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EN1 engrailed homeobox 1 [Homo sapiens (human)]

Gene Symbol EN1
Entrez Gene ID 2019
Full Name engrailed homeobox 1
Synonyms
General protein information
Preferred Names
homeobox protein engrailed-1
Names
homeobox protein engrailed-1
hu-En-1
engrailed homolog 1
homeobox protein en-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q14.2

Summary Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

131290

Disorder Html:





The following EN1 gene sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EN1 gene which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18410 NM_001426 Homo sapiens engrailed homeobox 1 (EN1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $319

*Business Day
**You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.


CloneID OHu18410
Accession Version NM_001426.3 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1179bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product homeobox protein engrailed-1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC012665.8. This sequence is a reference standard in the RefSeqGene project. On Feb 23, 2007 this sequence version replaced gi:7710118. Summary: Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGAAGAAC AGCAGCCGGA ACCTAAAAGT CAGCGCGACT CGGCCCTCGG CGCGGCGGCG 
GCGGCGACTC CGGGCGGCCT CAGCCTGAGC CTCAGTCCGG GCGCCAGCGG CAGCAGCGGC
AGCGGCAGCG ATGGAGACAG CGTGCCGGTG TCCCCGCAGC CTGCGCCCCC CTCGCCGCCC
GCGGCGCCTT GCCTGCCGCC CCTGGCCCAC CACCCGCACC TCCCCCCACA CCCCCCGCCC
CCGCCGCCTC AGCATCTCGC GGCGCCTGCT CACCAGCCGC AGCCAGCGGC CCAGCTGCAC
CGCACCACCA ACTTTTTCAT CGACAACATC CTGAGGCCGG ACTTCGGCTG CAAAAAGGAG
CAGCCGCCAC CGCAGCTTCT GGTGGCTGCG GCGGCCAGAG GAGGCGCAGG AGGAGGAGGC
CGGGTCGAGC GTGACAGAGG CCAGACTGCC GCAGGTAGAG ACCCTGTCCA CCCGTTGGGC
ACCCGGGCGC CAGGCGCTGC CTCGCTCCTG TGCGCCCCGG ACGCGAACTG TGGCCCACCC
GACGGCTCCC AGCCAGCCGC CGCCGGCGCG GGCGCGTCTA AAGCTGGGAA CCCGGCTGCG
GCGGCGGCGG CGGCCGCGGC GGCAGTGGCG GCGGCGGCGG CGGCCGCAGC AGCCAAGCCC
TCGGACACCG GTGGCGGCGG CAGTGGAGGC GGCGCGGGGA GCCCCGGAGC GCAGGGCACC
AAATACCCGG AGCACGGCAA CCCGGCTATC CTACTTATGG GCTCAGCCAA CGGCGGGCCC
GTGGTCAAAA CTGACTCGCA GCAGCCTCTC GTATGGCCCG CCTGGGTGTA CTGCACACGT
TATTCGGATC GTCCATCCTC CGGTCCGCGC ACCAGGAAGC TGAAGAAGAA GAAGAACGAG
AAGGAGGACA AGCGGCCGCG GACCGCGTTC ACGGCCGAGC AGCTGCAGAG ACTCAAGGCG
GAGTTCCAGG CAAACCGCTA CATCACGGAG CAGCGGCGGC AGACCCTGGC CCAGGAACTC
AGCCTCAACG AGTCCCAGAT CAAGATCTGG TTCCAGAACA AGCGCGCCAA GATCAAGAAA
GCCACAGGCA TCAAGAACGG CCTGGCGCTG CACCTCATGG CCCAGGGACT GTACAACCAC
TCCACCACCA CGGTCCAGGA CAAAGACGAG AGCGAGTAG
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeqNP_001417.3
CDS1017..2195
Misc Feature(1)897..899(+)
Misc Feature(2)1923..2102(+)
Misc Feature(3)1929..2096(+)
Misc Feature(4)1929..2096(+)
Misc Feature(5)1932..2084(+)
Misc Feature(6)2097..2192(+)
Exon (1)1..1878
Gene:EN1
Gene Synonym:
Exon (2)1879..2962
Gene:EN1
Gene Synonym:
Translation
Position Chain Variation Link
7 7 a, c dbSNP:543507125
30 30 a, c dbSNP:369695233
34 34 -, c dbSNP:570151367
63 63 a, t dbSNP:754361970
118 118 c, t dbSNP:545695228
119 119 c, g dbSNP:576107064
160 160 a, g dbSNP:557425078
174 174 c, g dbSNP:11123496
178 178 g, t dbSNP:767710382
185 185 g, t dbSNP:755541349
206 206 c, t dbSNP:13431464
245 245 a, g dbSNP:571989499
274 274 c, t dbSNP:555727573
383 383 -, t dbSNP:200885683
427 427 -, a dbSNP:70949945
427 427 a, g dbSNP:578236822
435 435 a, c dbSNP:3754856
436 436 a, c dbSNP:553650861
437 437 a, c dbSNP:535389404
440 440 a, c dbSNP:112793435
441 441 a, c dbSNP:111424175
443 443 a, c dbSNP:3754857
445 445 -, aaaaaaaaaaaaa dbSNP:765741774
445 445 -, aaaaaaaaaaaa dbSNP:754229408
457 457 -, ac dbSNP:760924950
457 457 a, c dbSNP:4989649
458 458 -, c, cc dbSNP:148664471
464 464 g, t dbSNP:567898845
481 481 g, t dbSNP:549581714
486 486 c, t dbSNP:537120804
491 491 a, c dbSNP:545062257
515 515 a, g dbSNP:189421997
523 523 a, g dbSNP:551623463
531 531 a, g dbSNP:533357702
611 611 c, g dbSNP:766615217
619 619 -, tt dbSNP:757423738
689 689 -, cttc dbSNP:778971874
712 712 a, c dbSNP:559513312
738 738 a, g dbSNP:111622005
773 773 a, g dbSNP:763099106
829 829 c, t dbSNP:548092701
859 859 a, g dbSNP:371365220
886 886 c, g dbSNP:773639330
994 994 c, t dbSNP:777820484
996 996 -, gggg dbSNP:771235468
1003 1003 a, c dbSNP:756383770
1005 1005 -, ggg dbSNP:763239181
1005 1005 g, t dbSNP:752754785
1012 1012 a, c dbSNP:562235225
1059 1059 c, g dbSNP:767769043
1080 1080 -, gcg dbSNP:773741503
1099 1099 c, g dbSNP:754948981
1131 1131 -, agcggcagc dbSNP:770234223
1138 1138 a, g dbSNP:751592150
1141 1141 g, t dbSNP:766166419
1182 1182 c, g dbSNP:544035952
1197 1197 a, g dbSNP:773079874
1199 1199 a, g dbSNP:764736993
1229 1229 c, t dbSNP:761460730
1235 1235 c, t dbSNP:776115617
1236 1236 a, c dbSNP:768214328
1240 1240 c, t dbSNP:760018133
1242 1242 a, c dbSNP:185308608
1243 1243 a, c dbSNP:771503290
1244 1244 a, g dbSNP:749569923
1247 1247 c, t dbSNP:778201908
1248 1248 c, t dbSNP:770132484
1259 1259 a, g dbSNP:748435259
1260 1260 c, t dbSNP:781395132
1261 1261 c, t dbSNP:372072112
1262 1262 g, t dbSNP:751719107
1274 1274 c, g dbSNP:779805579
1277 1277 g, t dbSNP:368360681
1280 1280 g, t dbSNP:750120580
1287 1287 c, t dbSNP:765148759
1290 1290 -, ctcacc dbSNP:748678232
1290 1290 c, g dbSNP:761442363
1293 1293 a, c dbSNP:753539334
1294 1294 a, c dbSNP:763567141
1295 1295 g, t dbSNP:564201323
1312 1312 c, t dbSNP:775091322
1313 1313 a, g dbSNP:771286294
1324 1324 a, c dbSNP:763582028
1325 1325 a, c dbSNP:773433067
1335 1335 a, g dbSNP:770328312
1342 1342 a, g dbSNP:748345272
1353 1353 c, t dbSNP:781523993
1362 1362 c, g dbSNP:769021668
1372 1372 a, c dbSNP:747001812
1379 1379 a, g dbSNP:780184340
1383 1383 c, t dbSNP:374171748
1396 1396 c, t dbSNP:750434634
1410 1410 c, g dbSNP:778551047
1421 1421 a, c dbSNP:145197387
1430 1430 a, t dbSNP:753667886
1435 1435 c, g dbSNP:763690981
1439 1439 g, t dbSNP:760336724
1440 1440 a, g dbSNP:752141919
1446 1446 a, c dbSNP:767109302
1449 1449 a, g dbSNP:763343479
1461 1461 a, g dbSNP:372175487
1466 1466 c, g dbSNP:765876115
1467 1467 g, t dbSNP:545629104
1470 1470 g, t dbSNP:777146825
1471 1471 a, g dbSNP:768930034
1476 1476 c, g dbSNP:747324353
1485 1485 c, t dbSNP:367875317
1488 1488 a, c dbSNP:772243299
1491 1491 c, t dbSNP:745761717
1497 1497 a, t dbSNP:778785708
1499 1499 a, c dbSNP:757212129
1501 1501 a, g, t dbSNP:777551857
1503 1503 a, g dbSNP:755706656
1505 1505 a, g, t dbSNP:79126103
1512 1512 a, g dbSNP:754466609
1513 1513 c, t dbSNP:751053539
1514 1514 c, t dbSNP:370114691
1516 1516 a, c dbSNP:762413106
1523 1523 c, g, t dbSNP:764613827
1524 1524 a, c dbSNP:376499328
1526 1526 a, g dbSNP:775823513
1528 1528 a, g dbSNP:541687588
1529 1529 c, t dbSNP:375477142
1530 1530 g, t dbSNP:370998698
1531 1531 c, t dbSNP:770790810
1535 1535 g, t dbSNP:749279186
1544 1544 a, c dbSNP:777519101
1555 1555 c, g dbSNP:755974267
1557 1557 a, g dbSNP:555899233
1568 1568 g, t dbSNP:747922948
1581 1581 c, g dbSNP:780848344
1583 1583 a, c dbSNP:538034026
1585 1585 c, t dbSNP:751045731
1588 1588 g, t dbSNP:766052837
1619 1619 -, ggcggcggcggc dbSNP:769035512
1628 1628 -, ggc dbSNP:781675263
1631 1631 c, g dbSNP:570600650
1637 1637 c, g dbSNP:77704181
1648 1648 c, t dbSNP:757827789
1653 1653 -, g dbSNP:779405956
1658 1658 c, g dbSNP:754447211
1660 1660 -, ggc dbSNP:750030729
1677 1677 a, t dbSNP:764334936
1681 1681 a, c dbSNP:761061103
1690 1690 a, g dbSNP:753029142
1691 1691 c, t dbSNP:767724585
1694 1694 c, g dbSNP:759684351
1695 1695 g, t dbSNP:774412937
1698 1698 a, g dbSNP:771044490
1710 1710 g, t dbSNP:762844167
1711 1711 c, t dbSNP:773090179
1712 1712 a, g dbSNP:769637221
1715 1715 a, g dbSNP:558210525
1717 1717 g, t dbSNP:780853902
1719 1719 c, t dbSNP:768348284
1727 1727 g, t dbSNP:377373176
1730 1730 c, g dbSNP:779690019
1733 1733 a, c dbSNP:758024077
1735 1735 c, g, t dbSNP:778294120
1744 1744 c, t dbSNP:368224377
1749 1749 c, t dbSNP:765546477
1751 1751 c, g dbSNP:753043668
1752 1752 a, g dbSNP:767839861
1758 1758 a, c, g dbSNP:374023978
1760 1760 a, g dbSNP:766615468
1761 1761 g, t dbSNP:201974100
1764 1764 a, g dbSNP:773292738
1773 1773 a, g dbSNP:769705589
1774 1774 g, t dbSNP:761721630
1782 1782 a, g dbSNP:776472651
1786 1786 a, t dbSNP:78210121
1787 1787 c, t dbSNP:377545740
1788 1788 g, t dbSNP:779812846
1790 1790 a, c dbSNP:373469424
1807 1807 a, c dbSNP:745319108
1814 1814 g, t dbSNP:368737948
1816 1816 a, t dbSNP:756643647
1824 1824 c, t dbSNP:753204936
1826 1826 c, t dbSNP:781585814
1827 1827 c, g dbSNP:755293277
1853 1853 a, t dbSNP:751939892
1862 1862 c, g dbSNP:566042334
1874 1874 c, t dbSNP:572958274
1877 1877 a, c, t dbSNP:765289549
1883 1883 a, g dbSNP:760696157
1896 1896 c, g dbSNP:375974616
1910 1910 -, gaa dbSNP:751701618
1913 1913 c, g, t dbSNP:369801550
1916 1916 a, g dbSNP:767480596
1928 1928 a, g dbSNP:150977527
1931 1931 a, g dbSNP:758612305
1940 1940 c, t dbSNP:139728151
1949 1949 g, t dbSNP:770636668
1958 1958 a, g dbSNP:748684153
1966 1966 a, g dbSNP:145326362
1972 1972 a, g dbSNP:769146878
1979 1979 a, g dbSNP:370594131
1985 1985 a, g dbSNP:780372731
2003 2003 a, g dbSNP:758801707
2021 2021 c, g dbSNP:367986532
2024 2024 a, g dbSNP:549340318
2027 2027 c, g, t dbSNP:374991047
2044 2044 a, g dbSNP:778069643
2045 2045 c, t dbSNP:76483309
2062 2062 a, t dbSNP:752734087
2075 2075 c, t dbSNP:767392804
2078 2078 a, g dbSNP:370237510
2079 2079 a, c dbSNP:200272085
2082 2082 g, t dbSNP:751378198
2084 2084 c, t dbSNP:765877485
2105 2105 a, c dbSNP:201019085
2106 2106 a, c dbSNP:772694757
2108 2108 c, g dbSNP:769343130
2109 2109 a, g dbSNP:765343713
2110 2110 a, g dbSNP:745951039
2114 2114 c, t dbSNP:139806570
2116 2116 g, t dbSNP:746164063
2124 2124 c, t dbSNP:72955069
2132 2132 c, t dbSNP:771057192
2133 2133 a, c dbSNP:749585707
2151 2151 a, c dbSNP:777982562
2153 2153 a, c, t dbSNP:752842693
2171 2171 c, t dbSNP:781213770
2175 2175 g, t dbSNP:754945309
2176 2176 a, g dbSNP:751304937
2183 2183 c, g dbSNP:766252884
2184 2184 a, g dbSNP:200716631
2189 2189 c, t dbSNP:750116642
2192 2192 a, g dbSNP:764899744
2196 2196 a, c dbSNP:564888659
2198 2198 g, t dbSNP:540240962
2204 2204 a, g dbSNP:772395203
2205 2205 g, t dbSNP:760157459
2209 2209 g, t dbSNP:371520426
2210 2210 c, g, t dbSNP:572940930
2213 2213 a, c dbSNP:749494873
2216 2216 g, t dbSNP:778104466
2218 2218 c, t dbSNP:368544860
2224 2224 a, c dbSNP:748169520
2229 2229 c, g dbSNP:781397520
2231 2231 c, g dbSNP:754857274
2232 2232 a, g dbSNP:747015385
2235 2235 a, g dbSNP:779682738
2237 2237 c, t dbSNP:758172081
2238 2238 a, c, g dbSNP:764811921
2240 2240 c, t dbSNP:756909659
2241 2241 g, t dbSNP:753343410
2245 2245 c, t dbSNP:763721244
2246 2246 a, c dbSNP:759941651
2254 2254 a, c, g dbSNP:189344595
2264 2264 a, t dbSNP:373562729
2268 2268 a, g dbSNP:148242115
2325 2325 a, g dbSNP:372423682
2347 2347 a, g dbSNP:557546742
2353 2353 g, t dbSNP:61734176
2364 2364 c, g dbSNP:571324706
2409 2409 a, t dbSNP:552966804
2419 2419 g, t dbSNP:536277496
2423 2423 c, g dbSNP:567318868
2433 2433 g, t dbSNP:549281143
2475 2475 a, c dbSNP:185363430
2536 2536 a, t dbSNP:180695746
2567 2567 c, t dbSNP:551554258
2570 2570 c, t dbSNP:751193119
2578 2578 -, att dbSNP:780016116
2582 2582 g, t dbSNP:35383982
2584 2584 a, g dbSNP:189453257
2602 2602 -, ataattatt dbSNP:559687383
2628 2628 a, g dbSNP:565028463
2640 2640 -, a dbSNP:71805137
2641 2641 -, a dbSNP:61275212
2641 2641 a, c dbSNP:111662957
2684 2684 a, g dbSNP:184945714
2692 2692 g, t dbSNP:373008661
2706 2706 c, g dbSNP:766205069
2712 2712 g, t dbSNP:143139406
2722 2722 a, g dbSNP:762832533
2758 2758 a, t dbSNP:560982281
2761 2761 c, t dbSNP:763166024
2826 2826 a, g dbSNP:542918453
2832 2832 c, t dbSNP:575916312
2920 2920 c, t dbSNP:55990007

Target ORF information:

RefSeq Version NM_001426
Organism Homo sapiens (human)
Definition Homo sapiens engrailed homeobox 1 (EN1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001426

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGGAAGAAC AGCAGCCGGA ACCTAAAAGT CAGCGCGACT CGGCCCTCGG CGCGGCGGCG 
GCGGCGACTC CGGGCGGCCT CAGCCTGAGC CTCAGTCCGG GCGCCAGCGG CAGCAGCGGC
AGCGGCAGCG ATGGAGACAG CGTGCCGGTG TCCCCGCAGC CTGCGCCCCC CTCGCCGCCC
GCGGCGCCTT GCCTGCCGCC CCTGGCCCAC CACCCGCACC TCCCCCCACA CCCCCCGCCC
CCGCCGCCTC AGCATCTCGC GGCGCCTGCT CACCAGCCGC AGCCAGCGGC CCAGCTGCAC
CGCACCACCA ACTTTTTCAT CGACAACATC CTGAGGCCGG ACTTCGGCTG CAAAAAGGAG
CAGCCGCCAC CGCAGCTTCT GGTGGCTGCG GCGGCCAGAG GAGGCGCAGG AGGAGGAGGC
CGGGTCGAGC GTGACAGAGG CCAGACTGCC GCAGGTAGAG ACCCTGTCCA CCCGTTGGGC
ACCCGGGCGC CAGGCGCTGC CTCGCTCCTG TGCGCCCCGG ACGCGAACTG TGGCCCACCC
GACGGCTCCC AGCCAGCCGC CGCCGGCGCG GGCGCGTCTA AAGCTGGGAA CCCGGCTGCG
GCGGCGGCGG CGGCCGCGGC GGCAGTGGCG GCGGCGGCGG CGGCCGCAGC AGCCAAGCCC
TCGGACACCG GTGGCGGCGG CAGTGGAGGC GGCGCGGGGA GCCCCGGAGC GCAGGGCACC
AAATACCCGG AGCACGGCAA CCCGGCTATC CTACTTATGG GCTCAGCCAA CGGCGGGCCC
GTGGTCAAAA CTGACTCGCA GCAGCCTCTC GTATGGCCCG CCTGGGTGTA CTGCACACGT
TATTCGGATC GTCCATCCTC CGGTCCGCGC ACCAGGAAGC TGAAGAAGAA GAAGAACGAG
AAGGAGGACA AGCGGCCGCG GACCGCGTTC ACGGCCGAGC AGCTGCAGAG ACTCAAGGCG
GAGTTCCAGG CAAACCGCTA CATCACGGAG CAGCGGCGGC AGACCCTGGC CCAGGAACTC
AGCCTCAACG AGTCCCAGAT CAAGATCTGG TTCCAGAACA AGCGCGCCAA GATCAAGAAA
GCCACAGGCA TCAAGAACGG CCTGGCGCTG CACCTCATGG CCCAGGGACT GTACAACCAC
TCCACCACCA CGGTCCAGGA CAAAGACGAG AGCGAGTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.