||ORF Nucleotide Sequence (Length: 5250bp)
||pcDNA3.1-C-(k)DYK or customized vector
|Tag on pcDNA3.1-C-(k)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||E3 ubiquitin-protein ligase UBR1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BE873236.1, AY061886.1,
AK127478.1 and BX648400.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 15, 2005 this sequence version replaced gi:28372496.
Summary: The N-end rule pathway is one proteolytic pathway of the
ubiquitin system. The recognition component of this pathway,
encoded by this gene, binds to a destabilizing N-terminal residue
of a substrate protein and participates in the formation of a
substrate-linked multiubiquitin chain. This leads to the eventual
degradation of the substrate protein. The protein described in this
record has a RING-type zinc finger and a UBR-type zinc finger.
Mutations in this gene have been associated with Johanson-Blizzard
syndrome. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC113505.1, AY061886.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: complete on the 3' end.