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GPR183 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GPR183
Entrez Gene ID 1880
Full Name G protein-coupled receptor 183
Synonyms EBI2
General protein information
Preferred Names
G-protein coupled receptor 183
Names
G-protein coupled receptor 183
EBV-induced G-protein coupled receptor 2
epstein-Barr virus-induced G-protein coupled receptor 2
Epstein-Barr virus induced gene 2 (lymphocyte-specific G protein-coupled receptor)
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q32.3

Summary This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

605741


mRNA and Protein(s)

mRNA Protein Name
NM_004951 NP_004942 G-protein coupled receptor 183



Homo sapiens (human) GPR183 NP_004942.1
Pan troglodytes (chimpanzee) GPR183 XP_001146657.1
Macaca mulatta (Rhesus monkey) GPR183 XP_001091970.1
Canis lupus familiaris (dog) GPR183 XP_005634101.1
Mus musculus (house mouse) Gpr183 NP_898852.2
Rattus norvegicus (Norway rat) Gpr183 NP_001102856.1
Gallus gallus (chicken) GPR183 XP_001231944.1
Danio rerio (zebrafish) gpr183 NP_001092711.1
Danio rerio (zebrafish) si:dkey-22o12.5 NP_001124284.1
Danio rerio (zebrafish) LOC100333319 XP_005160018.1
Xenopus (Silurana) tropicalis (western clawed frog) LOC101731463 XP_004911877.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GPR183 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR183 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu16498 NM_004951 Homo sapiens G protein-coupled receptor 183 (GPR183), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu16498
Clone ID Related Accession (Same CDS sequence) NM_004951
Accession Version NM_004951.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1086bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product G-protein coupled receptor 183
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313443.1, BC020752.1 and AW574697.1. On Jul 26, 2008 this sequence version replaced gi:50962860. ##Evidence-Data-START## Transcript exon combination :: AK313443.1, BC020752.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154361 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGATATAC AAATGGCAAA CAATTTTACT CCGCCCTCTG CAACTCCTCA GGGAAATGAC 
TGTGACCTCT ATGCACATCA CAGCACGGCC AGGATAGTAA TGCCTCTGCA TTACAGCCTC
GTCTTCATCA TTGGGCTCGT GGGAAACTTA CTAGCCTTGG TCGTCATTGT TCAAAACAGG
AAAAAAATCA ACTCTACCAC CCTCTATTCA ACAAATTTGG TGATTTCTGA TATACTTTTT
ACCACCGCTT TGCCTACACG AATAGCCTAC TATGCAATGG GCTTTGACTG GAGAATCGGA
GATGCCTTGT GTAGGATAAC TGCGCTAGTG TTTTACATCA ACACATATGC AGGTGTGAAC
TTTATGACCT GCCTGAGTAT TGACCGCTTC ATTGCTGTGG TGCACCCTCT ACGCTACAAC
AAGATAAAAA GGATTGAACA TGCAAAAGGC GTGTGCATAT TTGTCTGGAT TCTAGTATTT
GCTCAGACAC TCCCACTCCT CATCAACCCT ATGTCAAAGC AGGAGGCTGA AAGGATTACA
TGCATGGAGT ATCCAAACTT TGAAGAAACT AAATCTCTTC CCTGGATTCT GCTTGGGGCA
TGTTTCATAG GATATGTACT TCCACTTATA ATCATTCTCA TCTGCTATTC TCAGATCTGC
TGCAAACTCT TCAGAACTGC CAAACAAAAC CCACTCACTG AGAAATCTGG TGTAAACAAA
AAGGCTCTCA ACACAATTAT TCTTATTATT GTTGTGTTTG TTCTCTGTTT CACACCTTAC
CATGTTGCAA TTATTCAACA TATGATTAAG AAGCTTCGTT TCTCTAATTT CCTGGAATGT
AGCCAAAGAC ATTCGTTCCA GATTTCTCTG CACTTTACAG TATGCCTGAT GAACTTCAAT
TGCTGCATGG ACCCTTTTAT CTACTTCTTT GCATGTAAAG GGTATAAGAG AAAGGTTATG
AGGATGCTGA AACGGCAAGT CAGTGTATCG ATTTCTAGTG CTGTGAAGTC AGCCCCTGAA
GAAAATTCAC GTGAAATGAC AGAAACGCAG ATGATGATAC ATTCCAAGTC TTCAAATGGA
AAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004942.1
CDS175..1260
Misc Feature(1)151..153(+)
Misc Feature(2)268..345(+)
Misc Feature(3)301..>657(+)
Misc Feature(4)334..1098(+)
Misc Feature(5)406..459(+)
Misc Feature(6)490..555(+)
Misc Feature(7)550..576(+)
Misc Feature(8)622..678(+)
Misc Feature(9)751..819(+)
Misc Feature(10)757..975(+)
Misc Feature(11)898..969(+)
Misc Feature(12)1036..1110(+)
Exon (1)1..156
Gene:GPR183
Gene Synonym:
Exon (2)157..1785
Gene:GPR183
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_004951
Organism Homo sapiens (human)
Definition Homo sapiens G protein-coupled receptor 183 (GPR183), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_004951

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGGATATAC AAATGGCAAA CAATTTTACT CCGCCCTCTG CAACTCCTCA GGGAAATGAC 
TGTGACCTCT ATGCACATCA CAGCACGGCC AGGATAGTAA TGCCTCTGCA TTACAGCCTC
GTCTTCATCA TTGGGCTCGT GGGAAACTTA CTAGCCTTGG TCGTCATTGT TCAAAACAGG
AAAAAAATCA ACTCTACCAC CCTCTATTCA ACAAATTTGG TGATTTCTGA TATACTTTTT
ACCACCGCTT TGCCTACACG AATAGCCTAC TATGCAATGG GCTTTGACTG GAGAATCGGA
GATGCCTTGT GTAGGATAAC TGCGCTAGTG TTTTACATCA ACACATATGC AGGTGTGAAC
TTTATGACCT GCCTGAGTAT TGACCGCTTC ATTGCTGTGG TGCACCCTCT ACGCTACAAC
AAGATAAAAA GGATTGAACA TGCAAAAGGC GTGTGCATAT TTGTCTGGAT TCTAGTATTT
GCTCAGACAC TCCCACTCCT CATCAACCCT ATGTCAAAGC AGGAGGCTGA AAGGATTACA
TGCATGGAGT ATCCAAACTT TGAAGAAACT AAATCTCTTC CCTGGATTCT GCTTGGGGCA
TGTTTCATAG GATATGTACT TCCACTTATA ATCATTCTCA TCTGCTATTC TCAGATCTGC
TGCAAACTCT TCAGAACTGC CAAACAAAAC CCACTCACTG AGAAATCTGG TGTAAACAAA
AAGGCTCTCA ACACAATTAT TCTTATTATT GTTGTGTTTG TTCTCTGTTT CACACCTTAC
CATGTTGCAA TTATTCAACA TATGATTAAG AAGCTTCGTT TCTCTAATTT CCTGGAATGT
AGCCAAAGAC ATTCGTTCCA GATTTCTCTG CACTTTACAG TATGCCTGAT GAACTTCAAT
TGCTGCATGG ACCCTTTTAT CTACTTCTTT GCATGTAAAG GGTATAAGAG AAAGGTTATG
AGGATGCTGA AACGGCAAGT CAGTGTATCG ATTTCTAGTG CTGTGAAGTC AGCCCCTGAA
GAAAATTCAC GTGAAATGAC AGAAACGCAG ATGATGATAC ATTCCAAGTC TTCAAATGGA
AAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression
J. Allergy Clin. Immunol. 131 (4), 1075-1083 (2013)
Hulse KE, Norton JE, Suh L, Zhong Q, Mahdavinia M, Simon P, Kern RC, Conley DB, Chandra RK, Tan BK, Peters AT, Grammer LC 3rd, Harris KE, Carter RG, Kato A and Schleimer RP.


book

Identification of structural motifs critical for epstein-barr virus-induced molecule 2 function and homology modeling of the ligand docking site
Mol. Pharmacol. 82 (6), 1094-1103 (2012)
Zhang L, Shih AY, Yang XV, Kuei C, Wu J, Deng X, Mani NS, Mirzadegan T, Sun S, Lovenberg TW and Liu C.


book

EBI2 regulates CXCL13-mediated responses by heterodimerization with CXCR5
FASEB J. 26 (12), 4841-4854 (2012)
Barroso R, Martinez Munoz L, Barrondo S, Vega B, Holgado BL, Lucas P, Baillo A, Salles J, Rodriguez-Frade JM and Mellado M.


book

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature 491 (7422), 119-124 (2012)
Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and Cho JH.


book

Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)
J. Biol. Chem. 287 (42), 35470-35483 (2012)
Benned-Jensen T, Norn C, Laurent S, Madsen CM, Larsen HM, Arfelt KN, Wolf RM, Frimurer T, Sailer AW and Rosenkilde MM.


book

EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors
Curr Top Med Chem 11 (6), 618-628 (2011)
Norregaard K, Benned-Jensen T and Rosenkilde MM.


book

Structural motifs of importance for the constitutive activity of the orphan 7TM receptor EBI2: analysis of receptor activation in the absence of an agonist
Mol. Pharmacol. 74 (4), 1008-1021 (2008)
Benned-Jensen T and Rosenkilde MM.


book

Molecular pharmacological phenotyping of EBI2. An orphan seven-transmembrane receptor with constitutive activity
J. Biol. Chem. 281 (19), 13199-13208 (2006)
Rosenkilde MM, Benned-Jensen T, Andersen H, Holst PJ, Kledal TN, Luttichau HR, Larsen JK, Christensen JP and Schwartz TW.


book

Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors
J. Virol. 67 (4), 2209-2220 (1993)
Birkenbach M, Josefsen K, Yalamanchili R, Lenoir G and Kieff E.


 
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