||ORF Nucleotide Sequence (Length: 1458bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from DC412932.1, AK312291.1,
K02215.1, T97863.1 and AW128887.1.
This sequence is a reference standard in the RefSeqGene project.
On May 21, 2008 this sequence version replaced gi:73622269.
Summary: The protein encoded by this gene, pre-angiotensinogen or
angiotensinogen precursor, is expressed in the liver and is cleaved
by the enzyme renin in response to lowered blood pressure. The
resulting product, angiotensin I, is then cleaved by angiotensin
converting enzyme (ACE) to generate the physiologically active
enzyme angiotensin II. The protein is involved in maintaining blood
pressure and in the pathogenesis of essential hypertension and
preeclampsia. Mutations in this gene are associated with
susceptibility to essential hypertension, and can cause renal
tubular dysgenesis, a severe disorder of renal tubular development.
Defects in this gene have also been associated with non-familial
structural atrial fibrillation, and inflammatory bowel disease.
[provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: K02215.1, AK222815.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
COMPLETENESS: complete on the 3' end.