The following UBR1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the UBR1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
||ORF Nucleotide Sequence (Length: 5250bp)
||pcDNA3.1+/C-(K)DYK or customized vector
|Tag on pcDNA3.1+/C-(K)DYK
||C terminal DYKDDDDK tags
|ORF Insert Method
||CloneEZ® Seamless cloning technology
||Homo sapiens (human)
||E3 ubiquitin-protein ligase UBR1
||REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from BE873236.1, AY061886.1,
AK127478.1 and BX648400.1.
This sequence is a reference standard in the RefSeqGene project.
On Dec 15, 2005 this sequence version replaced gi:28372496.
Summary: The N-end rule pathway is one proteolytic pathway of the
ubiquitin system. The recognition component of this pathway,
encoded by this gene, binds to a destabilizing N-terminal residue
of a substrate protein and participates in the formation of a
substrate-linked multiubiquitin chain. This leads to the eventual
degradation of the substrate protein. The protein described in this
record has a RING-type zinc finger and a UBR-type zinc finger.
Mutations in this gene have been associated with Johanson-Blizzard
syndrome. [provided by RefSeq, Jul 2008].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
Transcript exon combination :: BC113505.1, AY061886.1 [ECO:0000332]
RNAseq introns :: mixed/partial sample support
COMPLETENESS: complete on the 3' end.