ATCACCCGCT GCACAGTGTG CCGCTGCCTG CCCAGGAGGA CTACTACAGT
CACCTGAAGA AGGAAAGCGA CAAGCCACTG TAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Increased aggregation of polyleucine compared with that of polyglutamine in dentatorubral-pallidoluysian atrophy protein
Neurosci. Lett. 552, 156-161 (2013)
Suzuki Y, Jin C and Yazawa I.


book

Hypoalbuminemia in early onset dentatorubral-pallidoluysian atrophy due to leakage of albumin in multiple organs
J. Neurol. 260 (5), 1263-1271 (2013)
Nagai S, Saito Y, Endo Y, Saito T, Sugai K, Ishiyama A, Komaki H, Nakagawa E, Sasaki M, Ito K, Saito Y, Sukigara S, Ito M, Goto Y, Ito S and Matsuoka K.


book

DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles
Neurobiol. Dis. 46 (2), 336-350 (2012)
Suzuki K, Zhou J, Sato T, Takao K, Miyagawa T, Oyake M, Yamada M, Takahashi H, Takahashi Y, Goto J and Tsuji S.


book

Dentatorubral-pallidoluysian atrophy: haplotype of Asian origin in 2 Italian families
Mov. Disord. 27 (3), 460-461 (2012)
Aridon,P., Tarantino,P., Ragonese,P., D'Amelio,M., Cinturino,A., Salemi,G., Gagliardi,M., Lo Re,V., Scarpitta,A., Gambardella,A., Quattrone,A., Annesi,G. and Savettieri,G.


book

Molecular cloning of a full-length cDNA for dentatorubral-pallidoluysian atrophy and regional expressions of the expanded alleles in the CNS
Am. J. Hum. Genet. 57 (5), 1050-1060 (1995)
Onodera O, Oyake M, Takano H, Ikeuchi T, Igarashi S and Tsuji S.


book

Abnormal gene product identified in hereditary dentatorubral-pallidoluysian atrophy (DRPLA) brain
Nat. Genet. 10 (1), 99-103 (1995)
Yazawa I, Nukina N, Hashida H, Goto J, Yamada M and Kanazawa I.


book

Structure and expression of the gene responsible for the triplet repeat disorder, dentatorubral and pallidoluysian atrophy (DRPLA)
Nat. Genet. 8 (2), 177-182 (1994)
Nagafuchi S, Yanagisawa H, Ohsaki E, Shirayama T, Tadokoro K, Inoue T and Yamada M.


book

DRPLA
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Tsuji,S.


book

Dystonia Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Klein,C., Marras,C. and Munchau,A.


book

Hereditary Ataxia Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Bird,T.D.


 
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